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Prion in Medical News

Protein Branded As Culprit in Mad Cow Disease

... say. Mad cow disease is considered a prion disease because it has been found to be tied to the prion protein, or PrP, which normally is found on the ... efforts to develop potential treatments for prion diseases or perhaps to prevent them from ...

Scripps Florida scientists devise accelerated method to determine infectious prion strains

... PLoS ONE on May 29, 2009. "Because some prion strains are pathogenic for humans and some are ... on the new study. "There are about 20 prion strains known in mouse models," Lasmzas said. "We ... of research." The Mysteries of Prions prion diseases, also called spongiform ...

Five UCSF Scientists Elected to National Academy of Sciences

... studying some of the most perplexing features of prion biology, including "species barriers," ... inhibit transmission between even closely related prion proteins, and prion strains wherein infectious particles composed of ...

Malaria Drug Doesn't Boost Survival Odds With Prion Diseases

... prolong survival of patients with brain-wasting prion diseases such as Creutzfeldt-Jakob disease (CJD), ... no way to prevent or reverse the progression of prion diseases. However, quinacrine -- an oral drug ... included 107 patients, aged 12 and older, with prion disease. They underwent neurological assessments ...

Scientists Spot New Clue to Alzheimer's

... linked to Alzheimer's and identified cellular prion proteins as the most likely culprit. It appears, ... that amyloid-beta peptides attach to cellular prion proteins, resulting in damage to brain cells. ... neurons sick," Strittmatter said. Cellular prion proteins are normally harmless and exist in all ...

Mutant proteins result in infectious prion disease in mice

... group of scientists has created an infectious prion disease in a mouse model, in a step that may help ... discovered that changing the structure of the prion protein by altering just two nucleic acids leads ... to investigate the specific changes in the prion protein that may contribute to chronic wasting ...

New Alzheimer's predictors advance earlier detection

... Early Phases of Creating a Vaccine against prion Disease Thomas Wisniewski, MD, Department of ... against a toxic and infectious version of the prion protein, which causes a group of brain diseases, ... animals could produce more antibodies against the prion protein in the mouth and blood system, preventing ...

First atomic-level look at a protein that causes brain disease

... brain diseases such as CAA. More common prion diseases include bovine spongiform encephalopathy ... step towards understanding the structure of the prion for CAA. This is a very basic study of the ... University, who took a fragment of the human prion protein for CAA and tagged it with chemical ...

American Chemical Society's weekly PressPac -- Feb. 27, 2008

... that detects record low levels of the deadly prion proteins that cause Mad Cow Disease and other so-called prion diseases. The sensor, which detects binding of prion proteins by detecting frequency changes of a ...

New prion protein discovered by Canadian scientists may offer insight into mad cow disease

... mad cow disease. Our team has defined a second prion protein called Shadoo, that exists in addition to the well-known prion protein called PrP said Professor David ... that folded into an abnormal shape and caused prion disease: end of story. This view is no longer ...

Germgard's New Room-Temperature Surgical Instrument Sterilizer Achieves Total Cycle Time of Three Minutes

... the process, confidently expecting no more than an unprecedented double cycle of six minutes total time for lumen devices such as endoscopes and for prion inactivation on neurological tools. Reduced cycle time and room-temperature sterilization are important since they reduce instrument damage, ...

Give the foie gras a miss

... of it affecting people has been seen. However, the suggestion from laboratory research is that amyloid fibrils may be transmitted in a similar way to prion diseases like BSE/CJD is cause for concern. Mice fed amyloid-affected beef, for instance, succumb to amyloidosis within weeks. Given that ...

American Chemical Society's Weekly PressPac -- June 18, 2008

... to detect the extremely low levels of prions possible in those materials. AD ARTICLE #1 FOR IMMEDIATE RELEASE "Persistence of Pathogenic prion Protein during Simulated Wastewater Treatment Processes" DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/es703186e CONTACT: Joel A. ...

