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Prostaglandins in Medical News

QLT announces interim data from a Phase II clinical trial and a device study for the Punctal Plug Drug Delivery System

... the eye over time through sustained release to the tear film. About prostaglandins prostaglandins represent the largest segment of the U.S. glaucoma market. Latanoprost is ...

Study demonstrates the anti-inflammatory properties of pine bark extract

... FLAP and COX-1 were monitored and the products these enzymes generate, prostaglandins and leukotrienes, were quantified. A baseline study revealed that the ... functions. "Standard NSAID medications reduce the production of prostaglandins by COX enzymes for lowering the pain," explains Dr. Canali. "In contrast, ...

Study Demonstrates the Anti-Inflammatory Properties of Pine Bark Extract on Inflammatory Mediators COX-2 and 5-LOX

... FLAP and COX-1 were monitored and the products these enzymes generate, prostaglandins and leukotrienes, were quantified. A baseline study revealed ... functions. "Standard NSAID medications reduce the production of prostaglandins by COX enzymes for lowering the pain," explains Dr. Canali. "In contrast, ...

New target for maintaining healthy blood pressure discovered

... PHILADELPHIA - In trying to understand the role of prostaglandins a family of fatty compounds key to the cardiovascular system in blood ... are indicators of the inflammatory response that marks these plaques. prostaglandins are produced during the oxidation of certain cell molecules by ...

Protein a possible key to allergy and asthma control

... Basophils and mast cells store and release substances such as histamine, prostaglandins and cytokines, which signal other immune system cells to ready for battle. ... cells. Normally, mast cells respond with an outpouring of histamine, prostaglandins and other substances that spur allergic reactions in other cells. ...

Prostaglandin receptor key to atherosclerosis development

... molecule), Linton and colleagues reasoned that this compound may play an important role in atherosclerosis. Mounting evidence supports roles for prostaglandins and their receptors in atherosclerosis, but only two prostacyclin and thromboxane-A2 have been considered in detail, he said. Linton, first ...

QLT announces encouraging Phase II data from core study of Punctal Plug Drug Delivery System

... with a goal of enabling delivery of a variety of drugs to the eye over time through sustained release to the tear film. About Prostaglandins prostaglandins represent the largest segment of the U.S. glaucoma market. Latanoprost is an active ingredient that has been approved by the Food and Drug ...

Clean, Chemical-Free Eye Cream Evening Primrose Oil: The Puffy-Eye Cure

... but is able to easily utilize the rare EFA gamma-linolenic acid. Evening Primrose oil is an extremely rich source of this hard-to-find EFA. Since prostaglandins need to be continually created in the body, regular use of Evening Primrose oil gives the skin a constant source of EFAs, maintaining the skin's ...

Couples with fertility problems where the man is over 35 have increased difficulty in conceiving

... fluid, and then inserted directly into the uterus. If the sperm are not washed they can cause uterine cramps which can expel the semen because of prostaglandins in the seminal fluid. 12236 couples who had consulted at the Centre between January 2002 and December 2006 were involved, and the husband's semen was ...

Abortion drug's off-label use may have led to deaths

... fetuses more vulnerable to certain microbes. "From this research, we are learning about how PGE2 regulates reproductive-tract immunity. Because prostaglandins are made in abundance in the pregnant uterus and have already been implicated in infections, we are increasingly realizing their potent immune ...

Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial

... cells is thought to control the synthesis of prostaglandins, which are substances believed to trigger cancer cell growth. Researchers believe that prostaglandins promote the growth of new blood vessels to feed tumors, and also protect new cancers from destruction by the body's immune system. Blocking the COX-2 ...

QLT initiates phase II study of punctal plug drug delivery system for glaucoma & ocular hypertension

... The punctal plug drug delivery system in this study consists of three different concentrations of latanoprost, a prostaglandin analogue. prostaglandins represent the largest segment of the U.S. glaucoma market, accounting for approximately $700 million in sales in 2005. Latanoprost is an active ...

