Blocking protein leads to fewer, smaller skin cancer tumors
... cell carcinoma to see if these patients have a polymorphism
on the MIF gene that would suggest a genetic ... cancer.
"If we find a correlation, a MIF-gene polymorphism
could become a biomarker to predict skin cancer. That would mean people who have a polymorphism
that makes them high MIF producers would be more ...
Exploring Genetic Link Between Migraines, Cardiovascular Trouble
"Their issue is that maybe an angiotensin-converting enzyme polymorphism
may account for some of the association between migraine and ... Lipton said. "They ruled out one [polymorphism], but it's a single polymorphism
in a gene and there could be a dozen that play in that gene, and if you ...
Calcium may be the key to understanding Alzheimer's disease
... regulation and amyloid beta levels in the brain. In this genetic study, a polymorphism
in the gene CALHM1 significantly increased the risk of sporadic, ... lab was responsible for showing that the Alzheimer's disease-associated polymorphism
disrupts the gene's function in cellular calcium regulation. These ...
How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?
... binding target. In this work we tested the hypothesis that MUC1 VNTR polymorphism
affects H pylori adhesion to gastric cells and thus plays an important ... World Journal of Gastroenterology.
The results showed that MUC1 VNTR polymorphism
influences the binding of H pylori to gastric cells, with the higher ...
Advanced targeted therapies effective as first-line treatment for lung cancer
... doublet chemotherapy. Researchers evaluated molecular markers including EGFR protein and EGFR gene copy number, EGFR- and KRAS-mutations and EGFR polymorphism
in order to potentially identify predictive markers for erlotinib therapy.
Both arms of the trial were well represented in patient and disease ...
Gene linked to increasingly common type of blood cancer
In the first genome-wide association study of non-Hodgkin lymphoma, scientists at UC Berkeley and TGen identified a SNP a single nucleotide polymorphism
that could determine susceptibility to follicular lymphoma. The SNP, a DNA variant within the more than 3-billion base pairs in the human genome, ...
Gene Studies Reveal Cancer's Secrets
... UGT2B28 genes were between 3.4 percent and 19.9, this did not increase the risk for prostate cancer.
"We did not see any association between polymorphism
of UGT2B17 and UGT2B28 with cancer," Setlur said during Tuesday's teleconference.
For more about cancer, visit the ...
Scientists Identify More Breast Cancer Genes
The newly identified genetic variations are located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide polymorphism
(SNP). SNPs, the most common type of genetic variation, affect just a single building block of DNA.
The function of the rs11249433 SNP is ...
Are vitamin supplements effective in celiac disease patients?
... against the effect of villous atrophy on homocysteine levels, irrespective to the genetic susceptibility status as manifested by carrying the C677T polymorphism
of 5,10-methylenetetrahydrofolate reductase.
Genetic Markers Identified for Alcohol Response in UCSF Gallo Study
... of alcohol and thus how prone they are to alcohol abuse.
The researchers found that a DNA sequence variation, known as a single nucleotide polymorphism
(SNP), on chromosome 15 is significantly associated with the level of response to alcohol and could signal the genetic factors that affect alcohol ...
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
... makeup, thereby reducing the risk of adverse events caused by inappropriate dosing.
McGinnis' research team were among the first to show that a polymorphism
in the warfarin drug target VKORC1 accounts for a major portion (~30%) of the variance in RD, and they have recently evaluated 1,523 Swedish patients ...
Presentations at AHA expand on clinical utility of deCODE's DNA-based tests
... Presenter: C.M. Ballantyne, Baylor College of Medicine
10:45-11:00am, Room 265-266, presentation number 4403, "Significant single nucleotide polymorphism
associated with atrial fibrillation located on chromosome 4q25 in a whole genome association study and association with left atrial gene expression." ...
Overeating? Blame Your Genes
... and the University of Texas at Austin.
"What is new here is that for the first time they have identified the consequences of this genetic polymorphism
[type] in how the brain functions," said Dr. Nora Volkow, who worked on earlier studies at Brookhaven National Laboratory that established the role ...
