UCI researchers find new way to fight cocaine addiction
... of the neurotransmitter have been detected in the nucleus
accumbens of drug addicts.
The study is the ... cocaine addiction and show that it occurs in the nucleus
accumbens, a portion of the forebrain believed to ...
Chung and Civelli believe MCH works in the nucleus
accumbens to increase the pleasure of eating. ...
Anti-Cholesterol Drug May Ease Back Pain
... discs. The researchers removed cells from the nucleus
pulposus (the jelly-like substance in the middle ... bone formation.
After 72 hours, the number of nucleus
pulposus cells had increased, the production of ... had decreased. Lovastatin caused no harm to the nucleus
pulposus cells, the researchers reported.
Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
... of a previously unknown mechanism in the nucleus
that processes non-coding RNA molecules.
... RNA segment was observed to migrate out of the nucleus
into the cell's aqueous cytoplasm. The longer ... split off from-- MALAT1--is "available" in the nucleus
for other cellular duties.
Pioneer(R) Surgical Technology's NuBac(R) Nucleus Replacement Device Wins FDA Approval for IDE Pivotal Study
... First Company to Reach Pivotal Study for Spine nucleus
MARQUETTE, Mich., Oct. 30 ... Many other companies, pursuing nucleus
have spent more time and ... The NuBac implant system is the only nucleus
Replacement device that
utilizes an articulating ...
Scientists shed light on long-distance signaling in developing neurons
... axon's tip sends key signals back to the cell nucleus
to ensure the neuron's survival," explains senior ... of communication between the growth cone and the nucleus
that we now describe."
As Dr. Jaffrey ... -- which may be many centimeters away from the nucleus
-- it senses a signal called nerve growth factor ...
RNA-associated introns guide nerve-cell channel production
... after being made in RNA are simply excised in the nucleus
before the messenger RNA is transported to the ... a process once believed to only take place in the nucleus
Now, in the current study, the ... that an intron-containing RNA outside of the nucleus
serves a critical cellular function.
Cochlear Americas Announces 2008 Graeme Clark Scholarship Winners
... with hearing loss at 8 months and received a nucleus
cochlear implant in her right ear at age 7 ... from hearing loss since age 3 and received a nucleus
cochlear implant at age 14. -- Michael Noble ... Noble was born deaf and received a nucleus
cochlear implant at age 2. -- Jentry Taylor ...
Overactive nerves in head and neck may account for 'ringing in the ears'
... in a part of the brain called the dorsal cochlear nucleus
that processes auditory and other signals.
In normal hearing, the dorsal cochlear nucleus
is the first stop in the brain for sound signals ... that normally convey signals to the cochlear nucleus
have an enhanced effect, says Shore, who is also ...
Initial Evaluation of New Nucleus Removal Device Provides Promising Results
... first product in development is a complete nucleus
device that seeks to remove the nucleus
pulposus from the lumbar disc
space, while not ... the clinical needs for safe
and complete nucleus
resection," said John Sherman, M.D., Medical ...
A new molecular zip code, and a new drug target for Huntington's disease
... huntingtin is expressed however, it enters the nucleus
as it should in response to stress, but it cannot exit properly, piling up in the nucleus
and leading to brain cell death in HD.
What is ... found that huntingtin can be sent to the nucleus
by protein modifying enzymes called kinases, and ...
WA discovery a key to blood cell development
... within blood cells, called Liar, that leads other molecules into the nucleus
of the cell, and could offer a key in treating prostate, breast and colon ... cell growth.
"LIAR is like a key, which opens a pathway into the nucleus
of a blood cell for a number of other molecules, allowing them to flow in ...
Pioneer(R) Surgical Technology, Inc. Closes $15 Million Series B Financing
... company to receive FDA approval to start the
IDE pivotal study for lumbar nucleus
replacement. The NuBac is a
minimally-invasive device and is the first in ... to the IMGCF portfolio."
The NuBac implant system is the only nucleus
Replacement device that
utilizes an articulating inner ball and socket ...
Heart regenerates after infarction -- first trials with mice
... suppress the activity of a gene regulator known as beta-catenin in the nucleus
of the heart cells. ( PNAS , online December 10, 2008, doi: ... the regeneration of the adult heart. They suppressed this factor in the nucleus
of the heart cells in mice.
