Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer
... Researchers have identified a new candidate tumor suppressor
gene in colorectal cancer and examined its use as ... gene 4 (NDRG4) as a novel tumor suppressor
The researchers analyzed NDRG4 ... this is the first study to describe a tumor suppressor
role for NDRG4 in cancer," the authors write. ...
Tips from the American Journal of Pathology
... Am J Pathol 2009, 174: 1745-1755
of Cytokine Signaling (SOCS)-1 Inhibits Prostate ... V, Brugger M, Hobisch A, Kenner L, Culig Z: suppressor
of cytokine signaling (SOCS)-1 is expressed in ... of Pathology .
TIP30 is a putative tumor suppressor
with decreased expression in numerous cancers ...
Late-breaking data to be presented at the American Society of Hematology Annual Meeting
... of anemia, and the discovery of a new tumor suppressor
gene in patients with myeloproliferative ... safety concerns.
TET2 is a Novel Tumor suppressor
Gene Inactivated in Myeloproliferative Neoplasms: ... that time.
This research unveiled a new tumor suppressor
gene called TET2 (Ten-Eleven ...
Cellular senescence a double-edged sword
... new paradigm for how oncogenes promote and tumor suppressor
genes slow down the development of cancer, and ... longer capable of dividing. Apoptosis as a tumor suppressor
has been well characterized through in vivo ... when cells lost the functions of the p53 tumor suppressor
"Our findings help explain why ...
Cold Spring Harbor science teams identify 13 new tumor-suppressor genes in liver cancer
... and Michael Wigler, Ph.D.
Pinpointing Tumor suppressor
Tumor suppressors are a crucial ... to be the location of most of the missing tumor suppressor
genes. A comparison of this list with the genome ... "trigger" such as the shutting off of a tumor suppressor
gene via RNAi would be sufficient to cause ....
New findings may improve treatment of inherited breast cancer
... cancer cases are caused by mutations in tumor suppressor
genes, such as breast cancer associated gene-1 (BRCA1). BRCA1 is the most frequently mutated tumor suppressor
gene found in inherited breast cancers and BRCA1 ... found that BRCA1 functioned as a tumor suppressor
by maintaining SIRT1 expression, which in turn ...
CSHL scientists trace causal link between a tumor suppressor gene and liver cancer
Focusing on a Suspected Tumor suppressor
genes play a vital role in intracellular ... utility."
"DLC1 is a chromosome 8p tumor suppressor
whose loss promotes hepatocellular carcinoma" ...
Also in the May 27 JNCI
... Overlapping Tumor suppressor
Genes Independently Involved in Melanoma
Mutations in the p14ARF tumor suppressor
gene (ARF) may play a role in melanoma, ... demonstrated that inactivation of the p16 tumor suppressor
gene occurs frequently in melanomas, it has been ...
Does 1q31.1-32.1 harbor a tumor suppressor gene related to Chinese SCC patients?
... deletion regions and then to find candidate tumor suppressor
genes. In a previous study, it was found that ... that the region might harbor the putative tumor suppressor
gene(s). However, the allelic deletion region ... loci and subsequently identify candidate tumor suppressor
This study found the critical and ...
AACR's Seventh Annual Landon Awards
... contributions to the discovery of p53 as a tumor suppressor
gene and his work in identifying its anti-cancer ... Best known for his co-discovery of the p53 tumor suppressor
protein, Levine has led the way in uncovering the ... to the realization that p53 is a pivotal tumor suppressor
gene which is mutated or otherwise inactivated in ...
Gene plays 'Jekyll and Hyde' in brain cancer
... in others it becomes whats called a tumor suppressor
gene, a type of gene often responsible for ... different story. PTEN is itself a tumor suppressor
gene. When PTEN becomes disabled in astrocytes, ... their way. This is because STAT3 acts as a tumor suppressor
normally in astrocytes. However, as more PTEN ...
JCI online early table of contents: Jan. 2, 2008
... suppress tumor formation, oncogenes and tumor suppressor
genes, respectively. Because various cancers are ... containing AHRR, scientists believe that a tumor suppressor
gene is located in that region. A new study by ... has provided evidence that AHRR has tumor suppressor
capabilities in a variety of human cancers.
Gene Variant Tied to More Aggressive Prostate Cancer
... Men with differing version of tumor suppressor
appear at increased risk, researchers say
... News) -- Men with a variant in the tumor suppressor
gene DAB2IP may have an increased risk of ... support and biologic relevance as a tumor suppressor
gene," wrote Dr. Jianfeng Xu, of Wake Forest ...
