crystallography in Medical News

New Jersey-Based Biotech Start-Up Nexomics Biosciences Gets Off the Ground

... scale protein production, Nuclear Magnetic Resonance (NMR), and X-ray crystallography for use in drug discovery efforts. Nexomics Biosciences has signed a ... scale protein production, Nuclear Magnetic Resonance (NMR), and X-ray crystallography for use in drug discovery efforts. The company provides customers with ...

Double binding sites on tumor target may provide future combination therapy

... doorway, keeping hormones from binding and signaling tumor growth. X-ray crystallography provided a snapshot of the interaction between Erbitux and the ... in Cancer Cell, Ferguson and Merck colleagues found again using X-ray crystallography -- that matuzumab binds in a different place from Erbitux. Their binding ...

First look at an enzyme target for antibacterial and cancer drugs

... Advanced Light Source (ALS), Berger and Dong obtained high resolution, 3-D crystallography images of the DNA binding and cleavage core of a topo II enzyme taken from ... multiple-wavelength anomalous diffraction (MAD) and monochromatic protein crystallography capabilities. The high brightness of the x-ray beams and the ...

Potent peptides inhibit HIV entry into cells

... the structure of these peptides bound to the target protein using x-ray crystallography at the NSLS. In this technique, researchers analyze how an extremely ... of future inhibitors," said paper co-author Annie Heroux, a biologist and crystallography specialist at Brookhaven Lab. This structure-assisted design led to the ...

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

... an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its portfolio of next-generation therapeutic candidates with the potential to address ...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

... BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for ...

BioCryst to Present at the 11th Annual BIO CEO & Investor Conference

... . The presentation will be archived for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

BioCryst Pharmaceuticals to Announce Fourth Quarter and Year End 2008 Financial Results on February 6, 2009

... Web cast will be archived and available for replay for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

E. coli persists against antibiotics through HipA-induced dormancy

... the molecular details of HipA's role in multidrug tolerance and HipB's role keeping HipA under wraps in a series of experiments: Using X-ray crystallography to determine and then compare the structures of several HipA complexes, they showed that HipA has a serine/threonine protein kinase fold and that it ...

Scientists reveal structure of new botulism nerve toxin subtype

... analyzed the molecular-level structures of various fragments of botulinum neurotoxin subtypes A to F, and that of the whole neurotoxin B, using x-ray crystallography at the National Synchrotron Light Source (NSLS) at Brookhaven Lab. In this technique, scientists beam high-intensity x-rays at a crystalline sample ...

Crystallography reveals the 3-D structure of mammalian sperm receptor

... contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N ...

Novel enzyme inhibitor paves way for new cancer drug

... to identify potential agents to inhibit PI3K, the scientists identified a protein kinase inhibitor known as DW2. The scientists then used X-ray crystallography to determine the three-dimensional structure of PI3K bound to DW2, using the structure as a starting point to fashion more effective PI3K inhibitors. ...

Varian, Inc. Acquires Oxford Diffraction, Ltd.

... research laboratories to determine the structure of both small molecules and large molecules such as proteins. For crystalline compounds, x-ray crystallography is the most powerful technique available for structural analysis. Nuclear magnetic resonance (NMR) provides complementary structural information for ...

IUPUI scientists report first 3-D view of anti-cancer agent

... wide range of cancers. Using X-ray crystallography, the scientists produced the first 3-D molecular level images of bleomycin bound to DNA. X-ray crystallography is a widely used analytical technique in which X-rays are directed through crystals and results are deduced from the pattern of diffraction of the ...

University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein

... enzyme structure. The team then used detergents to crystallize the enzyme and screened the protein crystals in Pitts new state-of-the-art X-ray crystallography facility, directed by Dr. Yeh. Next, they applied beams of high intensity parallel X-rays to the protein crystals in order to collect the ...

