GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... which is an early and rate limiting step in the biosynthesis of cholesterol. Lovastatin is ... and other products of the cholesterol biosynthesis pathway are essential components for fetal ... and possibly other products of the cholesterol biosynthesis pathway, MEVACOR is contraindicated during ...

Researchers genetically engineer micro-organisms into tiny factories

... the National Science Foundation to focus on the biosynthesis of a popular group of flavonoids called ... enzymes and natural feedstocks, microbial biosynthesis reduces or eliminates the need for petrochemical ... to identifying the pathways that lead to the biosynthesis of precursors for desired compounds. Further ...

A new class of anti-inflammatory drugs

... print]). Aspirin and the related NSAR drugs act on the arachidonic acid biosynthesis cascade, which plays a central role in the onset of pain and inflammation. ... of this new class of drugs is that they not only specifically target the biosynthesis of prostaglandin, but also of leukotrienes, which are metabolites in the ...

Existing anti-obesity drugs may be effective against flu, hepatitis and HIV

... acid metabolism could stop viral replication, because fatty acid biosynthesis is not essential in adult humans. It does appear, however, to be essential ... the American Cancer Society. "Recent studies have shown that fatty acid biosynthesis is important for the replication of diverse enveloped viruses," Munger ...

Researchers find possible target to treat deadly bloodstream infections

... the building blocks of DNA and RNA. The result suggested that the biosynthesis nucleotides is crucial for the growth of the bacteria in human blood, ... bacteria detected in their blood. Mankin said the enzymes of nucleotide biosynthesis could make excellent antibiotic targets. The UIC Center for Pharmaceutical ...

Scientists strike blow in superbugs struggle

... Micklefield, Smith and colleagues were the first to engineer the biosynthesis of lipopeptide antibiotics of this class back in 2002. They have now ... genetics. It follows the tradition of pioneering work in natural product biosynthesis and engineering that has come out of the UK. Scientists in Manchester ...

Beauty and grooming science evolves

... cosmetic compound, using human skin equivalents. The results demonstrated that the compound increased the expression of genes involved in lipid biosynthesis and metabolism of the stratum corneum, leading to new appreciation of its potential in improving barrier maintenance and repair. Hair Science ...

FASgen, Inc. Announces Research and License Agreement With Centocor, Inc.

... Oncology Research and Development division affiliates the opportunity to discover and develop novel small molecule inhibitors of the fatty acid biosynthesis pathway via selective inhibition of Fatty Acid Synthase (FAS) for use in Oncology. The FASgen researchers have extensive experience studying the ...

The Results From a Clinical Trial Led by the Montreal Heart Institute Demonstrate That Drug Reduces Inflammation in Patients With Serious Cardiovascular Disease

... events (MACE), including heart attack and stroke. VIA-2291 is designed to be a selective and reversible inhibitor of 5-LO, a key enzyme in the biosynthesis of leukotrienes, that are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis. ...

Melanin production discovered in fat tissue

... the incidence of chronic diseases among the morbidly obese. "This opens an entirely new avenue for medical interventions because the process of biosynthesis of melanin is relatively easy to meddle with," says Baranova. "We hope that this study will spur the development of preventive medications aimed at ...

To branch or not to branch

... that control the process in which a gene's DNA strands are read and rewritten as RNA strands. RA3 encodes a phosphatase that is important in the biosynthesis of a sugar, trehalose, thought to be an important developmental signaling molecule. Vollbrecht and his colleagues suggest that these three genes, ...

ASPB engages Latin America colleagues at Annual Meeting in Merida, Mexico June 22-25

... Dr. Marcos Buckeridge A novel alpha-galactosidase from coffee is likely to control mannan fine structure in developing seeds.Justin Maresh Alkaloid biosynthesis in Madagascar periwinkle (Catharanthus roseus) Symposium VI: President's Symposium - Organizer: C. Robertson McClung, Dartmouth College. C. ...

Researchers Pinpoint Link Between Caloric Restriction and Longevity

... findings were published in the Sept. 21 issue of Cell . "This is really a great paper, and it basically provides very new knowledge about how NAD biosynthesis is regulated in our cells," said Dr. Shin-ichiro Imai, an assistant professor of molecular biology and pharmacology at the Washington University ...

A Major Break Through in Treatment for Metabolic Syndrome

... "ARC105 represents a lynchpin for SREBPs control of cholesterol and lipid biosynthesis genes, which may provide a potential molecular Achilles heel that could be ... called RNAi, SREBPs were no longer able to activate cholesterol and lipid biosynthesis genes. To validate these findings in a physiological setting, the ...

Stem Cells Hold Promise for Treating Neurodegenerative Diseases

... was a demonstration that stem cell efficacy could be enhanced even without the need for genetic engineering. (The drug, a glycosphingolipid biosynthesis inhibitor, is in a class of compounds called "substrate reduction therapy" drugs.) This part of the study not only represented the first ...

Lead With a Poisonous Electron Shield

... becomes distorted and inefficient; the three remaining sites get a reduced efficiency. d-Aminolevulinic acid dehydratase is essential for the biosynthesis of hemoglobin. Inhibition of this enzyme disrupts the formation of blood to the point of anemia. At the active center, a zinc ion binds to four ...

Patients Can Report Statins' Adverse Effects on New Web Site

... Study. A statin is any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol. Statin cholesterol-lowering drugs are among the most prescribed drugs in the United States. According to Consumer Reports, two such ...

Cultivating gold on a fig tree

... of Nanotechnology, the journal of the Institute of Physics. The journal has hailed the experiment as " green chemistry " because following the biosynthesis of gold nanoparticles in Rhodococcus, its cells continued to multiply normally , as the metal ions used were not toxic to the cells . This eco- ...

Fresh approach to TB treatment

... the drug discovery programme.Professor Steven Kelley, of the Institute of Biological Sciences at University of Wales Aberystwyth, said:“The sterol biosynthesis pathways are commonly found in fungi, animals and plants but this was the first that this gene had been found in bacteria. We now see the gene in ...