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Substrate in Medical News

Expert consensus on catheter ablation of ventricular arrhythmias

... or identifying abnormal areas that contain the substrate for VA based on findings during sinus rhythm. ... no longer be triggered by catheters or no further substrate can be identified. Recent innovations in ... and facilitate identification of the arrhythmia substrate during stable sinus rhythm. Percutaneous ...

Catalyst mystery unlocked

... a perfect physical fit between catalyst and substrate is not necessary. "What really fits is the ... interaction between the enzyme active site to the substrate charges at the so-called transition state, where ... said. If Warshel is correct, catalyst and substrate would be less like lock and key, and more like ...

New ADDHERE(TM) Adhesive Tie Layer Bonds Acrylic Cap Layers to Substrates of Thermoplastic Polyolefin (TPO) in Production of Sheet for Use in Thermoforming

... to bond an acrylic layer onto a substrate of thermoplastic polyolefin (TPO) for use in ... same time, the absence of pigment from the TPO substrate means its performance properties can be easily ... thermoforming can be recycled back into the TPO substrate - both the line-trim from the sheet extrusion, ...

Making nanoparticles in artificial cells

... from the production chamber. Instead, the bubbles remain attached to their substrate via small membrane channels, like balloons tied to strings, and stand in a ... vesicles at first. The second ingredient only creeps gradually between the substrate and membrane into the channel and to the vesicle. In the vesicle, where ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in ... in sitagliptin transport has not been established. Sitagliptin is also a substrate of p-glycoprotein, which may also be involved in mediating the renal ...

Genetic difference predicts antidepressant response

... drug administered to treat CNS diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical ... view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases are genotyped to exclude the ...

Genetics May Determine Antidepressants' Effectiveness

... CNS (central nervous system) diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical ... view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases are genotyped to exclude the ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... and PRECAUTIONS, Drug Interactions). Lovastatin is a substrate for cytochrome P450 isoform 3A4 (CYP3A4) (see PRECAUTIONS, Drug ... Lovastatin, like several other inhibitors of HMG-CoA reductase, is a substrate of cytochrome P450 3A4 (CYP3A4). When lovastatin is used with a potent ...

A longer-living, healthier mouse that could hold clues to human aging

... (University College London) shows that mice lacking the insulin receptor substrate (IRS)-1 are more resistant to ageing than normal mice. The research adds ... The team studied knock-out mice engineered to lack either insulin receptor substrate (IRS)-1 or -2. These proteins are activated by insulin, a hormone that ...

Smith & Nephew Announces Launch of ACTICOAT Flex Wound Care Products in the USA

... "The Flex dressing allows exudate to pass through, which is a great advantage," he explained. "Combining the flexibility of the polyester mesh substrate with the proven effectiveness of ACTICOAT's nanocrystalline silver technology is an exciting and significant development for the ACTICOAT brand. The ...

Immunoassay at AACC 2009: Tosoh Launches AIA-2000 Automated Immunoassay Analyzer

... no pre-mixing, and no pre-measuring. AIA-2000 system features include: throughput of 200 tests/hour, 576 tips (6 tip racks), 2 substrate bottles, walk away time of 4 hours, 3 incubators with different processing steps, 2 sampling arms for faster processing of second reagent, and a full ...

Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings

... even in the presence of wound fluid and blood, and also in that the active component is non-leaching. Leaching antimicrobials can exit the base substrate dressing and potentially lead to interference in wound healing as well as to the creation of resistant strains of pathogens. Currently, the market ...

ThermoGenesis Appoints Chief Executive Officer J. Melville ('Mel') Engle to Board of Directors

... of Oxygen Biotherapeutics (OXBO), a company developing pharmaceuticals and medical devices in the field of oxygen therapeutics and continuous substrate monitoring. Engle holds a B.S. in Accounting from the University of Colorado and an M.B.A. in Finance from the University of Southern ...

DFG establishes nine new collaborative research centers

... biological signals. In addition to metabolic processes in tumour tissue, other cytobiological processes, such as proliferation, vascularisation and substrate transport, will also be addressed. Furthermore, the representation of cytobiological signals will be used for assessing the aggressiveness of a ...