This way they activated heart precursor ...
Protein compels ovarian cancer cells to cannibalize themselves
... extracellular signaling related kinase, or ERK. Activated ERK in the cell nucleus
fuels cancer growth. The research team earlier found that PEA-15 binds to ERK in the nucleus
and moves it out into the cytoplasm, preventing its growth effects.
Study shows that chronic grief activates pleasure areas of the brain
... of a female stranger.
The authors looked for activity in the nucleus
accumbens, a region of the brain most commonly associated with reward and ... loved one, only individuals with complicated grief showed significant nucleus
Complicated grief can be debilitating, ...
Lack of CHFR gene expression sets stage for breast cancer
... the new study, the researchers report what happens inside a dividing cell nucleus
when CHFR is missing.
One prime moment in which cancer can begin is ... one cell divides into two. In normal cell division, chromosomes inside the nucleus
copy themselves, then line up in the middle of a structure, the mitotic ...
Need microRNA processing? Get Smad
... Sackler School of Graduate Biomedical Sciences. "Smad proteins move to the nucleus
of the cell and interact with a specific complex, called the Drosha ... cell is to carry the instructions for making proteins from the DNA in the nucleus
to another part of the cell where the instructions are carried out and the ...
'Intrabody' can mop up mutant protein in Huntington's disease model
... that could distinguish between the accumulation of mutant proteins in the nucleus
and the cytoplasm," he says. "The intrabody binds huntingtin proteins with ...
The clumps of mutant huntingtin are also seen in the neuronal nucleus
and cytoplasm in a recently established transgenic monkey model of ...
Therapeutic Cloning Works in Mice With Parkinson's
... and reproductive cloning.
Both processes begin with the removal of the nucleus
from a single cell taken from any part of the body of a living adult organism. In the laboratory, this isolated nucleus
is then inserted into an egg cell that has been stripped of its own ...
Therapeutic cloning treats Parkinson's disease in mice
... diseases and in other organ systems.
In therapeutic cloning or SCNT, the nucleus
of a somatic cell from a donor subject is inserted into an egg from which the nucleus
has been removed. This cell then develops into a blastocyst from which ...
Same process discovered to both form skeleton and protect it for life
... domain (NICD), breaks away inside of the cell, travels to the cells nucleus
and influences gene expression there. Gene expression is the process ... proteins tail (NICD) inside the cell, freeing it to travel to the cell nucleus
and influence gene expression, unless DAPT interferes.
Research findings may lead to new ways to study and fight diabetes
... to link the two areas of study by identifying a single molecule in the nucleus
of cells that regulates the metabolism of both glucose and fatty acids. ... long known that fatty acids bind with a protein called PPAR-alpha in the nucleus
of cells. PPAR-alpha is a nuclear receptor, which means it is responsible ...
How red blood cells nuke their nuclei
... birds, have red cells that contain nuclei that are inactive. Losing the nucleus
enables the red blood cell to contain more oxygen-carrying hemoglobin, ... of the cell that contains the nucleus, a type of cell division. The nucleus
is then swallowed by macrophages (one of the immune systems quick-response ...
Scientists discover how gold eases pain of arthritis
... molecule, which means that it behaves one way when its inside the nucleus
of a cell, and quite another way when its released from the cell.
... inflammatory response.
Basically, keeping HMGB1 corralled inside the nucleus
is a good thing, when it comes to arthritis, says Pisetsky.
Area deep within the brain found to play role in sensory perception
... The ventrolateral nucleus
(VL) of the thalamus is connected to the cerebellum and motor cortex and ... occur in this region tend to be larger and therefore affect more than one nucleus
of the thalamus. Thalamic nuclei are dense clumps of nerve cells found ...
Pathway links inflammation, angiogenesis and breast cancer
... nuclear factor kappa B (NF"B) from the cytosol, allowing it to move to the nucleus
and activate genes that promote cancer growth.
IKKa throws switch ... growth and blocks programmed cell death. IKKa then works separately in the nucleus
and IKK in the cytosol to induce cancer through separate pathways. ...
