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Progesterone in Medical News

Emory researchers announce Phase III study of progesterone for traumatic brain injury

... to evaluate the effectiveness of the hormone progesterone on acute traumatic-brain-injured patients. ... in an earlier clinical trial that giving progesterone to trauma victims shortly following brain injury ... participants. It was designed to evaluate whether progesterone can be administered intravenously in a safe and ...

Fighting "Brain Fog": How the Right Hormones Can Improve Mental Sharpness for Women

... clinical studies have shown that bioidentical progesterone helps repair the central nervous system ... confusion simply by using an over-the-counter progesterone cream. Even after the body's level of estrogen ... brain)," says Randolph. "Bioidentical progesterone counters this effect. In addition to 'finding ...

RESOLVE: The National Infertility Association Announces Partnership With CutisPharma

... Focuses on Website Link to Introduce Consumers to progesterone Compounding Kits MCLEAN, Va., April 14 ... will introduce CutisPharma, Inc., makers of progesterone suppository compounding kits for in-pharmacy use, ... that may benefit millions of Americans needing progesterone products," said Barbara Collura, RESOLVE's ...

New Approach to Progesterone Supplementation in ART Revealed in Recently Published White Paper

... Expert Panel: Vaginal progesterone Preferred for Luteal Support in ART ... titled, Recommendations on the Use of Vaginal progesterone for Luteal-Phase Support in Assisted Reproductive ... 19, 2008 to discuss the utility of vaginal progesterone for luteal phase support during ART. After ...

Study identifies potential 'safe period' for hormone replacement use

... cancer, confirming that the use of estrogen plus progesterone increases the risk of both ductal and lobular ... use of a regimen that includes both estrogen and progesterone is more detrimental for the breast than the use ... the use of estrogen-only and estrogen and progesterone in current and former users of varying duration, ...

Effectiveness of Progesterone in Reducing Preterm Births May Be Altered by Genetic Predisposition

... -- New research that may explain why taking progesterone to prevent preterm birth is only effective for ... caproate (or 17P), a synthetic form of the progesterone hormone naturally produced during pregnancy, has ... the theory that genetic variation in the human progesterone receptor plays an important role in the ...

Seattle Reproductive Medicine Study Investigates Newly Formulated Medications for Luteal Support in IVF

... self-administer daily injections of progesterone from two to eight weeks after the egg retrieval ... a new study of an investigational formulation of progesterone could replace these painful intramuscular injections of progesterone in oil with less painful subcutaneous injections. ...

Research Identifies Predictors for Successful IVF

... levels and pregnancy rates of women using progesterone vaginal inserts (ENDOMETRIN) and IM-PIO for ... studies showed similar results. In one, serum progesterone levels following use of ENDOMETRIN (n=98) and ... About ENDOMETRIN ENDOMETRIN administered as a progesterone vaginal insert is indicated to support embryo ...

CutisPharma Announces Issuance of a Patent for Suppository Compounding

... he added. Currently CutisPharma has FIRST(R) progesterone Vaginal Suppository Unit-of-Use Prescription ... patented container. The line includes FIRST(R) - progesterone VGS 25, 50, 100, 200 and 400 representing various ... CutisPharma estimates that over 1.5 million progesterone suppository prescriptions are written in the U.S. ...

Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

... available antibodies to detect estrogen and progesterone receptors isoforms in female gerbil stomach. They ... activity, and that both estradiol (E2) and progesterone (P4) play differential roles in response to ... bands for estrogen receptor (ER)-alpha (68 kDa), progesterone receptor (PR)-A (85 kDa) and PR-B (120 kDa) were ...

Study examines association between caffeine consumption and breast cancer risk

... increased risk of estrogen receptornegative and progesterone receptornegative breast cancer, or tumors to which the hormones estrogen and progesterone do not bind, and a 79 percent increased risk for ... cancers negative for both estrogen receptors and progesterone receptors or larger than 2 centimeters, which ...

CerviLenz Receives JumpStart Investment

... the company. "But the recent emergence of progesterone as a therapy to substantially reduce the risk of ... 30 percent since 1980; however, new research with progesterone is predicted to reverse this trend. "In ... to identify women who may benefit from progesterone therapy or further consultation by a specialist. ...

Progesterone Won't Shield Women Against Alzheimer's

... 29 (HealthDay News) -- There's no evidence that progesterone -- which is often given with estrogen in hormone ... symptoms in the mice, while treatment with progesterone did not. In fact, when the mice were given both hormones, progesterone appeared to block estrogen's main benefit -- ...

