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Promoter in Medical News

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

... and biomarker. The researchers analyzed NDRG4 promoter methylation and expression in human colorectal ... chain reaction was used to examine NDRG4 promoter methylation as a biomarker in fecal DNA from 75 ... subjects. The researchers found that NDRG4 promoter methylation was more prevalent in colorectal ...

A breakthrough in gastric carcinogenesis

... (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to ... University examined the methylation status of the promoter region of CHFR and microsatellite instability ...

Synthetic gene circuit allows precise dosing of gene expression

... yeast's DNA. The gene circuit starts with a promoter that launches the tetracycline repressor gene, which then blocks yEGFP via a promoter for that gene, shutting down its expression. ... and an amplifier The team then made the promoter for the repressor identical to that used for ...

Mouth may tell the tale of lung damage caused by smoking

... 39 individuals (95 percent) with p16 and/or FHIT promoter methylation in the oral samples had promoter methylation in at least one matched bronchial ... 59 of the 86 (69 percent) individuals without the promoter methylation in the oral samples. Similar ...

Farnesoid X receptor regulates cystathionase

... In the present study the analysis of the human Cystathionase gene promoter demonstrates the presence of an inverted repeat sequence. Administration ... four copies of this putative IR1 resulted in transactivation of the CSE promoter in presence of an FXR ligand, while the mutation of the IR1 binding site ...

Scientists identify gene in breast cancer pathway

... that ZBP1 silencing occurs when a methyl group (CH3) attaches to ZBP1's promoter region (the segment of a gene where gene expression is initiated). The attachment of CH3 prevents the promoter from binding to a protein called beta-catenin. And without beta-catenin, ...

NYU study finds new risk factor for melanoma in younger women

... the gene is turned on and how many copies are produced within a cell. This promoter region is normally regulated by p53, a tumor suppressor gene implicated in ... the substitution of a single letter of DNA at a specific point in the MDM2 promoter can significantly ramp up gene production. The new study evaluated the ...

Team led by Scripps Scientists increases understanding of two types of blindness

... turned on where needed, the group also added a genetic sequence known as a promoter that signals the starting point for the transcription of GFAP. As a ... cellular components in the glial cells that would normally attach to this promoter on DNA and then begin production of GFAP, were tricked into also attaching ...

Plant flavonoid found to reduce inflammatory response in the brain

... signaling, called transcription factors, which bind to specific promoter regions on DNA and increase their transcription into RNA and translation ... to activate the AP-1 transcription factor prevented it from binding to the promoter region on the IL-6 gene and transcription came to a halt. To see if ...

NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents

... mediated via inhibition of DNA methyltransferases (DNMTs) expression and promoter de-methylation. This is the first report to show that NSAIDs may inhibit the expression of DNMTs to reverse promoter methylation and to reactivate gene transcription. The researchers say ...

Genomatix integrates genome-wide open chromatin from next generation sequencing

... a strong correlation is shown between open chromatin and the Genomatix promoter annotation. Distance correlations of sequence tags and transcriptional ... same gene locus, as postulated by Genomatix since its first genome wide promoter annotations in 2000. Genomic localization of identified sequences in ...

Don King Enlists Prizefighters Felix 'Tito' Trinidad and Roy Jones Jr. to Strike a Blow against Breast Cancer

... promoter and Pugilists Vow to 'KO Cancer' with Susan G. Komen for the Cure NEW YORK, Dec. 21 /PRNewswire/ -- promoter Don King and his boxers Felix "Tito" Trinidad and Roy Jones Jr. -- who ...

Cancer drug works by overactivating cancer gene

... cells because it causes the c-MYC oncogene to overproduce a cell-death promoter called NOXA. Their results place c-MYC and NOXA, well studied among cancer ... appears to combat tumor growth by increasing the activity of a cell-death promoter called NOXA in tumor cells, but not in normal cells. In the new study, the ...

Fourth Annual Capitol Classic Bike Race for Autism Awareness

... fees, prizes and donations visit www.bikeforautism.org . Interviews: Fraser autism experts Jay Dworsky, Event promoter and father of a son with autism Diane S. Cross, Fraser president and CEO Where: The streets surrounding Minnesota's State ...

p90RSK: A new therapeutic target for liver fibrosis?

... with RNAi targeted to p90RSK, the expression of collagen type I was down regulated according with that of p90RSK. However, collagen type I promoter activity was not alternated with up-regulation or down-regulation of p90RSK expression. Otherwise, p90RSK RNAi inhibited the proliferation of HSC ...

NASCAR Sprint Cup Series Race at Dover International Speedway Named the "Autism Speaks 400, presented by Heluva Good! Sour Cream Dips & Cheese"

... for more information. About Dover International Speedway Dover International Speedway is owned by Dover Motorsports, Inc. (NYSE: DVD), a leading promoter of motorsports events in the United States. DVD subsidiaries operate four tracks in three states, and present more than 400 motorsports events each ...