JCI online early table of contents: June 5, 2008

... nerve cell growth by a process that involved increased expression of the soluble factor SDF-1-alpha, the protein to which it binds, and cellular prion protein. In addition, when transplanted into mice, OECs and ONFs induced stem cells to home to the site of brain damage following a stroke. TITLE: ...

UIC chemists characterize Alzheimer's neurotoxin structure

... said the method can also be applied to structural studies of proteins associate with other neurodegenerative diseases, including Parkinson's, and prion diseases, such as Creutzfeldt-Jakob. "We're also interested in applying our technique in the nanoscience field to examine the formation process ...

Expert on Emerging Infectious Zoonotic Diseases Joining K-State as a Regents Distinguished Professor

... State's animal health and food safety and security programs. At the federal center, Richt worked in two areas: emerging viral diseases of swine and prion diseases, such as bovine spongiform encephalopathy, also called BSE or mad cow disease. He was the first in the U.S. to describe "atypical" BSE ....

Prions Prevent Alzheimers Disease

... A role for prion proteins, the much debated agents of mad cow ... of disease progression and in some forms of prion disease share genetic features. These parallels ... They found an apparent role for normal prion proteins in preventing Alzheimers disease. ...

New Insights into Prion Propogation

... is not fully understood. New insights into prion propagation reported in the Molecular Cell by ... baker's yeast, while Saupe's research looked at prion protein in another fungus. A key difference between the two is that the yeast prion proteins are rich in the amino acids glutamine ...

Prions Capacity can Be Aggrevated by Solid Particles

... a group led by University of Wisconsin-Madison prion expert Judd Aiken reports that prions, the ... such as deer and sheep, which are susceptible to prion infection, tend to consume a fair amount of dirt ... little is known about the routes of prion transmission in animals, but the new Wisconsin ...

Proteins Behind Mad Cow Disease may Protect Against Alzheimer's

... prions corrupt the normal version of the prion protein present in brain cells, causing them to ... on mice genetically engineered to lack the prion proteins, suggest that the prions may have a ... ageing has an effect on the ability of the prion proteins to protect against Alzheimer's. ...

Vaccine Prevents Prion Disease in Mice

... Annual Meeting in Boston, April 28 May 5, 2007. prion diseases, which include scrapie, mad cow disease, ... the mice's immune system, researchers attached prion proteins to a genetically modified strain of ... attenuated Salmonella strain, which expressed the prion protein. Then they were divided into two groups ...

Vaccine Prevents Prion Disease in Mice

... Annual Meeting in Boston, April 28 – May 5, 2007. prion diseases, which include scrapie, mad cow disease, ... the mice's immune system, researchers attached prion proteins to a genetically modified strain of ... attenuated Salmonella strain, which expressed the prion protein. Then they were divided into two groups – ...

Researchers Develop Resin Beads That Capture Mad Cow Disease Agent From Blood

... possible to use a resin filter to remove harmful prion proteins from the blood of an infected animal, ... major implications for the removal of infectious prion proteins – the agents associated with variant ... disease, mad cow disease, scrapie and other prion diseases in animals – during blood transfusions. ...

Study Finds Prion Proteins in Milk

... A study has identified the presence of normal prion proteins in milk from humans, cows, sheep//, and ... available at www.plosone.org. Infectious prion proteins cause transmissible spongiform ... In view of a recent study showing evidence of prion replication in the mammary gland of sheep with ...

Early Treatment May Thwart Mad Cow-Type Disease

... A number of brain diseases caused by mutant prion proteins, such as mad cow disease or scrapie in sheep, //might be averted if normal prion proteins can be depleted, researchers report. ... disease, is thought to be caused when prion protein in the brain becomes misfolded, and this ...

Potentially Pathogenic Virus Found in Mad Cow Cells

... the now conventional view that abnormally folded prion proteins are infectious, and instead suggests that abnormal prion proteins are late stage footprints left by the ... the particles did not bind antibodies for the prion protein, indicating they were not composed ...

