computational

Human gene number increases

...an the underlying sequence itself. Cooke says that computational methods, which look for similarities to known gene sequences, are difficult to get right. The final number will remain unknown until firm biological evidence, such as gene activity, confirms each gene's existence. Such an analysis identified an extra...

New technology to decipher neural connections dealing with heredity and environment

A study by the computational neuroscientist of Vanderbilt University have developed a new computer model// that will provide an insight into neural circuits that play a role in development. The computer model traces the neural circuits that make us apply previously learned rules...

New Bioinformatics Centre to open in Andhra

...rch institutions developing advanced technology in computational biology and bioinformatics in the post-genome age," said Bhaskar Patnaik, managing director of Sun Microsystems India. "Sun technologies will help set up one of the world's largest genetic databases, enabling scientists to share and participate in ...

With a healthy heart stick to the wild salmon

...l associate professor of biological statistics and computational biology. In the words of Dr. Knuth and Dr. Steven, "For a middle-aged guy who has had a coronary and doesn't want to have another one, the risks from pollutants are minor ones, and the omega-3 benefits him in a way that far outstrips the relatively...

Chemical Signaling Helps Regulate Sensory Map Formation In The Brain

...in. This is the first biological validation of a computational model developed in the early 1980s which suggested that two such forces would be necessary to guide axons as they establish the connections that relay spatial information from one part of the nervous system to another, says Yimin Zou, Ph.D., assistan...

microRNA And Its Role In Synaptic Regulation

...ility to store more information and have increased computational capacity in the brain. He thinks that this discovery can be put to use in case of treating disorders such as mental retardation and autism. It is found that deletion of Limk1 gene is associated with Williams syndrome, and that the alteration of th...

The Brain behind Facial Recognition

...their studies, the researchers first constructed a computational model that represented how their hypothesized neur...lts from the fMRI studies agreed with those of the computational model. The researchers concluded that "we have shown that a computational implementation of a phys...

The new face of vaccine development

...mmunologists and other scientists comfortable with computational modeling. To that end, he and his colleagues have established a Web site, http://glycam.ccrc.uga.edu that assists researchers who want to do their own structure prediction work. "There's still some education to do to get people who design vaccines ...

Sleeping Computers Yield Clues About Genetic Disorders

...ems Laboratory, which developed Superlink-Online’s computational infrastructure. According to Technion Ph.D. student Mark Silberstein, the system’s current developer, Superlink-Online’s already formidable power (it recently completed in 7 hours computations that would have taken a full year on a single computer)...

Hunt for Chromosomal Errors Which Cause Genetic Diseases

...ter resolution. His team is also developing better computational tools to evaluate data from these chips. “Our abil...ments in the resolution of the microarrays and the computational tools required to analyze and mine the data generated,” said Dr. Shaikh. As he pursues ongoing stu...

Cell Survival Depends on Chromosome Integrity

...nd pathways by developing and applying genetic and computational approaches, proteomics technologies, mass spectrometry technologies, single-cell profiling and other novel methods to detect, quantify and monitor lysine modifications on DNA-coiling histones. Histone modifications are critical for many biological pr...

New Tool to Diagnose and Treat Breast Cancer

...d and piloted a unique software platform utilizing computational clinical imaging techniques for the analysis and d...this study showed that MRI directed biopsies using computational clinical imaging led to definitive conclusions, demonstrating the clinical utility of this unique ap...

Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego

...nded the new project. "By developing and using new computational approaches, the group will improve our ability to accurately model the three-dimensional structures of proteins, which are invaluable to functional studies and rational drug design." Adam Godzik, Ph.D., is Professor and Director of the Bioinformati...

Diagnosing Schizophrenia

...e really mysterious, however these have inspired a computational technique that can see through the regions of the ... The researchers, who presented the technique at a computational intelligence conference in Vancouver, Canada, last week, now plan to expand their work to study more...

Computational Model Reveals Working of AZT in Body

A computational model has been developed by researchers at the Vir...this purpose, they have been developing a detailed computational model that allows scientists to simulate the biochemical reactions that take place when AZT is metab...