Also in the Sept. 9 JNCI
... , (203) 397-0440
Confirmation of Association with Chromosome 15 Locus and Familial Lung Cancer
Two single-nucleotide polymorphism
(SNP) variants on the short arm of chromosome 15 appear to be associated with familial lung cancer.
Several research groups recently reported an ...
ADHD Gene Doesn't Predict Response to Drugs
... the type of variant and response to methylphenidates; the drug reduced ADHD behavior in all individuals regardless of genotype.
"We expected this polymorphism
would also modulate response to medication, but it didn't," said Joober. "In other words, that means that whether you have the Val or Met allele, it ...
Vitamin D and breast cancer risk
... Hospitals investigated the effect of four of these polymorphisms on the risk of developing breast cancer. They found out that carriers of the Taql polymorphism
have a slightly increased risk of breast tumors that carry receptors for the female sex hormone estrogen on their surface. No effects on the overall ...
Large multicenter study suggests new genetic markers for Crohn's disease
... significant is not only the large sample size but also the method we used for screening, namely the use of a high-density, single-nucleotide polymorphism
genome-wide linkage process, says Brant. The new process is 10 times faster than older methods at searching the number of variations across the ...
Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
... study design, including 80 male patients with esophageal cancer and 480 controls (age and sex matched), the consumption of alcohol and the genetic polymorphism
of enzymes involved in the metabolism of ethanol was examined. This research was performed by doctors from the Laboratory of Gansu College of ...
Scientific poster abstracts from the 24th annual meeting of the American Academy of Pain Medicine
... Safety of Fentanyl Buccal Tablet for the Treatment of Breakthrough Pain in Opioid-Tolerant Cancer Patients
The Impact of CYP2D6 Genetic polymorphism
on Postoperative MorphineConsumption
Comparing the Safety and Tolerability of Duloxetine for the Management of Diabetic Peripheral ...
Gene Variant Tied to More Aggressive Prostate Cancer
... researchers who examined genetic clues in Swedish and American men with and without the disease.
The researchers identified a single nucleotide polymorphism
(SNP) -- a single base change in DNA -- located in the DAB2IP gene that was associated with aggressive prostate cancer in European and ...
Genetic differences point to ethnic and racial disparities in colorectal cancer risk
... prevalence in racial or ethnic populations, Garza said. These findings warrant larger studies to evaluate gene-environment interactions for the MTHFR polymorphism
and colorectal cancer risk in different racial or ethnic populations.
Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
... patients at Day 57 (p = 0.0301). -- CRP reductions were more likely in patients with a specified genomic biomarker, a single nucleotide polymorphism
(SNP) of a gene important in inflammatory pathways. The SNP was identified in 53 percent of the overall study population. -- In ...
Diabetes The Leveler-Sweeping Across Nations
... Dr V Mohan, director of the Madras Diabetes Research Foundation, the polymorphism
of the PPAR gamma gene Pro12 ala, which protects Europeans from the disorder is missing in Indians, while another polymorphism
of the same gene Thr Threonine, which triggers the disease, is present in ...
New Treatment For Psoriasis Is Highly Effective
... of Human Genetics annual meeting that psoriasis patients carry a common polymorphism
in the gene for p40 (IL12B) more often than control subjects. Further exploration led to a discovery of a second polymorphism
in the receptor for IL-23 that also associates with psoriasis. These ...
Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
... and colleagues have identified a candidate gene, Sipa1, with an amino acid polymorphism
that influences metastasis in cancer. Cancer mortality is most often the ... and discounting several of the genes, the authors found that Sipa1 had a polymorphism
that results in an Alanine to threonine substitution in a protein-protein ...
Inherited Genes Linked to Toxicity of Leukemia Therapy
... were the main treatment, a folate was linked to gastrointestinal toxicity, as it was during the continuation phase. And in all three phases, one polymorphism
was linked to hyperbilirubinemia, or jaundice, partly caused by the drug methotrexate.
"Scientists at St. Jude and elsewhere have ...
Hot Flashes: Studies Explore the Various Possibilities Involved
... more common in women who reported higher-than-average frequency, intensity and duration of hot flashes.
