Androgen in Medical News

Scientists discover key event in prostate cancer progression

... 24, 2009, issue of the journal Cell , focuses on androgen receptors, molecules located in the nucleus of ... that in androgen-independent prostate cancer, androgen receptors are reprogrammed to regulate a group of ... "Some late-phase prostate cancer does not require androgen hormones for tumor growth, but it does ...

UT Southwestern researcher named HHMI Early Career Physician-Scientist

... of cancer death in men becomes resistant to androgen deprivation therapy. The most well-known androgen is the male sex hormone testosterone. Although prostate cancer initially responds to androgen withdrawal, these tumors eventually become ...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

... Ga. A protein that helps regulate expression of androgen receptors could prove a new focal point for ... cells while expression of testosterone-fed androgen receptors is higher, they report in Proceedings ... this week. "An increase in the number of androgen receptors is believed responsible for prostate ...

Prostate cancer therapy increases risk of fractures and cardiovascular-related death

... that decrease testosterone levelscalled androgen deprivation therapy (ADT)are important and ... mortality are low among men treated with androgen deprivation therapy, preventive treatments may ... risk of these serious adverse outcomes related to androgen deprivation therapy," the authors wrote. They ...

Drug shows activity in men with advanced prostate cancer

... tumor growth. Many of these drugs disrupt the androgen (male hormone) receptor, which helps regulate ... that CRPC cells have increased expression of the androgen receptor and that overexpression of this receptor ... mouse models engineered to highly express the androgen receptor, mimic progression to ...

A potential new target for treatment of hormone refractory prostate cancer

... new study identifies a protein that modifies the androgen receptor (AR) and influences its ability to ... recurrent cancers, which no longer respond to androgen blockade and are resistant to current therapy." ... prostate cancer tissues that do not respond to androgen ablation and is required for prostate tumor ...

Medivation Receives FDA Permission to Initiate Phase 3 Trial of MDV3100 in Castration-Resistant Prostate Cancer

... a pivotal Phase 3 trial of MDV3100, its novel androgen receptor antagonist, in patients with metastatic ... and a poor prognosis. Overexpression of the androgen receptor is believed to contribute to the ... cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that ...

Ferring Pharmaceuticals Announces Immediate Availability of Degarelix for the Treatment of Advanced Prostate Cancer

... in women or pediatric patients. Long-term androgen deprivation therapy prolongs the QT interval. Physicians should consider whether the benefits of androgen deprivation therapy outweigh the potential risks ... therapy, and hormone therapy, also called androgen deprivation therapy (ADT). About Ferring ...

24th Annual EAU Congress highlights many new developments

... cancer has high initial response rates to androgen ablation. However, remissions are temporary ... with cytotoxic chemotherapy, including the androgen receptor, endothelin receptor, and molecular ... trial of denosumab in men receiving androgen deprivation therapy for non-metastatic prostate ...

Why prostate cancer patients fail hormone deprivation therapy

... VA Medical Center looked to a key player: the androgen receptors on prostate cancer cells. Using a ... acid RNA that prostate cells use to create androgen receptors, eventually identifying seven RNA sequences different from the "normal" androgen receptor already known to scientists. When they ...

Age alone should not be used to determine whether to treat prostate cancer with hormones

... PSA less frequently when treated with long-term androgen deprivation therapy. The benefit of long-term (i.e. 2-3 years) androgen deprivation therapy has been established in ... clinical trials. However, concern that androgen deprivation therapy may result in cardiovascular ...

Prostate Cancer Treatment Could Impair Men's Thinking

... is thought to help spur prostate cancer. So, androgen depletion therapy has been used for many years to ... animals and people that looked at the effects of androgen depletion therapy on cognition. They found that, ... full extent of cognitive problems brought on by androgen depletion, Nelson said. As for specific advice, ...

JCI online early table of contents: July 10, 2008

... cancer cell lines that lack expression of androgen receptors and that were derived from the bones of ... osteoblastic bone metastases progress. The androgen receptornegative prostate cancer cell lines ... in individuals with prostate cancer. TITLE: androgen receptornegative human prostate cancer cells ...

