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Silencing in Medical News

Scientists identify gene in breast cancer pathway

... cells, Dr. Singer and his team found that ZBP1 silencing occurs when a methyl group (CH3) attaches to ... silenced. The study also showed that the silencing of ZBP1 increases cancer cells' ability to ... According to the researchers, signs of ZBP1 silencing in breast cancer cells would indicate that a ...

Olivier Voinnet awarded 2009 EMBO Gold Medal

... work on the mechanisms and roles of gene silencing via RNA in plants. With this annual award, the ... contributions to our understanding of gene silencing via RNA have opened up new perspectives on how ... with significant implications for medicine. RNA silencing is a newly discovered and highly competitive ...

Researcher wins $1.2 million grant for gene regulation work

... recently discovered a direct link between RNA silencing and the genetic master switch controlling the sex ... process in gene regulation called the RNA-induced silencing complex (RISC) might interfere with or silence ... disease. "We want to know how RNA silencing affects fundamental gene expression," Horabin ...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

... they have taken on specialized roles in gene silencing in plants. This is important to prevent the ... RNAs (abbreviated as siRNAs) that specify the silencing of matching DNA sequences, whereas Pol V makes ... a while and then unexpectedly goes silent. The silencing process may have parallels to the pathway in ...

Bread mold may hold secret to eliminating disease-causing genes

... the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual ... such as those from the HIV virus. Meiotic silencing also occurs in worms, mice and human beings, said ... but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex ...

Gene 'knockout' floors tobacco carcinogen

... North Carolina State University have shown that silencing a specific gene in burley tobacco plants ... But their findings show that targeted gene silencing can work as well in the field as it does on the ... has a number of other targets for their gene silencing method. ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

... may provide insights into novel regulatory roles for noncoding RNAs in silencing tumor suppressor genes, while potentially revealing new therapeutic ... General Hospital, Boston, Massachusetts, is studying mechanisms of gene silencing by a class of small regulatory molecules called microRNAs. In addition to ...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

... in cancer drug development which focuses on expression (switching on) or silencing (switching off) of certain genes. Progen and its collaborators have ... known as lysine specific demethylase 1(LSD1), which contributes to the silencing of important tumor suppressor genes. They have successfully developed ...

Licorice compound offers new cancer prevention strategy

... either by treatment with a natural compound found in licorice or by silencing the 11βHSD2 gene prevents colorectal cancer progression in mice ... glycyrrhizic acid, the main sweet-tasting component of licorice, and by silencing the gene for 11βHSD2. Both treatments inhibited the production of ...

OHSU cancer institute researcher discovers new predictor of prostate cancer recurrence

... on cancer patients. The researchers found that men whose tumors showed a silencing of the gene CDH13 had a five-fold increased risk of prostate cancer recurrence compared with men whose tumors showed no silencing of this gene, according to Joshi Alumkal, M.D., OHSU Cancer Institute ...

Weill Cornell receives $2.4 million in grants from Gates Foundation to fight tuberculosis

... genes in M. tuberculosis. They have developed systems that allow silencing of mycobacterial genes in vitro and during macrophage infections. They are ... studies should provide proof-of-principle for the hypotheses that gene silencing can be used to: 1) identify biological processes that are essential for ...

Chemoprevention, naturally: Findings on plant-derived cancer medicines

... rich, dark color, and our findings show these compounds have a role in silencing cancerous cells, said Susan Mallery, D.D.S., Ph.D., professor in the ... the benefit of the tumor suppressor genes due to a second mutation or gene silencing event. Following the trial, the researchers noted that many lesions ...

OPKO's Bevasiranib Named One of Most Promising Drugs Recently Entering Phase III Trials

... -- OPKO Health, Inc. (Amex: OPK ) today reported that the gene silencing agent bevasiranib, OPKO's lead compound for the treatment of wet ... healthcare company. Its lead investigational drug, the pioneering gene silencing agent bevasiranib, has entered a pivotal Phase III trial after ...

Cell Structure Helps Direct Cancer Gene 'Switch'

... According to a statement from the university, "The study showed that silencing of transcription start sites in some cancer cells involves distinct ... of DNA that can lock or silence a gene -- may ultimately lead to [gene] silencing by enabling the stable presence of nucleosomes at the start sites of ...

