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Transduction in Medical News

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... native cellular binding sites reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor. YSA-mediated transduction was inhibited by addition of synthetic YSA ...

Potential Brain Cancer Drug for Children May Damage Bones

... - Animal Study Raises Caution on Using Signal transduction Inhibitors in Children - PHILADELPHIA, March ... would also occur in children, and while signal transduction inhibitors may still represent a highly promising ... patients who are adults. "Signal transduction inhibitors such as this drug may still ...

Potential brain cancer drug for children may damage bones

... Cell. The drug in question, HhAntag, is a signal transduction inhibitor--an agent that blocks signals along a ... current cancer research has focused on signal transduction inhibitors (STIs) because of their potential to ... would also occur in children, and while signal transduction inhibitors may still represent a highly promising ...

Pezcoller Foundation-AACR International Award for Cancer Research recognizes Axel Ullrich

... cited cancer scientists in the area of signal transduction research. We are proud to honor Axel ... the cancer problem through his study of signal transduction and genetics. For more than 25 years, ... signal transduction. Ullrichs work in signal transduction research has uncovered fundamental molecular ...

Brown researchers make major signal transduction discovery

... known as acetylation plays a central role in cytokine receptor signal transduction a fundamental biochemical cascade inside cells that controls the activity ... diseases, such as diabetes, cancer and heart disease, occur when signal transduction goes awry. That is why some drugs either inhibit or amplify signaling ...

Penn Veterinary Medicine report new strategy to create genetically modified animals

... to germ line genetic modification. It also demonstrates that germline transduction and germ cell transplantation in large animals provides an approach that ... transplantation model in the mouse to investigate whether AAV-mediated transduction of germ cells was possible and could result in transgene transmission, ...

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... solid tumors and hematological cancers. The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycle kinase inhibition. BIBW 2992 entered Phase IIb/III clinical development in NSCLC earlier in 2008 and was granted Fast ...

Keryx Biopharmaceuticals Inc. Regains Compliance With NASDAQ Listing Requirements

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. Receives Extension for Nasdaq Listing Compliance

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Stand Up to Cancer awards $73.6 million for novel, groundbreaking cancer research

... of Southern California; "Targeting the PI3K Pathway in Women's Cancers" / Leader: Lewis C. Cantley, Ph.D., Chief of the Division of Signal transduction at Beth Israel Deaconess Medical Center; Co-Leaders: Charles L. Sawyers, M.D., Director of the Human Oncology and Pathogenesis Program at Memorial ...

$18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research

... Cancer Center. "Targeting the PI3K Pathway in Women's Cancers" $15 million Leader: Lewis C. Cantley, Ph.D., Chief of the Division of Signal transduction at Beth Israel Deaconess Medical Center; Co-Leaders: Charles L. Sawyers, M.D., Director of the Human Oncology and Pathogenesis Program at Memorial ...

The future of personalized cancer treatment: An entirely new direction for RNAi delivery

... due to their size and negative electrical charge which prohibits them from readily entering cells. A small section of protein called a peptide transduction domain (PTD) has the ability to permeate cell membranes. Dowdy and colleagues saw the potential for PTDs as a delivery mechanism for getting siRNAs ...

Keryx Biopharmaceuticals, Inc. Announces First Quarter 2009 Financial Results

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

New Research Demonstrates that Wild Blueberries May Support Cardiovascular Health

... and their metabolites is not only accomplished through their antioxidant properties but also through their ability to act as regulators of signal transduction pathways and may also affect gene expression." Wild Blueberries and Antioxidants According to Susan Davis, MS, RD, Nutrition Advisor to the ...

Milestone tumor virus publication by Elsevier journal Virology

... advanced our understanding of basic biology. They have helped unravel some of the most complex aspects of the host cells they infect, from signal transduction cascades, to DNA replication, to transcription. In his editorial, the Editor of the Special Issue Paul Lambert, from the McArdle Laboratory for ...

Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS

... understanding of cancer biology and for the discovery and testing of targeted therapies." By employing a tissue recombinant system and a gene transduction system, researchers assessed the in vivo biological consequences of specific genetic alterations in the reconstituted breast tissue. Introduction of ...

GSK Submits TYVERB(R)/TYKERB(R) (lapatinib) for First-Line Treatment of Metastatic Breast Cancer in Europe, US

... Practice Oncology . 2008;5:531-542 2 Bedard PE, Freedman OC, Howell A et al. Overcoming endocrine resistance in breast cancer - are signal transduction inhibitors the answer. Breast Cancer Res Treat. 2008 108:307-317 ...

Keryx Biopharmaceuticals, Inc. Requests an Appeal Hearing After Receiving Notice of Delisting From Nasdaq

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

... Endocrine-Related Cancer 2003; 10;1-21 (2) Bedard PE, Freedman OC, Howell A et al. Overcoming endocrine resistance in breast cancer - are signal transduction inhibitors the answer. Breast Cancer Res Treat. 2008 108:307-317 (3) Prat, A and Baselga, J. The role of hormonal therapy in the management of ...

