Epithelium in Medical News

Mayo researchers find potential links between breast density and breast cancer risk

... the biopsies to determine the percentage of epithelium tissue, stroma, and fat content in each. The epithelium is primarily composed of milk glands and ductal ... found that areas of density contained much more epithelium (6 percent) and stroma (64 percent) and much less ...

Scientists discover who is likely to get dry eye syndrome after LASIK surgery

... procedures differ. In LASIK a flap of corneal epithelium is cut and lifted to allow the underlying stroma ... is placed down on the eye. In PRK the corneal epithelium is mechanically removed to allow laser shaping of the stroma. The epithelium then grows back over several days. LASIK and PRK ...

Diet and cancer prevention: New evidence for the protective effects of fruits and veggies

... oxidants and is typically reduced in Barretts epithelium compared to normal esophageal epithelium. ... are selectively delivered to the bladder epithelium through urine excretion. Using a rat model of ... than those in plasma, indicating that the bladder epithelium is most exposed to orally dosed ITCs. Indeed, ...

Stemedica Discovers Significant Breakthrough in the Use of Stem Cells and Stem Cell Factors for the Treatment of Retinal Degeneration

... are hereditary conditions in which abnormalities of the retinal pigmented epithelium (RPE) within the eye lead to progressive vision loss. According to one of ... types of human stem cells (hSC) were used in the study - retinal pigment epithelium (RPE), neural (NSC) and cilliary body (CB) - all obtained from human donor ...

Novel gene predicts local recurrence in early onset breast cancer

... ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the corresponding invasive cancer from the same patient. They found ... in the glands but was lost or downregulated in the transition from normal epithelium to DCIS in 10 of the 14 patient samples. ...

Novel gene predicts local recurrence in early-onset breast cancer

... ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the corresponding invasive cancer from the same patient. They found ... in the glands but was lost or downregulated in the transition from normal epithelium to DCIS in 10 of the 14 patient samples. ...

Research hightlights, AAO-SOE Joint Meeting, Nov. 9 sessions

... The Rajan-Mohan study involved 60 eyes total: in 40 eyes (group A) the epithelium was abraded, meaning the thin top layer of cells was scraped, and in 20 eyes (group B) the epithelium was left intact prior to treatment. Patients received follow-up exams at ...

Quintet of proteins forms new, early-warning blood test before heart attack strikes

... extracellular matrix protein, and so-called long palate, lung and nasal epithelium carcinoma-associated protein 1. All of the proteins are believed to ... secreted in a rare inflammatory disease; and long palate, lung and nasal epithelium carcinoma-associated protein 1, thought to play a role in innate immunity. ...

JCI online early table of contents: Nov. 6, 2008

... of the cells, identified as CD34+, to mice with a damaged esophageal epithelium reconstituted the lining of the esophagus. As the esophagus is often ... these data will provide new insight into the response of the esophageal epithelium following injury and initiate studies to determine whether dysregulation ...

Measle's Spread Doesn't Depend on Airways

... said. "It has long been assumed that measles virus infects the airway epithelium [surface lining cells] before infecting immune cells," senior author ... the airway epithelium. Also, the virus did not cross the respiratory epithelium and shed itself on its way out of the lungs. The measles virus can be ...

Mouth may tell the tale of lung damage caused by smoking

... The team examined the oral and lung lining tissue - called the epithelium - in 125 chronic smokers enrolled in a large, prospective lung cancer ... an increasing compendium of biomarkers to confirm the reliability of oral epithelium not only in lung cancer chemoprevention but also in therapeutic settings" ...

Genetic Breakthrough Spells Hope for Lung Fibrosis Patients

... the tissue that covers the surface of the lung's air sacs, were rapidly dying. "That could mean that drugs that are used to protect the epithelium in other illnesses, such as cancer, might help IPF patients survive an exacerbation. If we can keep them alive, there's a chance they could get a ...

A novel marker of colorectal carcinoma

... in 40% normal colorectal tissues by immunohistochemistry. There were significant differences between colorectal adenocarcinoma and normal control epithelium (P The result indicated that testing TSPAN1 expression in tissues would be a useful tool to evaluate the prognosis of patients with colorectal ...

