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Substitution in Medical News

Cephalon Announces FDA Advisory Committee Recommendation Against Approval of an Expanded Label for FENTORA

... patients) and/or improper dosing. The substitution of FENTORA for any other fentanyl product may ... fentanyl. As a result of these differences, the substitution of FENTORA for any other fentanyl product may ... fentanyl. As a result of these differences, the substitution of FENTORA for any other fentanyl product may ...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... Cardiotoxicity, infusion reaction, myelosuppression, liver impairment, substitution The use of DOXIL may lead to cardiac toxicity. Myocardial ... be reduced in patients with impaired hepatic function Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl ...

In the Case of Epilepsy, Generic Drugs and Random Product Substitution are Not Always "Good Medicine"

... can be extremely dangerous. The primary problem with random product substitution is that the Food and Drug Administration (FDA) does not require generic ... switching from a brand name to a generic or being subject to the random substitution of one generic for another. The study is expected to begin shortly, and ...

Frost & Sullivan: Ageing Population and Availability of Preventative Medicines Propels Growth of European Eye Health Ingredients Market

... as varying regulations that are hampering eye health claims, threats of substitution and the lack of market credibility. Fluctuating prices and constant price ... ultimately depends on overcoming obstacles such as variant regulation, substitution threats and the impact of fluctuating economies and prices. Legislation, ...

Universal Health Realty Income Trust Reports 2008 Fourth Quarter and Full Year Financial Results

... with the previously disclosed Chalmette Medical Center asset exchange and substitution transaction, and; (iii) a gain of $264,000, or $.02 per diluted share, ... (12) - (264) Gain on asset exchange and substitution agreement with UHS - Chalmette - ...

Universal Health Realty Income Trust Reports 2008 First Quarter Financial Results

... disclosed Chalmette Medical Center ("Chalmette") asset exchange and substitution transaction. Favorably impacting net income during the quarter ended March ... property - (252) Gain on asset exchange and substitution agreement with UHS - Chalmette - (789) ...

Nephrologists Indicate High Interest in AMAG Pharmaceuticals' Newly Approved Feraheme According to Latest BioTrends Report

... FMC's PhosLo is under mounting pressure from generic versions of the product and Nephrologists are showing little resistance - 80% either allow substitution or prescribe the generic version outright. Shire's Fosrenol is the only brand for which Nephrologists project significant increases in market share. ...

Rochester Medical Reports Third Quarter Results

... by other companies. Non-GAAP Net Income and constant currency have limitations as analytical tools and should not be considered in isolation or as a substitution for analysis of our results as reported under GAAP. Reconciliations of Net Income and Non-GAAP Net Income, and reconciliations of sales under GAAP ...

Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication

... if donor funding is reduced or stopped and governments have committed their resources elsewhere. Farag and colleagues point to how this funding substitution "requires the agencies responsible for donor coordination to pay special attention to what happens to the government share of health funding and to ...

‘HairConfirm' Is First Drug Test of Its Kind to Report Low/Medium/High Usage; Now Available at Local Discount Drug Marts

... In two independent studies, hair drug testing uncovered five to ten times more drug users than urinalysis. Urinalysis also carries the risk of substitution of a sample, dilution and addition of a foreign substance designed to skew the results. HairConfirm is now available at a local Discount Drug ...

Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study

... multiple dose levels of PEG-PAL. About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substitution therapy for the treatment of PKU. Pharmacology studies conducted in the PKU mouse model demonstrated that weekly subcutaneous administrations of ...

Rx for Africa, Inc. Signs Letter of Intent for Strategic Alliance with Rusan Pharma, Ltd. of India

... website: http://rxforafrica.com . About Rusan Pharma, Ltd. Established in 1994, Rusan specializes in the areas of pain management, substitution treatment, opioid withdrawal, anti- tuberculosis, psychiatric drugs and anti-infectives. Its facilities include an ultra-modern formulations unit ...

More stringent evaluation on the use of generic medications in thoracic transplantation

... a change in critical medication to avoid adverse effects such as toxicity or rejection Advocacy surrounding notification of an automatic generic substitution from the dispensing agencies to the prescriber ...

Is There a Nutritional Upside to a Down Economy?

