domain

A new recovery for heart attacks

...nd makes it less likely to be degraded. The other domain of HIF was known to be responsible for the actual activation of genes that helped cells adapt to low oxygen, however the molecular switch for that has to date been unknown.Dr Whitelaw and colleagues found under low-oxygen levels, HIF loses a hydroxyl...

Early rising from sleep can run in families

... phosphorylation site in the casein kinase I (CKI) domain of the gene. The behavior pattern is also known as first human mendelian circadian rhythm variant. The circadian clock is a cellular mechanism that sets various rhythmic activities inside the organisms. Genetic research had unveiled many of the com...

Children With Sinusitis Lead A Better Life After Surgery

...motional distress, and activity limitations. The domain scores as well as the total scores for all children improved significantly after surgery. Likewise, scores for overall quality of life also improved after surgery. This report confirms that caregivers report an improvement in quality of life in the...

Race Based Genome Project Launched By Mexico

...l release newly mined genomic data into the public domain as fast a technology allows, but Jimenez is quick to point out that the measure of the project’s success is not the science, but rather the medicines that come out of it. The close economic and political ties between the two nations lend a degree of ...

Synthetic protein found to relieve arthritis symptoms in animal model

... idea that the protein, called pre-ligand assembly domain protein or PLAD, might play a role in easing or comforting pain characteristic of rheumatoid arthritis is an incidental discovery. The original work was carried out on a very rare autoimmune disease called autoimmune lymphoproliferative syndrome (ALP...

India to maintain Public domain Registry database of clinical trials conducted in India.

...inical trials which would be available in a public domain which will provide transparent results and information for patients.// The detail of the new registry database was announced by Drug Controller General of India Ashwani Kumar. He announced the details of the registry during a two day workshop on 'B...

Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis

...nine substitution in a protein-protein interaction domain known as a PDZ domain. Sipa1 is a mitogen inducidble gene that encodes a GTPase activating protein (GAP) that negatively regulates RAP1 and RAP2 GTPases. Human SIPA1 has recently been found to interact with the water channel aquaporin 2 (AQP2), by ...

Valentine Day Becoming Popular In India

...owly percolating from the urban strongholds to the domain of smaller towns where the media has served to popularize and market once alien concepts. Source: IANS <br...

Disney’s New Attraction Showcases the Discoveries of the Himalayas Expeditio

...ysical thrills of a high-speed journey through the domain of the world's tallest mountain," said Dr. Russ Mittermeier, president of CI. "We are thrilled with Disney's dedication to conservation through their scientific and financial contributions to the expedition." Even though they faced rugged terrain and...

'Expedition Everest' Finds New Species

...ysical thrills of a high-speed journey through the domain of the world's tallest mountain, said Dr. Russ Mittermeier, president of CI. We are thrilled with Disney's dedication to conservation through their scientific and financial contributions to the expedition. Even though they faced rugged terrain and fr...

A Detail Analysis of Head and Neck Cancer

... initiated. Inside the LARG segment there is a PDZ domain which when introduced into the tumor cell, it binds up all available CD44 and EGFR, leaving them unavailable to initiate the deadly twin molecular pathways. In the future, LARG could be utilized as a drug target leading to a new therapeutic strategy....

Elders Too Are Keen To Chat On Internet On Par With Youngsters

... to be using instant messaging, which was once the domain of the young and diehard Internet users. The report says, "Senior netizens are becoming more comfortable adapting to the Internet, whether retired, salaried or entrepreneurs. These are successful senior Indians enjoying living life to the full and ...

Soccer Fans Seek Comfort From Alcohol

...udy was the discovery that credit in one masculine domain often spills over to resist pressure to engage in other masculine behaviors. For instance, ‘good sportsmen said that they were able to resist pressure to drink or drink excessively,’ according to de Visser. ‘The flip side of this is that men who fe...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

...ains to allow p53 to bind DNA as a dimer. The core domain is what's binding the DNA, but within the dimer, the two cores have to be in the proper orientation to bind DNA. "So we decided that we needed to somehow lock the protein into a conformation that's compatible with the dimer binding to DNA. We used ...

Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego

...we describe rearrangements of genomic elements and domain reshuffling in multi-domain proteins," said Pevzner. "We believe that they can also be used to recognize and describe the movements of micro-domains in protein structures, and that will be the focus of the Computer Science and Engineering department'...

Cell Behavior Better Understood with Nano Probe

...ying proteins, to sample biomolecules from a small domain and do it dynamically, thus enabling biochemical i...pillary forces to confine fluid within a nanoscale domain of the probe inlet (enabling natural separation of liquid and gaseous environments) and then used th...

