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Nucleotide in Medical News

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

... a multiple ascending dose trial with PSI-7851, a nucleotide analog polymerase inhibitor for the treatment of ... About PSI-7851 PSI-7851 is a uridine nucleotide analog currently in development for the treatment ... PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical ...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

... of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary nucleotide analog polymerase inhibitor of HCV that is being advanced into studies ... stage candidates are PSI-7851, an unpartnered, next generation HCV nucleotide analog which recently began Phase 1 clinical studies and Racivir, for the ...

Ovarian Cancer Breakthrough Heralds New Era of Treatment

... cell tumors. The culprit is a single mutation out of 3 billion nucleotide pairs that make up the genetic code of the tumor. The mutation is present ... range of genetic abnormalities, researchers found a mutation in a single nucleotide in the FOXL2 gene in every sample. The research team further validated ...

Mayo Clinic-led researchers confirm gene variants associated with the most common adult leukemia

... chromosomes. The first analysis of this data focused on the seven single nucleotide polymorphisms (SNPs) that European researchers had found. An SNP is a variation that occurs within a single nucleotide - the structural units of DNA - within a gene, and in most studies like ...

UNC study supports role of circadian clock in response to chemotherapy

... the prevention of new cancers. The enzyme system implicated called nucleotide excision repair repairs many types of DNA damage that come not just from ... or UV radiation. This damage is usually repaired by a process called nucleotide excision repair, which cuts out and replaces sections of damaged DNA. ...

DNA editing tool flips its target

... cells, methylation usually appears on double stranded DNA where the nucleotide Cytosine (C) is followed by Guanine (G). The complementary sequence on the ... recognizes the hemi-methylated DNA, Cheng says. It flips the methylated nucleotide out of the DNA helix, which only had been seen previously in enzymes that ...

NEJM editorial on significance and limitations of new lupus gene expression research

... research looks at how variations in a single DNA base pair, called single nucleotide polymorphisms (SNP), can be used to identify genetic variations among ... individuals. For example, in one specific gene the frequency of an A nucleotide in people with lupus might be significantly greater than in healthy ...

Isis Adds New Drug to Its Development Pipeline: ISIS 388626 Targeting SGLT2 for the Treatment of Type 2 Diabetes

... drug for a kidney target, ISIS 388626 is also unique due to its 12 nucleotide length rather than the more typical 18 - 21 nucleotide sequences that comprise Isis' other drugs. This attribute simplifies ...

GenVault's GenSolve(TM) Reagents Enable State-of-the-Art Genomic Analysis of Dried Blood Spots

... us to reproducibly recover sufficient quantities of DNA, of the correct size and quality, from dry archived FTA cards for analysis of 54,000 single nucleotide polymorphisms on Illumina's BovineSNP50 BeadChip," said Dr. Matthew McClure from the Division of Animal Science at the University of ...

Gene linked to increasingly common type of blood cancer

... three decades. In the first genome-wide association study of non-Hodgkin lymphoma, scientists at UC Berkeley and TGen identified a SNP a single nucleotide polymorphism that could determine susceptibility to follicular lymphoma. The SNP, a DNA variant within the more than 3-billion base pairs in the ...

New Map of Genomic Variation Will Enable Disease Research

... genome in the July 10 online edition of the journal Genome Research . In contrast to alterations to a single base of DNA, which are single nucleotide polymorphisms, or SNPs, often referred to as "snips," CNVs are larger variations in DNA structure. As changes to a single DNA letter, SNPs might be ...

Variants of 'umami' taste receptor contribute to our individualized flavor worlds

... receptor T1R1-T1R3. Comparing DNA structure to the glutamate taste responses of each individual, they found that variations (known as SNPs; single nucleotide polymorphisms) at three sites on the T1R3 gene were associated with increased sensitivity to glutamate taste. A fourth set of studies used in ...

Orochem Technologies Acquires Oligonet, a Custom Oligo Synthesis Business

... single to high throughput formats exemplified by DNA and RNA purification kits, protein purification plates and products for bioanalysis, and oligo nucleotide synthesis and purification. The company's core expertise is in the development of customized individual and high throughput Sample Preparation tools ...