Amira Pharmaceuticals and GlaxoSmithKline Enter Global Agreement for FLAP Inhibitor Program

... in the leukotriene pathway than a CysLT1 receptor antagonist, enabling it potentially to inhibit the production of all leukotrienes. Leukotrienes, prostaglandins and other arachidonic acid-derived lipids make up the eicosanoid family of inflammatory mediators. About GlaxoSmithKline GlaxoSmithKline is one ...

Protein suppresses allergic response in mice

... to sometimes become overactive and cause allergic reactions. The severity of an allergic reaction depends on the quantity of chemicals (histamines, prostaglandins and leukotrienes) released by mast cells. Serious, quick-onset allergic reactions affecting multiple organs of the body can lead to anaphylaxis, ...

Abnormal immune cells may cause unprovoked anaphylaxis

... and thus the anaphylactic reaction is called idiopathic. Anaphylaxis occurs when mast cells release large quantities of chemicals (histamines, prostaglandins and leukotrienes) that cause blood vessels to leak, bronchial tissues to swell and blood pressure to drop. Resulting conditions such as shock and ...

Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease

... in the leukotriene pathway than a CysLT1 receptor antagonist, enabling it potentially to inhibit the production of all leukotrienes. Leukotrienes, prostaglandins and other arachidonic acid-derived lipids make up the eicosanoid family of inflammatory mediators. About Amira Founded in 2005 and headquartered in ...

Specific antagonism lowers blood pressure

... of several soluble factors (known as prostaglandins) that can affect blood pressure and the effects of inhibiting the individual receptors for prostaglandins are not known. In an attempt to address this issue researchers from Vanderbilt University Medical Center identified a novel potential target for the ...

Omega-3 Again Linked to Lower Colorectal Cancer Risk

... called prostaglandins, which can be either pro- or anti-inflammatory. The prostaglandins derived from omega-3 fatty acids are said to be anti-inflammatory and may protect against the development of cancer, while prostaglandins derived from omega-6 fatty acids, like AA, are proposed to be ...

Fishing for a Speedy Recovery After Chemotherapy or Marrow Transplant

... by the body when inflammation is present such as after an injury and may be among the compounds that aid recovery. So it makes some sense that prostaglandins would have the ability to enhance regrowth of cells, Zon says. The zebrafish is ideal for investigating blood formation, says North. It ...

Hope For Bedwetting Children

... works. The increased prostaglandin production of the polyurics could account for the difference in excretion of sodium, the authors noted. prostaglandins counteract the actions of vasopressin and influence of how much sodium we excrete. Next step: Treatment Trial The researchers have begun ...

Hormone In Semen May Cause Cancer

... active women who are at risk of cervical or uterine cancer should encourage their partners to wear a condom to prevent increased exposure to the prostaglandins that might make their condition worse," said lead author Dr Henry Jabbour. ''This also highlights the potential for a new therapeutic approach ...

Proper Ratio Of Omega-3 And Omega-6 Could Reduce Prostate Cancer Growth

... According to the study it was found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) lead to the development of more anti inflammatory prostaglandins which reduce the growth of the prostate tumor. ...

Women, Exercise and Colon Cancer

... prospective cohort study of 31,783 American women has found no such link. Experts felt that since exercise is known to alter the production of prostaglandins and insulin besides increasing the gastrointestinal transit time, it might also play a constructive role in reducing the incidence of colon cancer. A ...

Grapefruit extract effective in stomach ulcer healing

... Disease Week? 2005 (DDW). The title of the study is “Role of Lipid Peroxidation, Expression, and Activity of Superoxide Dismutase and Endogenous prostaglandins in the Acceleration of Ulcer Healing by Grapefruit Seed Extract.” This effect is due to strong antioxidant properties shown by grapefruit extract. ...

Pain Killers Keep the Virus Away

... chemicals in the body that promote pain, inflammation and fever. So, scientists wondered if they could keep HCMV from replicating. Suppressing prostaglandins is easy. That's what so-called painkillers do. In the latest study, Thomas Shenk and his colleagues tried to prevent HCMV replication in human ...
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