Photos: Lumixyl(TM) Enters the Market to Improve the Appearance of Hyperpigmentation without Irritation and Side Effects
... a non-toxic, non-irritating, synthetic peptide
technology shown to significantly help improve ... Lumixyl's ground-breaking technology is the only peptide
shown to measurably promote healthy skin function ... skin that was treated with the Lumixyl peptide
expressed a reduced production of melanin by as ...
Tips from the journals of the American Society for Microbiology
... antibodies that target a gastrin-releasing peptide
which is known to play a key role in cancer ... and Vaccine Immunology .
(GRP) is an important human peptide
that regulates gastric acid secretion and motor ...
Caltech chemists say antibody surrogates are just a 'click' away
... group at one end. The alkyne group on the added peptide
can potentially chemically react with the azide group of the library's peptides, to create a new peptide
that is now two segments long.
However, the reaction can only occur when the second peptide
comes into close contact with the first on the ...
Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
... Clinic cardiology researchers have found a peptide
that helps preserve and improve kidney function ... blood pressure. Earlier variations of this peptide
caused blood pressure to drop limiting the ... and keep you out of the hospital."
This new peptide
(a unique link of amino acids) has been tested in ...
Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009
... symposia focused on the potential of peptide
therapy treatment approaches for type 2 diabetes, ... SYMPOSIA
"Effective Use of peptide
Therapies for Optimal Glucose and Weight Control ... healthcare providers understand the potential of peptide
therapy treatment approaches for diabetes. The ...
Study reveals current multi-component vaccines may need reworking
... when exposed to high enough levels of the peptide
Andrea Sant, Ph.D., ... the quality that confers immunodominance on a peptide
to be the strength and lifespan (kinetic ... pockets on the MHC class II molecule for a given peptide
to fit into it before the complex heads to the ...
Researchers identify potential therapeutic target in osteosarcoma
... with circulating particles that display a peptide
mimic of the natural ligand that binds IL-11Ra. ... particles called phages equipped with a peptide
that mimics IL-11, the receptor's natural ligand. ... is defined as BMTP-11 (Bone Metastasis Targeting peptide
11). The first clinical trial, in which BMTP-11 ...
Genes That Control Body's Salt Levels Are Identified
... genes for these peptides -- atrial natriuretic peptide
(ANP) and B-type natriuretic peptide
(BNP). They found three variants clearly related ... and, therefore, to lower blood pressure. Higher peptide
levels lead to lower blood pressure because ...
Targeted nanospheres find, penetrate, then fuel burning of melanoma
... Hollow gold nanospheres equipped with a targeting peptide
find melanoma cells, penetrate them deeply, and ... hollow, spherical gold nanospheres with a peptide
- a small compound composed of amino acids - that ... hollow gold nanospheres without the targeting peptide
were not. The targeted nanospheres were actively ...
Enzyme with a sugar antenna
... amino acid at a time is much too complex for long peptide
chains and sometimes doesn't work at all because ... chemical ligation". In this technique, one peptide
fragment is attached to the terminal cysteine group (sulfur-containing amino acid) of a second peptide
fragment by means of a thioester groupa selective ...
Process found to play role in rheumatoid arthritis could lead to new treatment
... In addition, the researchers identified a novel peptide
to inhibit PlGF action. When injected into arthritic mice, this peptide
reduced the severity of arthritis and prevented ... of antibody-induced arthritis.
they identified inhibits binding of PIGF to its ...
Peptimmune Grants Major Pharmaceutical Company Exclusive Option to License PI-2301 for Multiple Sclerosis
... "Peptimmune and its world-leading expertise in peptide
copolymers represent an attractive investment opportunity."
PI-2301 is a peptide
copolymer developed using Peptimmune's novel platform peptide
chemistry. PI-2301 is designed to enhance the ...
Merck Serono and Apitope Announce Licensing Agreement on Novel Peptide Therapeutics for the Treatment of Multiple Sclerosis
... and Commercialization of ATX-MS-1467, Apitope's peptide
Therapeutic for the Treatment of Multiple ... commercialize Apitope's product ATX-MS-1467. This peptide
therapeutic has completed an initial clinical ... and allergic disorders. Apitope's therapeutic peptide
technology platform is based on established ...