Targeting PARP1 Is Effective In Protecting HD Cells from Damage

... the Scripps Research Institute – world leaders in computational chemistry – to conduct a more comprehensive virtual screen and select additional promising candidates for drug development. ‘Inhibition of PARP1 activity is thought to be potentially beneficial for treatment of cancer, neurodegenerative conditions su...

A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity

... of statistics at UC Davis, performed an extensive computational analysis, comparing the genomes of humans, chimpan...chimpanzee genome. She and Haussler then devised a computational strategy for using the chimp genome and comparative genomics to identify regions of the human genome...

Elusive Step In DNA Mutation Uncovered By Researchers

...lopment of new modeling strategies and significant computational power. It also needed indispensable complementary and supplementary laboratory experiments. We were very fortunate to have this combination in our research team," he said. Source: EurekAler...

Latest Enhancements to the Free Access Grid Toolkit Now Available

...Science. ASCR is committed to delivering forefront computational and networking capabilities to extend the frontiers of science by bringing together world-class research efforts along with the knowledge, tools and facilities to revitalize high end computing and enable scientific leadership. The nation's first na...

An All Important Breakthrough Reached In Understanding T cell response For Parasitic Diseases

... undergraduates Melissa Cabinian and Matthew Crim; computational biologist Brent Weatherly of the CTEGD; former UGA postdoctoral fellow Susan Sullivan; doctoral students Matt Collins, Charles Rosenberg and Sarah Craven; Alessandro Sette of the La Jolla Institute for Allergy and Immunology in San Diego, Ca.; and Su...

Technology Predicts Outcome of Child Heart Surgery

.... To perfect their system, researchers combined computational and experimental studies to create a method of assessing an optimum vessel configuration. The group worked heavily with fluid dynamic studies in the lab to get the most accurate simulation of blood flow. Another tool, developed by a team led by Ja...

Montreal Researchers And US Develop Model Of Key Immune-System Component

... approaches of proteomics, functional genomics and computational analysis, we have generated a model of that we believe will facilitate our understanding of infectious diseases and expedite the development of new strategies to fight pathogens." "It is exciting to see that systems biology has the power to unravel...

Protein ‘Fingerprint’ in Spinal Fluid Could Spot Alzheimer’s Disese

...” technology, detailed image analysis, and complex computational and statistical analyses to simultaneously compare 2,000 cerebrospinal fluid proteins from 34 patients with autopsy-proven Alzheimer’s disease to those of 34 age-matched controls without the disease. “Just as the human genome reflects the array of ...

Researcher Discovers Target Site for Developing Mosquito Pesticides

...m with 590 personal computers. Terascale refers to computational power measured in the unit of teraflops, which is a processor capable of a speed of one trillion floating-point operations per second. A single teraflops computer is comparable to a computer that can search at least 50,000 Manhattan phonebooks in one...

Mayo Researcher Discovers Target Site for Developing Mosquito Pesticides

...m with 590 personal computers. Terascale refers to computational power measured in the unit of teraflops, which is a processor capable of a speed of one trillion floating-point operations per second. A single teraflops computer is comparable to a computer that can search at least 50,000 Manhattan phonebooks in one...

Research on to Find Link Between Airborne Pollutants and Respiratory Illness

...ce Apportionment and Analytical Cores. Much of the computational and analytical work will be conducted in the CARES laboratories on the Clarkson campus. "One of the main foci for our group will be the development and application of analytical methods to identify the reactive oxygen compounds associated with par...

Scientists Map Key Landmarks in Human Genome

... gene microarray studies followed by sophisticated computational data analysis to pin down the nucleosome locations...of the analysis involved processing the data using computational algorithms devised by Dana-Farber faculty member X. Shirley Liu, PhD, and her postdoctoral fellow Ju...

New Computed Imaging Technique Uses Hazy Images to Improve View

...ois at Urbana-Champaign have come out with a novel computational image-forming method // that is used for optical microscopy, which is capable of generating clear, three-dimensional images from hazy and unclear data. The technique, named Interferometric Synthetic Aperture Microscopy, ISAM is beneficial to optica...

