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HIV Drugs Linked to Increased Risk of Heart Attack

... a protease inhibitor and a nucleoside reverse transcriptase inhibitor such as abacavir or didanosine. ... For commonly used drugs called nucleoside reverse transcriptase inhibitors such as zidovudine, stavudine or ... heart attack. However, the nucleoside reverse transcriptase inhibitors abacavir and didanosine were ...

Overlooked Mutation Can Spur HIV Drug Resistance

... into a broad category of drugs called reverse transcriptase inhibitors (RTIs), so named because they target a ... the key points of resistance lay on the reverse transcriptase molecule, and so they designed their tests ... that's also essential to proper reverse transcriptase function. "Our logic for the current study ...

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

... inhibitor, is overall as effective as widely used efavirenz, a reverse transcriptase inhibitor, the researchers found. Raltegravir also had faster onset of ... FDA. Other types of antiretroviral drugs inhibit HIV's protease or reverse transcriptase enzymes. Guidelines from the U.S. Department of Health and Human ...

Ardea Biosciences Reports Progress of Clinical Development Programs; Provides 2008 Outlook; Announces 2007 Financial Results and Provides 2008 Financial Guidance

... and favorable resistance profiles for our non-nucleoside reverse transcriptase inhibitor (NNRTI) family of compounds against HIV at the 15th Annual ... Our most advanced drug candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for the treatment of HIV. ...

AAHIVM Encouraged by TMC125 Approval

... anti-HIV medication TMC125 (etravirine), the first non-nucleoside reverse transcriptase inhibitor (NNRTI) to be introduced in nearly 10 years, and the first to ... that partially or completely stop the NNRTI from binding to the reverse transcriptase enzyme, causing the drug to lose effectiveness. "With the FDA's ...

Ardea Biosciences' Lead NNRTI for HIV, RDEA806, to Enter Phase 2a Proof-of- Concept Clinical Trial

... viral load. About RDEA806 RDEA806 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for the potential treatment of HIV infection. Based on ... programs include: RDEA806, the Company's lead non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV, which entered a Phase 2a ...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

... from two Phase 3 studies (DUET-1 and DUET-2) showed that significantly more treatment-experienced HIV-1-infected adults with non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI) resistance had an undetectable viral load (<50 HIV-1 RNA copies/mL) while taking INTELENCE(TM) ...

Also in the March 24 JNCI

... Stimulates Telomerase Activity in Tissue Culture Cells Infection with human cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) gene in both normal human cells and tumor cells grown in culture. HCMV has been suspected of causing or promoting cancer, but the ...

Tibotec Submits Application to U.S. Food and Drug Administration Seeking Traditional Approval for INTELENCE(TM) (etravirine)

... to the U.S. Food and Drug Administration (FDA) seeking traditional approval for INTELENCE(TM) (etravirine) tablets, a non-nucleoside reverse transcriptase inhibitor (NNRTI). The application for traditional approval includes 48-week data from two Phase 3 studies known as DUET-1 and DUET-2. INTELENCE is ...

Herpes drug inhibits HIV replication, but with a price

... The anti-herpes drug acyclovir can also directly slow down HIV infection by targeting the reverse transcriptase (RT) enzyme, researchers report in this week's JBC . This beneficial effect does pose a risk though, as HIV-infected cells treated with acyclovir ...

HIV prevention researchers to compare common ARV as a pill and vaginal gel in unique study

... of one of the most widely used regimens for treating HIV. The active ingredient in tenofovir belongs to a class of ARVs called nucleotide reverse transcriptase inhibitors (NRTIs), which act against HIV by targeting a key enzyme the virus needs to make a copy of its genetic material an essential step for the ...

Breast Cancer Vaccines Look Promising

... an immune response against cancer cells already in the body. In her study, Domchek used pieces of a protein called human telomerase reverse transcriptase (hTERT) peptide to vaccinate 19 women with breast cancer that had spread. The peptide is nearly universally overexpressed in human cancers and is ...

Ardea Biosciences Announces Upcoming Corporate Meetings

... in clinical trials and several others in preclinical development and discovery. Our most advanced drug candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for the treatment of HIV. We have evaluated our second generation NNRTI, RDEA427, for the treatment ...