Oxygen Biotherapeutics, Inc. Files Cosmetic Product Ingredient Statement for new Oxycyte-based Cosmetic Gel

... Inc. is dedicated to commercializing innovative pharmaceuticals and medical devices in the field of oxygen therapeutics and continuous substrate monitoring. The company has under development a perfluorocarbon therapeutic oxygen carrier and liquid ventilation product (Oxycyte(R)) and an ...

Fish researcher demonstrates first 'non-visual feeding' by African cichlids

... deep sea." Webb analyzed video of the swimming behavior of the fish in response to live and dead brine shrimp located on the surface of the sandy substrate in a tank. She compared the fishes' ability to detect prey under light and dark conditions, and looked at their ability to detect prey when the ...

Oxygen Biotherapeutics, Inc. Establishes Warfighter Division

... Inc. is dedicated to commercializing innovative pharmaceuticals and medical devices in the field of oxygen therapeutics and continuous substrate monitoring. The company has under development a perfluorocarbon therapeutic oxygen carrier and liquid ventilation product (Oxycyte(R)) and an ...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... if possible. Tasigna inhibits human P-glycoprotein. If Tasigna is administered with drugs that are substrates of Pgp, increased concentrations of the substrate are likely and caution should be exercised. Tasigna may also induce CYP2B6, CYP2C8, and CYP2C9. Therefore, Tasigna may alter serum concentration of ...

Derma Sciences Gains FDA Clearance for Novel BIOGUARD(TM) Barrier Dressing with NIMBUS(R) Technology

... target-specific kill, what makes BIOGUARD different from other infection control dressings is the permanent, non-leaching bond between the dressing substrate and the active agent. The NIMBUS cationic biocide is permanently bonded to the gauze, keeping it from depleting in the presence of wound fluid and ...

NSF International Offers Answers to Rising Toy Safety Concerns

... December 21, 2008. Several other requirements for toys will take affect in 2009 when third party testing will be required for assessing lead in the substrate material, phthalates, physical, and mechanical testing. WHO: By law, all manufacturers who wish to sell toys in the U.S. in 2009 must ...

E6 Ventures Invests in Novel Coatings Developer, Diamond Hard Surfaces Ltd

... that ranges from one to 60 microns. The low temperatures at which the coating can be applied mean that there is minimal effect on the substrate material and the process is applicable to a wide range of materials. Unlike other coatings, Adamant(TM) diamond hard surfaces do not require ...

New Approach Keeps Tumor Cells From Refueling

... main fuel, the study authors said. "Using models of tumor cells, we found that well-oxygenated cells use lactate [lactic acid] as a preferential substrate to produce energy," said lead researcher Pierre Sonveaux, an associate professor at the University of Louvain Medical School in Brussels. In other ...

Does HBV infection induce acute cellular DNA damage?

... downstream targets including Chk1, p53 and H2AX. In contrast to ATR and its target, the phosphorylated form of ATM at Ser-1981 and its downstream substrate Chk2 phosphorylation at Thr-68 did not visibly increase upon infection. However, the level of Mre11 and p21 were reduced beginning at 0.5 h after ...

Neurogenesis in the adult brain: The association with stress and depression

... rapidly led to the formulation of the 'neurogenesis hypothesis' of depression, which says that adult neurogenesis in the hippocampus is a candidate substrate for both the etiology and the treatment of major depressive disorders. However, according to the current view, newborn cells in the hippocampus per ...

Researchers unveil vital key to cancer

... researchers to "see" the protein's atomic structure for the first time. Their structure revealed the pocket where Mps1 binds to ATP, the natural substrate from which Mps1 transfers a phosphate group to its cellular target proteins. Further work showed the protein in complex with the ATP-competitive ...

