Navigation Links
adenosine in Medical News

Prune juice not necessary: New research should make bowel movements easier

... present on human nerves in the gut (a type of adenosine receptor). The first group of mice had normal adenosine receptors on these nerves and normal bowel ... The second group of mice completely lacked these adenosine receptors and showed familiar signs of ...

Cordex Pharma Submits to the FDA an Amended Special Protocol Assessment for ATPace

... is an investigational stable formulation of adenosine 5'-triphosphate (ATP) administered by intravenous ... treatments for PSVT. Currently, adenosine is the only approved drug for the acute treatment ... more efficacious than the initial labeled dose of adenosine in terminating PSVT. While both ATP ...

JCI online early table of contents: Feb. 16, 2009

... METABOLIC DISEASE: adenosine signaling links alcohol and liver disease ... liver in mice. Further analysis revealed that adenosine mediated its effects in mice via two proteins, the adenosine A1 and A2B receptors. The authors therefore ...

Support cells, not neurons, lull the brain to sleep

... of compensating. Prior studies pointed to adenosine as a trigger for sleep pressure. The chemical ... the dnSNARE transgene, to block the release of adenosine and other chemicals from astrocytes. The ... used certain compounds to block the effects of adenosine on neurons. Neurons have several types of ...

Duska Therapeutics and DSM Pharmaceuticals in Manufacturing Collaboration for PSVT Drug Product

... ATPace, a stable liquid formulation of adenosine 5'-triphosphate (ATP) for intravenous injection, ... in the United States alone. Currently, adenosine is the only approved treatment for PSVT in ... adenosine in terminating PSVT. While both ATP and adenosine inhibit atrio-ventricular nodal conduction, ATP ...

Duska Therapeutics Receives Comments From FDA on Phase 3 ATPace(TM) Protocol Synopsis

... drug for the acute treatment of PSVT." ATPace, adenosine triphosphate injection, is a proposed drug for the termination of PSVT. The bradycardic effect of adenosine triphosphate, in particular its blockade of ... PSVT in the United States alone. Currently, adenosine is the only approved treatment for PSVT in ...

Caffeine Could Stave Off Multiple Sclerosis

... four building blocks of DNA, from binding to the adenosine receptor at the cellular level. When adenosine cannot bind to receptors at the cellular level, ... a scientific point of view, the bottom line is, adenosine in this mouse model is needed for the ...

Research sheds new light on heroin addiction

... of heroin addiction by manipulating the adenosine A2A receptor, which plays a major role in the ... Using mice specifically bred without the adenosine A2A receptor, Prof Andrew Lawrence and his team ... these findings strongly suggest that the adenosine A2A receptor is involved in regulating the ...

Food as Medicine?

... to block a compound called adenosine. "Inhibiting adenosine prevents the infiltration of lymphocytes [a type ... reduction in the brain pathology," Bynoe said. adenosine plays a crucial role in many body processes, ... the same receptors as adenosine, preventing the adenosine from attaching to cells in the central nervous ...

JCI online early table of contents: March 13, 2008

... EDITOR'S PICK: High levels of the molecule adenosine linked to priapism Priapism (prolonged penile ... Further analysis indicated that high levels of adenosine induced priapism through stimulation of the A2B adenosine receptor in ADA-deficient mice. As ...

Sleep chemical central to effectiveness of deep brain stimulation

... Center, gives an unexpected nod to a role for adenosine and to cells called astrocytes that were long ... role for adenosine, which is surprising. adenosine in the brain is largely a byproduct of the chemical ATP, the source of energy for all our cells. adenosine levels in the brain normally build as the day ...

Cordex Receives Special Protocol Assessment Approval from FDA for ATPace(TM)

... (SPA) process. ATPace(TM) is a novel stable liquid formulation of adenosine 5'-triphosphate (ATP). It is being developed as a therapeutic and ... new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play ...

Cordex Pharma Files ATPace Formulation Patent

... its lead product, ATPace. ATPace is a stable liquid formulation of adenosine triposphate (ATP) for intravenous administration. ATPace is being ... new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play ...

Scientists Spot Eye Development 'Switch'

... team found that a short burst of an energy and signaling molecule called adenosine triphosphate (ATP), followed by accumulation of another molecule called adenosine diphosphate (ADP), is an important signal for initiating expression of Eye ...

Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development

... In vitro studies show that it is highly active against Mycobacterium tuberculosis ( M.tb) . TMC207 has a unique mechanism of action targeting adenosine triphosphate (ATP) synthase, which M.tb , requires to generate its energy supply. Currently, TMC207 is being studied in a Phase II clinical trial in ...

While you were sleeping

... said. "A lack of oxygen in the brain during even small time increments of obstructive sleep apnoea caused levels of the high-energy currency adenosine triphosphates (ATP) to fall and levels of inorganic phosphate to rise, without the usual changes in phosphocreatine or brain pH the mechanisms that ...

