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Phenotypic in Medical News

January American Naturalist highlights

... selection on morphological traits and drive phenotypic divergence. "Genetic constraints and ... the form that matches the season. This is called phenotypic plasticity, and in this species it has evolved as ... evolution of lifespan is closely associated with phenotypic plasticity. Is it a general mechanism" We think ...

AdvanDx Receives FDA 510(k) Clearance for GBS PNA FISH(R) for Rapid Detection of Group B Strep from Lim Broths

... taken for further culture workup and identification using conventional, phenotypic methods. This process can take anywhere from 3 to 4 days, and while Lim ... sensitive and selective for Group B Strep, the subsequent workup and phenotypic identification can be time consuming and may miss some true positive ...

Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Research Awards

... the extent of EMT in bleomycin induced pulmonary fibrosis and identify the phenotypic differences between EMT derived and non-EMT derived fibroblasts, and ... Acquiring knowledge regarding the origins of lung fibroblasts and specific phenotypic characteristics of subtypes of this cell population will improve ...

Sex Hormone Protein May Predict Type 2 Diabetes

... the researchers found. "To our knowledge, there are few biomarkers for type 2 diabetes prediction that have presented both genetic and plasma phenotypic evidence like ours," Liu said. The report was published in the Aug. 5 online edition of the New England Journal of Medicine . For the study, ...

GeneGo Awarded NIH Grant to Develop Pharmacogenomics Software Suite

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

... following points should be considered when initiating therapy with PREZISTA/rtv: Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/rtv. The use of other active agents with PREZISTA/rtv is associated with a greater likelihood of ...

Eli Lilly and Company Announces New Drug Discovery Initiative

... and Company will be engaging researchers from around the world in a new and unique drug discovery initiative. The initiative, called the Lilly phenotypic Drug Discovery Initiative, or PD2 (pronounced PD-squared)*, uses Lilly-developed disease-state assays and a secure web portal to evaluate the ...

GeneGo and OmicSoft Announce Integration

... integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Advanced Analytical Reveals New Platform for Rapid Genotypic Identification of Microorganisms at ASM 2009

... Clinic, added; "We evaluated the differentiation of various microorganisms on a prototype instrument and compared it with other genotypic and phenotypic methods. The instrument is capable of identifying organisms quickly and easily. The implementation of such technology in the clinical laboratory ...

iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

... aortic valve disease." iZumi and CiRA respectively offer the capability to take skin cells from a diseased patient with known genotypic and phenotypic information and reprogram the cells to behave similarly to human embryonic stem cells. These iPS cells can then be changed into various cell types in ...

PREZISTA(R) Now Available for Pediatric Patients Six Years of Age and Older as part of HIV Combination Therapy

... initiating therapy with PREZISTA/r in treatment-experienced pediatric patients: Treatment history and, when available, genotypic or phenotypic testing should guide the use of PREZISTA/r. The use of other active agents with PREZISTA/r is associated with a greater likelihood of ...

Washington University Becker Library Makes MetaCore Accessible Throughout the University

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

A new light on tumor immunotherapy for gastric cancer

... with cytokines for 8 d showed the character of typical mature DCs. However, immature DCs cultured with cytokines for 5 d did not have typical DCs phenotypic markers and could not stimulate allogeneic T cells. Ex vivo primed T cells with SGC-7901 tumor cell lysate-pulsed (TP) DCs were able to induce ...

Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology

... Therapy Poster III Presentation Time: 5:30 PM - 7:30 PM Location: Moscone Center, Hall A Poster Board no.: III-745 Abstract 1555 TITLE: phenotypic and Functional Effects of Novel Akt Inhibitor Perifosine on Immune System Session Name: Lymphocytes and Lymphocyte Activation Poster I ...

Monogram Biosciences Collaborates with Gilead Sciences for Elvitegravir Phase III Studies

... is the only commercially available phenotypic test for measuring susceptibility to entry inhibitors. Similarly, PhenoSense Integrase(TM), which is a phenotypic test for measuring susceptibility to integrase inhibitors, is expected to be introduced commercially soon. Trofile(TM) is a patient selection ...