TGen and USC researchers find genetic markers to help fight diabetes

... to TZD response. To identify other variants that predict response to TZDs, TGen researchers performed a genome-wide analysis of 115,352 single nucleotide polymorphisms, or SNPs (a DNA sequence variation within the more than 3 billion base pairs in the human genome). In addition, the scientists also ...

Genomas Presents Drug-Specific Genetic Determinants of Statin Safety and Efficacy at the XV International Symposium on Atherosclerosis

... in lipid clinics at Hartford Hospital (Hartford, CT) and the University of California, San Francisco . Researchers genotyped 384 SNPs (single nucleotide polymorphisms) from 222 cardiometabolic and neuroendocrine genes with a potential role in determining the safety and efficacy of statins. The study ...

Researchers at Case Western Reserve discover a new way the body fights fungal infection

... drug development. Another area of interest is the investigation of how small differences between individuals in immune related genes, called single nucleotide polymorphisms or SNPs, affect susceptibility to fungal and other infections. "If we can identify patterns of SNPs that make people more likely to ...

Is there any association between COX2 and colon cancer?

... fully understand the relationship between genetic variation and the protective effect of NSAIDs on colon cancer risk. They found that no single nucleotide polymorphisms (SNPs) in either gene were individually statistically significantly associated with colon cancer, nor did they statistically ...

Genetic marker may predict early onset of prostate cancer

... tumors carry a fusion gene called, TMPRSS2-ERG, which may have a role in prostate cancer formation. Recently, scientists reported that a single nucleotide polymorphism, called the Met160Val SNP (also referred to as rs12329760), is associated with the gene fusion. Specifically, prostate cancer patients ...

Pharmasset to Present at Deutsche Bank Healthcare Conference

... clinical trial in combination with Pegasys plus Copegus through a strategic collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV that has completed a Phase 2 clinical trial. ...

Gene Studies Reveal Cancer's Secrets

... times higher than that of the general population," she noted. An earlier analysis identified seven DNA sequencing aberrations called "single nucleotide polymorphisms" (SNPs) that might lead to chronic lymphocytic leukemia. In the current study, researchers confirmed these findings in a separate ...

Genetic analysis may predict risk of invasive bladder cancer

... Hushan Yang, Ph.D., a postdoctoral fellow at M. D. Anderson and the first author of this study, and colleagues evaluated a panel of 59 single nucleotide polymorphisms in 35 major inflammation genes in all participants that had been treated with BCG therapy, the current treatment standard for ...

Genetic variants predict recurrence of bladder cancer, patient survival

... author Hushan Yang, Ph.D., a postdoctoral fellow in the Department of Epidemiology at M. D. Anderson. Yang and his colleagues evaluated 59 single nucleotide polymorphisms (SNPs) in 35 major inflammation genes. Using a combined analysis, they stratified patients into multiple risk groups. Those patients ...

New biomarker may predict leukemia aggressiveness

... may have, their availability and usefulness are limited. In previous work, Insel's group had discovered that among a group of enzymes, cyclic nucleotide phosphodiesterases, one of the phosphodiesterases, PDE7B, was 10 times higher in CLL patients than in healthy individuals. PDE7B controls the levels ...

Scientists Identify More Breast Cancer Genes

... risk. The newly identified genetic variations are located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide polymorphism (SNP). SNPs, the most common type of genetic variation, affect just a single building block of DNA. The function of the rs11249433 ...

Pharmasset to Present at Two Upcoming Investor Conferences

... clinical trial in combination with Pegasys(R) plus Copegus(R) through a strategic collaboration with Roche. An IND for PSI-7851, a second generation nucleotide HCV inhibitor was filed in January 2009. Racivir, which is being developed for the treatment of HIV in combination with other approved HIV drugs, has ...

Omega-3 Fatty Acids Guard Against Advanced Prostate Cancer

... men with aggressive prostate cancer and 478 healthy men. The researchers collected data on the men's diet and genetically assessed nine cox-2 single nucleotide polymorphisms. "We detected strong protective associations between increasing intake of long-chain omega-3 polyunsaturated fatty acids and more ...

Omega-3 fatty acids reduce risk of advanced prostate cancer

... with aggressive prostate cancer and 478 healthy men. Diet was assessed by a food frequency questionnaire and researchers genotyped nine COX-2 single nucleotide polymorphisms. Researchers divided omega-3 fatty acid intake into four groups based on quartiles of intake. Men who consumed the highest amount ...