New Experts Help New England Peptide Combat Global Acetonitrile Shortage; Company Integrating Cost-Effective Chemical Solvent Alternatives
... strategic usage of new solutions are two leading peptide
experts, Dr. Robert Hammer and Dr. Robert Hodges. ... recent months, NEP has added a globally-renowned peptide
researcher, Dr. Robert Hodges, to its Scientific Advisory Board (SAB) and named a peptide
chemistry expert, Dr. Robert Hammer, as its new ...
Vigorous Treadmill Workout Curbs Appetite Hormones
... hormones: ghrelin (which stimulates appetite) and peptide
YY (which suppresses appetite).
During the ... (aerobic exercise), ghrelin levels dropped and peptide
YY levels increased, indicating that the hormones ... decreased, but there was no significant change in peptide
YY levels. The appetite hormone effects of both ...
Sigma-Aldrich Enters Distribution Agreement With AlphaGenix, Inc.
... its components; and HydroMatrix(TM),
a synthetic peptide
scaffold that offers the precision and control of ... natural 3-D architecture of a highly
Over the past decade, researchers ... comprised of extracellular
matrix components and peptide
nanofibers that have cell culture and ...
Peptimmune Announces the Second Close of Series D Private Financing
... About PI-2301
PI-2301 is a second generation peptide
copolymer from a similar
compound class as ... been optimized using Peptimmune's novel platform peptide
in pre-clinical studies, has shown ... focused on the development of peptide
therapies to improve the
management of chronic ...
Novel hydrogel systems for dentin regeneration
... generation of delivery systems are synthetic peptide
hydrogels, which provide a nanostructured matrix ... the results of studies on hydrogels made of peptide
amphiphiles, where a short peptide
sequence is ... design concept, where the self-assembly of peptide
chains is achieved without attaching a ...
Breast Cancer Vaccines Look Promising
... human telomerase reverse transcriptase (hTERT) peptide
to vaccinate 19 women with breast cancer that had spread. The peptide
is nearly universally overexpressed in human ... vaccine using nanoparticles loaded with the HER2 peptide
that carry an immune system-stimulating peptide, ...
Brown chemists create cancer-detecting nanoparticles
... the nanoparticle's size and the thickness of the peptide
coating, which ensures the nanoparticle attaches ... their nanoparticles with a two-nanometer thick peptide
coating 10 times thinner than the coating ... of the team's work is discovering that the RGD peptide
coating binds almost seamlessly to the U87MG ...
JCI table of contents: May 22, 2008
... antibody that recognizes DNGR-1 was linked to a peptide
it delivered the peptide
specifically to DCs expressing CD8-alpha. CTL responses directed to the peptide
were induced in mice vaccinated with the ...
Heart Hormones Beat Back Cancers in Mice
... treatment with any of four human cardiac peptide
hormones, mice engineered to develop human ... of four cardiac hormones: long acting natriuretic peptide
(LANP), vessel dilator (VDL), kaliruretic peptide
(KP), or atrial ...
Peptide discovered in scorpion venom may hold key to secretory diseases
... Researchers have discovered a peptide
in scorpion venom that may hold the key to ... and Cystic Fibrosis Foundation.
toxins from scorpions, snakes, snails and spiders ... chromatography (HPLC) to extract the novel GaTx1 peptide
from the complex venom of the Giant Israeli ...
NuView Radiopharmaceuticals, Inc. Secures Exclusive Rights From Thomas Jefferson University for a Tumor-Specific Imaging Agent for the Diagnosis of Breast and Prostate Cancers
... human tumors over-express vasoactive intestinal peptide
and pituitary adenylate cyclase-activating peptide
(PACAP) receptors known
as VPAC1, VPAC2 and PAC1. ... evaluations are currently under
way for specific peptide
analogues for PET imaging of these cancers.
Protein Nasal Spray Revives Sleep-Deprived Monkeys
... all night, at least in monkeys.
Orexin-A is a peptide
(a kind of protein) made in the brain to regulate ... sleep, the brain attempts to make more of the peptide
to preserve alertness but often fails to fight ... same pattern of activity when they were given the peptide
as when they had not lost any sleep.
Xenome Enters Into Joint Research Collaboration to Discover Novel Peptide Therapeutics with Amylin Pharmaceuticals
... focus on
the discovery and development of novel peptide
therapeutics for a range of
metabolic and ... the peptides from
Xenome's proprietary bioactive peptide
library derived from natural
sources. Amylin will ... has successfully created several peptide
therapies for the
treatment of diabetes and ...
