21st Century Obesity Pandemic Still Suffering From Effects of Tuberculosis Plague of the 1800s
Fat comes in two kinds. There is subcutaneous
fat stored under the skin. This is a simple bank ... said. The idea would be to send fat cells to the subcutaneous
regions. That would reduce the pro-inflammatory ... stores and help reduce the burden of fat cells on subcutaneous
What are the ...
Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study
... to assess the safety and tolerability of single, subcutaneous
injections of PEG-PAL in subjects with PKU. The ... were to evaluate the pharmacokinetics of single, subcutaneous
injections of PEG-PAL administered at escalating ... immune response and steady state PK of subcutaneous
injections of multiple dose levels of PEG-PAL.
SIMPONI(TM) (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
... First subcutaneous
Anti-TNF to Launch with Three Rheumatic ...
In the U.S., SIMPONI is approved as a 50 mg subcutaneous
injection once a month and is indicated:
... cartilage and tissue. The first once-monthly subcutaneous
anti-TNF-alpha therapy, SIMPONI is approved for ...
New drug shows promising results for psoriatic arthritis
... to be beneficial within two weeks of the first subcutaneous
injection in a phase II rheumatoid arthritis ... drugs. Patients were randomized to receive subcutaneous
injections of placebo, golimumab 50 mg, or ... agents that have been studied in this disease. subcutaneous
administrations were well tolerated. Only a small ...
Research highlights new approaches to prevent blood clots
... to one of two treatment arms: once-daily subcutaneous
injections of nadroparin (3,000 IU) or placebo. ... similar efficacy and safety between once-weekly subcutaneous
injections of indaparinux with standard treatment ... thrombosis were randomized to receive weekly subcutaneous
injections of 3 mg idrabiotaparinux (385 ...
New Skin Rejuvenation Discovery Receives Commercial Backing
... the RHAMM protein
increases the deposition of subcutaneous
fat while decreasing unhealthy
visceral fat. This ... skin to replace volume lost
with the decrease of subcutaneous
fat that accompanies the aging process.
These ... controllable re-growth of the patient's
fat in targeted areas to help restore a ...
Centocor, Inc. Submits Application to FDA Requesting Approval of Golimumab for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
... the approval of golimumab
(CNTO 148) as a monthly subcutaneous
treatment for adults with active forms
of ... is being studied as an every four week subcutaneous
is also being studied as an ... requesting the approval of golimumab as a
treatment for the same indications.
Subcutaneous administration of an antiemetic for treating vomiting caused by chemotherapy
... The subcutaneous
administration of granisetron, an antiemetic ... when injected intravenously. The advantage of the subcutaneous
method is the ease of treatment for ...
Home use and emergencies
This is why subcutaneous
administration opens new perspectives, providing ...
Modest gain in visceral fat causes dysfunction of blood vessel lining in lean, healthy humans
... internal organs -- rather than fat deposited as subcutaneous
fat, just under the skin, that predicts ... and significantly increased their visceral and subcutaneous
In the weight-maintainer group, the ... of the study.
Visceral fat gain -- but not subcutaneous
fat gain -- was significantly correlated with the ...
New Survey Reveals Kidney Patients' Concern About Medicare Policies
... would not mind receiving ESA
therapy by the subcutaneous
(SC) route -- which would mean that ... statements that patients wouldn't
mind additional subcutaneous
injections. Survey comments illustrated how
strongly most patients objected to subcutaneous
administration of ESAs. For
example, Kathe ...
Novo Nordisk Insulin Analogs Have Proven Safety Profiles
... detemir [rDNA origin] injection) is indicated for once- or twice-daily subcutaneous
administration for the treatment of adult and pediatric patient with type ... may be needed in patients with type 2 diabetes. When used in an external subcutaneous
insulin infusion pump, NovoLog(R) should not be mixed with any other ...
Depression linked with accumulation of visceral fat
... amount of visceral fat, it is an inaccurate measure because it includes subcutaneous
fat, or fat deposited just beneath the skin.
The researchers found a ... activity. The study found no association between depressive symptoms and subcutaneous
fat. The findings were the same for both black and white women.
Ferring Pharmaceuticals Announces Immediate Availability of Degarelix for the Treatment of Advanced Prostate Cancer
... cancer were randomized to either degarelix or leuprolide: a degarelix subcutaneous
(under the skin) injection of 240 mg for one month with monthly ... an initial testosterone surge. Degarelix is administered monthly by subcutaneous
injection. The starting dose is 240 mg, followed by monthly maintenance ...
NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting
... Product Candidate NVC-422 Demonstrates Ability to Treat subcutaneous
EMERYVILLE, Calif., March 4 /PRNewswire-FirstCall/ -- ... not only on the skin surface, but also showed potent ability to kill subcutaneous
organisms by route of the hair follicles."