Quark Pharmaceuticals Presents Data on Synthetic siRNAs for Prevention of Ocular and Inner Ear Sensory Cell Damage

... Dr. Feinstein also reported results demonstrating effective delivery of synthetic siRNAs to the inner ear, which resulted in protection of hearing epithelium from ototoxic and noise-induced damage. These studies were performed in collaboration with Prof. Jayakrishna Ambati, University of Kentucky College ...

Sirion Therapeutics Announces Positive Results From Interim Analysis of Phase II Trial and Receives FDA Fast Track Designation for Fenretinide

... About Geographic Atrophy Geographic atrophy (GA) is characterized by confluent areas of cell death in photoreceptors and retinal pigment epithelium (RPE). GA is bilateral in more than half of afflicted patients and largely the cause of legal blindness from age-related macular degeneration. The ...

QLT announces completion of Phase Ia safety trial of its synthetic retinoid product

... for 11-cis-retinal which is an essential component of the retinoid-rhodopsin cycle and visual function. Two different gene mutations (Retinal pigment epithelium protein 65 (RPE65) and lecithin-retinol acyltransferase (LRAT) result in an inadequate production of 11-cis-retinal and occur in approximately 10% of ...

A potential molecular target for biotherapy esophageal squamous cell carcinomas

... China detected the expression of E-cadherin and N-cadherin in 62 cases of normal esophageal epithelium, 31 cases of adjacent atypical hyperplasia epithelium and 62 cases of esophageal squamous cell carcinoma.Their study will be published on February 14, 2009 in the World Journal of Gastroenterology . ...

Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Research Awards

... of Epithelial Mesenchymal Transition (EMT) to Pulmonary Fibrosis." EMT is induced by transforming growth factor beta signaling in the alveolar epithelium and plays a pivotal role in determining whether the response to tissue injury leads to normal repair or lung fibrosis. Dr. Tanjore's study seeks to ...

Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds

... renewed. These cells then grew into esophageal lining tissue in a three-dimensional culture apparatus. "These tissue culture cells formed a mature epithelium sitting on top of the matrix," says Rustgi. "The whole construct is a form of tissue engineering." The investigators then tested their pieces of ...

Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery

... pathophysiology of inherited metabolic genetic disorders. COMMON AND CANCER TYPE-SPECIFIC LOSS-OF-HETEROZYGOSITY (LOH) IN THE TUMOR STROMA AND epithelium OF 3 CARCINOMA TYPES ASSOCIATED WITH CLINICAL OUTCOME A team of researchers led by Charis Eng, M.D., Ph.D., Chair and Director of Cleveland ...

Wound Management Technologies, Inc. Announces FDA Clearance of 510k

... prepare the granulation tissue for epidermal migration by maintaining a uniform, low density granulation tissue more easily modified by the migrating epithelium thus improving the rate of epithelialization of a chronic wound and reducing scarring. The product has been cleared and is indicated for topical ...

The miseries of allergies just may help prevent some cancers, study finds

... However, both glia (which participate in signal transmission in the nervous system, and whose stem cells are exposed to chemicals from the nasal epithelium via the olfactory tract), and pancreatic cells (which can be exposed to intestinal contents if the intervening sphincter malfunctions) "can sometimes ...

Ellex Announces Six-Month Results on Retina Regeneration Therapy

... this is the mildest laser therapy to be tested in a clinical setting which has demonstrated a selective and therapeutic effect on the retinal pigment epithelium (RPE)." Ellex 2RT uses a custom designed, Q-switched green YAG laser that produces very precise, three-nanosecond pulses of 532nm light energy. ...

Pneumatosis cystoids intestinalis after fluorouracil chemotherapy

... Fluorouracil is most commonly used chemotherapeutic agent in clinical oncology treatment. The cytotoxic effect of fluorouracil on intestinal epithelium can play a role in the pathogenesis of PCI. Severe erosion and ulceration in the ileum after fluorouracil chemotherapy is known. This mechanism is ...

Protein 'switch' suppresses skin cancer development

... in IKKα expression promotes the development of chemically induced papillomas and carcinomas, which are benign and malignant tumors of the epithelium respectively. Epithelial cells make up the outer layers of skin and the inner linings of many organs, including the lungs and the gastrointestinal, ...

JCI table of contents: June 20, 2008

... identify this protein. TITLE: Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed AUTHOR CONTACT: Roberto Cattaneo Mayo Clinic, Rochester, Minnesota, USA. Phone: (507) 538-1188; Fax: (507) 266-2122; E-mail: ...