Chemoprevention, naturally: Findings on plant-derived cancer medicines
... colleagues also examined samples for three tumor suppressor
genes in order to determine what researchers call ... cells chances of losing the benefit of the tumor suppressor
genes due to a second mutation or gene silencing ... to normal, retaining both copies of each tumor suppressor
gene. We speculate that the chemopreventive ...
Study details regulation of vital tumor suppressor gene p53
... (PHILADELPHIA) So vital is the p53 tumor suppressor
gene in controlling cancer that its dysfunction ... the bodys management of this all-important tumor suppressor
gene and the protein it produces. The experiments ... the September 6 issue of Nature.
The p53 tumor suppressor
is extremely potent in halting cell growth, says ...
Pathway links inflammation, angiogenesis and breast cancer
... patients whose tumors had the TSC1/TSC2 tumor suppressor
complex blocked by phosphorylation did not ...
Rapamycin is a powerful immune system suppressor
used to protect organ transplant recipients ... proteins, Hung notes. In the case of the tumor suppressor
and the oncogene, CBP will bind to only one at a ...
Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists
... By dissecting the mechanism by which lincRNAs influence tumor suppressor
pathways, she hopes to identify new markers for cancer diagnosis as well ... insights into novel regulatory roles for noncoding RNAs in silencing tumor suppressor
genes, while potentially revealing new therapeutic targets for the ...
Process controlling T cell growth and production identified
... infections. At the same time, they determined that expression of the tumor suppressor
gene called KLF4 was reduced in these mice.
"We discovered that ELF4 directly activates the tumor suppressor
KLF4, which signals cell cycle arrest in nave CD8 T cells," Lacorazza ....
JNCI April 28 tip sheet
... , 301-496-6641
Clusterin Acts as a Tumor suppressor
Gene in Mouse Models of Neuroblastoma
Reduced expression of clusterin in ... to our knowledge, the first evidence to show that clusterin is a tumor suppressor
gene that is negatively regulated by the proto-oncogene MYCN," the authors ...
Reversing effects of altered enzyme may fight brain tumor growth
... Guan said.
He added that IDH1 appears to function as a tumor suppressor
gene that when altered and turned off can contribute to tumor formation ... in normal human cells has two copies), which is different from most tumor suppressor
genes. Most either have genetic material that is deleted or truncated not ...
Mayo researchers discover mechanism of cell type-specific signaling in tumor development
... "We found that a protein called Erbin, in cooperation with the NF2 tumor suppressor
Merlin, controls the outcome."
Erbin, the researchers found, controls the tumor suppressor
gene Merlin. When Merlin is absent or mutated, the result is schwannoma, a ...
Gene helps protect tumor suppressor in breast cancer
... researchers found Rak can stabilize PTEN protein and function as a tumor suppressor
gene to prevent breast cancer development.
To examine the correlation ... tumors.
"To further assess whether Rak is a bona fide breast tumor suppressor
gene, we sought to determine if loss of Rak expression would transform ...
Tumor suppressor may attenuate fibrotic disease
... , also reveals an intriguing but unexpected regulatory role for a tumor suppressor
gene in fibrotic disease.
Platelet derived growth factors (PDGF) ... progressive fibrosis in multiple organs. Interestingly, loss of the tumor suppressor
Ink4a/Arf dramatically accelerated the development of fibrotic lesions. ...
Gene may lead to early onset of brain tumor
... to 15 months.
Through blood samples, researchers looked at the tumor suppressor
TP53 gene. This gene acts as a tumor suppressor
and is involved in preventing cancer.
People younger than 45 with ...
Escape cancer, but age sooner? The dark side of the tumor suppressing process
... tissue-altering molecules, as do cells that lose functions of the tumor suppressor
protein p53. The study therefore explains why the presence of senescent ... study defines a new paradigm for how oncogenes promote, and how tumor suppressor
genes suppress the development of cancer," said Campisi. "The established ...
CSHL scientists show how a protein that determines cell polarity prevents breast cancer
... dramatic result pointed to Scribble, a cell shape regulator, as a tumor suppressor
in breast epithelial cells.
The targets of tumor suppressors are ... as the loss of the Scribble protein, which thus is revealed to be a tumor suppressor
Cells engineered by the CSHL team to lack Scribble and ...
USC researchers identify novel approach for suppressing prostate cancer development
... and development resulting from the loss of PTEN, a powerful tumor suppressor
gene for a number of human cancers.
Researchers spent more than three ... that had been genetically engineered to have both the GRP78 and PTEN tumor suppressor
genes inactivated. The research was conducted by Yong Fu, a Ph.D. ...
