Scientists Show Stem Cells Don't Cause Cancer
... treat disease has been the possibility that the retrovirus
used to implant the cells might cause cancer, but ... that these stem cells can be implanted using a retrovirus
without fear of causing cancer.
"This is a ... In addition, there has been a fear that using a retrovirus
to implant stem cells results in an increased ...
Viruses for a healthy pregnancy
... in the February issue of Microbiology Today.
infections represent the most intimate ... in the germ line. As a result, an endogenous retrovirus
(ERV) can exist for millions of years.
Over ... there are some related viruses in animals. For a retrovirus
to become part of the host genome it is usually ...
Coming Soon: Lung-Cancer Spray?
... disorders and offers numerous advantages over more invasive modes of delivery."
In the study, researchers used a lentiviral vector derived from a retrovirus
able to infect non-dividing cells, causing lasting genetic changes. The lentiviral vector included a carboxyl-terminal modulator protein (CTMP), ...
Vaporized viral vector shows promise in anti-cancer gene therapy
... of non-small cell lung carcinomas were associated with the activation of the Akt signaling pathway. They chose a lentiviral vector, derived from a retrovirus
and known for its ability to infect nondividing cells and effect persistent genetic changes. They transfected the lentiviral vector with a negative ...
A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier
... Cancer Institute (NCI). These reports followed the publication by Dr. Montagnier and his co-workers who showed the first existence of this new retrovirus
and subsequently contributed to demonstrate its causative role in AIDS."
Drs. Gallo and Montagnier are participating in a symposium, "25 Years ...
Exploring the frontiers of retrovirology
... BioMed Central recently announced the launch of "Frontiers of Retrovirology", an international conference that will bring together leading human retrovirus
researchers to review current progress and to chart future challenges.
HIV affects 33 million individuals worldwide. To date, 25 million have died ...
New Roche Dual Target HIV-1 Test Approved for Use in European Union
... million people became newly infected, and 2.1 million died of AIDS,
including 330,000 children.
The human immunodeficiency virus (HIV) is a retrovirus
that infects cells
of the human immune system, destroying or impairing their function. In the
early stages of infection, the person has no symptoms. ...
Hopes for AIDS Vaccine Still Alive Despite Setbacks
... for when you get exposed to HIV."
But there's yet one more hurdle unique to HIV. Unlike standard flu or cold viruses, HIV -- a more primitive retrovirus
-- actually inserts a piece of its DNA into the genome of the human host cell.
This "integration" begins within hours or days of infection, mainly ...
Recipe for cell reprogramming adds protein
... the reprogramming process time-consuming and highly inefficient.
To bypass these obstacles, the Whitehead researchers replaced c-Myc and its retrovirus
with a naturally occurring signaling molecule called Wnt3a. When added to the fluid surrounding the cells being reprogrammed, Wnt3a promotes the ...
Dr. Anthony Fauci reflects on 25 years of HIV
... On the 25th anniversary of the first scientific article linking a retrovirus
to AIDS, Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, ...
JCI table of contents: Feb. 21, 2008
... expressed by healthy cells. The gene responsible for making this protein was part of a region of human chromosome 6 derived from a human endogenous retrovirus
(HERV) type E. The authors therefore suggested that HERV-E is activated in metastatic kidney cancer providing a protein target for the immune system. ...
Anti-parasite drug may provide new way to attack HIV
... Dewhurst. Carlos Maximiliano and Vicente Planelles led the effort in Utah. Retrovirology publishes peer-reviewed, high-impact articles on basic retrovirus
research. The journal is edited by Kuan-Teh Jeang, M.D., Ph.D., head of the Molecular Virology Section at the National Institute of Allergy and ...
A taxing issue: How human T-lymphotropic virus
... represent the first time that a reduction in histone protein levels has been linked to viral infection and the development of cancer.
HTLV-1 is a retrovirus
that causes adult T-cell leukaemia/lymphoma (ATLL). A single protein made by the virus, Tax, is thought to be enough to trigger cancer development. ...