Better treatment selection and improved therapies -- key to improving prognosis in acute HF

... of the heart muscle's contraction.3 * Improved therapies. Many new agents are currently under development, said Professor Metra, which include adenosine type 1 receptors antagonists to enhance the diuretic effects of furosemide and increase renal blood flow, new vasodilators with different mechanisms ...

Schering-Plough Starts Patient Enrollment in Phase 3 Trial for Acadesine, an Investigational Agent Being Studied for Prevention of Complications From Cardiac Surgery

... SGP ) today announced the start of patient enrollment in RED-CABG, the Phase 3 Trial for acadesine, an investigational, potentially first-in-class adenosine regulating agent (ARA). Acadesine was licensed from PeriCor Therapeutics, Inc., a privately held specialty biopharmaceutical company. Acadesine is ...

Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers

... Cordex Pharma, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of ...

Surveyed Experts Indicate that Biogen Idec's Adentri Has Advantages Over Nitroglycerin in the Treatment of Acute Heart Failure

... for acute heart failure in 2012, following its approval for the indication. Adentri has competitive advantages because it will be one of the first adenosine A1 receptor antagonists for use in acute heart failure. "Interviewed physicians believe that this class of drugs and, particularly, Adentri can ...

Bioenergy Ribose Found to Improve Vitality, Aerobic Fitness and Mental Outlook

... helps counter fatigue, a common effect of aging. D-ribose is a naturally occurring five-carbon sugar the body uses as the foundation for adenosine triphosphate (ATP)--the compound that carries energy throughout cells and powers all its functions. Although ribose is produced by the body, it is ...

Cordex Pharma Sets Fourth Quarter 2008 Program Update Call

... Cordex Pharma, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of ...

E. coli persists against antibiotics through HipA-induced dormancy

... then compare the structures of several HipA complexes, they showed that HipA has a serine/threonine protein kinase fold and that it binds tightly to adenosine triphosphate (ATP), a common characteristic of kinases. Phosphorylation occurs when an enzyme binds to both ATP and to its target protein. Assays ...

Another reason to avoid high-fat diet -- it can disrupt our biological clock

... circadian rhythmicity. Fasting resulted in a phase advance. The high-fat diet resulted in a phase delay. Fasting raised and the high-fat diet reduced adenosine monophosphate-activated protein kinase (AMPK) levels. This protein is involved in fatty acid metabolism, which could be disrupted by the lower ....

Duska Therapeutics Acquires Technology for ATPotent Sperm Motility Program

... Inc. (Duska) is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging new pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of ...

Existing anti-obesity drugs may be effective against flu, hepatitis and HIV

... into complex molecules (e.g. DNA). A significant example is the breakdown of blood sugar (e.g. glucose) and its conversation via chain reactions into adenosine triphosphate, the energy-storing currency of cellular life. As an important offshoot of that process, glucose can also be converted into fatty acids, ...

Satellite Healthcare Announces 2008 Norman S. Coplon Extramural Grants : Grants Foster Next-Generation Kidney Disease Researchers

... Extramural Grant recipients are: Gabriela Garcia, M.D. Baylor College of Medicine "Arrest of Kidney Disease Progression by A2A adenosine Receptor Activation" Yoshi Hall, M.D. University of Washington "Disparities in end-stage renal disease among Asians and Pacific ...

Cylex Announces Significant Expansions and Reassignments of Personnel

... immunity (CMI) in adult patient populations undergoing immunosuppressive therapy for organ transplantation by measuring the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the ...

Sagent Pharmaceuticals Launches Amiodarone HCl Injection, USP

... Group, Germany. Gland Pharma's research and development operation develops niche products from active pharmaceutical ingredient to finished dosages. adenosine is one of many approved abbreviated new drug applications from the Gland Pharma's growing portfolio. For more information about Gland Pharma, ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... and metalloproteinase domain 17 (ADAM17), TACE; acidic fibroblast growth factor (aFGF); activin receptor IIA (ActrIIA); adenosine deaminase; adenosine monophosphate (AMP); alpha5beta1 integrin; alphanubeta3 integrin; alphanubeta5 integrin; alpha-fetoprotein (AFP) receptor (RECAF); Akt; anaplastic ...

Study Suggests Green Tea May Support the Medical Treatment of Stomach and Colon Cancer

... without green tea extract. Protein levels of the tissues were studied and adjusted to equal concentrations. Xanthine oxidase (XO) and reduced adenosine deaminase (ADA) enzyme activities were measured before and after the incubation period. Percentage changes for the 3 different concentrations of ...