A breakthrough in gastric carcinogenesis

... advantage does not lead to either p53 mutation or CIN in gastric cancer. This is the first study to show the striking relationship between CHFR silencing and microsatellite alteration in gastric cancer. ...

Researchers work to boost effectiveness of the flu vaccine

... MCG researchers, led by Drs. Mellor and David Munn, showed in 1998 that fetuses use IDO to avoid rejection by the mother's immune system. IDO's silencing effect is hijacked by tumors and chronic infectious agents like HIV to avoid getting eliminated by the immune response. Acute infections such as the ...

Falcon Genomics Awarded Patent for Innovative Cancer Test

... Drugs Research and Development in Philadelphia, PA (February 19, 2009) represent the first reported use of high-throughput one-step delivery of silencing RNA (siRNA) into cells growing in an anchorage-independent manner with real-time evaluation of cell growth. "Cancer is analogous to a ...

The future of personalized cancer treatment: An entirely new direction for RNAi delivery

... a maximum RNAi response. Similar results were obtained in primary cells and cancer cell lines. "We were subsequently able to introduce gene silencing proteins into a large percentage of various cell types, including T cells, endothelial cells and human embryonic stem cells," said Dowdy. ...

Vitamin A signals offer clues to treating autoimmunity

... vaccines against many infectious agents since the calming receptor is known to respond to bacteria and viruses as well as yeast. In addition, silencing the calming receptor's messages might boost the immune system's ability to fight a chronic infection. The results are published in the March 2009 ...

PNAS announces 2008 Cozzarelli Prize recipients

... this article is available: http://www.pnas.org/content/105/32/11035 Class II (Biological Sciences): "MicroRNA-directed transcriptional gene silencing in mammalian cells," by Daniel H. Kim, Pl Strom, Ola Snve, Jr., and John J. Rossi http://www.pnas.org/content/105/42/16230 Class III ...

New genes involved in acute lymphoblastic leukemia play fundamental role in prognosis of the disease

... the worst prognosis and survival rates. These are the patients amongst whom the disease is much more resistant to treatment and amongst whom a silencing of the expression of the microRNAs is produced, according to the specialist. Most efficacious pharmaceutical drugs Given these result, ...

RNs Charge Jackson Health System, Service Union Broke State Law in Harassment of Hospital Nurses

... Alliances with controversial large corporate employers such as Wal-Mart which subvert genuine healthcare reform. silencing dissent of its own members through lawsuits, sham elections, and physical intimidation. NNOC/CNA is the nation's largest RN ...

Work with fungus uncovering keys to DNA methylation

... very nicely, in a couple different ways, that protein phosphatase PP1 is required for normal DNA methylation. "DNA methylation is involved in a silencing of invasive DNA as well as a variety of normal genes, including those on the inactive X chromosome, those subjected to imprinting, and well as tumor ...

Study first to show that RNA interference can facilitate vaccine development

... Athens, Ga. - Pharmaceutical companies and universities are racing to develop drugs that use the gene silencing mechanism known as RNA interference to treat a host of diseases. Now, a new study opens up an entirely new possibility for this powerful tool: ...

Gene Behind Childhood Anemias Found

... both diseases, Orkin said. "We now have a target that if we could modulate it directly, we could increase fetal hemoglobin and reverse the silencing and reawaken the fetal gene in an adult," Orkin said. "That would have tremendous therapeutic implications in both of those disorders." While he ...

Conference report highlights new research into drug delivery to treat eye disease

... peptides, proteins and nucleic acid drugs. His group is focused on using a family of acid-sensitive polymers to help deliver one of the latest drugs, silencing RNA (siRNA). Another group of presenters discussed the use of nanoparticles, microbeads and microneedles. Mansoor M. Amiji, PhD, said that ...

Healthcare Workers Picket Their National Union to Protect Their Voice for Patients

... has also threatened to break up UHW and create a new local for healthcare workers, run by appointees from the national office, as another means of silencing internal critics. "Healthcare workers make the decisions in UHW because we know what the challenges are," said Anita Wiltz, a nursing assistant at ...