7 outstanding young gastroenterologists receive AGA Foundation 2008 Research Scholars Award

... Migration: Implications in Colon Cancer Metastases University of California, San Diego Yuko Mori-Akiyama, MD The Role of SOX9 in the Intestinal epithelium and in Colorectal Cancer Progression The University of Texas M. D. Anderson Cancer Center Richard J. Saad, MD (Designated RSA related to ...

Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial

... and other imaging techniques are important, for lung cancer, it may be vital to examine actual tissue to see what the markers are doing in the actual epithelium of the lung so as to best understand if an individual has a higher or lower risk of developing lung cancer." Celebrex is in a class of medications ...

Combined physical and genetic map finds cancer's 'ignition key'

... is strongly associated with smoking, which studies show is a factor in half of cases The research model can be used to study other cancers of the epithelium -- the tissue that lines the surfaces and cavities of the body's organs. Epithelial cancers, or carcinomas, make up 80 percent of all cancers. The ...

Unexpected role: EGFR protects cancer cells from starving

... that it may be necessary to knock down both EGFR's glucose-related role and its growth-inducing kinase activity in order to attack cancers of the epithelium - tissue that lines the surfaces and cavities of the body's organs. Epithelial cancers, or carcinomas, make up 80 percent of all cancers. EGFR ...

Calorie restriction inhibits, obesity fuels development of epithelial cancers

... of the Department of Carcinogenesis and of M.D. Anderson's Science Park - Research Division in Smithville, Texas. Epithelial cancers arise in the epithelium - the tissue that lines the surfaces and cavities of the body's organs. They comprise 80 percent of all cancers. "Calorie restriction and obesity ...

Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can

... of the Department of Carcinogenesis and of M.D. Anderson's Science Park - Research Division in Smithville, Texas. Epithelial cancers arise in the epithelium - the tissue that lines the surfaces and cavities of the body's organs. They comprise 80 percent of all cancers. "Calorie restriction and obesity ...

Calorie restriction limits and obesity fuels development of epithelial cancers

... of the Department of Carcinogenesis and of M.D. Anderson's Science Park - Research Division in Smithville, Texas. Epithelial cancers arise in the epithelium - the tissue that lines the surfaces and cavities of the body's organs. They comprise 80 percent of all cancers. "Calorie restriction and obesity ...

Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion

... activity reduced the cancer cell movement and invasion through the basement membrane (a thin, delicate layer of connective tissue underlying the epithelium of many organs). The researchers now plan to study the effects of macrophages and inflammation and NF-kappaB inhibiting treatments in vivo, in a ...

'Innocent bystanders' can be the cause of tumor development

... neighboring epithelial cells by signals mediated by the growth factor TGF, but this signaling is reduced in the studied tumors. As a consequence, the epithelium undergoes accelerated proliferation. The same intercellular signaling defect was also noted in the Peutz-Jeghers polyposis caused by hereditary LKB1 ...

Rockefeller University's Center for Clinical and Translational Science funds pilot studies

... instructor in clinical investigation, to determine if significant weight loss achieved by dieting decreases chronic inflammation in the colorectal epithelium and reduces fecal calprotectin levels. Alexander Ploss, postdoctoral associate in Charles Rices Laboratory of Virology and Infectious Disease, to ...

Scripps research scientists discover chemical triggers for aggression in mice

... brain. The first, called the vomeronasal organ (VNO), is located above the roof of the mouth in the nasal cavity. The second is the main olfactory epithelium (MOE), found under the eyeball at the top back portion of the nasal cavity. Which of these two organs is the main starting point for the ...

Aerosol launches immune response in lungs to wipe out lethal infections

... believe the entire defense against invaders is accomplished by local cells in the lung's lining, called the epithelium. Their research shows the epithelium floods its lining fluid with anti-microbial polypeptides in response to ALIIS inhalation. These natural antibiotics are virtually lying in wait for ...

JCI table of contents: Nov. 15, 2007

... with bowel injuries. TITLE: Milk fat globuleEGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium AUTHOR CONTACT: Xiao-Di Tan Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Phone: (773) 755-6380; Fax: (773) ...

JCI table of contents: Nov. 8, 2007

... cause of oral thrush, might be controlled in the mouth. In the study, immune cells known as PMNs were shown to protect oral reconstituted human epithelium from invasion by C. albicans and from cell injury. However, PMN-mediated protection was not provided directly, rather it was provided indirectly by ...