Nastech Pharmaceutical Company Announces Promotion of Rick Costantino, Ph.D., to Chief Scientific Officer of Delivery
... development of new
drug delivery technologies for peptide
and protein therapeutics. Paul
Johnson, Ph.D., ... of non-invasive delivery options for peptide
therapeutics," stated Steven C. Quay, ... of new drugs and delivery systems for peptide
drugs." Dr. Quay added, "I would ...
M.D. Anderson-led team reports possible key to autoimmune disease
... HOUSTON A human peptide
that acts as a natural antibiotic against ... publication in Nature.
This combination of the peptide
and self-DNA activates the same immune response ... tissue that activates the dendritic cells. The peptide
is a member of a family of antimicrobial peptides ...
Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
... in several solid tumors including pancreatic cancer. YSA, a small peptide
ligand that binds the EphA2R with high affinity, was inserted into the HI ... reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide
in the HI loop restored adenoviral transduction of EphA2R-expressing cells ...
Synthetech Announces Fiscal 2009 Results
... also impact our contract drug synthesis market where our traditional peptide
building block products are sold. Despite potential adverse effects on ... We develop and manufacture amino acid derivatives, specialty amino acids, peptide
fragments and proprietary custom chiral intermediates and specialty ...
Estrogen linked to lowered immunity in fish
... researchers also suspect that hepcidin may act as an antimicrobial peptide
in mammals, fish and frogs. Antimicrobial peptides are the first line of ... in two ways. "First," said Robertson, "hepcidin could be an antimicrobial peptide
that actually kills pathogens. Or it could be more complex. To live, a ...
... iron oxide particles with a fluorescence dye, RNA fragments, and a special peptide
attached. The peptide
is present to specifically identify the cancer cells; the RNA fragments ...
Rheumatoid Arthritis Therapeutics in Thailand
... history, blood tests, rheumatoid factor (RF), anti-cyclic citrullinated peptide
(Anti-CCP), and X-ray.
(Logo: ... factor (RF). The other supporting tests are: anticyclic citrullinated peptide
(Anti-CCP), erythrocyte sedimentation rate (ESR), and X-ray."
Gold Nanospheres Show Promise in 'Boiling' Out Cancer
... directly to the melanoma cells by a special protein fragment called a peptide
placed inside the nanosphere. Using a technique known as photoablation ... eight times more effective in killing the cancer than those without the peptide
guidance system, according to researchers who were to present the findings ...
Alzheimer's Drug May Someday Help Head Trauma Victims
... showed that brain injury in mice resulted in substantially more amyloid peptide
than normal. They then found that amyloid peptide
production after brain injury was reduced in mice that received an ...
Takeda Receives New Information on Alogliptin (SYR-322) NDA
... (DPP-4), which metabolizes the insulin-increasing hormones glucagon-like peptide
1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP). By maintaining the blood levels of GLP-1 and GIP, DPP-4 inhibitors ...
GSK Initiates Phase III Programme for Novel Type 2 Diabetes Medication, Syncria(R) (albiglutide)
... safety and tolerability of the investigational GLP-1 (Glucagon-like peptide
1) agonist Syncria(R) (albiglutide) in men and women with type 2 diabetes. ... is an investigational biological, injectable form of human GLP-1 -- a peptide
that acts throughout the body to help maintain normal blood-sugar levels ...
Nile Therapeutics to Present at the 27th Annual J.P. Morgan Healthcare Conference
... development programs for its lead compound, CD-NP, a novel chimeric peptide
for the treatment of acute heart failure.
About Nile Therapeutics
... developing its lead compound, CD-NP, a novel rationally designed chimeric peptide
in clinical studies for the treatment of heart failure; 2NTX-99, a small ...
CEL-SCI Launches Study to Determine Long Lasting Beneficial Effects of its Rheumatoid Arthritis Vaccine
... epitope linked to a T-cell binding ligand (TCBL) can be manufactured by peptide
synthesis or by covalently linking the two peptides. Depending upon the ... it would appear that the L.E.A.P.S. construct represents a chimeric peptide
with bi-functional behavior.
CEL-SCI Corporation is developing ...
Nile Therapeutics, Inc. Reports 2008 Third Quarter Financial Results
... Development Update
CD-NP is a novel chimeric natriuretic peptide
in clinical development
for the treatment of ADHF. CD-NP was designed to ... developing its lead compound, CD-NP, a novel rationally
designed chimeric peptide
in clinical studies for the treatment of heart
failure; 2NTX-99, a small ...