Keryx Biopharmaceuticals Receives Nasdaq Notification

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2008 Financial Results

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Third Quarter 2008 Financial Results on Tuesday, November 11, at 8:30 A.M. EST

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Study Confirms Effectiveness of Magnetic Therapy in Pain Relief

... simply dulling the pain, as do over-the-counter and prescription drugs, the QuadraBloc's™ magnetic field literally alters the electrochemical transduction of the pain signals.. "This study shows that pain relief does not require pharmaceuticals with potentially dangerous side effects," ...

How do Lactobacilli treat Helicobacter pylori-related diseases?

... from LBG culture MRS broth (LBG-S). It was demonstrated that LBG-S had the same inhibitory effect on H. pylori SS1-LPS-activated TLR4 signaling transduction as viable LBG. In a recent novel study, two soluble proteins with molecular sizes of 75 and 40 kDa were purified from supernatant recovered from ...

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2008 Financial Results

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

New MagnaBloc™ Product Available from Gradient Medical

... will also be releasing several new products within the next few weeks." Put simply, the QuadraBloc uses magnetic principles to disrupt the transduction of the electrochemical pain signals to the brain. QuadraBloc uses not one but four magnets and a focusing ring placed in a square or diamond ...

St. Jude study shows how T cell's machinery dials down autoimmunity

... provide insight into how autoimmune diseases start. One implication of our findings is that a relatively small defect in the efficiency of signal transduction through the T cell receptor could give rise to a subtle failing in negative selection, which gives rise over a long period of time to a few overly ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting

... broad activity as an anti-angiogenic and anti-proliferative agent is shown to reside in its ability to target and inhibit the PI3K/Akt/mTOR signal transduction pathway as a TORC1/TORC2 inhibitor. The first of the two presentations, "Palomid 529, a Non-Steroidal Small Molecule Anti-Angiogenic Agent Inhibits ...

BioForm Medical Acquires Facial Aesthetic Nerve Ablation Technology

... to create RF heat lesions in nerve tissue. The ACI device uses minimally-invasive bi-polar radiofrequency energy selectively to weaken nerve signal transduction with durable effects. The use of this technology on nerves that control the muscles of the forehead may reduce the appearance of frown lines, ...

Cancer prevention: stopping cancer before it can start

... resulted in a more potent inhibition of androgen-independent growth than either drug alone. The agents appear to work by inhibiting a signal transduction pathway that is important for the growth of these cancer cells, Zheng said. Although a high dose of celecoxib has been linked to a small increase ...

'Nanomachine' Releases Anticancer Drugs Inside Cells

... activated by where the light is shining," Fuyu Tamanoi, a professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics group at UCLA's Jonsson Comprehensive Cancer Center, said in a prepared statement. He and colleague Jeffrey Zink, a professor of ...

UCLA researchers design nanomachine that kills cancer cells

... of chemistry and biochemistry, and Fuyu Tamanoi, UCLA professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics program at UCLA's Jonsson Comprehensive Cancer Center. Tamanoi and Zink are two of the co-directors for the Nano Machine Center for ...

Wake Forest to host nanomedicine workshop

... institutions as far away as New Zealand will attend the workshop. Presentations will cover such topics as the pharmacology of nanomaterials, heat transduction in nanoparticles, combining hyperthermia and mild hyperthermia with chemotherapies and extending hyperthermic therapies to noncancerous diseases. ...

New Drug for Brain Cancer Too Dangerous for Pediatric Patients

... cancers may place pediatric patients at risk for bone damage and stunted growth, an animal study suggests. The new red flag concerns a signal transduction inhibitor (STI) medication known as "HhAntag", a drug developed to treat medulloblastoma brain tumors by short-circuiting tumor growth on the ...

USC researchers discover novel way to develop tumor vaccines

... cells and pathological autoimmune toxicities. The study identified a new molecular player called A20, an enzyme that restricts inflammatory signal transduction in dendritic cells. When it is inhibited, the dendritic cells overproduce an array of cytokines and co-stimulatory molecules that triggers unusually ...

High zinc status in lung cells slows growth and induces DNA damage-induced gene expression

... proteins was Gadd45 dependent. Thus, the researchers demonstrated for the first time that an elevated zinc status modulated the p53 and p38 signal transduction pathways to produce a delay at G2/M during cell cycle progression in NHBE cells. Lei says the use of normal human cell types to evaluate the ...

Experimental Biology 2008 Today's Research: Tomorrow's Health, April 5-9

... RNA world; molecular structure and dynamics; new understanding of metabolic control mechanisms in cancer, diabetes, and neurodegeneration; signal transduction and post-translational modifications in cancer, microbial pathogenesis and progeria; therapeutic targeting of signaling pathways in human diseases; ...
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