Raptor Pharmaceuticals Corp. and TorreyPines Therapeutics, Inc. Announce Merger Agreement

... Company Focusing on Improved Drug targeting and Reformulation of Existing Therapeutic ... development candidates and preclinical drug targeting platforms designed to improve drug delivery of ... existing treatments, through enhanced drug targeting or reformulation of existing therapeutic ...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

... were among the advances in potential therapies targeting two abnormal brain proteins - beta amyloid and ... enhancing, or suppressing an immune response) targeting beta amyloid is being researched widely by ... Aging) Moran Boimel, et al -- Immunotherapy targeting Pathologically Phosphorylated Tau In A Tauopathy ...

Purdue researchers create prostate cancer 'homing device' for drug delivery

... tumors, and, if they could be linked to this new targeting molecule, we could have a two-pronged attack for ... the tumors." There also is potential for the targeting molecule to be used to attack the vasculature of ... and first author of both papers, compared the targeting molecule to a homing device. "The molecule ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... vector was produced on 293T cells. Specific targeting of this novel adenoviral vector to pancreatic ... specific in vitro targeting, in vivo targeting to subcutaneous growing human pancreatic cancer ... ) mouse model however, no increased adenoviral targeting to subcutaneously growing human pancreas cancer ...

UNC study suggests new approach to common cause of blindness

... that leads to macular degeneration. Furthermore, targeting this new protein may prove to be safer and more ... the generation of abnormal blood vessels. Drugs targeting CCR3 were significantly more effective than those targeting VEGF, meaning this could represent a new therapy ...

New antibiotics could come from a DNA binding compound that kills bacteria in 2 minutes

... drugs. As this antibiotic compound operates by targeting DNA, it should avoid all current resistance ... on the application of this useful property for targeting the DNA of cancer cells as it could bind to, coil ... that it might also be a very clever way of targeting drug-resistant bacteria. New research at the ...

Amgen Highlights Data to Be Presented at ASCO

... effects of the key molecules in development targeting these pathways. The clinical benefits and safety ... study provide proof-of-concept for specifically targeting the RANK Ligand pathway. ... Amgen's growth regulation program is focused on targeting cellular pathways that regulate cell ...

Positive Results for Ophthotech's Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome

... clinical trials. E10030 is an aptamer targeting PDGF, a key molecule involved in the recruitment ... data from oncology and ophthalmic studies targeting the molecules regulating pericyte and endothelial ... an anti-angiogenic monoclonal antibody targeting the a5B1 integrin, both currently in a Phase I ...

U.S. Rep. Connolly, Inova Health System Physicians, Public Health Groups Call for Congressional Action to Protect Kids from Tobacco

... report "Deadly in Pink: Big Tobacco Steps Up Its targeting of Women and Girls," issued by the American ... chapter in the tobacco industry's long history of targeting women and girls, which has had a devastating ... describes the tobacco industry's long history of targeting women and girls. In the 1920s, ads for Lucky ...

Frost & Sullivan Lauds Veran Medical for its IG4 Plug-n-Play Navigation System

... as the IG4, which enables accurate and efficient targeting of very small lesions in the lungs. The ... 4D registration capability for precise targeting of lesions via its FDA cleared platform. The ... for the clinical staff, and increase targeting accuracy enabling physicians to cost effectively ...

Researchers identify potential therapeutic target in osteosarcoma

... agents directly to osteosarcoma cells by targeting the receptor with circulating particles that ... was negative. "This indicates that therapeutic targeting of IL-11Ra may yield anti-tumor, anti-metastasis ... The drug is defined as BMTP-11 (Bone Metastasis targeting Peptide 11). The first clinical trial, in which ...

Health Groups Slam Tobacco Marketing to Women

... to Deadly in Pink: Big Tobacco Steps Up Its targeting of Women and Girls . The report was issued by ... latest in the tobacco industry's long history of targeting women and girls, the report said. Smoking ... other types of cancer. "Big tobacco's blatant targeting of women is just an extension of a decades-long ...

Deadly in Pink: New Report Warns Big Tobacco Has Stepped Up Targeting of Women and Girls

... report, "Deadly in Pink: Big Tobacco Steps Up Its targeting of Women and Girls," was issued by the American ... chapter in the tobacco industry's long history of targeting women and girls, which has had a devastating ... "Big Tobacco's blatant targeting of women is just an extension of a decades-long ...

JCI online early table of contents: Feb. 16, 2009

... EDITOR'S PICK: targeting the protein AEG1 impairs human liver cancer ... for HCC progression. They therefore suggest that targeting this gene (AEG1), or the protein that it ... A2B receptors. The authors therefore suggest that targeting these adenosine receptors may prove to be an ...