Food additive may one day help control blood lipids and reduce disease risk
... was the distance of the two proteins from each other, according to Semenkovich. PPAR-alpha is a nuclear receptor. That is, it's housed in the nucleus
of the cell. Fatty acid synthase, on the other hand, lives out in the cell body, or cytoplasm.
"The neighborhoods where PPAR-alpha and fatty acid ...
Scientists discover key event in prostate cancer progression
... of prostate cancer.
The study, published in the July 24, 2009, issue of the journal Cell , focuses on androgen receptors, molecules located in the nucleus
of cells of the prostate gland and other tissues. Male sex hormones androgens bind with these receptors to activate genes that control cell growth. ...
Pioneer Surgical Technology, Inc. Names Thomas J. McLeer as Chief Marketing Officer and General Manager of Spinal Operations
... they offer diverse spinal fusion systems. Pioneer's signature articulating P3(TM) technology - Pioneer PEEK- on-PEEK , is vital to their nucleus
replacement system, NuBac(TM), which is currently in U.S. clinical trials. Pioneer's focus on innovation has resulted in over 100 U.S. and foreign ...
Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award
... was appointed a Howard Hughes Medical Institute Early Career Scientist.
Malik studies genetic conflict. He sees battles raging within a cell's nucleus
as genes jockey for evolutionary dominance. These clashes can have a long-term impact on organisms, as they sometimes alter the function of essential ...
Cell Protein Could Help Spur Malignancy
... into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments.
STAT3, which has a role in the cell nucleus
regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said the study's ...
Joan Massagué wins BBVA Foundation Frontiers of Knowledge Award in Biomedicine
... such as malformations and cancer. Massagu and his group identified the molecular pathway conveying the TGF- signal from the cell membrane to the nucleus
rather like decoding the language it uses to communicate with other molecules and in this way have helped to elucidate one of the fundamental ...
Wistar Institute team finds key target of aging regulator
... to a specific site (lysine at position 16 or K16) on histone H4histones are proteins that package and organize the long strands of DNA within the nucleus
and also are central regulators in turning genes on and off. The study reveals that removal of this acetyl group by Sir2 near the chromosome endsthe ...
Study further expands understanding of leptin's role in brain neurocircuitry
... its effects on the central nervous system. Over the years, investigators have pinpointed a region of the brain's hypothalamus known as the arcuate nucleus
(ARC) as one key area where leptin exerts its influence, and within the ARC, they have identified two types of leptin-responsive neurons, the ...
NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
... study published online in Nature Immunology ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus
at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. Researchers led by Jane A. Skok Ph.D., assistant ...
Regulating the sugar factory in diabetes
... in ARNT. If liver cells are treated with insulin, there will be a small increase in ARNT protein. The insulin will also help move the ARNT into the nucleus
of the cell, where it does its job as a master regulator.
The paper concludes that a decline in ARNT isn't limited to the beta cells of people ...
CoreSpine Technologies(TM) Receives Clearance to Market Surgical Disc Preparation Device
... device developer, announced today it has received 510(k) clearance to market from the U.S. Food and Drug Administration (FDA) for its XTEND-ST(TM) nucleus
"The clearance of the XTEND-ST device is truly a significant achievement for CoreSpine," said Christine Horton, Chief ...
Five UCSF Scientists Elected to National Academy of Sciences
... the relationship between chromosome structure and function.
A chromosome is a thread-like package of genes and other DNA located in the nucleus
of a cell. In spite of considerable effort over the past few decades, only recently has it been possible to determine the nature of even the simplest ...
Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder
... transporter genes and abnormal brain volumes in brain regions implicated in OCD such as the thalamus ('grand central station' in the brain), caudate nucleus
(brain's secretary), anterior cingulate cortex (brain's arousal center) and orbital prefrontal cortex (brain's executive decision maker).
UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells
... Blelloch, with hundreds of microRNAs discovered in the last eight years across a broad range of species, from plants to animals.
Produced in the nucleus
and released into the cytoplasm, microRNAs home in on messenger RNAs that share part of their genetic sequence. When they find them, they latch on, ...