DNA editing tool flips its target

... "Otherwise, losing DNA methylation marks can have serious consequences, causing genes to become active at the wrong places and times." "Gene silencing via DNA methylation is critical for normal development and for curbing the runaway cell division that characterizes cancer," said Peter Preusch, PhD, ...

Activation of LYN kinase is associated with imatinib-resistance in CML patients

... by BCR-ABL in CML cells. In the current study, Donato and colleagues have expanded that work and examined the impact of overexpression and gene silencing of LYN kinase in CML cell lines treated with imatinib. They also determined the level of LYN activation in samples from 12 imatinib-resistant ...

Gene silencer and quantum dots reduce protein production to a whisper

... in the Journal of the American Chemical Society . "This work helps to overcome the longstanding barrier in the siRNA field: How to achieve high silencing efficiency with low toxicity," said co-author Shuming Nie, a professor in the Wallace H. Coulter Department of Biomedical Engineering, jointly ...

MicroRNA controls expression of oncogenes

... malignancies, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. The researchers went on to show that transcriptional silencing of miR-203 lead to upregulation of the oncogene ABL1 and the BCR-ABL1 oncogenic fusion protein in various mouse and human hematopoietic malignancies. ...

Protein plays key role in transmitting deadly malaria parasite

... the parasite to enter the mosquitos salivary glands. While more studies are needed, lead author Fabian Saenz, PhD, said the finding suggests that silencing the receptor for MAEBL in the mosquito salivary gland might block passage of the parasite through the mosquito, thereby preventing human infection ...

ASPB engages Latin America colleagues at Annual Meeting in Merida, Mexico June 22-25

... Vielle Calzada. John Jones The origins and early dispersal of Maize: The Palynological and Archaeological Evidence. Vicki Chandler Epigenetic silencing Across Generations. Erik Vollbrecht The maize inflorescence: development, domestication and insights into grass evolution. Jean Phillipe Vielle ...

How embryonic stem cells develop into tissue-specific cells demonstrated

... sequences that the researchers were able to establish exactly how and at what point the stem cells developed into specific tissue cells and when the silencing occurs. ...

MicroRNAs appear essential for retinal health

... birth that just did not work. Production of microRNAs is dependent on Dicer, an enzyme widely used by living things to kick-start the process of silencing unwanted genetic messages. By breeding mice that lack one or both of the forms or alleles of the gene that produces Dicer in the retina, scientists ...

Penn researchers discover 'modus operandi' of heart muscle protein

... filaments to the sarcomere, the part of the heart that controls contractions or pumping. When Lmod was knocked down in cardiac muscle cells by an RNA silencing technique, the sarcomeres became completely disorganized and could not direct muscles to contract. Proper localization of Lmod in heart cells is ...

Too many gene copies stimulate tumor cell growth

... protein activity were detected in tumors that did not exhibit duplication of the region of DNA containing the BRAF gene. As pharmacologic and genetic silencing of the BRAF signaling pathway and the BRAF gene, respectively, prevented tumor cells from low-grade gliomas growing in culture, it was suggested that ...

JCI online early table of contents: April 8, 2008

... protein activity were detected in tumors that did not exhibit duplication of the region of DNA containing the BRAF gene. As pharmacologic and genetic silencing of the BRAF signaling pathway and the BRAF gene, respectively, prevented tumor cells from low-grade gliomas growing in culture, it was suggested that ...

Open Biosystems' Open Access RNAi Program Continues to Gain Momentum Worldwide

... stable knock-down experiments for pre-clinical models." said Dr. Chris Boshoff, Director, UCL Cancer Institute, http://www.ucl.ac.uk/cancer "Gene silencing using RNAi is gaining popularity around the world as researchers realize and witness its value both for understanding gene function and for the ...

Michael J. Fox Foundation Commits Up to $2 Million to Improve Drug Delivery for Parkinson's Disease

... the use of proteins, including trophic factors such as GDNF, and other biologics being developed by biotechs. Genetic material, used in gene silencing or gene therapy approaches, also cannot cross the blood-brain barrier and currently can be delivered only via surgical intervention. Molecular ...
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