Blood transfusion study: Less is more
... into the health care reform debate.
A wide variation
in care is a hot-button issue, as lawmakers and ... to assess patient outcomes as well as hospital variation
in blood use.
Blumberg and lead author Mary ... from 2003 to 2006. They found that 30 percent of variation
in transfusion practices seemed to be due to ...
Cell division find prompts overhaul of immune response modeling
... Hodgkin said although there was considerable variation
in the number of divisions cells went through ... aware that cells never behave identically. This variation
is usually dismissed as 'noise' or irrelevant ... thought that by ignoring the immense amount of variation
in cells we might be missing something ...
Genetic Variation Associated With Survival Advantage in African Americans With HIV
... cell count (known as leukopenia) and a genetic variation
that is found mainly in persons of African ... African Americans with HIV who possess both a variation
in the gene for the Duffy antigen receptor for ... researchers tested for the presence of the DARC variation
and evaluated patients' WBC counts from diagnosis ...
Variants of 'umami' taste receptor contribute to our individualized flavor worlds
... code for this receptor correspond to individual variation
in sensitivity to and perceived intensity of ... findings bolster our understanding of human taste variation
and individual differences in tastes for ... tract, liver and pancreas, coding variation
in the T1R3 gene may also influence how proteins ...
GIE: Gastrointestinal Endoscopy June issue study highlights
... rates at screening colonoscopy found a wide variation
among endoscopists, though researchers note that ... study is needed to determine the reasons for the variation
and their clinical significance. Also in the June ... Studies of screening colonoscopy have documented variation
in adenoma (benign growth) detection rates ...
Health Plans Prepare for Health Care Reform: Comparative Effectiveness, Consumerism Drive Future Changes, According to Deloitte Study
... collaboration with providers.
in actuarial models is likely to decrease as care ... discovered with comparative effectiveness. As variation
decreases, risk margins charged to customers will ... in health care spending and reduce inappropriate variation
in the system."
Genes May Boost Harm to Kids From Secondhand Smoke
... lung function and growth, including genetic variation
and environmental exposures such as tobacco smoke ... transferase (GST) genes. Overall, we found that variation
in several of the GST genes was important. This ... three specific halotypes (patterns of genetic variation
within genes) that had a significant effect on ...
Gene Test May ID Younger Women at Risk for Melanoma
found in more than 40% of females under 50 raises ... WEDNESDAY, March 25 (HealthDay News) -- A genetic variation
that's associated with a nearly fourfold ... School of Medicine.
Identification of this variation
in a gene called MDM2 could lead to a screening ...
NYU study finds new risk factor for melanoma in younger women
... NYU Langone Medical Center report that a genetic variation
leads to a nearly four-fold increase of melanoma ... gene) in cells. In the presence of the genetic variation
in MDM2, originally identified by the laboratory ... estrogen levels and who also have the genetic variation
would be expected to have higher estrogen-related ...
Gene Discovered for Most Common Form of Epilepsy
... News) -- Researchers have linked a genetic variation
to a common form of epilepsy in children, ... members who had the condition. They found a gene variation
-- in a gene called ELP4 -- that appeared to be ... next challenge is to figure out how the genetic variation
affects the makeup of the brain.
St. Jude finds more than 100 gene variations linked with response to leukemia treatment
... Sciences chair. "We focused on genomic variation
that is inherited and affects all cells in the ... and excretion. In almost all cases, gene variation
predicting faster elimination of the drugs from ... effectively to overcome the patient's own genetic variation
and reduce the chance of treatment failure."
In Kids, Genes May Affect Leukemia Treatment
... the researchers found.
"Some of the gene variation
is likely to cause differences among patients in ... for cancer, we will need to consider the genetic variation
that each patient has inherited, in addition to the genetic variation
that is unique to the tumor cells," Relling said. ...
Researchers Report Progress in Fight Against Fat
... Two drugs and a genetic variation
are focus of promising studies
... sought to understand more about a genetic variation
that appears to help make thin people slim and ... a study of mice suggests that people who have the variation
are generally skinner than others, but their ...