Following are the details ...
Cynosure Obtains Favorable Markman Rulings in Patent Infringement Case Against CoolTouch
... (the 873 patent), which relates to methods for liquefying and removing subcutaneous
fat cells through the use of laser energy. Cynosure is the exclusive ... in early 2007, uses a 1064 nm Nd:YAG laser to deliver energy directly to subcutaneous
fat cells, causing them to rupture. The emitted fat-melting energy also ...
Juva Skin Banishes Bumps with New UniForm Cellulite Therapy Handpiece
... heat with the mechanical application allows for deep penetration into the subcutaneous
tissues for much better results."
UniForm was developed ... levels, while the mechanical massager stimulates circulation to subcutaneous
tissues. The result is a dramatic reduction in the appearance of ....
Medarex to Receive Milestone Payment for Approval of STELARA(TM) (Ustekinumab) for the Treatment of Moderate to Severe Plaque Psoriasis
... of moderate to severe plaque psoriasis, as an infrequently administered subcutaneous
STELARA, generated using Medarex's UltiMAb(R) ... CNTO 148), currently under review for marketing approval as a once-monthly subcutaneous
anti-TNF-alpha human antibody in the U.S. and in Europe for the treatment ...
Phase 2a Data for MEDI-528 Presented at CHEST 2008
... in Philadelphia, Pennsylvania.
The presentation, entitled "Multiple subcutaneous
Doses of MEDI-528, A
Monoclonal Antibody Against Interleukin-9 in Mild and ... that the data demonstrate an acceptable safety profile for
doses of MEDI-528.
IL-9 is one of at least 29 naturally ...
The missing link between belly fat and heart disease?
... in the belly around the major organs, while others received transplants of subcutaneous
fat the type thats found just under the skin throughout the body.
... as the leptin-deficient mice had. Meanwhile, those that received subcutaneous
fat did not experience an increase in atherosclerosis despite having ...
Immunosyn Announces the Successful Completion of First Phase 'Proof of Concept Trial' in Europe for Treatment of Diabetic Ulcers With Biopharmeceutical SF-1019
... its effect on Diabetic Polyneuropathy in Type 1 Diabetes
Mellitus by both subcutaneous
injection and by topical application.
Regarding the "Proof of Concept ... in that a 5mm deep wound became closed, needs, as
expected, unlike the subcutaneous
method, more short-term development in
order to improve the delivery ...
Cynosure Files Patent Infringement Lawsuit Against CoolTouch Inc.
... (the 873 patent), which covers technology using
laser energy to remove subcutaneous
fat. Cynosure is the exclusive licensee
of the 873 patent, which is owned ... in early 2007, uses a 1064 nm Nd:YAG
laser to deliver energy directly to subcutaneous
fat cells, causing them to
rupture. The emitted fat-melting energy also ...
Once-Weekly Exenatide Showed Statistical Superiority in Glucose Control Compared to BYETTA in Head-to-Head Study
... one or more oral antidiabetic
agents. Subjects were randomized to receive subcutaneous
either once- weekly exenatide 2.0 milligrams or BYETTA taken ... are working together to develop exenatide
long-acting release injection, a subcutaneous
injection of exenatide for
the treatment of type 2 diabetes based on ...
Baxter Reports Strong Third Quarter Sales and Earnings
... Halozyme's proprietary Enhanze(TM) Technology to the development of a subcutaneous
route of administration for Baxter's GAMMAGARD LIQUID(TM) 10% [Immune ... using GAMMAGARD LIQUID 10% - currently administered intravenously - subcutaneous
administration with Enhanze Technology may increase convenience and ...
Investigational New Drug Application for 'Fat Melting' Injections Cleared by the FDA
... Injection lipolysis
involves the injection of various compounds into the subcutaneous
is not currently approved by the FDA for subcutaneous
injection for any
purpose. "We are pleased to finally have the approval ...
Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment
... an established treatment for prostate cancer, FIRMAGON does not induce an initial testosterone surge. FIRMAGON is administered monthly by subcutaneous
injection. The starting dose is 240 mg, followed by monthly maintenance doses of 80 mg. FIRMAGON is available for order through traditional and ...
Zogenix and Astellas Enter Exclusive Co-Promotion Agreement in the US for Newly Approved Sumavel(TM) DosePro(TM)
... needle-free delivery system. Sumavel DosePro received FDA approval in July 2009 and is a first-of-its-kind needle-free delivery system for subcutaneous
sumatriptan, a treatment that provides migraine relief within 10 minutes for some patients.
"Partnering with Astellas is a significant ...
Large abdominal wall lipoma causes bowel obstruction
... pelvic bone. Colon gas in the left colon shifted to the right upper side. Computed tomography (CT) of the abdomen demonstrated a large mass in the subcutaneous
adipose tissue at the left lower abdominal wall.
