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Proliferation in Medical News

New Insight Into Primate Eye Evolution

... only a minor difference in the timing of cell proliferation can explain the multiple anatomical differences ... cellular and genetic pathways that coordinate proliferation during development have been fine-tuned since the ... by studying how changes in the regulation of proliferation during development can lead to dramatic changes ...

Process controlling T cell growth and production identified

... on how ELF4 affected the process of inhibiting proliferation of CD8 T cells. Using mice generated to lack ... the absence of ELF4 eliminated control over the proliferation of CD8 T cells. "If we can control ELF4 ... understanding the process that controls T cell proliferation will help in future research. ...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

... Progen also presented an update on its cell proliferation technology at the AACR Conference. Progen's lead cell proliferation product, PG11047, targets hyper-proliferating ... latest findings in Progen's epigenetics and cell proliferation technologies represented another important ...

Also in the April 7 JNCI

... TGF- is a cytokine that promotes cell proliferation in a variety of tissues and its expression has ... gastric cancer cell lines. They then investigated proliferation of these cells in culture and tumor growth and ... receptor did not increase cancer cell proliferation in vitro but increased tumor growth when the ...

JCI online early table of contents: Nov. 6, 2008

... into the signaling molecules that control the proliferation of HCC cells, and suggest that targeting one of ... into mice. Mechanistically, decreased proliferation and tumor development were associated with ... human HCC cells transplanted into mice. TITLE: proliferation of human HCC cells and chemically induced mouse ...

Protein 'switch' suppresses skin cancer development

... a sentry, monitoring and, when necessary, halting proliferation of these important cells. In the first mouse ... functions as a sentry that monitors keratinocyte proliferation and then induces terminal differentiation. In one ... factors previously found to regulate keratinocyte proliferation and differentiation. Another experiment ...

Cancer research highlights

... of rapidly growing cells. A rapid rate of cell proliferation is one characteristic of highly malignant tumors. Song and colleagues found no major changes in proliferation heterogeneity over the course of radiotherapy ... wash out the contrast because they have a greater proliferation of blood vessels, while benign lesions have a ...

Sound Pharmaceuticals Receives Additional DoD Funding for Its Hearing Regeneration Product

... inhibitor or CKI. CKIs shut down cell division or proliferation in many developing cells and tissues and are ... of mammals (cochlea), p27Kip1 prevents cellular proliferation and regeneration. For this reason, sensorineural ... Results indicate that renewed supporting cell proliferation and hair cell regeneration occur in animals that ...

Clinical study shows biological and clinical activity in relapsed leukemia patients

... in cancer cells that promotes their survival, proliferation and metastasis. The ongoing Phase 2 single-arm ... in cancer cells that promotes their survival, proliferation and metastasis. Galectin-3 is part of a family ... leukemia worldwide. CLL is characterized by proliferation of malignant white blood cells, referred to as ...

How does CO2 insufflation pressure affect proliferation and improve apoptosis?

... there were no obvious effects on MKN-45 cells proliferation and apoptosis. At 15 mmHg CO2 insufflation pressure, cells proliferation was inhibited and apoptosis improved. It may be ... behavior. Some authors showed an increase in cell proliferation and tumor growth and others found beneficial ...

Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial

... has proven to be safe and reduces a specific proliferation measurement of precancerous lesions in the lung, ... that a higher dose of Celebrex could decrease the proliferation marker KI-67 in these patients, as seen through ... Celebrex that decreases the expression of this proliferation marker." These findings are also significant ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting

... The second presentation, "Muller Cell proliferation and Glial Scar Formation Is Reduced Following ... Palomid 529 dramatically reduces the intraretinal proliferation induced by detachment and subsequently reduces ... signaling events leading to endothelial cell proliferation forming capillaries, moving outward from the ...

T-Cell Duplication Delayed Up to 3 Days After Infection

... in La Jolla, Calif., said this delay in T-cell proliferation may be an evolutionary safeguard against the risk ... rapid for both naive and memory cells." Once proliferation of both types of cells started, there was a ... Scripps team used laboratory animals to trace the proliferation of CD4 and CD8 memory T-cells. CD4 cells help ...

Injection of human umbilical cord blood helps the aging brain

... accompanies aging is a result of the decrease in proliferation of stem cells, not the loss of cells. In the ... new cells. A potent stressor of stem cell proliferation is inflammation. Prior to this study, the ... aged laboratory rats and that the increased cell proliferation continued for at least 15 days following a single ...

