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Thymus in Medical News

Rare disorder gives modelers first glimpse at immune system development

... DURHAM, N.C. -- Children born without thymus glands have given Duke University Medical Center ... Biology, tracked three young patients after thymus tissue transplantation to measure the growth of a ... all of its diversity. Duke University pioneered thymus transplantation for children born with DiGeorge ...

UBC research finds molecular "key" to successful blood stem cell transplants

... blood. The stem cells then need to travel to the thymus - an organ near the heart - and produce T-cells, ... is the failure of stem cells to repopulate the thymus and generate T-cells. Without T-cells the patient ... a molecule called S1P that can tell the thymus to "open the gates" and accept more stem cells. ...

Scripps Research cancer biology department awarded more than $8 million in new research grants

... Petrie's work understanding regrowth of the thymus in adults and the elderly. Decreases in T cell ... cells (which form the supportive framework of the thymus and other organs). Using an experimental model of thymus regrowth, Dr. Petrie and his colleagues will seek ...

New UGA research on gene sheds light on T-cell production

... be crucial to maintaining the production of the thymus and its disease-fighting T-cells after an ... could help scientists find out how to turn the thymus back on so it could produce T-cells long after it ... Xiao, also of the University of Georgia. The thymus is an organ located in the upper part of the ...

Cells on path to becoming mature T-cells more flexible than commonly thought

... found that progenitor cells that make it to the thymus have not yet committed to either the myeloid or ... to becoming T cells by the time they get to the thymus gland. ETP cells retained the ability to become ... asked whether some of the myeloid cells in the thymus normally arise from ETPs. The process of T-cell ...

Stimulating Thymus Reactivates T-Cell Production

... News) -- It's possible to stimulate the thymus gland to produce new immune system T-cells in ... of the immune system and severe infection. The thymus gland produces T-cells early in life but ... is the first to show that therapy can help boost thymus function in adults. The two-year study of 22 ...

Reunion with patient inspires follow-up study on treatment for DiGeorge syndrome

... transplant on a baby girl who was born without a thymus gland and was suffering from severe immune ... Hospital UCLA. "This also suggests that the thymus may not be necessary for immune development after ... other tissues, such as the skin, may serve as a thymus equivalent." DiGeorge syndrome is a common ...

Study identifies key player in the body's immune response to chronic stress

... increased rate and immune system organs like the thymus and spleen lose mass and begin to atrophy, said ... OPN mice experienced weight loss, spleen and thymus atrophy, and a reduced number of white blood ... White blood cell death in the spleen and thymus was evident only in the mice with normal OPN, Shi ...

Dendritic cells ensure immune tolerance

... cells, even the first, central screening of autoreactive T cells in the thymus runs only at reduced efficiency," reports Vhringer. "In these animals, the thymus releases T cells that react to the body's own material. These are then ...

Genetic evidence points to potential therapeutic bypass for autoimmune process

... impaired in the thymus. Mutations in Carma1 can result in a failure of the thymus to produce Treg cells, said senior investigator Kasper Hoebe, Ph.D., a ... can result in development of Treg cells. This means if the process in the thymus breaks down, as in the case with Carma1 mutations, inducing Treg cells ...

Cells from the Research Institute of the MUHC on the road to China

... the pancreas is not the only insulin-producing organ of the body. The thymus also produces a small quantity of insulin. While insufficient to regulate ... years and has succeeded in creating a culture line of insulin-producing thymus cells. His goal is to find a drug that would trigger these cells to ...

JCI table of contents: Feb. 21, 2008

... that the frequency of a marker of cells that have just been made in the thymus was increased in those individuals infected with HIV-1 who were taking ... ACCOMPANYING COMMENTARY TITLE: Growth hormone resurrects adult human thymus during HIV-1 infection AUTHOR CONTACT: Frank Miedema University ...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

... to deal with viral infections, or just to complete their normal life cycle. Cells lining the gut, for example, or immune cells in the spleen and thymus are meant to live only a couple of days. "You lose three-quarters of a million cells per second in your body due to apoptosis," noted Guy Salvesen, ...

Viral Genetics Has Option Under Issued Key Patent for Cancer Drug

... Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The company recently entered into an Exclusive License Agreement with the University of Colorado and V-Clip ...

CORRECTION: Viral Genetics Pursues Promising New Therapy for Lyme Disease With Grant from Time for Lyme, Inc.

... Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The company recently entered into an exclusive license agreement with the University of Colorado and V-Clip ...

Five UCSF Scientists Elected to National Academy of Sciences

... to the pancreatic beta cells, which are destroyed by the immune system in type I diabetes; he found, for example rare tolerance-inducing cells in the thymus that express the beta-cell specific insulin gene. As a graduate student, Hanahan developed high efficiency plasmid transformation methods and E. ...

AAI honors Chen Dong for breakthrough T lymphocyte research

... Th1 or Th2 pathways. It was black and white, one or the other," Dong said. T cells are lymphocytes, a type of white blood cell produced by the thymus equipped with receptors that recognize and bind to antigens, pieces of invading organisms presented to the T cells by dendritic cells. The bound ...

Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes

... for Human Immunology at Emory University. In childhood, new T cells are continually produced in the thymus, she says. But after about age 40, the thymus "involutes" or shrinks and ceases to function. After that, the immune system has to make do with the pool of T cells it already has. "What we see ...

UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases

... movement throughout the body by interacting with its receptor. The patient's antibodies blocked the signaling that triggers T-cell movement from the thymus and lymph nodes into blood and then into many organs. Researchers then explored whether the woman's antibodies effectively could inhibit an ...

Researchers find new way to block destructive rush of immune cells

... sense and follow chemicals and molecules they are attracted to toward wherever those attractants are most concentrated. T cells, named after the thymus (T) where they mature, move toward the byproducts of bacteria and viruses. The second migratory mechanism is propulsion. In between infections ...

SLU researchers show how to stop muscle weakness caused by myasthenia gravis

... the other symptoms are prevented or reversed as well. Myasthenia gravis cant be cured, but it is sometimes be treated with surgery to remove the thymus (which plays a role in the immune system) or with various drugs. Surgery often doesnt bring relief, however, and the medications typically decrease ...

Researchers train the immune system to deliver virus that destroys cancer in lab models

... has spread. Dr. Vile and colleagues theorized that they could control the spread of cancer through the lymphatic system (bone marrow, spleen, thymus and lymph nodes) by manipulating the immune system. Researchers zeroed in on immature T-cells from bone marrow, programming them to respond to ...

UF researchers track genetic journey of HIV from birth to death

... development. We found that the late-stage viruses, the X4 viruses, were localized predominantly in the thymus, Goodenow said. It says that the thymus is the place where these viruses develop, or at least where theyre localized and replicate. The origin of the X4 viruses has puzzled scientists ...

Thymus Transplants Give Hope to Babies With Fatal Immune Disease

... three in September, thanks in large part to a thymus transplant she received at Duke University ... show that 75 percent of the babies who received a thymus transplant were alive after one year. The ... However, about 1 percent of these babies have no thymus at all, a situation that ends in death, usually ...

Aggressive Stem Cells Might Improve Transplant Outcome

... cells or donated cells—normally gather in the thymus gland in the chest. There the stem cells receive ... both of these antibodies to pieces of human thymus glands. The pieces of thymus glands used in the study had been removed from ...

Regulatory T-cells – Protector or Cause of Diseases

... college of Georgia, studied the T-cells in the thymus and their subsequent movement in the body, using ... T cells learn what to protect while in the thymus and that everything the cells learn may not be ... autoimmune disease. T cell schooling in the thymus peaks in the first six weeks of life in the ...

T-cells Developed from Human Embryonic Stem Cells

... Those cells were then injected into a human thymus gland that had been implanted in a mouse, and the thymus then changed those blood-forming cells into T-cells. Located just above the heart in humans, the thymus is the organ where T-cells develop. It gradually ...

Autoimmune Diseases – Newer Preventive Measure

... cells come out of the bone marrow and go to the thymus where all T cells go for a process of positive ... expression in the thymus, Dr. Mi says. The thymus is supposed to express most body proteins so any ... have learned medullary epithelial cells in the thymus are critical to proper iNKT cell development. A ...

Heart transplanted infants better model for developing AIDS treatment

... team would be studying the immune system of thymus removed heart transplanted infants. The research team found that these infants had their thymus removed and though there T-cell count is very low ... in their study followed up infants who had their thymus removed during heart transplants and the ...

Thymus transplant could save babies

... Babies born without a thymus - an essential immune system component - can get ... are born in the United States each year without a thymus gland, and they always die because they cannot develop an immune system. The thymus is the organ that programs the T-cells that ...

Study Reveals Effects of WBCs on Transplanted Kidney

... IRI, white blood cells were taken from mice that had undergone experimentally induced IRI. These cells were injected into mice engineered without a thymus gland, which produces T cells. A comparison group of genetically engineered mice got no injections. After the researchers temporarily stopped ...

White Blood Cells Can Both Hurt and Help Transplanted Kidneys

... IRI, white blood cells were taken from mice that had undergone experimentally induced IRI. These cells were injected into mice engineered without a thymus gland, which produces T cells. A comparison group of genetically engineered mice got no injections. After the researchers temporarily stopped ...

Rituximad Can Treat Chronic Graft-Versus-Host Disease: Study

... others, that indicates that immune system B cells, as well as T cells, play a critical role in GVHD. (T cells are so named because they mature in the thymus gland, while B cells are derived from bone marrow.) This hypothesis gained traction when laboratory studies and small clinical trials showed that ...

Biotech drug causing anemia-EPREX

... in vanishingly small number of people and patients affected with this disease need regular blood transfusions. PRCA, though linked to disease of the thymus gland, some viruses and other auto-immune diseases, has never been linked to kidney diseases or drugs used to treat it, till recently. A special ...

Safety of soy under suspicion

... in the womb and during breast feeding has the biggest impact. The researchers also found that the male rats exposed to genistein had a slightly large thymus gland, an organ that produces immune cells. They also found that moderate levels of genistein had an even bigger effect on male rats than large ....
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