Binding in Medical News

Stopping harmful oral bacteria in its path is goal for Case Western Reserve researcher

... in the genes of F. nucleatum . This adhesin, or binding agent, on the bacteria allows them to connect ... In tests, bacteria without FadA had less binding capability compared to those with the adhesin, ... Her research group will look not only at the binding agent but the receptors on the host epithelial ...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

... analogs have been tested for IGF-1 receptor binding in the early research phase and only insulins with a binding ratio between the insulin and IGF-1 receptors ... development(3). Studies on receptor binding and cell growth together show that insulin ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the ... further increase the specificity of this vector, binding sites for native adenoviral receptors, the ... They found that ablation of native cellular binding sites reduced adenoviral transduction at least ...

New antibiotics could come from a DNA binding compound that kills bacteria in 2 minutes

... A synthetic DNA binding compound has proved surprisingly effective at binding to the DNA of bacteria and killing all the bacteria it touched within two minutes. The DNA binding properties of the compound were first discovered ...

Blood protein may hold key to stopping tumor growth in cancer patients

... for tumor growth, researchers found that the binding of the two proteins actually assists in new blood ... hypothesis that if they can somehow prevent the binding of ferritin and HKa, it will allow HKa to prevent ... It is therefore possible that by increasing the binding of ferritin to HKa, one could increase the rate ...

Important new model shows how proteins find the right DNA sequences

... to look through the millions of nearly identical binding alternatives and find the right place to bind. ... it would simply be impossible for them to find a binding place in a reasonable time, since the proteins ... so many DNA-binding proteins also bind auxiliary binding sites close to the regulatory site, thus forming ...

EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution

... and peak finding, and performs automated binding pattern identification. For RNAseq experiments, ... groups of identified genes, transcription factor binding site (TFBS) analysis ( identification, over-representation, binding partner analysis, framework identification, ...

The Bachmann-Strauss Dystonia & Parkinson Foundation: New Study Identifies Gene Mutations as Cause of Dystonia in Amish-Mennonite Families

... also revealed that the THAP1 gene has DNA binding and apoptosis (or cell death) functions, neither ... factor", a mutation that impairs DNA binding could upset that balance and, as a consequence, ... or off, contributing to dystonia. "The DNA binding function attributed to this gene has not ...

Bound by attention: Bringing rats and humans together

... brain gets distracted, our ability for feature binding is reduced and we may inadvertently end up biting ... a good candidate for playing a role in feature binding as well. A group of volunteers participated in a feature binding task (choosing among various shapes and colors), ...

Brain's Serotonin May Explain Seasonal Mood Changes

... Higher binding potential in winter could clarify why people feel ... tomography (PET) scan to assess serotonin binding potential, which indicates serotonin transporter density. The higher the serotonin binding potential, the less serotonin that is circulating ...

PET scans help identify mechanism underlying seasonal mood changes

... (PET) scan to assess serotonin transporter binding potential value, an index of serotonin transporter density. The higher the binding potential value, the less serotonin circulates in ... or spring and summer. "Serotonin transporter binding potential values were significantly higher in all ...

New approach, old drug show promise against hepatitis C, Stanford research shows

... is that a protein called NS4B is instrumental in binding some of the genetic material, or RNA, and ... is an essential player in the virus' process of binding RNA. This is a necessary step in the virus' ... found 18 drugs that substantially reduced NS4B binding to its target RNA, but they focused on clemizole ...

Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers

... a fruit fly protein, acts as a decoy' receptor, binding growth factors that promote the progression of ... binds and activates EGFR. Argos mimics EGFR by binding to EGF. But, unlike EGFR, Argos does not signal ... found that Argos works this way in the fruit fly, binding and neutralizing the fly version of EGF called ...

Plant flavonoid found to reduce inflammatory response in the brain

... electromobility shift assays, which measure the binding of transcription factors to DNA promoters, Jang ... by preventing activator protein-1 (AP-1) from binding the IL-6 promoter. AP-1 is in turn activated ... the AP-1 transcription factor prevented it from binding to the promoter region on the IL-6 gene and ...