Research shines spotlight on a key player in the dance of chromosomes

... location to another in the cell, a job that requires precision, in both the location and the timing of delivery. They are fueled by a small molecule, adenosine tri-phosphate (ATP). Some motor proteins are essential to mitosis the process by which cell division occurs in higher organisms. During cell ...

Duska Therapeutics Plans 505(b)(2) NDA Filing Route for ATPace(TM)

... California, is an emerging biotechnology company that is focused on the development of therapeutic, medical device and diagnostic products related to adenosine 5'-triphosphate (ATP) and cell-surface P2 receptors (P2R). Duska owns or has exclusive license rights to a number of proprietary products, four of ...

Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection

... award. Mitochondria, small organelles within the cells, use a process called Oxidative Phosphorylation to generate the vast majority of the adenosine triposphate (ATP) molecules that cells utilize to function properly. If the mitochondria become less efficient with age or disease, they use less up ...

Western Reserve Heart Care Receives ICANL Nuclear Medicine Accreditation

... received both the nuclear medicine and the echocardiography accreditations in our first year in business." Western Reserve Heart Care offers both adenosine and exercise treadmill nuclear stress tests. Nuclear stress testing is a complex imaging technique that uses non-harmful radioisotopes to diagnose ...

Study helps explain fundamental process of tumor growth

... to make tumors in vivo. The findings are consistent with the idea that tumor cells preferentially use glucose for purposes other than making adenosine triphosphate (ATP), the energy currency used by normal cells. We suspect that this mechanism evolved to ensure that fetal tissues only use glucose ...

In silico modeling helps predict severity of mitochondrial disease

... diabetes, stroke, heart failure and epilepsy are passed from mother to offspring. Mitochondria are the engines present in each cell that produce adenosine triphosphate (ATP), the key energy currency that drives metabolism. Mitochondria also have their own DNA (mitochondrial or mtDNA) that encodes a ...

JCI online early table of contents: Jan. 2, 2008

... seizures, it was suggested that ADK-based treatment strategies might provide a new approach for the treatment of individuals with epilepsy. TITLE: adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice AUTHOR CONTACT: Detlev Boison Legacy Clinical Research, ...

Cancer gene drives pivotal decision in early brain development

... in neural stem cells. Studies of these mice revealed that the Nf1 protein, neurofibromin, controls the activity of two signaling pathways, the cyclic adenosine monophosphate (cAMP) pathway and the Ras pathway. This allows neurofibromin to regulate the development of both neurons and astrocytes. "We found ...

In Landmark Phase III Head-to-Head Study, Prasugrel Statistically Superior to Clopidogrel in Reducing Risk of Heart Attack

... with acute coronary syndrome undergoing PCI. Prasugrel works by inhibiting platelet activation and subsequent aggregation by blocking the P2Y12 adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets from clumping or sticking together, which can result in ...
Other Contents
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
(Date:10/15/2014)... 2014 Sandata Technologies, LLC, an industry ... care, today announced it released a case study ... Visit Verification™ Solution (EVV™)  for Quality Care Services, ... company founded in 1996 and has five locations ... The study details the challenges facing Quality ...
(Date:10/15/2014)... rapidly and to an unexpected extent. The outbreak does ... the virus shows a new disease dynamic in regions, ... reason, the German National Academy of Sciences Leopoldina, acatech ... the Union of the German Academies of Sciences and ... today. , In the statement the academies call for ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
(Date:10/20/2014)... It’s hard to imagine what it’s like to live without ... world, it’s a reality. And while new shoes are considered ... walk barefoot on rocky terrain or sewage-lined streets just to ... , Buckner International's Shoes for Orphan Souls ... to encourage support for Air1 and while also providing new ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 Hastings and ... 30 years of service throughout the greater Phoenix area ... legal representation with regard to catastrophic automobile accidents. Statistics ... the country and throughout Arizona. As such, Hastings and ... for legal representation for those who have been injured ...
(Date:10/19/2014)... This report provides comprehensive information on ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ... late-stage and discontinued projects. , Partial Seizures are ...
(Date:10/19/2014)... SweetDressy.com, a professional company of women’s dresses and ... evening dresses . All the company’s old and ... discount is up to 66 percent off. , ... fashion field. Its dress specialists are striving to make ... of the world. All the company’s items are unique, ...
(Date:10/19/2014)... that causes inflammation in the spinal joints and ... ancient Egyptian royal families. Now a new study ... journal of the American College of Rheumatology (ACR), ... condition called diffuse idiopathic skeletal hyperostosis (DISH) in ... 20th Dynasties. , Ankylosing spondylitis is a ...
Breaking Medicine News(10 mins):Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4Health News:Promotion For Beautiful Long Evening Dresses Launched By SweetDressy.com 2Health News:Mummy remains refute antiquity of ankylosing spondylitis 2
Other TagsOther Tags