Vaginal progesterone gel may improve infant outcomes and...

... a positive association between the use of vaginal progesterone and infants overall health at birth. Babies born ... singleton preterm birth prevention study with progesterone looking specifically at a group of 46 women with ... (16%) newborns of mothers treated with vaginal progesterone gel needed to be admitted to neonatal intensive ...

HRT: A Boost for Libido, But Not Memory

... estrogen plus progesterone, suggesting that progesterone could be the active factor. "It's saying the progesterone is good for sexuality but probably not so good ... but these trials looked at combined estrogen and progesterone therapy. Only one study has looked at ...

Researchers identify key proteins needed for ovulation

... hormone triggered the ovary's release of the egg and the production of progesterone by the granulosa cells. In the current study, the researchers discerned ... are essential to both ovulation and the conversion of the other cells to progesterone producers, according to Dr. Richards. An important role of the ERK1 and ...

March of Dimes Provides $2.7 Million in New Funding For Preterm Birth Research

... of the onset of preterm labor." Caspase-3 is positively regulated by progesterone and other studies have shown that regular injections of a form of progesterone found naturally during pregnancy can prevent some preterm births in women ...

Breastfeeding, other factors may affect risk of breast cancer type

... cancer, which are classified by expression of the estrogen receptor, the progesterone receptor, and the HER2 receptor. Some breast cancer types express one or ... 1,023 women with breast cancer whose cells express the estrogen and progesterone receptors (called luminal cancers), 39 women with HER2-overexpressing ...

Hormone Therapy Safe, Effective for Women Entering Menopause

... Spain. Some of the key findings included: Combined estrogen and progesterone do not increase heart disease risk in women aged 50 to 59. Estrogen ... some cognitive decline in this age group. Combined use of estrogen and progesterone may increase the risk of breast cancer after 5 years of use; ...

Survival shortened when ER/PR negative breast cancer spreads to the brain

... to their brain, have found that women whose tumors do not have estrogen or progesterone receptors have the worst overall outcomes. Because of this, these patients ... cancer that does not exhibit HER2 growth factors or estrogen (ER) or progesterone receptors (PR) as well as HER2 positive cancers that are also ER/PR ...

Biomarker may be an early predictor of advanced breast cancer

... to make tumors grow in the breast. These moleculesestrogen receptor (ER), progesterone receptor (PR) and HER2are used as biomarkers for diagnosis and ... negative for estrogen receptor, 19 were positive and 37 were negative for progesterone receptor, and 26 were positive for HER2 with 30 negative. ...

Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium

... DX assay, for measuring the hormone receptors, estrogen receptor (ER) and progesterone receptor (PR) in early breast cancer patients. A separate study identified ... high degree of agreement in the assessment of estrogen receptor (ER), progesterone receptor (PR) and hormone (HR) status. -- Abstract #87 Poster ...

US Oncology Research Network Participates in Phase III Follow-up Study to BiPar's Investigational Cancer Drug BSI-201

... III, Multi-center, Open-Label, Randomized Trial of Gemcitabine/Carboplatin (G/C), with or without BSI-201, in patients with Estrogen Receptor (ER), progesterone Receptor (PR), and HER2-negative metastatic breast cancer. Joyce O'Shaughnessy, M.D. , co-chair of the US Oncology Breast Cancer Research ...

JNCI news brief: Breast cancer hormone receptor status and risk of a second primary tumor

... from the National Cancer Institute's Surveillance, Epidemiology, and End Results database to analyze whether a first tumor's estrogen receptor and progesterone receptor content and the age or race of the woman has anything to do with her risk of a second tumor. They found that women who have had breast ...

African-American women with advanced breast cancer often forego vital treatment

... were in African American women. Triple negative tumors accounted for 29 percent of the cases. These cancers do not express the estrogen receptor, the progesterone receptor or the human epidermal growth factor receptor 2 (HER2) and therefore do not respond well to therapies that target these proteins (such as ...

Breast cancer etiology may vary by subtype

... associations by subtype lend further support to the growing evidence base that breast cancer is a heterogeneous disease defined by estrogen receptor, progesterone receptor, and Her2 expression with distinct etiologic pathways and prognoses". The researchers found that patients with luminal B tumors were ...