LOH analysis on 4q in sporadic colorectal carcinoma
... Hospital of Qingdao University Medical College, expressed that tumor suppressor
genes may exist on 4q in sporadic colorectal carcinoma.
The classic mechanism of tumor suppressor
gene (TSG) inactivation is described by two-hit modes in which one allele ...
Bacterial peptide provides new insight into common tumor suppressor
... , advances the understanding of one of the most frequently disrupted tumor suppressor
proteins in human cancer and provides new insight into the regulation of ... kinase inhibitor p27kip1 is one of the most frequently dysregulated tumor suppressor
proteins in human cancers and it correlates directly with patient ...
Effect of mutant p53 stability on tumorigenesis and drug design
... to treatment, emphasizes Dr. Lozano.
One function of the p53 tumor suppressor
is to arrest the cell cycle in response to DNA damage. For years it has ... only p53.
Targeted drug therapies aimed at activating p53 tumor suppressor
activity via the disruption of the normal Mdm2/wild-type-p53 interaction ...
Arsenic-based therapy shown to help eradicate leukemia-initiating cells
... at Beth Israel Deaconess Medical Center (BIDMC) has found that a tumor suppressor
protein known as PML appears to be the factor that enables LICs to ...
The investigators set out to analyze expression of PML, a tumor suppressor
protein that controls fundamental processes such as apoptosis, cellular ...
Fighting a Fungus That Thrives on Tomatoes
... fusarium wilt disease.
The University of Amsterdam team found that a suppressor
protein secreted by some strains of the fungus enables it to overcome two ... genes. However, a third resistance gene specifically targets the suppressor
protein, making the plant fully resistant to any fungal strain that ...
Study raises questions about prostate cancer therapies targeting IGF-1
... target receptor could have unexpected results especially if a major tumor suppressor
gene p53 is already compromised, according to new research by ... cell stasis and death, both of these processes are regulated by the tumor suppressor
gene p53 that is commonly mutated in human prostate cancers. Hence the ...
Tailoring glioblastoma therapies: 1 size does not fit all
... Bonni and colleagues now report that STAT3 can function as either a
or an oncoprotein. Using a mouse model system of two common genetic ... activation -- the researchers show that PTEN regulates STAT3 tumor suppressor
function, while STAT3 cooperates with the EGFRvIII oncoprotein to promote ...
Gene found to play a suppressor role in skin cancer development
... genetic evidence that Activating Transcription Factor 2 (ATF2) plays a suppressor
role in skin cancer development. ATF2 is a protein that regulates gene ... exposed to carcinogens enhances skin tumor formation, suggesting a tumor suppressor
role for ATF2 in keratinocytes.
Important support for the finding ...
Pharmion and MethylGene Present Favorable Clinical Data From Combination MGCD0103/Vidaza(R) Study in Myelodysplastic Syndromes and Acute Myelogenous Leukemia at The 49th American Society of Hematology (ASH) Meeting
... Vidaza reverses the effects of
DNA hypermethylation with subsequent tumor suppressor
MGCD0103 exerts its epigenetic effects by acting as an ... HDAC inhibitor. Together, the two act synergistically to
gene re-expression and favorably influence the clinical
course of cancer. ...
CSHL scientist recognized for accelerating cancer gene research
... model for liver cancer research, which enabled him to identify new tumor suppressor
genes in liver cancer.
Lars has done an outstanding job integrating ... to continue his project on in vivo RNAi screening to identify new tumor suppressor
genes in liver cancer. In particular the grant will enable the project to ...
JCI table of contents: Nov. 15, 2007
... University of Michigan, Ann Arbor, has identified the protein FOXP3 as a suppressor
of tumor growth promoted by SKP2, leading the team to suggest that defects ... Together, these data led the authors to conclude that FOXP3 is a suppressor
of tumor development induced by SKP2.
TITLE: FOXP3 is a novel ...
Advances in drug screening: building a better haystack for the needles of tomorrow
... a plant compound that blocks the breakdown of the well known tumor suppressor
protein called p53.
The samples in the Repository exist as extracts ... A 208.
Half of all cancers occur because of a mutation in the tumor suppressor
gene p53, while in numerous other cancers its protein is deregulated, ...
DMP1 deletion cooperates with oncogenic K-ras in lung cancer
... have identified the transcription factor DMP1 as a pivotal tumor suppressor
for both human and mouse lung cancers, especially in carcinomas that ... is an excellent system for studying human NSCLC.
Dmp1 is a unique tumor suppressor
that activates Arf expression and thus induces p53-dependent cell cycle ...