Study Supports Popular HIV Drug Regimen

... HIV-positive patients at 55 treatment centers. The patients took one of three regimens, two of which included older drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). Doctors consider them to be effective, but they can cause a variety of side effects. The researchers found that the ...

Idenix Pharmaceuticals Reports Fourth Quarter and Year-End 2007 Financial Results

... of Tyzeka/Sebivo in the United States and Europe. -- The expansion of Idenix's pipeline to include a novel non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 that is currently in clinical development, and several novel direct-acting HCV product candidates, ...

Anti-HIV gel proven safe, tolerable for women

... theyre not bothered by the gel, Hoesley said. The active ingredient in tenofovir gel is a class of anti-retroviral drugs called nucleotide reverse transcriptase inhibitors, which act against HIV by blocking the virus ability to replicate and grow inside the body. ...

Trial finds tenofovir gel safe for daily use and most women adhered to study regimens

... widely used regimens for treating HIV. The active ingredient in tenofovir gel belongs to a class of anti-retroviral drugs called nucleotide reverse transcriptase inhibitors, which act against HIV by targeting a key enzyme the virus needs to copy itself before taking over a host cell. The topical gel form of ...

Test Detects Sensitivity to HIV Drug

... also known by the brand name Ziagen, which is found in compound drugs known as Trizivir and Epzicom. The drug is known as a nucleoside reverse transcriptase inhibitor and works by preventing the AIDS virus from going through the motions of multiplying. About 8 percent of patients suffer from ...

Tibotec Pharmaceuticals a Respectful Partner to HIV Community in Pricing of Novel New HIV NNRTI, INTELENCE

... WASHINGTON, Jan. 31 /PRNewswire/ -- The FDA approved Tibotec Pharmaceutical's novel non-nucleoside reverse transcriptase inhibitor (NNRTI) INTELENCE(R). The company also announced introductory pricing for the eagerly anticipated new compound at $21.80 per day, ...

Bristol-Myers Squibb Company Reports Financial Results for the Fourth Quarter and Twelve Months of 2007

... period in 2006 primarily due to increased demand in Latin America and Europe. -- Sales of the SUSTIVA(R) Franchise, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV, increased 17%, including a 5% favorable foreign exchange impact, to $260 million in the fourth quarter of ...

IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide

... In March 2004, IPM signed an agreement with Johnson & Johnson subsidiary Tibotec Pharmaceuticals Ltd. to develop the company's non-nucleoside reverse transcriptase inhibitor dapivirine as a microbicide. In October 2005, IPM entered agreements with Merck & Co. and Bristol-Myers Squibb to develop CCR5 blocker and ...

Improved diagnosis of cutaneous leishmaniasis thanks to new techniques

... can also contribute to predicting the clinical outcome. Although QT-NASBA was highly sensitive, another technique, the so-called real-time Reverse transcriptase PCR was found to be more suitable due to its greater time efficiency and lower costs. In practice, neither of these two techniques will be quickly ...

amfAR announces inaugural Mathilde Krim Fellowship Awards for AIDS research

... drugs, patients often develop drug resistance to all currently available drug classes, including the two currently available types of reverse transcriptase inhibitors (RTIs). Dr. Marchand and his colleagues have discovered a new type of compound that blocks the reverse transcription process but differs ...

Idenix Pharmaceuticals Reports Third Quarter and Nine Month Financial Results

... a single-dose pharmacokinetic (PK) study and a 7-day multi- dose study in healthy volunteers for the company's non-nucleoside reverse transcriptase inhibitor (NNRTI) candidate IDX899 for the treatment of HIV. The full preclinical data and these first human data were submitted for ...

Study Compares First-Line Drug Therapies For Treating HIV

... the therapy consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) with efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), suppressed the virus to ... for the treatment of HIV. Nucleoside reverse transcriptase inhibitors, or NRTIs, prevent healthy T cells ...

Resistance Already Emerging in First Months of Treatment Despite Viral Load Decline

... varied, but all contained 3TC combined with another nucleoside reverse transcriptase inhibitor (NRTI) plus either a protease inhibitor (PI) or a nonnucleoside reverse transcriptase inhibitor (NNRTI). Fourteen of the patients were chronically ...