Genes Seem to Affect Tissues Differently
... amount of protein it tells cells to produce. Such variation
can lead to alternative splicing, a process that ... director of the Center for Human Genome variation
at Duke's Institute for Genome Sciences and ... up a very comprehensive picture of how genetic variation
influences gene expression in specific tissues," ...
Gene Ups Risk for Those on Blood-Thinner Plavix
... MONDAY, Dec. 22 (HealthDay News) -- A gene variation
can make younger heart attack patients more prone ... an accompanying comment in the journal.
in response is partly due to genetics, but there ... Among these patients, 28 percent carried a gene variation
called CYP2C19*2. ...
Annual report to the nation finds declines in cancer incidence and death rates
... in the Midwest and the South. The geographic variation
is even more extreme among women, for whom lung ... staggering toll of tobacco on our society."
in smoking prevalence among the states is ... many types of cancer. This type of geographic variation
in smoking-related cancers is due to smoking ...
Chromosome Linked to Diabetics' Heart Risks
... Genetic variation
identifies those with poor glucose control likely ... research, a new study has identified a genetic variation
that increases the risk of coronary artery ... diagnosed with CAD) who were tested for a gene variation
of chromosome 9p21 and checked for long-term ...
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
... with a particular health condition, or with variation
in patient response to prescribed drugs.
In ... can cause patients to exhibit 10- to 20-fold variation
in the required dose (RD) of warfarin needed to ... SNPs and genes that are related to dose variation
requirements could be used to better estimate the ...
New study replicates association between genetic variation and antidepressant treatment response
... 15, 2008 Pharmacogenetics, the study of genetic variation
that influences an individual's response to ... hormones, the glucocorticoids. In prior studies, variation
in this gene was associated with the emergence of ... Now that this current report has also implicated variation
in the FKBP5 gene as related to antidepressant ...
3 sequencing companies join 1000 Genomes Project
... the most detailed map to date of human genetic variation
as a tool for medical research. The new ... produced a comprehensive catalog of human genetic variation variation
that is organized into neighborhoods called ...
JCI table of contents: May 22, 2008
EDITOR'S PICK: Its not an AKT: genetic variation
affects brain region dysfunctional in ... have indicated that in healthy individuals, variation
in a gene known as AKT1 affects the structure and ... and Surgeons, New York.
TITLE: Genetic variation
in AKT1 is linked to dopamine-associated ...
Keck Futures Initiative awards $1M for 15 research projects
... Medical School, Cambridge, Mass.
COPY NUMBER variation
AND EXCEPTIONAL HUMAN HEALTHSPAN: THE ASHKENAZI CENTENARIANS - $87,500
Human genomic length variation
ranging from 500bp to 5 Mb, also known as structural or copy number variation
(CNV), has been shown to influence complex traits ...
Combined physical and genetic map finds cancer's 'ignition key'
... and malignant to their underlying genetic variation
or regulation, the team also identified a crucial ... superimposing the low-resolution map of genetic variation
over the geographic map of the organs tissue, ... controls matched for age and gender. The specific variation
was present in 2.78 percent of patients and every ...
Study breaks ground in revealing how neurons generate movement
... responds to a stimulus there is always a slight variation
in its performance, a phenomenon that ... unique they proposed that some aspects of neural variation
may reflect behavioral variation.
They used ... velocity. They also measured the degree to which variation
shared across two pairs of concurrently active ...
Gene Variant Boosts Risk for Stress-Related Ischemia
... News) -- Researchers have identified a gene variation
in heart disease patients who are so vulnerable ... called ischemia.
Patients with this particular variation
of the adrenergic beta-1 receptor gene are three ... and about two-thirds of them had the particular variation
of the adrenergic beta-1 receptor gene associated ...
More Gene Variations Found That Raise Prostate Cancer Risk
... to being able to develop a profile of genetic variation
which predicts for increased risk of the disease. ... report, Dr. Stephen Chanock, head of the Genomic variation
Section at the U.S. National Cancer Institute, ... Stephen Chanock, M.D., head, Genomic variation
Section, U.S. National Cancer Institute, ...