Researchers Make Strides in VCJD Detection

... impairment that strikes in the early stages of prion diseases such as vCJD and BSE has been identified ... Researchers led by Giovanna Malucci at the MRC prion unit at University College, London (UCL), used ... of drugs to identify if any can be used to stop prion production, but the next step in their research ...

Role of Hsp 104 in the Spread of Prion Diseases

... Protein’s role in the spread of the lethal prion diseases has been brought to light by researchers ... responsible for the spread and multiplication of prion diseases. This protein breaks up groups of such ... helped them understand the spreading of prion diseases and their role in diseases like ...

Single Protein Plays A Major Role In Prion Diseases

... A single protein plays a major role in deadly prion diseases by smashing up clusters of these ... we studied has a big impact on how fast prion diseases spread and may also play a role in the ... propagation process - fragmentation of existing prion complexes. Once converted, the thinking goes, ...

Milk Might Transmit Mad Cow Disease

... loses control and the animal ultimately dies. prion proteins are believed to cause the disease. // A mad cow’s milk may contain these prion proteins and the disease might be transmitted ... Western University School of Medicine, detected prion protein (PrPC)-the precursor of prions (PrPSc)-in ...

Genetic-Engineered Cows Resist Mad Cow Disease

... they call gene targeting. "By knocking out the prion protein gene and producing healthy calves, our ... successfully demonstrated that normal cellular prion protein is not necessary for the normal ... in cloning technology, said: "We anticipate that prion protein-free cows will be useful models to ...

Juvenile Diabetes may Be Caused by Mad Cow Protein

... displayed a few strange traits, molecules of prion protein aggregated in the beta cells of islets of ... the regulation of blood glucose, the function of prion protein is not completely understood. A ... in our lab, of someone who had a background in prion protein biology _ that's Alex Strom _ and ...

Prion Disease Agent Causes Heart Damage

... that heart infection could be a new aspect of prion diseases, including those that affect humans and ... unusual because unlike other infectious diseases, prion diseases appear to be transmitted by a protein, ... cellular protein, the prion. "Until now, prion disease has been thought of as a chronic ...

Early Diagnosis of CJD Seems Possible

... Dr Saa's team uses a new technique that detects prion proteins. They are infectious agents which cause vCJD. Prior to this test prion concentrations can be detected in the brain and ... amplification (PCMA) amplifies the quantity of prion proteins in any sample taken from the body. Out ...

New insight for neuro-degenerative diseases discovered

... have found novel insights into how abnormal prion proteins work. Researchers have observed genetically engineered mice producing prion protein without a glycophosphoinositol (GPI) cell ... of scrapie disease when inoculated with scrapie prion protein. These mice had developed plaques in ...

Brain diseases an outcome of cannibalism

... in the DNA of people around the world. Other prion researchers want to verify the findings with data ... it is also possible that eating animals with prion diseases could have contributed to the spread of ... in the DNA of people around the world. Other prion researchers want to verify the findings with data ...

Molecular Basis Of ALS Found

... disorders, including ALS and Alzheimer's, Parkinson's and prion diseases, but the relevance of these aggregates to the diseases is not ... "This phenomenon is in some ways akin to the recruitment noted in prion disorders and provides molecular sites for therapeutic intervention." This ...

Deer once again in trouble, due to deer disease!

... This is proof enough to say that deer muscle harbours this infectious prion protein and that muscle alone can trigger the wasting disease. ... lead investigator of the study said, "We don't know how the infectious prion goes from the central nervous system into the muscle. But it raises the ...

New Study Questions Cannibalism As A Worldwide Selective Force

... with cannibalism has not been a major selective driving force on the prion protein gene, as has been recently proposed. The study also has ... or for evaluation of historical patterns of human migration. The prion protein gene (PRNP) encodes a protein that can abnormally fold and amass ...
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