... as a calorie-saving option as it has 60 percent fewer calories and 75 percent less fat than the original, but is still full of flavor. Try this substitution when creating a classic favorite like a Tuna Nicoise Salad. "When building a meal that includes higher ticket items, like fruits and vegetables, ...

Report Reveals Disparities in Pharmaceutical Treatment for Minority Patients

... be considered in selecting drugs and dosages, in the composition of drug formularies and preferred drug lists, and in determining the scope of drug substitution policies. The report emphasizes that therapy must be tailored to individual needs and stereotyping and overgeneralization in caring for diverse ...

Photos: Generic Pharmaceuticals Saved $734 Billion over Last Decade

... both branded and generic products to estimate cost savings. For an explanation of the study methodology see www.gphaonline.org . The generic substitution rate in the U.S. in 2008, according to IMS statistics, was approximately 69%, with generic medicines filling more than 2.6 billion of the ...

Rochester Medical Reports Second Quarter Results

... by other companies. Non-GAAP Net Income and constant currency have limitations as analytical tools and should not be considered in isolation or as a substitution for analysis of our results as reported under GAAP. Reconciliations of Net Income and Non-GAAP Net Income, and reconciliations of sales under GAAP ...

Reversing effects of altered enzyme may fight brain tumor growth

... through the HIF-1 pathway. But Guan noted, "IDH1 is not your usual suspect as a cancer gene." He explained that the alteration in IDH1 is a substitution of an amino acid in one copy of the gene without losing the other normal copy (every gene in normal human cells has two copies), which is different ...

New Report Defines Challenges for New Entrants in Key Rheumatology Markets

... their rheumatology practice in 2015? How do their choices differ by geography, and why? How will the availability of biosimilars for substitution of first generation biologics impact the environment for new entrants? What is the preferred anti-TNF drug, and why? Where will new ...

Thomson Reuters Study Finds Step Therapy Programs May Increase Overall Healthcare Costs for Employers

... a first-line medication before they can receive coverage for a second-line medication. (Step therapy is not the same as programs which encourage the substitution of a generic medication for the same brand name medication. Step therapy requires certain types of medications within a class of drugs to be used ...

NYU study finds new risk factor for melanoma in younger women

... of p53, it can keep p53 levels low, reducing the cell's protection against turning into a cancer cell. Scientists have shown that the substitution of a single letter of DNA at a specific point in the MDM2 promoter can significantly ramp up gene production. The new study evaluated the effects of ...

'Personalized' genome sequencing reveals coding error in gene for inherited pancreatic cancer

... says James Eshleman, M.D., Ph.D., associate professor of pathology and oncology. The search yielded one gene variant, PALB2, resulting from a substitution of a single DNA letter coding for cytosine with a different one that codes for thymidine. The research team then scanned for the PALB2 gene in 96 ...

NutriSystem.com Gets a Complete Makeover

... NutriSystem foods, and customize online meal planners to suit their needs. Additionally, visitors to the site can access recipes and grocery list substitution recommendations, designed to provide NutriSystem customers the freedom of preparing their own meals at home, or enjoy dining out with friends and ...

SSRI Antidepressants May Lower Adult Suicide Risk

... University of Illinois, said it's alarming that "concerns about the risk of suicide in youth have led not only to fewer SSRI prescriptions without substitution of alternative medications or psychotherapies, but also to a decrease in predicted rates of diagnosis of mood disorders." More information ...

Rochester Medical Reports First Quarter Results

... information provided by other companies. Non-GAAP Net Income has limitations as an analytical tool and should not be considered in isolation or as a substitution for analysis of our results as reported under GAAP. Reconciliations of Net Income and Non-GAAP Net Income are presented at the end of this press ...

Also in the Jan. 27 JNCI

... an isoleucine-substituted KIT protein were able to grow in the presence of imatinib in vitro. Modeling showed that only the KIT with an isoleucine substitution had both a high enough affinity for ATP to promote cell growth and a low enough affinity for imatinib to be resistant to treatment. "We believe ...

Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade

... generic versions of sildenafil become available. The new Pharmacor report entitled Erectile Dysfunction finds that while therapeutic substitution of less-expensive, generic sildenafil for branded phosphodiesterase type 5 (PDE5) inhibitors will contribute to a significant loss of sales for Eli ...