"Tarakeswar Alu"- buy potatoes online !!

... MCX is led by an expert management team with deep domain knowledge of the commodities futures market. Source:IANS...

Luxury Spas Ride Boom in Wellness Industry in Poland

...sm, they have been revamped and are now mostly the domain of senior citizens - not only from Poland. Last year the country's state tourist board launched a media blitz in Western Europe featuring a buxom young nurse. Designed to attract attention to Poland's sanatoria, she stood against a backdrop of l...

Face – off! This ain’t no Sci-i

...vastating and more research should go into the new domain of full face transplants. Prof. Butler claims that the 60% of the public are with him who recognize his work which spans the whole of last decade. He hopes to raise the ￡20,000 expected to cover each operation instead of expecting the NHS to be bu...

Enzyme to Boost Effect of Tumor Vaccine

...ltered the enzyme so that it targeted a particular domain on the plasma membrane of the cell where signaling occurred, making the action of Akt1 more specific. They then eliminated a small part of the Akt1 molecule that had a negative or inhibitory effect. 'It turned out that the altered molecule was much m...

Molecular ‘On/Off Switch’ Controls Immune Defenses Against Viruss

...ite that controls the actions of each protein. The domain is the key site that regulates the ability of RIG-I to bind to its signaling partners, including LGP2, acting as a switch for controlling immune response, Dr. Gale said. “Hepatitis C and others viruses hijack this signaling pathway to stop immune d...

New Mechanism for Nutrient Uptake Discovered

...ant ammonium transporters are controlled. A switch domain in the protein facilitates rapid and sensitive control of ammonium transport to preclude over-accumulation of an ion that is beneficial at low concentrations, but potentially toxic at high concentrations. This is a major advance in the field of plant...

Pregnant Women Must Eat Fish-experts Warn

...quence of causing harm in a specific developmental domain - verbal development - where protection was originlly intended. "We recorded no evidence to lend support to the warnings of the US advisory that pregnant women should limit their seafood consumption. "In contrast, we noted that children of mother...

Key Science Web Sites Buried in Information Avalanche

...se appear in the top 30 search results for generic domain keywords. In addition, a number of institutions, people and other key organisations and resources failed to appear in the top 30 search results. The role search engines play can vary according to topic. In the HIV/AIDS and the Internet and society ...

Concurrent Health Problems Take Heavy Toll on Seniors

...in the cardiovascular system). Functioning in each domain can range from high-functioning, even protective, zones (e.g., high levels of high-density-lipoprotein cholesterol) to severe dysfunction (as in end-stage disease). The research presented in the special section was inspired and guided by issues rai...

Landmark Study Prompts Rethink of Genetic Code

...lix ladder. The data is being placed in the public domain to help medical and other research....

GAB2-A New Alzheimers Gene Identified

...eve that deposition of this data set in the public domain will open a new era in Alzheimer research. When a scientist suspects a particular gene or pathway maybe implicated in Alzheimers disease, they will use these data to see if there is genetic evidence supporting their idea. Reviewing these data in an h...

Protein Targets for Carcinogenesis

...dependent reaction is the presence of a Ub-binding domain (UBD) in the protein that is able to recognize Ub. This type of protein is of utmost importance for the cell because it can distinguish between ubiquitinated and non-ubiquitinated proteins, explains Dr. Daniela Hoeller, the responsible scientist. UBD...

Indian Government Asks the Supreme Court to Keep Off Environmental Issues

...es through submissions on aspects which are in the domain of forestry science." Such a situation may not only lead to errors of judgment but also result in accentuating poverty and social unrest, it said. The Bench, set up to prevent the depletion of forest wealth, has served its purpose. The country ha...

The Importance of Junk DNA

...equence is critical to formation of the functional domain boundaries for this locus. Functional domains ar...ary to activate or repress a particular gene. Each domain is an entity unto itself that is defined, or bracketed, by a boundary, much as words in a sentence a...

New Insights into Prion Propogation

...he researchers showed, by fusing the prion-forming domain of the fungal protein to a reporter protein, that the fungal prion could propagate in yeast. "We showed that the fusion formed a prion in yeast and it was infectious," Liebman said. "It's the first time a prion from one organism has been propagated...

Scientists Identify Antibodies That Block Human and Animal SARS Viruses

...e glycoprotein that is called the receptor binding domain (RBD). One of the antibodies, called S230.15, was found in the blood of a patient who had been infected with SARS and later recovered, while the second antibody, m396, was taken from a library of human antibodies the researchers developed from the bl...