First evidence for DNA-based vaccination against chronic hepatitis C

... a T cell vaccine based on a codon-optimised HCV non-structural (NS) 3/4A DNA-gene expressed under the control of the cytomegalovirus immediate-early promoter (ChronVac-C) delivered by in vivo electroporation (EP). A first phase I/IIa clinical trial in HCV infected patients is currently ongoing. ...

Mylan Announces Intention to Purchase Remaining Interest in Matrix Laboratories and Delist Matrix from Indian Stock Exchanges

... 77% over Matrix's average share price during the last month and last six months, respectively. If as a result of the delisting offer, the total promoter shareholding (including 4.97% shares held by the Indian promoter) exceeds 90% of all outstanding shares, Matrix will be delisted from the Bombay ...

Electronic Health Record Advances Patient-Centered Cancer Care at Cancer Treatment Centers of America

... analysis. CTCA is also using the EHR system to improve clinical care as well as patient satisfaction. CTCA tracks patient satisfaction using the Net promoter Score (NPS) methodology, among other measures. On average, more than 90 percent of cancer patients treating at one of its hospitals are willing to ...

Electronic Health Record Advances Patient-Centered Cancer Care

... analysis. CTCA is also using the EHR system to improve clinical care as well as patient satisfaction. CTCA tracks patient satisfaction using the Net promoter Score (NPS) methodology, among other measures. On average, more than 90 percent of cancer patients treating at one of its hospitals are willing to ...

Nonin Medical, Inc. Makes History With the First Continua(TM) Certified Product

... ) "I'm proud to welcome the first Continua Certified product to the global marketplace from industry leader and Continua promoter member Nonin Medical, Inc.," said David Whitlinger, Continua Health Alliance President. "Nonin Medical's engineers have worked diligently with other ...

Engineered virus targets and kills apparent cancer stem cells in neuroblastoma

... oncolytic herpes simplex virus called rQNestin34.5 on cells. Developed by cancer researchers Ohio State University, rQNestin34.5 carries a molecular promoter for nestin, which causes it to seek out the protein and cancerous, or precancerous, cells where nestin resides. The virus is genetically programmed ...

Gene associated with reduced mortality from acute lung injury

... pulmonary disease. After sequencing the EC-SOD gene in 52 randomly selected people, they discovered 28 different places within the gene and its promoter that showed variations. Many of the variations, known as single nucleotide polymorphisms (SNPs) occurred together. The researchers then looked at ...

Burn Machine Speed Bag Knocks 'em Out at Shriners Wheelchair Bodybuilding Camp

... camp really took the possibilities to a whole new level." Led by Nick Scott, a former Shriners patient and a wheelchair bodybuilding (WCBB) promoter and competitor, the camp was the first ever of its kind. Teens from around the country spent one week learning about fitness techniques for strength ...

Retired Heart Surgeon Dr. Dwight Lundell Celebrates 65th Birthday as an Ironman Participant

... for November 23rd in Tempe, Arizona. He will do a 2.4-mile open water swim, then a 112-mile bike race, followed by a 26.2-mile marathon run. The promoter for the event is NA Sports and the media is invited by going to ( http://www.nasports.com/media.php ) Dr. Lundell is best known for his ...

Zoom and Pan with Mike and Mary using Instant Demo screen recorder v7.0

... authorship details and link to a web address. The new control styles add a state-of-the-art appearance to the presentations. Whether you're a promoter who needs to create a self-running demo that prospects can view with their favorite web browser, a tech support person who needs to reduce support ...

LOH analysis on 4q in sporadic colorectal carcinoma

... carcinoma. The classic mechanism of tumor suppressor gene (TSG) inactivation is described by two-hit modes in which one allele is mutated (or promoter hypermethylation or a small intragenic deletion) and the other allele is lost through a number of possible mechanisms, resulting in LOH at multiple ...

Gene variants linked to metabolic syndrome and HDL cholesterol levels

... "We're going to follow up on the HDL component of the study," Love-Gregory says. "We're also going to look for additional variants in the promoter region of the gene that controls how the gene is regulated. And we're planning to look for evidence of these gene variants and their associations ...

Families shed light on likely causative gene for Alzheimer's

... a change in either side of a rung. "The mutation could be a deletion of some of the nucleotides, could be an insertion, or something in the promoter gene that turns the gene off so it's never transcribed. It could be a wide variety of things, and that is what our next step is to identify the ...

Stanford researchers synthesize compound to flush HIV out of hiding

... of which promote tumor growth, so it had no initially perceived use in fighting cancer. But NIH researchers found that prostratin was not a tumor promoter and checked to see if perhaps it could help combat HIV, which is when its remarkable ability to flush out the dormant virus was discovered. ...