Scientists discover a mechanism that can send cells on the road to cancer

... reproducing, E2F is known to be inhibited by its binding to another protein, called Rb, or retinoblastoma ... S-phase, Dr. Tansey said. The E1A protein, after binding Rb, is capable of physically pulling it off the ... published its current paper, no one knew how E1As binding with p400 affected the process. E1As Role ...

How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?

... important to know factors that influence the binding of the bacteria to gastric cells. MUC1, a mucin ... has been recently identified as an H pylori binding target. In this work we tested the hypothesis ... showed that MUC1 VNTR polymorphism influences the binding of H pylori to gastric cells, with the higher ...

Researchers discover new way to reverse poor circulation and heal wounds

... found that fibronectins structure to include a binding site, a place where most of its interactions with ... ability to pass on biochemical messages. That binding site, however, is normally buried until certain ... vasodilator, nitric oxide, and perhaps by binding to heparan sulfate proteoglycan molecules on the ...

Breaking down Huntington's disease one protein at a time

... have determined the shape and structure of a binding site that may prove useful in combating the ... these two proteins, which would prevent the binding of HIPPI," said Ybe, who led the research. ... disease. They learned that the potential binding surface of HIPPI in HIP1 has an unexpected shape ...

Researchers uncover more about how poxviruses evade the immune system

... of a powerful substance called interferon-gamma binding protein, which is notorious for the role it plays ... The research explores the interferon-gamma binding protein found in the mousepox virus one of the ... the structure and actions of interferon-gamma binding protein is incredibly exciting, given the ...

New computational technique can predict drug side effects

... to an off-target protein that has a similar binding site, or lock, side effects can result. To ... then use computer analysis to search for other binding sites that match that drug binding site like looking for other locks that can be ...

A new computational technique predicts side-effects of a major cancer drug

... outcomes. The identification of a secondary binding site with adverse effects opens the door to changing the drug to maintain binding to the intended target, but to reduce binding to the off-target. This work is just the ...

How one virus uses mimicry to replicate successfully

... we see that the E1A protein displaces E2F by binding to a specific location on pRb, Marmorstein says. ... on the study, first had to identify suitable binding partners for the protein. Because E1A is so flexible, it needs binding partners to crystallize, Liu says. By forming ...

Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology

... of Pepscan Therapeutics commented: "Functional binding proteins directed against GPCRs are in ... of human lipocalins, a family of natural ligand binding proteins. Anticalins are selected to have prescribed binding properties with selectivity and affinity ...

Advances in drug screening: building a better haystack for the needles of tomorrow

... molecules that are able to inhibit protein/DNA binding is daunting, so most drug developers have looked ... stuck to other molecules without specificity, binding studies to determine if the molecule stuck to DNA, binding studies to determine if the molecule stuck to ...

Influenza: Insights into cell specificity of human vs. avian viruses

... strongly to the trachea and bronchi, but virus binding to the bronchioles and alveoli (deeper within the ... cell types, demonstrating that factors other than binding ability must contribute to the pathogenicity. ... of the factors that are critical for virus binding and infection, enabling the future development ...

Why don't painkillers work for people with fibromyalgia?

... with fibromyalgia were found to have reduced binding ability of a type of receptor in the brain that ... has been slow. Opioid pain killers work by binding to opioid receptors in the brain and spinal cord. ... more depressive symptoms had reductions of MOR binding potential in the amygdala, a region of the brain ...

Discovery supports theory of Alzheimer's disease as form of diabetes

... how that process gets initiated. We found the binding of ADDLs to synapses somehow prevents insulin ... on dendrites to which ADDLs are bound. ADDL binding clearly damages the trafficking of the insulin ... In addition to finding that neurons with ADDL binding showed a virtual absence of insulin receptors on ...