The new study tied the same genetic polymorphism
to lower levels of an androgen known as DHEA-S, and to lower progesterone levels.
These are the first studies to find evidence of a genetic ...
Genetic Test for Type II Diabetes Moves Closer
... about the specific genetic mutations associated with Type II diabetes to develop better treatments.”
The researchers used two single nucleotide polymorphism
(SNP) comparative genomic hybridization (CGH) platforms for identifying the gene mutations; Illumina's Infinium Human1 and Human Hap300 Beadarrays. ...
South Asians in US More Prone to Heart Disease
Dr. Dodani and her colleagues suspected that if a subject had thickening of the carotid arteries, he or she would also have dysfunctional HDL and a polymorphism
of the Apo-A1 gene. This is the first time researchers have examined a possible correlation between the gene polymorphisms, dysfunctional HDL and ...
More Americans Die Due To Side Effects From Prescription Drugs Every Year: Report
... testing – say the experts.
“Individuals injured by adverse drug effects are increasingly likely to bring lawsuits alleging that they have a polymorphism
or biomarker conferring susceptibility to the drug that should have been identified and used to alter their drug treatment,” wrote Gary Marchant, ...
Does Aspirin Crystallize?
... first case in which two different “polymorphic” structures exist in one single crystal. So is aspirin polymorphic or not? Should the definition of polymorphism
be updated? Such questions are not just philosophical in nature, but could have tangible implications in patent law, because each polymorph of a ...
Surprising Interaction Between Genes, Gender, and Hypertension
... low blood pressure,” said O’Connor.
Several diseases are caused by a variation on a single gene on the chromosome, called a single nucleotide polymorphism
(SNP, pronounced “snip”). Examples of so-called SNP diseases are sickle-cell anemia and Huntington’s disease, where a single variant or mutation has ...
Gene Linked With Aggressive 'Wet' Form Of AMD
... dry AMD are associated with a variant in the complement factor H (CFH) gene on chromosome 1.
Hoh now reports they have found a single nucleotide polymorphism
(SNP)—a one-base change in the sequence—of the regulatory part of the HTRA1 gene on chromosome 10 that leads to greatly increased risk of developing ...
Genetic Variations In Detoxifying Genes Lead To Lou Gehrig's diseases
... variations (polymorphisms) on the chromosome region encompassing PON2-PON3 were strongly associated with sporadic ALS.
"Thus, single nucleotide polymorphism
genotyping in the intergenic regions of the PON gene cluster, and replication, gene expression, gene-gene interaction and PON serum/enzymatic studies ...
Gene Variations Raise the Risk of Childhood Cancer Survivors
... found that polymorphisms in the GSTP gene significantly increased a patient’s risk for CHF after treatment with anthracyclines,'said Dr. Aplenc. One polymorphism
increased risk by five times; another variant was linked to a tripling of risk.
The research group chose particular genes as candidates for study ...
Malfunction Of Key Growth Factor Increases Mortality Rate From Pulmonary Fibrosis In Blacks
... track as the disease's population." First step is "we need to find or develop a suitable animal model where PF can be imposed. Also we plan to do polymorphism
studies because probably there are some Whites that have differences in the c-Met function due to damage or signaling difficulties and the results ...
Coffee Increases Heart Attack Risk In Slow Caffeine Metabolizers
... CYP1A1 gene.
Those who had the *1F allele and drank 2-3 cups of coffee had a 36% increased risk of heart attack. Young individuals with this polymorphism
were particularly at increased risk. With increase in frequency of coffee consumption (4 cups or more), the risk rose to 64%. The risk of heart ...
NIH To Launch Two Major Gene and Disease Projects Soon
... is yet another technique that would be taken up by the researchers, who would concentrate largely on the identification of single nucleotide polymorphism
(SNPs) that are believed to confer enhanced or decreased disease susceptibility.
A lot of financial resources have been spent on the ...
Dry Earwax Mystery Solved: Ear Wax Gene Identified
... sex appeal on account of reduced sweat and body odour.
The result of this interesting study represents the first example of single nucleotide polymorphism
(SNP), being linked to a visible physical trait. The article appears in the latest issue of the journal Nature Genetics. ...