In the current case, the patient was diagnosed with Proteus syndrome based on certain diagnostic ...
Young Black, Hispanic Women Tend to Develop 'Love Handles'
... and Hispanic young adults tended to pack on both visceral adipose tissue (VAT), the fat found in the abdominal cavity around internal organs, and subcutaneous
abdominal tissue (SAT), the visible, pinchable fat known as "love handles." However, the increase was notably higher in women than men.
"Our data ...
FDA Approves NovoLog(R) Labeling Update
... visit www.novonordisk-us.com .
(1) Revised NovoLog Prescribing Information. "Dosage and Administration." Section 2.3. "Continuous subcutaneous
insulin infusion (CSII) by external pump."
NovoLog(R) is a registered trademark of Novo Nordisk A/S.
Johnson & Johnson and Elan Corporation plc Announce Definitive Agreement for Alzheimer's Immunotherapy Program and Equity Investment
... disease. The lead compound (bapineuzumab), administered intravenously once every three months, is currently in Phase 3 clinical trials. A subcutaneous
formulation, administered once a week, is currently in Phase 2 trials. In addition, a vaccine for Alzheimer's disease (ACC-001) is also under ...
New Vaccine from Intervet/Schering-Plough Animal Health is First for Canine Influenza Virus
... is intended as an aid in the control of disease associated with canine influenza virus infection, a type A, subtype H3N8. It is administered by subcutaneous
injection in two doses, two to four weeks apart. It may be given to dogs six weeks of age or older and can be given annually as a component of ...
Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
... cancer was investigated on established human pancreatic cancer cell lines. Upon demonstrating specific in vitro targeting, in vivo targeting to subcutaneous
growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector.
They found that ...
Novo Nordisk Warns Customers About Stolen Insulin
... quality for our products.
About Levemir (R) (insulin detemir [rDNA origin] injection)
Levemir(R) is indicated for once- or twice-daily subcutaneous
administration for the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who ...
New Directions in Angioedema: A Focus on Etiologies and Clinical Approach
... Series for Healthcare Professionals
VOORHEES, N.J., June 10 /PRNewswire/ -- Angioedema is a clinical syndrome characterized by localized, subcutaneous
and/or submucosal swelling. Diagnosing the underlying cause of angioedema can be challenging, as there are multiple etiologies of this condition, all ...
Amgen's Denosumab and Eli Lilly's Forteo/Forsteo Will Drive Robust Annual Growth in the Osteoporosis Drug Market From 2013 to 2018
... to switch patients to PTH analogues and novel agents such as denosumab. The uptake of denosumab, which has a convenient dosage regimen of bi-annual subcutaneous
injections, will drive the agent to achieve blockbuster sales of $2 billion in 2018 for the treatment of osteoporosis and osteopenia. The report also ...
Body Shaping Gets the Spotlight with Industry Experts and Celebrity Guest to Showcase SmoothShapes(R) and SmoothLipo(TM) Systems at THE Aesthetic Show in Las Vegas
... Photomology, to be truly successful in reducing cellulite in my patients. Photomology is a unique technology used to treat the condition and subcutaneous
fat by synergistically combined dynamic laser and light energy with vacuum and mechanical massage," said Dr. Shamban.
Dr. Miles Graivier ...
AIM Health Group Inc. reports largest quarterly profit since going public and announces filing of financial results for the three months ended March 31, 2009 on SEDAR
... Centres where we provide medical and complementary alternative medical care, (ii) Infusion Services where we provide intravenous infusions and subcutaneous
injections to patients suffering from rheumatoid arthritis, Crohn's disease, ITP and other inflammatory diseases, (iii) Pharmaceutical Research ...
Stem Cell Study Offers Hope for Targeting Tumors
... breast and cervical cancer cells in laboratory cultures, according to British researchers. When tried on mice, the specialized cells shrunk subcutaneous
breast tumors by about 80 percent, and when injected intravenously, they helped destroy about 38 percent of metastasized lung tumors in rodents.
NovaBay Pharmaceuticals, Inc. Reports First Quarter 2009 Financial Results
... at the American Academy of Dermatology 67th Annual Meeting that showed NVC-422 achieved significant anti-mycological efficacy in-vivo in treating subcutaneous
dermatophyte infections based on an established pre-clinical model. Importantly, these data combined with the past preclinical work that showed ...
Cimzia(R) (certolizumab pegol) Now Available for Self-Administration in Adult Patients With Moderate to Severe Crohn's Disease
... who have had an inadequate response to conventional therapy. The new prefilled syringe is now available to Crohn's patients taking Cimzia(R) for subcutaneous
self-administration once every four weeks after initial doses once a physician has provided instruction for proper use.
The Crohn's approval ...