Health Care Spending in U.S. Grew at Lowest Rate in a Decade

... in spending on prescription drugs will be short-lived. "The slower growth in prescription drug spending, largely attributed to the increased substitution of generics for blockbuster brand name drugs whose patents expired, underscores the importance of generic drugs in restraining cost growth for ...

Despite Availability of Generic Equivalents, Two-Thirds of Neurologists Will Continue to Prescribe Branded Anti-Epileptic Drugs to Epilepsy Patients

... Stem the Tide of Generics in Epilepsy, Migraine, Neuropathic Pain or Bipolar Disorder? finds that while physicians' determination to resist generic substitution of branded AEDs at the pharmacy level varies hugely by indication, it does not vary as significantly by brand. "Currently, 54 percent of the ...

Celebrity Mental Health Musings Take Center Stage as Psych Central Adds New Blog

... been taken by more than 50,000 people and continually generates feedback lauding its accuracy. Neither Psych Central nor Sanity Score are a substitution for professional diagnosis or treatment. Psych Central and Sanity Score are registered trademarks or common law marks of Liviant LLC. All other ...

New therapy prevents dangerous side effect for lymphoma patients

... 4 percent of patients, down from a historical rate of around 10 percent. The key ingredient in pushing the MDS rate to zero, Samaniego says, was substitution of fludarabine with pentostatin. Both are nucleoside analogs, which interfere with DNA reproduction, and target lymphoid cells, making them ...

Health Care Without Harm, WHO Announce Partnership for Global Reduction of Mercury-Based Medical Devices

... can join via the Partnership website, www.mercuryfreehealthcare.org ." The Partnership is based on both WHO and HCWH's ongoing efforts for substitution of mercury-based medical devices. It is also a component of the UN Environment Programme Mercury Products Partnership. At the Delhi ...

Major North American breakthrough for dialysis patients

... with HD. Some statistics on the treatment of end-stage renal disease: At the end of 2003, there were 29,551 Canadians undergoing renal substitution treatment and that number is expected to double over the next ten years; Among that number, 61 % were in dialysis. Of these patients, 81 % were in ...

Medicare's Online Tools Will Help Beneficiaries With Prescription Drug and Health Plan Choices for 2009

... compared to retail drug costs. The Web site also includes an enhancement that allows beneficiaries the potential to further reduce costs based on the substitution of drugs which are lower cost but within the same therapeutic class. This feature allows users to choose among all less expensive drugs available ...

Rochester Medical Reports Record Fourth Quarter Sales and Record Annual Sales

... provided by other companies. Non-GAAP Net Income has limitations as an analytical tool and should not be considered in isolation or as a substitution for analysis of our results as reported under GAAP. Reconciliations of Net Income and Non-GAAP Net Income are presented at the end of this press ...

Dermatitis Can Have Many Causes

... of dermatitis, Taylor said. Treatment depends on the cause of the dermatitis. "For allergic contact dermatitis, it involves allergen omission or substitution and generally using topical or occasionally systemic corticosteroids to relieve the symptoms," Taylor said. The second most common sites for ...

Psych Central Selected by TIME Magazine as Top 50 Web Site in 2008 for Its Top Mental Health Content and Social Media Platform

... more news from Psych Central, please visit http://psychcentral.com/about/press_releases/ . Neither Psych Central nor Sanity Score are a substitution for provide professional diagnosis or treatment. Psych Central and Sanity Score are registered trademarks or common law marks of Liviant LLC. All ...

Improving survival rates among users of left ventricular assist devices

... of LVAD patients, and thereby reduce the risk of complications, the study suggests replacing 1 plasma volume using fresh frozen plasma as the substitution fluid prior to surgery. According to this single-center study, a series of patients who underwent plasma exchange before LVAD implantation had ...

Rat study suggests why teens get hooked on cocaine more easily than adults

... and Andersen, may require atypical strategies for drug abuse intervention during the adolescent period, such as extended treatment that involves substitution with different rewards, for example, exercise or music. Brenhouse wonders whether teens may learn best when rewards are involved. Harnessing their ...

Study questions 'cost of complexity' in evolution

... 70 skeletal characteristics in the mouse, the researchers identified total of 102 genomic regions that affect the skeleton. They concluded that substitution in each genome segment affected a relatively small subset of characteristics and that the effect on each characteristic increased with the total ...
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