Targeted nanospheres find, penetrate, then fuel burning of melanoma

... HOUSTON - Hollow gold nanospheres equipped with a targeting peptide find melanoma cells, penetrate them ... 1 issue of Clinical Cancer Research . "Active targeting of nanoparticles to tumors is the holy grail of ... experiments demonstrated the first in vivo active targeting of gold nanostructures to tumors in conjunction ...

APIC 2009 'Targeting Zero' Initiative Offers Practical Tools, Evidence-Based Elimination Strategies to Prevent the Deadliest Healthcare-Associated Infections

... Epidemiology (APIC) has expanded its successful targeting Zer o initiative for 2009 to offer comprehensive ... healthcare-associated infections (HAIs). targeting Zero features Webinars, conferences and ... success stories on performance improvement. targeting Zero was initiated in 2008 with educational ...

Wyeth Pharmaceuticals and Santaris Pharma Announce Strategic Alliance to Develop RNA-based Medicines

... Acid (LNA) drug platform, which allows specific targeting and regulation of microRNAs (miRNAs) and ... Wyeth explores a fourth platform technology targeting RNAs, which complements our expertise in small ... LNA Drug Platform for developing new therapies targeting RNAs." About the Locked Nucleic Acid Drug ...

Drug Shields Mice From Emphysema

... to curb the progression of the disease by targeting the Nrf2 pathway. "The result demonstrates ... This study provides hope that strategies aimed at targeting the Nrf2 pathway might be effective in inhibiting ... be done in COPD patients to test the strategy of targeting Nrf2, to test the efficacy in reducing the burden ...

UCLA scientists find cell pathway driving a deadly sub-type of breast cancer

... and represents a class of genes called proteasome targeting complexes. The work shows that basal cancer cells ... gene p27 by making a new type of proteasome targeting complex. The gene p27 is one of a handful of ... Center. "The possibility that this new proteasome targeting complex might provide targets for therapeutic ...

Fitness Model / Entrepreneur Targets Childhood Obesity and Makes Headlines Nationwide With New Franchise Offering

... have made available a new fitness franchise targeting childhood obesity. In 2007, data showed that 15% ... to open a non-profit organization, MDT Network, targeting childhood obesity. Her goals are to help all ... winning combination of business and fitness targeting America's youth. Franchise opportunities ...

JCI online early table of contents: Aug. 1, 2008

... authors therefore suggest that combining drugs targeting IAPs with RTK inhibitors might prove beneficial ... CB1 is currently limited by the side effects of targeting CB1 in the brain, anxiety and depression. ... 2 diabetes. The authors therefore suggest that targeting liver CB1 might provide an effective way to treat ...

Researchers hone technique to KO pediatric brain tumors

... drug, because in these initial nanoparticles, no targeting groups were included and also the entire drug ... released. The identification and attachment of targeting ligands onto the nanoparticles and the rate and ... to target the tumors through the use of active targeting ligands and also through passive diffusion, as ...

Immune Design Announces $18 Million Series A Financing

... with improved adjuvants and novel technologies targeting and controlling dendritic cells, which ... new vaccine technologies to Immune Design. "By targeting dendritic cells, we hope to both improve the ... adjuvants and novel technologies targeting and controlling dendritic cells, which have ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... may appear in several groups) are: 41 agents targeting the vascular endothelial growth factor (VEGF) pathway 18 agents targeting the ErBb family (EGFr, HEr2, etc.) 13 agents targeting the Aurora kinase family 11 histone deacetylase ...

Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting

... Show ABT-263 and ABT-869 to be Promising in targeting Cancer Cells' Underlying ... online today at http://www.asco.org . By targeting a key survival mechanism of cancer cells, ... diseases. Additionally, Abbott scientists are targeting another vital characteristic of cancer cells with ...

Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel

... international clothing and accessory chain stores targeting mainly girls and women under age 40; and similar ... was examined from accessory and clothing stores targeting younger women under age 40 and those ... whereas only 1.7 percent of earrings from stores targeting women over 40 tested DMG positive. "Except for ...

Micromet, Inc. Reports First Quarter 2008 Financial Results

... provided proof of concept for a BiTE antibody targeting CD33 with potential use in the treatment ... leukemia (AML), and a BiTE antibody targeting MCSP with potential use in the treatment ... a therapeutic window of a BiTE antibody targeting EpCAM in a relevant animal species. -- In March, ...

drugstore.com inc. Reports Results for the First Quarter of 2008

... improve operational efficiencies throughout 2008- targeting to exit the year with gross margins above ... For the second quarter of 2008, the company is targeting net sales in the range of $118.0 million to ... fiscal year 2008 guidance. The company is now targeting net sales in the range of $490.0 million to ...

