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Nematode in Medical News

New devices to boost nematode research on neurons and drugs

... flows through it. We can change the solution the nematode is exposed to in ways that are relevant to the ... amplitudes and wavelengths to manipulate how a nematode moves. Instead of using posts to mimic real soil, ... said. At least 50 percent of the proteins in the nematode brain are identical to those in human brains. "C. ...

The onchocerciasis parasite showing signs of resistance

... caused by Onchocerca volvulus, a parasite nematode worm transmitted to humans by a species of black ... as a marker of resistance to ivermectin in other nematode species parasitic on cattle. As a control, they ... These results could be the sign of adaptation of nematode worm populations to repeated treatments using ...

Researchers gain ground in efforts to fight parasite infection

... author of the new study in PNAS, had made the discovery in C elegans, a nematode about the size of a pinhead. In the new study, the UT Southwestern ... source the host is available," Dr. Mangelsdorf said. Many infectious nematode larva live in the soil, often in areas where proper sanitation is lacking. ...

Researchers ID Suite of Genes in Aging Process

... these biomarkers to test anti-aging drugs. The study, which included nematode worms, microarrays that measure changes in gene expression, and complex ... while other 70-year-olds seem prematurely aged. The same is true of the nematode worms used in the study. The Buck Institute team conducted individual ...

Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction

... targets for both designing and testing drugs which could mimic the effects of dietary restriction in humans," said Kapahi. The research involved nematode worms that were genetically altered to both under and over-express HIF-1. The animals, which are the most-often used model to study aging, were fed ...

Worms Reveal More of Longevity's Secrets

... Kaeberlein, an assistant professor of pathology at the University of Washington, Seattle, said in a university news release. His team found that nematode worms live longer if they're also able to switch on the hypoxic response when oxygen levels are normal. In addition, the worms' cells contain fewer ...

New research on mutation in yeast can enhance understanding of human diseases

... a fundamental question: "What is the baseline rate and spectrum of mutation in yeast?" They found that, like the previously studied mutations in the nematode Caenorhabditis elegans, the yeast Saccharomyces cerevisiae had a very high rate of mutation from generation to generation. Its patterns of ...

Nuvelo Announces Presentations on NU206 and rNAPc2 at 2008 American Association for Cancer Research Annual Meeting

... and therapeutic potential of NU206 (R-spondin1) for chemotherapy or radiation-induced oral mucositis, and preclinical data evaluating recombinant nematode anticoagulant protein c2 (rNAPc2) in mouse models of colorectal cancer, will be presented at the 2008 American Association for Cancer Research (AACR) ...

Could Hydrogen Sulfide Hold the Key to A Long Life?

... to put mice into a state of reversible metabolic hibernation -- has now been shown to significantly increase life span and heat tolerance in the nematode worm, or C. elegans. These findings by Mark Roth, Ph.D., a member of the Center's Basic Sciences Division, and Dana Miller, Ph.D., a postdoctoral ...

A longer-living, healthier mouse that could hold clues to human aging

... on Ageing, led by Professor Linda Partridge. The teams at the Centre analyse the cellular and biochemical mechanisms of ageing in fruit flies, nematode worms and mice, and in particular the role of insulin signalling. Their work was recognised in June 2007 by a Strategic Award from the Wellcome Trust ...

Gene Behind Lincoln’s Diseas

... found that when the gene was disabled in tiny nematode worms, their nerve cells literally broke. ... of anemia. The Utah biologists showed in nematode worms, frequently used as genetic stand-ins for ... them strength. When 1-millimeter-long nematode worms were bred with the mutant gene, they lacked ...

Nobel Prize for Medicine

... was required. The ideal solution proved to be nematode Caenorhabditis elegans . This worm, ... that the cell lineage is invariant, i.e. every nematode underwent exactly the same program of cell ... cell death. By establishing and using the nematode Caenorhabditis elegans as an experimental model ...

Bacterial Protein Shows Promise in Treating Intestinal Parasites

... of more effective treatments for hookworm and other soil-transmitted nematode infections, which are a major global health problem in developing ... this global health problem. “Our ability to control parasitic nematode infections with chemotherapy on a global scale is dependent on the ...

Researchers Discover Breakthrough in Major Third World Scourge

... the world, and which may lead to more effective therapies against nematode parasites. The breakthrough research in host protection against nematode parasites was published in the August 2006 issue of the prestigious ...

Study Shows Tomosyn Plays an Important Role in Learning and Memory

... strength is really important.’ Richmond and her colleagues used the soil nematode worm Caenorhabditis elegans to study the function of tomosyn using a ... regulating the efficiency and strength of the synapse.’ Because the nematode C. elegans uses proteins in its nervous system comparable to those in ...

Gene Responsible for Ageing Process Discovered and Calorie Restriction Could Help

... know whether calorie restriction really works in humans. Studies in primates suggest it does." The latest study focussed on a gene common to nematode worms, mice and humans. When the gene was blocked in the worms, the benefits of a calorie-restricted diet were lost and the worms lived shorter ....

Gene Responsible for Ageing Process Discovered – and Calorie Restriction Could Hel

... know whether calorie restriction really works in humans. Studies in primates suggest it does." The latest study focussed on a gene common to nematode worms, mice and humans. When the gene was blocked in the worms, the benefits of a calorie-restricted diet were lost and the worms lived shorter ....

Specially Developed Proteins Could Help Resist Ageing

... – oxidation is considered a major cause of ageing. In small-scale studies, Mikhail Shchepinov, a former Oxford University scientist, has found nematode worms – used extensively in ageing research - live 10% longer when they are fed nutrients enriched with a heavy isotope of hydrogen, deuterium. ...

Nobel Prize for Gene ‘Silencing

... until Mello and Fire unraveled the mystery of RNA interference, now widely known as RNAi. Fire and Mello carried out their study on a nematode worm called, Caenorhabditis elegans . Injecting these worms with ‘sense’ mRNA or RNA strand that had complementary base pairs to the transcribing ...

Innovative yeast genome may handle Cancer Clues

... of organisms, including humans, whose cells contain a nucleus to be decoded. Humans have an estimated 30,000-40,000 genes while brewer's yeast, the nematode worm, fruit fly and mustard weed, which have all been mapped, have between 6,000 and 26,000 genes. Professor Gordon McVie, a co-director with ...

Cancer gene mystery to be cracked!

... a process called RNA interference to switch off certain genes and leave others unaffected. This process was first identified as taking place in the nematode worm. It was discovered that the worm used tiny pieces of double-stranded RNA to switch off rogue genes that would otherwise harm it. Subsequently, ...
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