Drug Used to Prevent HIV Transmission from Mother to Child Damages DNA

... which typically include AZT (zidovudine), a nucleoside reverse transcriptase inhibitor (NRTI), have reduced the rate of transmission from mother to ... who are not breast fed. NRTIs work by inhibiting the viral reverse transcriptase and by incorporating into the viral DNA and terminating nascent strands, ...

Drug Used to Prevent HIV Transmission from Mother to Child Damages DNA

... which typically include AZT (zidovudine), a nucleoside reverse transcriptase inhibitor (NRTI), have reduced the rate of transmission from mother to ... who are not breast fed. NRTIs work by inhibiting the viral reverse transcriptase and by incorporating into the viral DNA and terminating nascent strands, ...

A More Convenient HIV Treatment Is as Effective as More Complex Regimens

... Regimens to treat HIV infection that are based on a non-nucleoside reverse transcriptase inhibitor (NNRTI) are at least as effective as treatment with a protease ... HIV. The drug contains emtricitabine and tenofovir, two nucleoside reverse transcriptase inhibitors, plus efavirenz. The components of the drug were previously ...

Reducing the Risk of Protease Inhibitor-Related Atherosclerosis

... of Kentucky found that when mice were given a nucleoside reverse transcriptase inhibitor (NRTI) and a protease inhibitor in combination, it prevented ... knowledge, these are the first data that indicate that nucleoside reverse transcriptase inhibitors can limit the atherogenic (tendency to form lipid deposits in ...

Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.

... proteins are very important at the three stages of infection. Reverse transcriptase converts the viral RNA into DNA. Integrase brings the ends of the DNA ... are various drugs like AZT and other combination drugs to inhibit Reverse transcriptase and Protease proteins but no single drug to act on Integrase. ...

New "second-line" AIDS Drug Shows Promise in Trials

... Etravirine, also called TMC125, is designed as an alternative for patients who are resistant to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). An international consortium of doctors has been testing etravirine on NNRTI-resistant patients in two 48-week trials, ...

New Drugs Show Promise in Fighting Drug-Resistant HIV

... and placebo controlled -- is the pivotal registration and efficacy trial for TMC125 (it is in a class of HIV drugs called non-nucleoside reverse transcriptase inhibitors [NNRTI]). The Lancet study found that at the 24th week, patients who received TMC125 in combination with TMC114 achieved superior ...

Challenges in Entecavir Drug Treatment

... a polymerase enzyme in the hepatitis B virus that helps produce new viral DNA. However, the hepatitis B polymerase closely resembles the reverse transcriptase enzyme that HIV uses to copy its genome inside an infected cell. Thus, there was a possibility that treating co-infected patients for hepatitis B ...

Flash-heating Inactivates HIV in Breast Milk: Study

... breast milk found that cell-free HIV had been inactivated in all of the heated samples. The researchers note that they used a reverse transcriptase (RT) assay to test for an enzyme produced by viable HIV since traditional tests for HIV do not distinguish between dead and live viruses. The RT ...

New Drugs Hold Hope for HIV Patients

... USA. The three new drugs are the HIV integrase inhibitors, R5 inhibitors, and etravirine (TMC125), a second-generation non-nucleoside reverse transcriptase inhibitor. HIV patients in deep salvage means those people who have developed multidrug resistant HIV that does not respond to drug ...

Swedish Biotech Licenses HIV Drug to China for Development

... The Swedish biotechnology company Medivir announced yesterday that it has licensed its experimental non-nucleoside// reverse transcriptase inhibitor (NNRTI), code-named MIV-160, to the Chinese company Guangdong Lantai Viewland Pharmaceutical for the China region. Medivir will retain the ...

New Drug Offers Promise as Single Treatment for HIV

... interest in MK-0518 because it works in a different way than other anti-HIV drugs. Previous antiretroviral drugs target enzymes called reverse transcriptase and protease, which play key roles in the virus' ability to reproduce itself. MK-0518 targets a "third enzyme" called integrase, which is found ...

Sour Taste Sensors Identified

... that are expressed in many different tissues. "That got it down to about 900 candidates," she said. Huang then used a technique called reverse transcriptase polymerase chain reaction (RT-PCR) to find which of the candidates were expressed specifically in taste receptor cells. Of the approximately 30 ...
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