The Diagnosis Every Woman Dreads - Ovarian Cancer

... and the disease is not discovered until the cancer has spread. The ovaries are almond-sized organs that produce the hormones estrogen and progesterone and they release eggs during the monthly cycle. After menopause, the ovaries stop releasing eggs and make fewer hormones. Symptoms of ovarian ...

Novel gene predicts local recurrence in early onset breast cancer

... However, lack of DEAR1 expression was associated with triple-negative breast cancer, which indicates poor prognosis because it lacks estrogen or progesterone receptors and does not express HER2, three targets for therapy. Lack of DEAR1 expression also was associated with a strong family history of breast ...

Novel gene predicts local recurrence in early-onset breast cancer

... However, lack of DEAR1 expression was associated with triple-negative breast cancer, which indicates poor prognosis because it lacks estrogen or progesterone receptors and does not express HER2, three targets for therapy. Lack of DEAR1 expression also was associated with a strong family history of breast ...

UAB wins $6.4 million nonprofit grant to fight aggressive breast cancer

... it reflects on our excellence in translational research." Triple-negative breast tumors lack receptors for the hormones estrogen (ER-negative) and progesterone (PR-negative), and for the protein HER2. This makes them resistant to several powerful cancer-fighting drugs like tamoxifen, aromatase inhibitors and ...

Penn study examines power of exercise to prevent breast cancer

... Each woman will give daily urine samples at points during the trial, which will allow investigators to measure their levels of estrogen, progesterone and other sex hormones. The women's body composition will also be measured, and they will receive breast MRIs at no cost to them before and after the ...

Black Women at Higher Risk for Aggressive Breast Tumors

... and race/ethnicity, and pathological features including the "triple negative" pattern -- tumors that lack expression of the estrogen receptor, the progesterone receptor, and the HER2 gene. "The odds of having a triple negative tumor were three times higher for black women than for non-black women in the ...

Risk of aggressive breast cancer subtype 3 times higher for black women

... and race/ethnicity, and pathological features including the triple-negative pattern - tumours that lack expression of the estrogen receptor, the progesterone receptor and the HER2 gene According to Rosenberg, "The odds of having a triple negative tumour were three times higher for black women than for ...

Traumatic Brain Injury: UCSF Neurosurgeon Calls For More Research, Improved Treatment Standard

... applied to TBI clinical trials, including one scheduled to take place at UCSF later this year -- the ProTECT trial -- that will study the use of progesterone in the treatment of acute brain injury. Increasing Awareness In the long term, he said, overhauling the way TBI is currently studied and treated ...

Research shows biopsy of recurrent breast cancer can alter treatment

... of the original cancer with the results of the new biopsy by analyzing the predictive markers that influence breast cancer tumor growth estrogen, progesterone and Her2 status. The presence, absence and/or combinations of these markers become the map oncologists use to determine the most effective treatment ...

March 2009 Mayo Clinic Women's HealthSource Highlights Molecular Breast Imaging, Canes and Walkers, Training for an Event and Hormone Therapy for Women

... and osteoporosis. In 2002, a large study called the Women's Health Initiative (WHI) found that older women taking estrogen plus a synthetic form of progesterone (progestin) had a small but increased risk of heart disease, stroke, breast cancer and blood clots. Because of this research, many women discontinued ...

2009 DeLee Humanitarian Award goes to Marshall Lindheimer, M.D., of the University of Chicago

... during pregnancy. With another University of Chicago colleague, Edward Ehrlich, Lindheimer elucidated the roles of the hormones aldosterone and progesterone in sodium and potassium regulation during pregnancy. Working with John Davison, of Newcastle upon Tyne University, England, Lindheimer mapped out ...

Menopause Drug Tied to Breast Cancer Recurrence

... Peter Kenemans, of the VU University Medical Center in Amsterdam, Netherlands, and colleagues. Tibolone acts like the female hormones estrogen and progesterone in relieving menopausal symptoms. But, unlike estrogen and progesterone, it has been believed that tibolone would reduce the risk of some cancers. ...

New genomic test can personalize breast cancer treatment

... predictive for chemotherapy response. The test was more predictive than typically used clinical molecular markers such as estrogen receptor status, progesterone receptor status or HER2 gene expression status. They found that luminal A was not sensitive to the chemotherapy, suggesting that patients with this ...

Researchers identify risk factors for contralateral breast cancer

... and multiple tumors in the original breast were all strong predictors for contralateral breast cancer. Patient race, estrogen receptor status and progesterone receptor status were not associated with increased risk. "We went from having very little information on the benefit of this procedure for ...
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