Hormone Therapy Shows Little Benefit Against Prostate Cancer

... a simple "wait-and-see" approach. Men taking androgen deprivation therapy, which shuts off male ... that would make it worthwhile, Ennis said. And androgen deprivation therapy has been shown to have a ... American Cancer Society. "A lot of doctors give androgen deprivation therapy without any evidence that ...

Androgen Production Continues in Prostate Cancer Tumors

... hormone that promotes prostate cancer growth. androgen therapy, which involves the use of surgical ... cure. Eventually, the cancer becomes resistant to androgen deprivation and continues to grow. "We found that despite the suppression of circulating androgen levels to very low or castrate levels, metastatic ...

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

... as inevitably the cancer becomes resistant to the androgen deprivation and continues to grow. A team of ... found that despite the suppression of circulating androgen levels to very low or castrate levels, metastatic ... prostate tissue in men with normal circulating androgen levels (collected at the time of prostate ...

Men With Low Testosterone Not Receiving Treatment

... men with the low testosterone, also known as androgen deficiency. Only 11 were prescribed treatment. ... Mass., and colleagues. Men with untreated androgen deficiency were most likely to have low ... said. They also found that all men with androgen deficiency (treated and untreated) were more ...

Many men with low testosterone levels do not receive treatment

... The majority of men with androgen deficiency may not be receiving treatment despite ... Medicine, one of the JAMA/Archives journals. androgen deficiency in men means the body has lower than ... increased in recent years, treatment patterns for androgen deficiency are not clearly understood in ...

NYU Langone Medical Center's tip sheet to the 44th annual meeting of ASCO

... is ongoing. New Strategy May Restore androgen Sensitivity to Some Prostate Cancers Abstract # 5065 androgen receptor (AR) overexpression and sensitivity to ... favorable than for cancers that are responding to androgen suppression therapy, one of the mainstays of ...

Study reveals inaccuracies in studies of cancer treatment

... looked at data on a hormone therapy called androgen deprivation in men with stage III prostate cancer. Randomized clinical trials have shown that androgen deprivation can improve survival in these ... than 5,000 men, they found that men treated with androgen deprivation actually had a higher risk of death ...

Hormone refractory prostate cancers more likely to spread to other organs

... Prostate cancers that are resistant to androgen deprivation therapy are more invasive and more likely to spread to other organs than androgen dependent prostate cancers, UCLA cancer ... found. Virtually all prostate cancers are androgen dependent at first, but they progress and become ...

DDT Compound Speeds Breast Cancer Growth

... in Quebec found that the metabolite blocked the androgen receptors (AR) found on certain human breast ... When added to cancer cells having AR, potent androgen compounds slow the tumor's growth. But the ... known as CAMA-1 actually accelerated, even when androgen was present to try to mitigate the presence of ...

How DDT metabolite disrupts breast cancer cells

... suggest a mechanism whereby p,p'-DDE opposes the androgen signalling pathway that inhibits growth in ... the estrogen receptor alpha (ERa) and the androgen receptor (AR), either with or without ... to over express the AR. Adding the potent androgen dihydrotestosterone together with estradiol to ...

Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer

... Of these patients, 127 had been treated with androgen deprivation therapy. The researchers found Stat5 ... Nevalainen shows that Stat5 interacts with the androgen receptors and keeps them transcriptionally ... growth, and whether or not Stat5 synergizes with androgen receptors activated by adrenal androgens, which ...

Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer

... cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation ... men in the Western World, is controlled by the androgen receptor, especially at the initial stages of ... or to interfere with their function via the androgen receptor. At the first stage of the research, ...

New research may show why some prostate cancer recurs after treatment

... However, over time cancer cells can become androgen independent, and grow even in the presence of ... drugs also showed surprisingly high levels of androgen in their prostates even with low levels in their ... were removed from each patient, and examined for androgen levels and the presence of the enzymes ...