Death Rates From Cardiovascular Causes Vary Widely Across Europe
... and Spain. There is considerable within-country variation
in IHD in Germany, the U.K. and Poland," she ... to CVD, there is a different pattern of regional variation
compared with IHD. CVD mortality is reduced in ... and Spain. There is considerable within-country variation
in Italy, Spain, Portugal and the U.K."
Mitochondrial 'bottleneck' cracked
... This difference is thought to explain the variation
in the severity of the disease between siblings however the mechanism responsible for this variation
was not understood for many years.
Now this ... eventually form the eggs. This leads to the wide variation
in the severity of disease. Depending on which ...
Story ideas from Molecular and Cellular Proteomics
... email: firstname.lastname@example.org
in Platelet Protein Expression within the Elderly
in human platelets in the elderly population is ... requires knowing the extent of natural protein variation
in the population, which arises from a ...
Project Will Map Genomes of 1,000 People Worldwide
... and medically relevant look at human genetic variation
As outlined by an ... understanding the small fraction of genetic variation
among humans can help explain individual ... give biomedical researchers a genome-wide map of variation
down to the 1 percent level. This will change the ...
International consortium announces the 1000 Genomes Project
... to drugs or reaction to environmental factors. variation
in the human genome is organized into local ... give biomedical researchers a genome-wide map of variation
down to the 1 percent level. This will change the ... provide a deeper understanding of human genetic variation
and open the door to many other new findings of ...
Johns Hopkins to participate in 1000 Genomes Project
... headway in creating a map of common DNA variation
in humans, the HapMap Project, and applied it ... Its crucial to complete the catalog of common variation
in DNA, the small fraction of genetic material ... give biomedical researchers a genome-wide map of variation
down to the 1 percent level. This will change the ...
BRCA Mutations Don't Raise Breast Cancer Risk Equally
... Study finds wide variation
among families with carriers
TUESDAY, ... breast cancer.
In fact, a new study finds wide variation
in risk among families carrying the mutations, ... it."
Experts have hypothesized that there is variation
in the risk of breast cancer in general due to ...
International research collaboration narrows focus on genetic cause of Kawasaki disease
... San Diego (UCSD), have discovered a new genetic variation
that affects a childs risk of getting Kawasaki ... of the arteries throughout the body. The genetic variation
influences immune activation and the response to ... studies will identify additional sites of genetic variation
and may capture enough of the genetic influence ...
Mortality rates 71 percent lower at top-rated hospitals: HealthGrades 2008 hospital-quality study
... company. The study, which documents a wide variation
in the quality of care between the ... to reduce mortality rates, a significant variation
in quality among the nations best and ... preventable deaths.
The study also found wide variation
in risk-adjusted mortality at the state and ...
Cancer researchers seek safe reduction of radiotherapy
... than others: that is, there is an individual variation
in tissue response. Some patients will be very ... investigate associations between common genetic variation
and a patient's risk of radiation induced ... The technology allows us to look at the variation
and expression of genes to see which genes ...
The aye-ayes have it: The preservation of color vision in a creature of the night
... on color vision to better understand genetic variation
between human and other primate populations and ... than men.
These three genes may explain all the variation
that we might see across human populations in ... Verrelli. But how did our range of color vision variation
come to be in the first place"
To help trace ...
Genetic testing may be valuable in treating colorectal cancer
... to improve survival. But for more than one in 10 of these patients, a variation
in their DNA means that this treatment could result in a severe reduction ... possible subsequent death. A new genetic test can identify those with the variation
in order to lower the treatment dose -- however, it has been unclear ...
Study estimates radiation dose, cancer risk from coronary artery calcium screening
... lung, thyroid, esophagus, bone surface and adrenal glands. "The wide dose variation
also resulted in wide variation
in estimated radiation-induced cancer risk," they continue. "Assuming ...
Oncology Care Quality Improvement Program Introduced by Bipartisan Coalition Dedicated to Better Cancer Care Nationwide
... calls for adherence to evidence-based guidelines which will reduce variation
in care for patients and help physicians make clinical decisions with ... The OCQI aims to foster evidence-based guideline adherence to minimize variation
and reduce errors in care, offers patient education and care coordination ...