How DDT metabolite disrupts breast cancer cells

... The team tested the effect of p,p'-DDE on the proliferation of CAMA-1 cells, a human breast cancer cell line ... cells. p,p'-DDE had a similar effect on the proliferation of MCF7-AR1 cells, an estrogen responsive cell ... investigating the effect on breast cancer cell proliferation of a complex mixture of environmental chemicals, ...

Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership

... under the auspices of The Global Initiatives for proliferation Prevention Program. PRC is the most frequently ... About The Global Initiatives for proliferation Prevention Program of the U.S. Department of ... The mission of The Global Initiatives for proliferation Prevention program encourages and ...

Penn study finds pro-death proteins required to regulate healthy immune function

... death are also necessary for the maturation and proliferation of immune cells. Activation of T-cell receptors ... stimulated on mutant cells lacking both proteins, proliferation was severely reduced relative to normal cells. ... And because ROS tell the cell to divide, cell proliferation is compromised. Although Thompsons group ...

Study in this Week's Issue of Cell Finds Injected Growth Factor Spurs Heart Regeneration

... production of a cellular receptor for NRG1, known as ErbB4, cardiomyocyte proliferation was further enhanced, demonstrating that NRG1 works by stimulating this ... placed over the site of cardiac injury in rats, it induced cardiomyocyte proliferation and improved heart function (Nature Medicine 2007; 13:962-9). Similar ...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

... cells. miR-143 was found to block the expression of factors that promote proliferation by VSMC precursors. Surprisingly, miR-145 activated the expression of ... of miR-143 and miR-145 was reduced to almost nothing where disease-related proliferation of VSMC had thickened blood vessel walls. These findings suggest that ...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

... the insulin molecule that an insulin analog can increase the risk of cell proliferation via the IGF-1 receptor. Prescribing Information for Levemir(R), ... Ensmann H, Mayer D (2009) Analysis of signalling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines. ...

Prospect Therapeutics' In Vitro Studies Demonstrate that GCS-100 Drug Binds to and Blocks the Effects of Galectin-3

... an important role in tumor cell survival, new blood vessel growth, cell proliferation and tumor metastasis, which is the spread of cancer beyond its primary ... of angiogenesis Inhibition of cancer cell proliferation Inhibition of metastasis ...

Defeating nicotine's double role in lung cancer

... the expression of the nicotine receptors, which leads to increased cell proliferation and inhibition of apoptosis, further setting the stage for cancer. ... found that unaffected (i.e., noncancerous) cells showed no inhibition of proliferation when treated with α-CbT, suggesting that the treatment would have ...

Vaporized viral vector shows promise in anti-cancer gene therapy

... pathway, which has been shown to be an important regulator of cell proliferation and cancer progression. A recent report found that 90 percent of non-small ... would theoretically inhibit Akt signaling, thus suppressing cancer cell proliferation and tumor growth. Using a mouse model of lung cancer, the researchers ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

... Diagnostics. Anti-EGFR therapies are designed to impede cellular proliferation caused by activation of EGFR, but can trigger several side effects, ... with the cell's epidermal growth factor receptor to impede cellular proliferation and prompt tumor cell death. RAS is a family of genes encoding ...

Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting

... angiogenesis and granulation tissue formation through the recruitment and proliferation of cells such as monocytes, fibroblasts and endothelial cells, which are ... wound bed. PDGF-B is also known for its ability to stimulate repair cell proliferation so those cells that have migrated into the wound bed and are exposed to ...

A potential drug for liver carcinoma

... and L-02 cells were cultured and the inhibitory effect of ADFMChR on their proliferation was measured by MTT assay. The apoptosis of HepG2 cells was determined by ... Western blotting. They found that ADFMChR significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner, with little effect on growth of ...

Fate Therapeutics Adds Pratik Multani, M.D., M.S., as Vice President Clinical Development to Advance Upcoming Clinical Programs of Stem Cell Modulators

... cell technology platform to develop SCMs that can direct adult stem cell proliferation and function. Adult stem cells are naturally-occurring cells found in ... identification of small molecules and biologics that can direct stem cell proliferation and function. Fate Therapeutics is developing these small molecule and ...

p90RSK: A new therapeutic target for liver fibrosis?

... down-regulation of p90RSK expression. Otherwise, p90RSK RNAi inhibited the proliferation of HSC significantly. These results indicate that P90RSK was a critical ... responsible for excessive collagen expression via the initiation of HSC proliferation during liver fibrosis. Lacking of the knowledge about pathological ...

Recent developments at Burnham Institute for Medical Research, May 2009

... of Bioorganic and Medicinal Chemistry Letters . Keeping B lymphocyte proliferation in check In response to pathogenic challenge, B lymphocytes rapidly ... of CD98 function could be useful as a therapeutic means to block B cell proliferation in the context of leukemia or lymphoma as well as antibody-dependent ...