1 in 4 Men Over 30 Has Low Testosterone

... other proteins. Low testosterone can indicate androgen deficiency if it is accompanied by low sex drive, ... likely to cause the number of men suffering from androgen deficiency to increase appreciably." New ... the men in this study suffered from symptomatic androgen deficiency. Older men were especially prone: over ...

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

... the safety of BP-GMAX-CD1 and AP1903 in a minimum of 24 patients with androgen independent prostate cancer (also known as castrate resistant prostate ... autologous vaccine, is in clinical development for patients with advanced, androgen independent prostate cancer. BP-GMAX-CD1 and follow-on product candidates ...

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

... FIRMAGON is not indicated in women or pediatric patients. Long-term androgen deprivation therapy prolongs the QT interval. Physicians should consider whether the benefits of androgen deprivation therapy outweigh the potential risks in patients with ...

Heart, Bone Problems May Follow Prostate Cancer Treatment

... treating prostate cancer with the testosterone-lowering treatment known as androgen deprivation therapy may raise men's risk for developing bone fractures and ... fresh light on the question of how best to weigh the potential benefits of androgen deprivation therapy (ADT) against the potentially serious complications ...

New Prostate Cancer Drug May Hold Promise

... Sawyers said. "We found that resistant tumors have higher levels of androgen receptors. What we showed was that cells, by making more of these ... therapy." About half of all prostate cancers have the overgrowth of androgen receptors that MDV3100 is designed to attack, Scher noted. Side effects ...

Cancer treatment may result in bone loss

... to patients who didn't receive the therapy. Similarly, men who received androgen deprivation therapy to treat their prostate cancer had an increased risk ... Prostate cancer patients who received bisphosphonate treatment and androgen deprivation therapy did show an increase in bone loss. In the same vane, ...

New research on sexual function

... of feeding any remaining cancerous cells. However, researchers argue that androgen therapy may actually restore sexual function faster post-prostatectomy than androgen deprivation with (PDE ) 5 inhibitors. New studies are underway to test ...

Inheritance of hormonal disorder marked by excessive insulin in daughters

... in a control group. They specifically looked for the early onset of androgen -- male hormones -- production, and production of excess insulin. "We ... which becomes more pronounced as they pass through puberty. Since the androgen levels were comparatively normal throughout puberty, and insulin ...

Celebrex Plus Lipitor Could Fight Prostate Cancer

... men in the United States. In the early stages, prostate tumors depend on androgen (male) hormones such as testosterone to grow. As such, early treatment ... eventually lose their effectiveness. Tumors that are dependent on androgen are typically less aggressive than later tumors that don't rely on ...

Cancer stem cell marker also drives transcription in normal cells

... were shown to be required for full transcriptional activation by the androgen receptor. This finding is clinically significant as androgen receptor activity is often deregulated in prostate cancer. The ...

UC Davis researchers identify a cellular pathway that makes prostate cancer fatal

... Androgens, such as testosterone, are known to promote tumor growth. While androgen suppression treatments slow the progress of prostate cancer, they do not ... things about prostate cancer is that after a period of success with androgen suppression therapy, the cancer starts to thrive again, deVere White ...

Standard treatment for prostate cancer may encourage spread of disease

... A popular prostate cancer treatment called androgen deprivation therapy may encourage prostate cancer cells to produce a ... nestin gene was active. What was different, Berman speculated, is that androgen deprivation therapy, a treatment that reduces testosterone in the body, is ...

Acupuncture, Exercise May Ease Polycystic Ovarian Syndrome

... age who suffer from a common endocrine disease called polycystic ovarian syndrome (PCOS). Women with the condition have elevated levels of androgen hormones -- including testosterone -- and often develop ovarian cysts, irregular menstrual cycles and infertility. A key feature of the disease is an ...

Promising Therapy for Prostate Cancer

... if we were sending him samples from the same patient." Ipilimumab is an antibody that appears to greatly magnify the cancer-killing action of androgen ablation, a hormone therapy that helps shrink prostate cancer by eliminating testosterone from the body. Following the additional treatment, the ...