KineMed Licenses GeneGo's MetaCore

... at the right time," said Gregory Hayes, Ph.D., Director of Oncology Research at KineMed. GeneGo's genetic pathway database aligns with KineMed's phenotypic pathway analysis and facilitates identification of genetic polymorphisms and expression patterns that directly link genetics with KineMed's in vivo ...

When disease discriminates: Women and COPD

... manifestation? Why does COPD progress more swiftly in women? Do outcomes differ because of gender bias in diagnosis, physiological differences, or phenotypic differences in their disease? Whatever the question, whether it is about the biological nature of the disease or clinical impact of therapeutic ...

Flip-flopping gene expression can be advantageous

... may play a role in genes can alternate between on and off settings. Scientists studying bacteria have simply not had the tools to understand phenotypic variability, said Ting Lu, lead author of the study who was a UCSD graduate student in the lab of bioengineering professor Jeff Hasty. (Lu is ...

Hopkins researchers release genome data on autism

... specialized areas of expertise will we gain an understanding of what makes some children susceptible, says Daly. Todays release of genetic and phenotypic data on autism marks a significant achievement for the autism research community, says Thomas Insel, Ph.D., director of the National Institute for ...

GeneGo Licenses MetaCore Data Analysis Suite to AVEO Pharmaceuticals

... an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics, metabolomics, microRNA assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological pathways and networks. ...

Autism Consortium releases data on genes involved in autism to researchers worldwide

... technology developed by Affymetrix on genetic data from more than 3,000 children with ASD and their families. Todays release of genetic and phenotypic data on autism marks a significant achievement for the autism research community, said Thomas Insel, Ph.D., Director of the National Institute for ...

UC San Diego researchers improve accuracy of breast cancer prognoses

... of our approach is the ability to identify crucial genes that fly under the radar of conventional gene expression analyses, said Ideker. The phenotypic changes most indicative of breast cancer metastasis need not be regulated at the level of expression, the authors write. The researchers also show ...

NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity

... examining whether these longevity genes affect the incidence of cognitive impairment in relation to the presence of favorable genotypes and their phenotypic expression. We are very grateful to the NIH for its support, said Dr. Barzilai, who also is the Ingeborg and Ira Leon Rennert Professor of Aging ...

Microbiotic technology developed for microinjection of zebrafish embryos

... embryos into a regular pattern within seconds and injecting 15 embryos (chorion unremoved) per minute with a success rate, survival rate, and phenotypic rate all close to 100%. The system and performance were reported in the journal PLoS ONE in an article entitled, A Fully Automated Robotic System for ...

Fluorescent markers to distinguish Trypanosoma brucei strains causing Sleeping Sickness

... the distinction of parasite genotypes based on an easily recognizable phenotypic trait. The authors conclude that the distinction of live parasites based on an easily recognized phenotypic trait and the physical separation of genotypes from mixed infections made ...

First Bacterial Genome Transplantation Changing One Species to Another

... M. capricolum chromosome disappeared having been replaced by the donor M. mycoides LC chromosome, and the M. capricolum cells took on all the phenotypic characteristics of M. mycoides LC cells. As a test of the success of the genome transplantation, the team used two methods -- 2D gel ...

Black and White in ‘Shades of Grey

... the requirement, enhanced by the selective trends of nature. This resulted in a ‘descent with modification’ as proposed by Darwin, providing the phenotypic variations characteristic of the humans. Discrimination, in some form or the other, has always been part of the history of the human race. ...

Parkinson's Disease And Genetics

... in many other neurological diseases." "The NINDS Human Genetics Resource Center has created a resource that allows broad sharing and access to phenotypic and genotypic data, as well as biological samples, with no restrictions. This approach to open, public sharing of genetic materials and data is ...

Genetic Mutation in Mice Suggests Extinct Mammoth Had Light and Dark Fur

... of mammoths during the last Ice Age were likely composed of dark- and light-coated individuals. “While there is growing evidence that phenotypic differences between organisms, like humans and chimps, are largely controlled by changes in gene regulation, these two studies are striking examples ...
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