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axon in Medical News

Alseres Pharmaceuticals, Inc.'s Chairman, Peter Savas, Reviews Company's Progress in its Annual Letter to Stockholders

... the action of Rho, a key enzyme that prevents axon (nerve) regeneration. Rho potentially plays an ... pro-regenerative pathways that stimulate axon regeneration and for approaches to deactivate anti-regenerative pathways that inhibit axon regeneration. We believe that our Rho ...

Scientists shed light on long-distance signaling in developing neurons

... very tips of the developing neuron's long, skinny axon affect gene transcription back in the cell's ... recent years, scientists discovered that as the axon reaches its target -- which may be many ... get passed from the growth cone at the tip of the axon back to the cell's "command center," the nucleus? ...

Eye Scan May Help Diagnose, Treat MS

... In fact, according to the study authors, axon degeneration resulting from "demyelination" and ... "This allows you to measure the thickness of the axon itself," O'Looney explained. The cost of the ... forward in developing new drugs to protect the axon from damage, we need a way to measure that. And ...

Brain cells work differently than previously thought

... then relays the processed information along an axon to a terminal that links to another cells ... with hearing that contained a brain cell with an axon connecting to the cortex. Using nicotine, they stimulated the axon to determine how it would affect a signal the ...

Lab-grown nerves promote nerve regeneration after injury

... Smith and colleagues have successfully grown, transplanted, and integrated axon bundles that act as 'jumper cables' to the host tissue in order to bridge ... a cylinder that looks similar to the longitudinal arrangement of the nerve axon bundles before it was damaged. The long bundles of axons span two ...

Novel Photoconductive Cellular Depolarization Technology Reveals Insight Into Neuronal Growth, Guidance, and Regeneration

... recovery. Given this, researchers have sought to better understand how axon guidance is mediated in order to potentially aid in recovery following ... These observations suggest a signaling pathway for activity-dependant axon guidance in which growth guidance both spatial and temporal is mediated by ...

EURYI project to understand how the brain wires during embryogenesis

... have already broken new ground by demonstrating the link between axon formation, and migration of cells, within the brain. While axon guidance and cell migration have been usually studied as independent ...

Alseres Shares Begin Trading on the Pink Sheets OTC Market

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres and BioAxone Amend License Agreement for Cethrin(R) and Rho Inhibitor Technology

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres Pharmaceuticals, Inc. Receives Notice of De-Listing of Its Securities for Failure to Regain Compliance with Continued Listing Requirements

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

CSHL neuroscientists propose project to comprehensively map mammalian brain circuits

... marking their extent through the expression of a fluorescent protein. The utility of these techniques is in tracing projection neurons either from axon terminals to potentially distant cell bodies or vice-versa. Together, the tracers will provide a view of the pattern of inputs and outputs for a ...

Alseres Pharmaceuticals, Inc. Announces $200,000 Financing

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

UNT Health Science Center Researchers Discover Eating Less May Not Increase Life Expectancy

... enzyme research, particularly related to glaucoma, in the journal Molecular Vision . The study found that modifying a protein may eventually lead to axon degeneration in glaucoma. Results from the study were also published in Proteomics Weekly. Dr. Shigehiko Ogoh found that a combination of ...

Evolution and epilepsy

... provides a vivid example of the ability of evolution to build very complex structures through a series of incremental steps. "The vertebrate axon is elegant and extremely intricate, with a central fiber contributed by a neuron and a jelly-roll like myelin wrapping made by other cells called ...

Alseres Pharmaceuticals, Inc. Receives Notice of Non-Compliance with Continued Listing Requirements

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres Pharmaceuticals, Inc. Announces $1 Million Financing

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward- looking statements can be ...

USC researchers identify key mechanism that regulates the development of stem cells into neurons

... of neural stem cells and neurons are unclear, Lu notes. Ryk functions as a receptor of Wnt proteins required for cell-fate determination, axon guidance and neurite outgrowth in organisms. Researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC ...

Alseres Pharmaceuticals, Inc. To Host Third Quarter 2008 Conference Call

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

New Pathways Studied to Repair Nerves

... of those cells engineered to lack the two growth-inhibiting genes survived, compared to 20 percent of the cells carrying those genes. Significant axon growth was seen in up to 10 percent of the mice lacking the genes. Genetic engineering is not necessary to achieve that kind of nerve growth, He ...

Common epilepsy drug could prevent and treat Alzheimer's disease

... that if we used VPA in the early stage of Alzheimer's disease, in model mice, it reduced plaque formation and further prevented brain cell death and axon damage," says Song, who is a Canada Research Chair in Alzheimer's disease and Director of the Townsend Family Laboratories in UBC's Faculty of ...