Scientists Assess Risk of Flu Pandemic Spread Via Global Airlines

... the worldwide pattern of diseases. Using advanced computational tools, the team was able in both studies to simulate how an influenza pandemic would spread, both over time and geographically, and to provide forecasted scenarios and confidence intervals. Here's one scenario the model predicts: A flu virus, say, ...

Web-Based Genomics Tool Designed to Help Predict Disease Susceptibility

... of informatic resources that we and others in the computational biology community are developing to expedite and a...tion concerning genetic influences of disease with computational predictions of the impact of genomic changes on protein structures and functions. It has a user-frie...

Computer Tool Helps Pinpoint Risky Gene Mutations

...etic variations that may be harmful or benign. Our computational test may help pinpoint which one it is. We hope the system will eventually give counselors and doctors an important new tool to help them advise patients about whether they need to take preventive steps to keep cancer from developing.” Karchin, who...

Researchers Identify Gene That Plays Key Role in Size of Dogs -- and Probably in Humans

..., assistant professor of biological statistics and computational biology at Cornell. The researchers began by comparing the DNA of individuals within a single dog breed that shows great variation in skeletal size -- Portuguese water dogs -- and identifying regions of the genome that differ between small and larg...

Scientists Identify Genes Activated During Learning and Memory

...ellon University scientists show how an innovative computational approach can provide a rapid way to identify the likely members of this long sought-after set of genes. 'The work could ultimately lead to the development of drugs to treat neurological disorders,' said Alison Barth, assistant professor of biol...

Researchers Cracking the Human Genome Function

...idge, UK, and the NHGRI. UW researchers also led a computational analysis project that integrated data from multipl...in the genome. The UW ENCODE team of molecular and computational biologists focused on identifying functional elements hidden in non-gene DNA by carefully mapping ho...

Developing Antimetastasis Therapy- An Early Stage of Tumor Control.

...the tumor-lymphatic microenvironment and developed computational models to calculate the gradients of the signaling molecule. The study provides the first evidence that tumor cells can both produce and use the same signaling molecule, and it highlights the significance of the biophysical environment in the vici...

Researchers Identifies Molecules That is Effective in Fighting Against Breast Cancer

The Hamilton researchers used state-of-the-art computational techniques in a novel way to design molecules that...did not. The Hamilton researchers used advanced computational methods to predict the structure and dynamics of active peptides, leading to discovery of smaller pe...

"Decryption" of Enzyme's Functions Paves Way for Future Drug Discovery

...esearchers say that the key to their success was a computational feat: simulating candidate substrates that mimicked unstable "intermediate" molecules - those that exist only briefly as the catalyst turns the substrate into a new molecule. "To tell the truth, we were very surprised that the docking approach wor...

Women, Younger Patients at Greater Lifetime Cancer Risk from CT Scan

...ted with radiation exposure from a CTCA by using a computational model, and integrating the most current data available on health effects of radiation. According to the researchers, the lifetime cancer risk estimates for standard cardiac scans varied from 1 in 143 for a 20-year-old woman to 1 in 3,261 for an 80-...

Kerala Institute to Hold International Seminar on Drug Discovery

...lecule in biochemistry) and protein preparation in computational studies, docking in virtual screening of ligands and focused library design of selective estrogen receptor. Modulators using combinatorial docking method, quantum mechanics in structure based drug design, novel methods to predict protein conformati...

CT Scan Radiations may Lead to Cancer

...ted with radiation exposure from a CTCA by using a computational model and integrating the most current data available on health effects of radiation. Lifetime cancer risk estimates for standard cardiac scans varied from 1 in 143 for a 20-year-old woman to 1 in 3,261 for an 80-year-old man. Use of simulated elec...

Translating Structure into Function

... configuration. The key to the teams success was a computational feat: simulating candidate substrates that mimicked unstable intermediate molecules those that exist only briefly as the catalyst turns the substrate into a new molecule. Because these intermediates are unstable, scientists have until now been una...