Minnesota partnership advances potential MS therapy

... early stages of developing a promising and innovative therapeutic approach to a very challenging condition. The importance of the antibody as a promoter of myelin repair (remyelination) was recognized in studies using experimental animal models of multiple sclerosis. The studies were directed by Moses ...

Genome analysis reveals new protein associated with breast cancer progression

... cells from patients with estrogen-dependent breast cancers, the researchers found estrogen affected 1,615 genetic regions. One of those was the promoter for the gene for c-MYC, which, when activated, could bind another set of overlapping 311 genetic regions. Both estrogen and c-MYC interact with ...

Crannose(TM) Extra Strength Women's Health Formula Targets Urinary Tract Infections

... pre-mix or beverage sachet formula. According to Dr. Rudi E. Moerck, President of Valensa, there is a viable and growing market for a natural promoter of urinary tract health that can affect the conditions that lead to urinary tract infections (UTIs). "Antibiotics are the standard drug-based ...

Neuronal regulators offer potential targets for cancer

... He reasoned that these proteins might promote tumor formation if expressed outside the nervous system. The RNAi screen netted a known tumor promoter called ß-TRCP. Further genetic tests revealed that ß-TRCP binds directly to REST, tagging it for destruction. But REST must be primed with a ...

Race Central Launches Vigor Latino 5K Run/Walk, Promoting Hispanic Health, Fun and Fitness

... the importance and joy of exercise and the maintenance of a healthy lifestyle," said Judy Ikenberry, one of the founders of Race Central and the promoter of the event. "Vigor Latino will be a fun-filled day of activities for the whole family, not to be missed," added Tania Baxter, Race Director. The ...

Pacemaker tune-up works chemical wonders on damaged hearts in dogs

... is linked to arrhythmia, and tumor necrosis factor-alpha (TNF), which is also tied to damaging inflammation and cell death. The enzyme Akt, a promoter of cell survival when turned on, was markedly less active in the group whose hearts continued to beat out of sync. Researchers next plan to look ...

Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma

... A gene crucial for embryonic development can quickly become a potent cancer promoter in adult mice after a genetic misalignment, according to researchers from Fox Chase Cancer Center, causing white blood cells to become cancerous ...

JCI online early table of contents: Feb. 7, 2008

... of transcription of the renin gene and thereby the maintenance of blood pressure. TITLE: A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation AUTHOR CONTACT: Keiji Tanimoto University of Tsukuba, Tsukuba, Ibaraki, Japan. Phone: 81-29-853-6070; Fax: ...

Evolution of human genome's 'guardian' gives people unique protections from DNA damage

... to look systematically at small DNA sequences associated with the promoters, or enhancers, of specific genes that carry out orders from p53. These promoter elements act like antennae responding to activated p53 by boosting target gene expression and function inside a cells nucleus. By comparing these ...

JCI online early table of contents: Jan. 10 2008

... promoter, from which AE2b1 and AE2b2 are expressed. TITLE: Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells AUTHOR CONTACT: Juan F. Medina University of Navarra School of Medicine, Pamplona, Spain. Phone: 34-948-194700, Ext. 4001; ...
Other Contents
(Date:8/28/2014)... at the University of Minnesota have developed an animal ... used for muscle regeneration research as well as studies ... The research is published in the current edition of ... no treatment for FSHD, which is thought by many ... FSHD is an unusual genetic disorder because, unlike most ...
(Date:8/28/2014)... compounds that could positively impact the global ... possible, thanks to researchers in Penn State,s ... suppository made from the seaweed-derived food ingredient ... Tenofovir provides a woman-initiated, drug-delivery vehicle that ... transmitted infections during unprotected heterosexual intercourse, the ...
(Date:8/28/2014)... new roads will be built worldwide by 2050. Many ... where they bring an influx of destructive loggers, hunters ... has created a ,global roadmap, for prioritising road building ... demands of development and environmental protection. , The map ... natural importance of ecosystems and a ,road-benefits, layer that ...
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(Date:8/30/2014)... Acne is a common problem millions of American cope ... than a daily nuisance, for some, it can have a crippling ... even lead to dramatic mood swings and depression. , Those ... up their skin. In some cases, that can make the problem ... error, those on a quest for clearer skin can now view ...
(Date:8/30/2014)... New York, New York (PRWEB) August 30, 2014 ... and other incretin mimetic claims continue to move forward ... a statement issued by AstraZeneca PLC on July 31, ... have been named in 409 product liability claims that ... cancer. Court documents indicate that many of these claims ...
(Date:8/30/2014)... HealthDay Reporter FRIDAY, Aug. 29, ... on for broken bones or other orthopedic trauma shops around ... Less-educated patients and patients who had used narcotic painkillers ... said study lead author Dr. Brent Morris, a shoulder and ... suggests that doctors aren,t talking to one another about the ...
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