GeoVax Co-Founder Dr. Harriet Robinson Named 2007 AAAS Fellow
HIV/AIDS vaccine scientists. Recognized by the AAAS section on medical sciences, Dr. Robinson was
elected for her outstanding work on retrovirus
biology and the development
of DNA vaccines with special emphasis on HIV/AIDS vaccines. In addition to
her role as GeoVax's Chief Scientific Advisor, ...
Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
disease progression and the onset of AIDS in their HIV-infected patients." About HIV and AIDS HIV, or the human immunodeficiency virus, is a retrovirus
cells of the human immune system, destroying or impairing their function.
The most advanced stage of HIV infection is AIDS, or ...
T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
... require other co-stimulatory signals to fully activate T cells, according to Dr. Brentjens.
Dr. Brentjens and his colleagues used an engineered retrovirus
to insert the chimeric antigen receptor gene into T cell DNA. Retroviruses insert DNA derived from their RNA into that of a host cell, which then ...
In-Vivo Gene Therapy Technique to Cure XSCID in Basset Pups
... and Harry L. Malech took a different approach by directly injecting the retrovirus
vector containing the corrective gene into the bloodstream of XSCID dogs ... the researchers treated. The fourth dog received the lowest dose of the retrovirus
vector the virus that had been engineered to pass on the gene leading ...
Urban Monkeys Source Of Virus Infections
... of the macaques tested positive for simian foamy virus (SFV), a primate retrovirus
that so far has not been shown to cause disease in humans, but that has ... settings in Asia. Two of the monkeys tested positive for simian retrovirus
(SRV), which, though it has been shown to infect humans in a laboratory ...
Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours
... to treat colon cancer, researchers extracted the mesenchymal stem cells from human fat tissue, and after expanding their number in the lab, used a retrovirus
vector to insert the gene cytosine deaminase into the cell.
The gene can convert a less toxic drug, 5-fluorocytosine (5-FC), used in ...
Ancient Viral Defense may Explain Susceptibility to HIV: Study
... A gene that protected man from an ancient retrovirus
that infected chimps and other primates millions of years ago may be one reason why our species is susceptible to HIV, said a study released ...
Disturbing Trend in AIDS Cases In US
... At the 14th annual retrovirus
conference in Los Angeles, it was reported that AIDS cases have been steadily increasing in the United States//. According to Harold Jaffe, a ...
XDR-TB: the Latest Global Terror
... of such a pathogen,' says Dr. John Mellors, professor of medicine at the University of Pittsburgh and vice chairman of the scientific program at the retrovirus
Such strains have now been reported in 28 countries with the bulk of them mainly in China, India and Russia.
Concludes Nunn, ...
Researchers Explore the Effect of Engineered Immune Cells on HIV
... to insert DNA that will counteract the infection.
The "Cadillac" of this gene delivery system is an HIV-based "lentiviral vector," a type of retrovirus
that uses the backbone of a virus to infect both dividing and nondividing cells. Wang says lentiviral vectors are very efficient delivery vehicles ...
Viruses Can Cross Species Barrier
... of every thousand who visit a monkey temple in Bali, Indonesia, will be infected with simian foamy virus (SFV) from a monkey bite. SFV is a primate retrovirus
that so far has not been shown to cause disease in humans. Monkey temples are religious sites that have become gathering spots for populations of ...
Cancer-Causing Virus Synthesizes Protein To Help Sustain Itself In Host Cells
... in the host. //
The study examines the function of a protein called HBZ, which is made by the human T cell leukemia virus type 1 (HTLV-1), a retrovirus
and a distant cousin to HIV, the cause of AIDS.
The findings indicate that HBZ enhanced the ability of HTLV-1 to establish a persistent ...
More about HIV
... HIV or human immunodeficiency virus is a retrovirus
that binds to receptors found on membranes of immune system T cells. When HIV attacks a cell, the virus is internalized, copied into DNA, then ...