Cholesterol byproduct blocks heart health benefits of estrogen

... binds. The normal result of this estrogen binding is that blood vessel walls remain elastic and ... inhibit estrogen function in vascular tissue by binding to estrogen receptors, said Dr. Mangelsdorf, a ... this estrogen again, the damage caused by 27HC binding to the estrogen receptors in the cardiovascular ...

Carbohydrate acts as tumor suppressor

... National Academy of Sciences . The specialized glycans are capable of binding to laminin and are attached to the α-DG cell surface protein. This binding facilitates adhesion between epithelial and basement membrane cells and ...

Purdue researchers create prostate cancer 'homing device' for drug delivery

... so that its cargo would not keep it from properly fitting into the binding site. The spacer also was designed to improve binding of the targeting molecule to PSMA. ...

Structures from the human immune system's oldest branch shed light on a range of diseases

... is spread across the entire C3b complex," notes Lambris. Factor H binding inhibits C3 convertase activity and prevents the complement response from ... disease. "We observed that mutations in factor H could weaken its binding activity to C3b, and thus may lead to a loss of regulatory activity in the ...

Drugs against winter vomiting disease one step closer

... describes how the virus for winter vomiting disease can attach to cells by binding to special sugar chains. One of these chains is characterised in that it ... the sugar chains to prevent the virus infecting the cells by blocking its binding structures. "Our results suggest that the sugar chains that have ...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... L.E.A.P.S. technology. Each L.E.A.P.S. construct is composed of a T cell binding ligand (TCBL) which has previously demonstrated the ability to induce and ... containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently ...

Defeating nicotine's double role in lung cancer

... postulated that this finding may be due to the reduced number of receptor binding sites on normal cells as opposed to cancerous cells. Conversely, they reported that cancer cells with the greatest number of receptor binding sites seemed to respond with the greatest sensitivity to the treatment. ...

FDA Approves SAMSCA(TM) (tolvaptan), the First and Only Oral Vasopressin Antagonist to Treat Patients With Clinically Significant Hypervolemic and Euvolemic Hyponatremia

... The unique mechanism of action of SAMSCA selectively blocks the binding of vasopressin to the V2-receptors in the collecting duct of the kidney. If the V2-receptors are left unblocked, the binding of vasopressin with these receptors can cause water retention resulting in ...

Farnesoid X receptor regulates cystathionase

... sequence in the 5' flanking region of CSE gene containing a potential IR1 binding site. Co-transfection of HepG2 cells with luciferase reporter vector ... CSE promoter in presence of an FXR ligand, while the mutation of the IR1 binding site abrogates this response. The functionality of this IR1 site was also ...

Scientists identify gene in breast cancer pathway

... few years ago, Einstein scientists discovered a gene called ZBP1 (zipcode binding protein 1), which helps cells to move, grow and organize spatially. "ZBP1 ... expression is initiated). The attachment of CH3 prevents the promoter from binding to a protein called beta-catenin. And without beta-catenin, the ZBP1 gene ...

Presented Data Confirm That RAPAFLO(TM) (silodosin) Provides Rapid, Highly Effective, Symptom Relief for Benign Prostatic Hyperplasia (BPH) Patients

... receptor antagonist. RAPAFLO (TM) maximizes target organ activity by binding with high affinity to the alpha (1A) receptors concentrated in the ... and results in improved urine flow and a reduction in BPH symptoms. The binding affinity for the alpha (1B) receptors that cause smooth muscle in ...

Beating a Global Killer: HIV/AIDS

... autoantibody based fractionated proteins, has an affinity to pathogenic binding and simultaneously produces effects of immune homeostasis in the presence ... demonstrated increased synthesis of Th-1 cells. IPF displayed spontaneous binding with gp41 when prepared for gel electrophoresis, and subsequent fusion ...

Also in the Feb. 10 JNCI

... Previous studies suggest that the tumors may become dependent on its binding to particular receptors, referred to as dependence receptors. In the absence of netrin-1 binding these receptors trigger cell death. However netrin-1's potential role in ...