Wake Forest researchers say popular fish contains potentially dangerous fatty acid combination

... that in next month's Journal, he will publish a rebuttal to this month's editorial. "We have known for three decades that arachidonic acid is the substrate for all pro-inflammatory lipid mediators," Chilton said in an interview. "The animal studies say unequivocally that if you feed arachidonic acid, the ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

... of California, San Francisco, California, is investigating the molecular mechanism by which the Hsp90 protein chaperone affects the folding of substrate proteins. The effect of Hsp90 on folding is important because this chaperone activates a wide variety of proteins that are over-expressed in ...

Canary Foundation and American Cancer Society Award Five Postdoctoral Fellowships in Early Cancer Detection

... of protease activities in diseased and healthy tissue samples by simultaneously investigating the activity of proteases on thousand of substrate peptides. Initial efforts will be devoted to samples from patients with lung, ovarian, breast, and prostate cancers due to the difficulties ...

Tracking Cancer Drug's Effectiveness

... glow. Using a technique called bioluminescence imaging (BLI), the University of Teexas Southwestern Medical Center team added a molecule substrate called luciferin to the bloodstream of mice with human breast cancer tumors. The tumors had been altered to carry the firefly gene, so they would ...

Fireflies' glow helps UT Southwestern researchers track cancer drug's effectiveness

... imaging (BLI) can be used to determine the effectiveness of cancer drugs that choke off a tumors blood supply. The technique requires a substrate called luciferin to be added to the bloodstream, which carries it to cells throughout the body. When luciferin reaches cells that have been altered ...

EGFR protects cancer cells from starvation via a kinase-independent mechanism

... intracellular glucose levels by stabilizing the sodium/glucose transporter 1 (SGLT1) via a kinase-independent mechanism. Glucose is a major energy substrate for all cells, and without appropriate amounts, cells essentially starve to death through a process called autophagic cell death. Cancer cells are ...

American Heart Association Launches First of New Journals - Circulation: Arrhythmia and Electrophysiology Premieres

... will present critical new research on topics such as devices for arrhythmia management, catheter ablation, the pathophysiology of the arrhythmia substrate and novel biologic therapies. Commentaries and reviews on topics of special interest, editorials and opinion pieces, and other special features will ...

Laser Energetics Files Patent Application for a New BrightStar(TM) Alexandrite Laser

... the company builds, the IR and UV light this laser emits can be transmitted into applications requiring beam transport through a fiber optic to a substrate or target. "Our future patent will ensure our competitive edge in the marketplace for years to come," stated Battis. "The company is hard at work ...

University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein

... make conclusions based on a single structure, the team additionally determined the structures of GlpD bound with its metabolic product and several substrate analogues to evaluate the enzyme in its native and combined forms. By careful unraveling of this collection of structures, researchers could gain a ...

A device that measures optimum state of an organ prior to transplanting has been patented

... the National Centre for Microtechnology (CNM-CSIC) and the Carburos Metlicos company and patented in conjunction with I2M Design S.A., uses a polymer substrate that represents a great advance in biomedical instrumentation, as it does not produce injury in the tissues during transport or surgical manoeuvres. ...

Scientists solve structure of gene regulator that plays key role in cancer

... to convert its substrates to the resulting protein products. The chemical mechanism differs from those employed by other HATs in that the histone substrate binds only transiently, leaving after a very brief encounter. This hit-and-run mechanism is consistent with the enzymes ability to acetylate a ...

Caught in the act: The dynamic dance of enzymes

... and her team demonstrated that the enzyme adenylate kinase, and presumably many more, engages in a dynamic dance even before its catalytic datethe substrate to which it bindsshows up. If one of the constants of life is change over time, implicit in this truth is how macroscopic change, such as the ...

Mom's Low Cholesterol Tied to Preemie Births

... "Cholesterol is a building block for membranes, hormones and proteins, so it makes sense that if you have low cholesterol, your baby won't have the substrate it needs to grow." Each year, more than half a million babies are born prematurely in the United States, according to the March of Dimes. ...

Treating obstructive sleep apnea, preventing heart attacks and strokes

... accept CPAP than in those who do not, as opposed to any direct benefit of CPAP itself. Whereas physiological studies suggest that OSA provides a substrate for the development of atherosclerosis, and epidemiological and observational studies suggest an association between OSA and odds of having ...
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