Genes May Decide Which Smokers Get Lung Disease

... chromosome 20, with asthma. The researchers from the Wake Forest University School of Medicine and Saint Louis University identified five single nucleotide polymorphisms (SNPs) -- human DNA sequence variations -- in ADAM33 that were more common in smokers with COPD than in those without the disease. ...

Pharmasset to Present at Two Upcoming Investor Conferences

... clinical trial in combination with Pegasys(R) plus Copegus(R) through a strategic collaboration with Roche. An IND for PSI-7851, a second generation nucleotide HCV inhibitor was filed in January 2009. Racivir, which is being developed for the treatment of HIV in combination with other approved HIV drugs, has ...

Study Pinpoints New Gene for Cystic Fibrosis

... identified, all related to immune cell function. To identify additional candidates, Karp and his team scanned 100,000 genetic markers, called single nucleotide polymorphisms, across the genomes of two large cohorts of people with CF, looking for markers that segregated with airway disease severity. Of the ...

New genomic markers associated with risk of heart disease and early heart attack

... of the population at 2.25-fold increased risk for MI". This study set out to find "single letter" differences in gene sequences (known as single nucleotide polymorphisms, SNPs) in 26,000 individuals in ten countries in order to explain why the pattern of early onset heart attack is often clustered in ...

Genome Study Points to New Culprit for Schizophrenia

... change of direction in genetics research on schizophrenia. Over the past two decades, researchers have identified dozens of genes and single nucleotide polymorphisms (SNPs or "snips") that could be linked to schizophrenia. But this new study dismisses all of them. "The literature is replete with ...

UVA researchers uncover gene's role in severity of drinking

... 2009 issue of Alcoholism: Clinical & Experimental Research, analyzed the associations between six different DNA sequence variations, or single nucleotide polymorphisms, of the serotonin transporter gene with the levels of drinking intensity among 275 alcohol-dependent individuals seeking treatment. ...

Johns Hopkins researchers discover new schizophrenia gene

... region of chromosome 10 that previously had been implicated to contain genes that contribute to the condition. They analyzed more than 1,400 single nucleotide polymorphisms, or SNPs for short, to see if any particular SNPs were more frequently carried by schizophrenia patients than unaffected people. ...

Effectiveness of Progesterone in Reducing Preterm Births May Be Altered by Genetic Predisposition

... Human Development Maternal-Fetal Medicine Unit Network and the University of Utah , assessed whether women with genetic variations known as single nucleotide polymorphisms (SNPs) in the human progesterone receptor gene were more or less likely to respond to 17P for the prevention of recurrent spontaneous ...

In Kids, Genes May Affect Leukemia Treatment

... time, we used a genome-wide strategy to interrogate over 500,000 variations in inherited DNA to find common gene variations called SNPs, or single nucleotide polymorphisms, that predicted response to chemotherapy," said lead researcher Mary V. Relling, who chairs the pharmaceutical department at St. Jude ...

Scientists unmask genetic markers associated with psoriasis

... for the first time by this study, and two more have since been confirmed by these researchers. Research details The team looked for single nucleotide polymorphisms (SNPs), or DNA changes, at 438,670 sites in 1,359 psoriasis cases and 1,400 healthy controls. Initial scans signaled differences in at ...

Genetic interactions are the key to understanding complex traits

... 99 percent efficiency; the vineyard strains are far less efficient, at seven percent. The scientists discovered that just four variants, or single nucleotide polymorphisms (SNPs), in three yeast genes account for nearly 90 percent of the genetic contribution to sporulation efficiency. By moving each of the ...

Gene associated with reduced mortality from acute lung injury

... selected people, they discovered 28 different places within the gene and its promoter that showed variations. Many of the variations, known as single nucleotide polymorphisms (SNPs) occurred together. The researchers then looked at the various forms of the EC-SOD gene in two groups of patients with ...

Wyeth Pharmaceuticals and Santaris Pharma Announce Strategic Alliance to Develop RNA-based Medicines

... uptake. The LNA-based therapeutics also demonstrate improved binding affinity to their target RNA, which increases potency many-fold over other nucleotide therapeutics. About Santaris Pharma Santaris Pharma is a privately held biopharmaceutical company with exclusive pharmaceutical rights ...
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