Enzyme structure reveals new drug targets for cancer and other diseases

... is not active in the human body, so it has been used exclusively as a research tool. In the new study, the investigators combined X-ray crystallography with detailed enzymology to understand how p300/CBP works. Their three-dimensional crystal structure provides an image of how a key part of ...

Breaking down Huntington's disease one protein at a time

... of cells. The loss of large amounts of nerve cells leads to a loss of motor function, and eventually brain function, too. Ybe and Niu used X-ray crystallography to look at an area of interest on the surface of HIP1, which works in concert with clathrin to traffic nutrients into a cell, and has long been ...

Study Spotlights a Natural Infection Fighter

... returned to its normal state. Previous research indicated that a protein called sulfiredoxin (Srx) participated in that process. The team used X-ray crystallography to understand how Srx worked with Prx. The technology allowed the team to capture the process in three dimensions. What the research team found is ...

Researchers solve first structure of a key to intact DNA inheritance

... know these details we can design highly specific drugs to disrupt their actions," Schmacher notes. The researchers used a technique called X-ray crystallography to discern the structure of both proteins connecting to the plasmid DNA. This technique first requires purification and crystallization of the ...

Revealing the workings of 'Mother Nature's blowtorch'

... involve breaking the molecule at the sticking point, which happens to be the part that controls its interaction with cytochrome P450. So while crystallography can offer some information on structure, it can't provide insights into exactly what goes on between P450 and b5 during their cozy, membrane-bound ...

Genetic Factors Behind Mosquitoes Resistance to Malaria Identified

... National Academy of Sciences, the researchers used a method called X-ray crystallography to uncover TEP1s three-dimensional structure. It was found that ... who was awarded the 1988 Nobel Prize in chemistry for using X-ray crystallography to describe the structure of a protein involved in photosynthesis. ...

Obesity Drug may Hold Potent Cancer Treatments

... treatment target because theoretically you don't have to worry about harming nearby healthy tissue," Kridel said. Scientists used X-ray crystallography to get a three-dimensional snapshot of the drug interacting with the protein. "Understanding this drug-protein interaction is essential for ...

Research Leads to First Treatment for Drug-Resistant HIV

... of Medicine and Mitsuya co-authored the papers with Ghosh. Mitsuya characterized the molecules' effectiveness and Walters and Weber performed the crystallography that provided images of the molecules' structures. "It is very important to have an image of the structure to see exactly how the inhibitors ...

Finally, The First Ever Treatment for Drug-Resistant HIV

... of Medicine and Mitsuya co-authored the papers with Ghosh. Mitsuya characterized the molecules' effectiveness and Walters and Weber performed the crystallography that provided images of the molecules' structures. "It is very important to have an image of the structure to see exactly how the inhibitors ...

Study Highlights How Bacteria Respond To Changes In Environment

... such sensing properties as well as engineering bacteria that respond to stimuli such as pollutants or explosives. Using a combination of X-ray crystallography to determine the structure of receptors and enzymes and a novel spectroscopic technique for measuring interactions between them, Crane's group was ...

Study Would Pave Way for the Development of New Drugs That Targets TB Proteasome

... proteasome structure was revealed by Guiqing Hu and collaborators using cryo electron microscopy in Brookhaven Lab’s Biology Department and by x-ray crystallography at the Lab’s National Synchrotron Light Source. The biochemical studies were conducted at Weill Medical College of Cornell University by Gang Lin in ...

Three dimensional structure of apolipoprotein revealed

... of Cardiovascular Disease have for the first time created the three dimensional structure of apolipoprotein E using X-ray crystallography. X-ray crystallography technique // is used for determining three dimensional structures so molecules by determining the x-ray diffraction patterns of the crystals present ...

Researchers Discover Protein That Causes Malaria

... to glycophorin A—with the rationale that such information might reveal strategies for preventing and treating malaria—the researchers used x-ray crystallography to determine the atomic structure of a key portion of the EBA-175 protein called the RII domain. The results revealed that two molecules of RII ...