Reeve Foundation Recruits Distinguished Stem-Cell Neurobiologist - The Salk Institute's Samuel L. Pfaff, Ph.D. - to its International Research Consortium

... -- Stem cells and fate choices: How do stem cells "choose" from among a variety of fates and acquire their specific identities as motor neurons? -- axon guidance: How do motor axons -- the slender projections from nerve cells -- travel from the brain or spinal cord to their target destinations ...

Alseres Pharmaceuticals, Inc. Reports Second Quarter 2008 Operational and Financial Results

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres Pharmaceuticals to Host 2008 Second Quarter Conference Call

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres Pharmaceuticals, Inc. Reports First Quarter 2008 Operational and Financial Results

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres Pharmaceuticals to Host 2008 First Quarter Conference Call

... and Cethrin, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

Alseres Pharmaceuticals, Inc. Complies With NASDAQ Rule Regarding Recently Filed 10-K

... and CETHRIN, the prospects of the Company's CNS and regenerative therapeutics programs, the Company's strategies to develop and commercialize axon regeneration technologies and the breadth of the Company's technologies and intellectual property portfolio. Forward-looking statements can be ...

DNA Fingerprints Predict Brain Disorders

... was at higher risk for developing the disorders, according to the study published online in PLoS One . The variations were found by studying the axon guidance pathway, a complex collection of chemical signals that wire the brain during fetal development, and maintain and repair brain circuits ...

Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway

... pieces of this shipping system goes awry. The transport performed by dynein and kinesin is required for continuously providing new proteins to the axon and synapse to maintain normal cellular function, and is also required to remove old, misfolded, or aggregated proteins for degradation. Just as ...

Transplanted Bone Marrow Cells Aid Nerve Regeneration

... the insulating myelin around the axons of peripheral nerve cells. "The differentiated cells ... contributed significantly to the promotion of axon regeneration through the tube. This success may be a further step in developing artificial nerves," Yamakawa said. The study was published in the ...

Bone marrow cell transplants help nerve regeneration

... nerve stumps, with healthier vascularity. The differentiated cells, similar to Schwann cells, contributed significantly to the promotion of axon regeneration through the tube, explained Yamakawa. This success may be a further step in developing artificial nerves. Grafting self-donated ...

Imaging shows structural changes in mild traumatic brain injury

... versus abnormalities in the myelin (the protective sheath that, if damaged, can disrupt signals between the brain and other parts of the body.) If an axon is severed, the damage generally cannot be repaired. "We found that the milder injuries had less myelin damage, and the more severe injuries had ...

Vanderbilt nets brain gene research center

... Western Reserve University, Genetic networks establishing serotonergic neuronal identity Pat Levitt, Ph.D., Vanderbilt, Serotonin modulation of axon guidance during brain development Randy Blakely, Ph.D., Vanderbilt, Signaling networks sustaining serotonin transport Elaine Sanders-Bush, ....

Parkinsons Disease can Be Predicted by Metabolic Pathway

... and remodeling of brain circuits (so-called axon guidance pathway). This raises speculation for ... Study Methods The researchers studied the axon guidance pathway, which includes at least 128 ... siblings. Researchers identified SNPs within axon guidance pathway genes and used statistical ...

Nanomedicine Gives the Way for Nerve Cell Regeneration

... tension to the regrowing axon, we may be able to enhance the regenerative axon growth in vivo". This mechanically induced neurite outgrowth may provide a ... the possibility of using magnetic nanoparticles for enhancing in vivo axon regeneration, this work may have significant implications for the ...

Basis for Nerve fiber Damage in Multiple Sclerosis Discovered

... chemical fuel for cells – available in cells, which eventually can lead to axon cell degeneration and death. In addition to the energy-production ... "Significantly, these are the first antibodies to be identified with axon activity, which is a new area researchers are exploring in the pathology ...

Growth Factors Help Neurons to Reach Their Correct Destination

... does not necessarily rely on an entirely new set of molecules to govern axon navigation, but instead uses growth factors already involved in embryonic ... during embryonic development will be missing.’ Hence the need to identify axon guidance factors. He continues, ‘It is not enough to make the right cell ...

'Oncomodulin'- Path To Nerve Regeneration

... nerve injury on adding oncomodulin with other growth promoting factors the axon growth doubled. In another experiment oncomodulin was mixed with a sugar ... postdoctoral fellow Dietmar Fischer, PhD in which natural inhibitors of axon growth are suppressed and growth factors are activated and thus this ...

Autoimmune Response in Multiple Sclerosis

... that surrounds the axons of nerve cells is attacked by the bodys own T cells, resulting in slowed and disrupted nerve impulses and, ultimately, axon loss . Myelin basic protein (MBP) is a major component of the myelin sheath and when used as an antigen will induce experimental autoimmune ...

NMNAT Protein Protects Against Nerve Cell Degeneration

... normally. They send out axons (tendril extension of the nerve that grow into the brain) and make synapses (the functional connection between a nerve axon and the target cell)," said Bellen. However, late in the development of the eye, the insects in the pupal stage begin to sense light. As the ...
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