Tiny magnets offer breakthrough in gene therapy for cancer

... of Keele, said: Though the concept of magnetic targeting for drug and gene delivery has been around for ... By harnessing and enhancing the monocytes' innate targeting abilities, this technique offers great potential ... team are now looking at how effective magnetic targeting is at delivering a variety of different ...

Isis Reports Financial Results and Highlights for Fiscal year 2007

... discovery and development of antisense drugs targeting PCSK9, an important regulator of the ... * Isis licensed alicaforsen, an antisense drug targeting ICAM-1 for ulcerative colitis, to Atlantic ... in discovering and developing antisense drugs targeting microRNAs. * Kleanthis G. Xanthopoulos, ...

New target for cancer therapy may improve treatment for solid tumors

... targeting and killing the non-malignant cells that surround ... role in tumor growth. We already knew that targeting the stroma is essential for eradicating ... of tumors for more than 80 days. Although targeting the stroma didn't eliminate all cancer cells, it ...

Microsoft Launches Fund to Enable Patient-Centric Health Solutions

... 1: Primary Prevention Applications Proposals targeting primary prevention could help people and ... or in an urgent care setting. Proposals targeting acute care scenarios might track progress, ... and environmental factors. Proposals targeting this track might choose to create online ...

JCI table of contents: Jan. 24, 2008

... Although it has been proposed that drugs targeting the in vivo differentiation of these cells might ... drugs that are capable of specifically targeting MSCs and that can also regulate their ... Healthcare System. TITLE: Pharmacologic targeting of a stem/progenitor population in vivo is ...

Pharmion and MethylGene Present Favorable Clinical Data From Combination MGCD0103/Vidaza(R) Study in Myelodysplastic Syndromes and Acute Myelogenous Leukemia at The 49th American Society of Hematology (ASH) Meeting

... of cancer. Pharmion strongly believes that by targeting two separate epigenetic pathways simultaneously, the combination of drugs targeting DNA methylation and histone deacetylation can ... MGCD265 is an oral kinase inhibitor targeting the c-Met, Tie-2, Ron and VEGF receptor tyrosine ...

Advances in Blood Cancer Therapy to be Highlighted at American Society of Hematology Conference

... in immunotherapies, personalized medicine and targeting transcription factors. Immunotherapies: ... of Perugia, Italy, (Dec. 9, 7:30 a.m.). targeting transcription factors: Transcription factors are ... are good targets for new drug development. -- targeting RUNX1 in Leukemia, John H. Bushweller, Ph.D., ...

Micromet and MedImmune to Present New Clinical Data for Anti-CD19 BiTE(R) Antibody at American Society of Hematology Annual Meeting Showing Objective Clinical Responses in Relapsed Non-Hodgkin's Lymphoma Patients

... T-cell engaging antibody, or BiTE(R) antibody, targeting the CD19 antigen, which is uniquely expressed on ... studies of MT103, three other BiTE antibodies, targeting EpCAM (CD326), CEA and MCSP, are in ... adecatumumab (MT201), a human monoclonal antibody targeting EpCAM expressing tumors. Adecatumumab is being ...

Gates Foundation Commits to Expansion of HIV Prevention in China

... New initiative to support prevention programs targeting high-risk groups SEATTLE, Nov. 13 /PRNewswire/ ... will increase access to HIV prevention programs targeting those most vulnerable to infection, ... Expanding effective HIV prevention programs targeting high-risk groups, including injection drug ...

JCI table of contents: Nov. 8, 2007

... to mount strong antiviral CD8+ T cell responses targeting the lymphocytic choriomeningitis virus glycoprotein (GP). By contrast, CD8+ T cell responses targeting tumors engineered to express the same GP protein ... lung damage, and led the authors to suggest that targeting this pathway might provide a new approach to ...

Written Statement of Kevin J. O'Connor, Chairman of the Department of Justice Task Force on Intellectual Property, at the Senate Judiciary Committee Hearing on Intellectual Property Enforcement

... an integral part of President Bush's Strategy targeting Organized Piracy, or "STOP", initiative. This ... federal enforcement operation targeting traffickers in counterfeit and pirated goods that ... These and earlier Department-led operations targeting online piracy, are examples of an unprecedented ...

Novel strategy under study for aggressive leukemia

... take direct hits at the mutant protein by targeting HSP 90, a molecular chaperone, which, in this ... is particularly susceptible to depletion by targeting it with HSP 90 or histone deacetylase inhibitors. ... the synergy of kinase inhibitors. We are targeting HSP 90, which folds and keeps this abnormal ...