How cells change gears: New insights published in Nature Genetics

... "Leukemia" refers to a variety of pathologies involving uncontrolled proliferation of white blood cells. Understanding the role of the transcriptional ... phase of the project, researchers introduced a compound that stopped cell proliferation in the myeloid leukemia cell line. Next, they collected as much ...

Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting

... with XMT-1107, which targets a novel mechanism to inhibit endothelial cell proliferation and has the potential to target a wide variety of angiogenic tumors," said ... vitro, was highly active in human umbilical vein endothelial cell (HUVEC) proliferation assays, and showed anti-angiogenesis activity in vivo in the Matrigel plug ...

Transplanted liver cells function in older animals but do not proliferate as much as in younger ones

... rats (more than 35 weeks). After six weeks, the amount of hepatocyte proliferation was determined by an assay of CD26 enzyme activity. The recipient animals ... to inject IGF1 in old rats and see if this pretreatment would increase the proliferation levels of hepatocyte cells. ...

Dr. Larry Brilliant Joins Jeff Skoll to Combat Global Challenges

... initiatives to combat climate change, water scarcity, pandemics, nuclear proliferation and Middle East conflict. Brilliant will also serve as senior adviser to ... failure to address critical issues like climate change and nuclear proliferation aren't just making these challenges more difficult; they're putting life ...

Also in the March 24 JNCI

... cancer-related viruses stimulate telomerase activity, which promotes cell proliferation and immortalization. To learn whether HCMV induces telomerase activity, ... and precancerous cell lines. Overexpression of FASN increased cell proliferation and substrate-independent growth. When immortalized prostate epithelial ...

JCI online early table of contents: March 9, 2009

... STEM CELLS: The protein MuPAR regulates the proliferation and mobilization of blood stem cells The mechanisms underlying the ... in the bone marrow. When MuPAR was deleted or inhibited, HSPC proliferation was increased, but the ability of these cells to home and adhere to the ...

Compounds that trigger beta cell replication identified by JDRF funded researchers

... Foundation (GNF) have identified a set of compounds that can trigger the proliferation of insulin-producing cells in the pancreas, using sophisticated ... beta cell development in the embryo. A second appears to induce beta cell proliferation via an ion channel, which regulate the flow of ions across cell membranes. ...

What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?

... PPAR- gamma agonist pathway on PPAR- gamma , troglitazone, suppresses the proliferation of colon cancer cells, and induces apoptosis, and expression of the growth ... This report shows that ciglitazone and troglitazone suppress the proliferation of stomach cancer cells via the arrest of G1 phase. The arrest of G1 phase ...

Scientists uncover indicator that warns leukemia is progressing to more dangerous form

... and BCR fuse and produce a hybrid BCR-ABL enzyme that drives the excessive proliferation of white blood cells. CML progresses from a chronic stage in hematopoietic ... to the enzyme GSK 3 beta that prevents beta-catenin activation of cell proliferation occurs only in the GMP leukemia stem cells, which are only about 1 in 20 ...

Also in the Jan. 27 JNCI

... Introduction of the mutant gene into cells grown in vitro increased their proliferation rate and increased expression of genes associated with cancer cell growth. ... the amount of activated STAT-3 protein, which promotes survival and proliferation in cancer cells. Overexpression of STAT-3 in cultured cells eliminated the ...

Key to treating cancer may be finding its original cell

... that cancer biologists need to learn more about the genes that regulate proliferation (cell division), differentiation, survival, and programmed cell death in normal cells. A mutation in a proliferation gene, for example, can send the cell on a path of exaggerated division of ...
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(Date:10/15/2014)... and to an unexpected extent. The outbreak does not ... virus shows a new disease dynamic in regions, where ... the German National Academy of Sciences Leopoldina, acatech – ... Union of the German Academies of Sciences and Humanities ... , In the statement the academies call for the ...
(Date:10/15/2014)... Rosenstiel Award for Distinguished Work in Biomedical Science by ... of genomic instability and its implications for the immune ... to win the Rosenstiel Award; the first, Rod McKinnon, ... the Charles A. Janeway Professor of Pediatrics and Professor ... at the Howard Hughes Medical Institute at Boston Children,s ...
(Date:10/14/2014)... published in Cancer Research shows SIRT6—a protein ... cancers—can promote the development of skin cancers by turning ... of sun-damaged skin cells. , Previously considered protective, SIRT6 ... sirtuins that help regulate genomic stability and prevent some ... repair DNA damage, which can lead to cancer. This ...
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