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Necrosis in Medical News

Is RTA a new potential option for the treatment of hydatid cysts?

... damage hydatid cysts, causing cyst wall necrosis through a heat-related mechanism, and, secondly, whether the heat-related coagulative necrosis of the cyst wall allows the parasitic endocyst to ... and was followed by pathology examination. necrosis of the endocyst with a 100% success rate was seen ...

Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center

... replacement revision Treatment of avascular necrosis A painful disease, avascular necrosis can deteriorate a person's bones and destroy ... and ways fix the problem. "Avascular necrosis is a condition where the bone loses circulation ...

New Hope for Relief of Chronic Sciatica

... a unique therapeutic that neutralizes TNF (tumor necrosis factor), holds promise as a treatment for ... a unique therapeutic that neutralizes TNF (tumor necrosis factor), holds promise as a treatment for ... Shubayev, and R.R. Myers, Distribution and tumor necrosis factor-alpha isoform binding specificity of ...

Biologics Don't Raise Cancer Risk in Rheumatoid Arthritis Patients

... no connection between drugs that block tumor necrosis factor and malignancies TUESDAY, ... But it's been unclear whether blocking TNF (tumor necrosis factor) increases the risk of cancer, according ... "Despite foreseen fears, blocking the tumor necrosis factor does not make patients more prone to ...

Popular osteoporosis drugs triple risk of bone necrosis

... The research is the largest study of bone necrosis and bisphosphonates, a class of drugs used by ... the first study to explore the link between bone necrosis and specific brands of bisphosphonates, such as ... the research after academic papers began linking necrosis of the jaw with the use of bisphosphonates. ...

Clues to Cell Death Could Fight Disease

... life-threatening conditions, scientists say. necrosis is not the same as apoptosis -- natural, healthy programmed cell death. necrosis is an unplanned cell death caused by outside ... It was long believed that the process of necrosis was chaotic and irreversible, note researchers at ...

Pathway to cell death redefined in landmark study

... protein, SRP-6, that can potentially halt necrosis in its path. Further, the research team realized ... senior author. But our research indicates that necrosis can be interrupted and possibly repaired, even ... protector SRP-6 is missing. A cascade of cell necrosis begins in SRP-6-deficient animals exposed to a ...

Pathway to cell death redefined in landmark study

... protein, SRP-6, that can potentially halt necrosis in its path. Further, the research team realized ... senior author. But our research indicates that necrosis can be interrupted and possibly repaired, even ... protector SRP-6 is missing. A cascade of cell necrosis begins in SRP-6-deficient animals exposed to a ...

Dangerous Liaisons

... as hybrid necrosis. "We suspected that hybrid necrosis is always caused by the same biochemical ... more detail, they found that the gene that causes necrosis in hybrids, but not in the parents, is normally ... in contrast to many hereditary diseases, the necrosis is not due to each parent carrying a defective ...

Swelling After Knee Injury May Hinder Healing

... immune system proteins -- interleuken-1 and tumor necrosis factor -- produced by the body during swelling ... could be used to block interleuken-1 and tumor necrosis factor and help heal knee injuries and ... is a drug that blocks the effects of tumor necrosis factor that is used widely and effectively in ...

Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers

... (FDA) announcement regarding the results of a safety review of Tumor necrosis Factor (TNF) blockers [marketed as Remicade(R) (infliximab), Enbrel(R) ... ABOUT ENBREL ENBREL is a soluble form of a fully human tumor necrosis factor (TNF) receptor. ENBREL was first approved in 1998 for adult ...

Statins can protect against Alzheimer's disease, according to new study

... had showed that these statins stimulate the protective capacity of tumor necrosis factor, which is a key player in the brain's immune response. Dolga has demonstrated in animal experiments that this tumor necrosis factor has a strong beneficial effect on nerve cells and can protect nerve ...

New Immune Approach for Treatment of Alzheimer's Disease

... p. 25. 7. McAlpine, F.E. and M.G. Tansey, Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer's. J Inflammation ... K., S. Kikuchi, V.I. Shubayev, and R.R. Myers, Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered ...

Cimzia(R) (certolizumab pegol) Now Available for Self-Administration in Adult Patients With Moderate to Severe Crohn's Disease

... that Cimzia(R) (certolizumab pegol), the only PEGylated anti-TNF (Tumor necrosis Factor) approved in the U.S. for reducing signs and symptoms of Crohn's ... (certolizumab pegol) Cimzia(R) is the only PEGylated anti-TNF (Tumor necrosis Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively ...

Nektar Announces UCB's Cimzia(R) Approved by U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

... Cimzia(R) (certolizumab pegol), the only PEGylated anti-TNFa (Tumor necrosis Factor alpha), for the treatment of adult patients with moderately to ... About Cimzia(R) Cimzia(R) is the only PEGylated anti-TNF (Tumor necrosis Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively ...

UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

... (FDA) approved Cimzia(R), the only PEGylated anti-TNF (Tumor necrosis Factor), for the treatment of adult patients with moderately to severely ... CIMZIA (R) Cimzia (R) is the only PEGylated anti-TNF (Tumor necrosis Factor). Cimzia (R) has a high affinity for human TNF-alpha, ...

Cathepsin B increases apoptosis in fulminant hepatic failure

... The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence ... or activity of cathepsin B. The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence ...

Enbrel(R) (etanercept) Is the First Biologic With Published Efficacy and Safety Data for up to a Decade of Continuous Use for the Treatment of Moderate to Severe Rheumatoid Arthritis

... patients. ABOUT ENBREL ENBREL is a soluble form of a fully human tumor necrosis factor (TNF) receptor and has 16 years of collective clinical experience ... taking prescription ENBREL? ENBREL is a type of protein called a tumor necrosis factor (TNF) blocker that blocks the action of a substance your body's ...

Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease

... Tracey, MD, figured out that macrophages in the spleen were making tumor necrosis factor, a powerful inflammation-producing molecule. When they stimulated ... goes from the base of the brain into thoracic and abdominal organs, tumor necrosis factor (TNF) production in the spleen decreased. This study complements ...

Pediatric researchers find possible 'master switch' gene in juvenile arthritis

... TRAF1 and C5. The TRAF1 gene codes for a protein that regulates tumor necrosis factor, a chemical strongly associated with JIA. However, the researchers ... at Children's Hospital. "We currently use medicines called tumor necrosis factor blockers to treat children with JIA. However, not all children ...

Study Shows Increased Out-of-Pocket Expenses May Negatively Influence Initiation of TNF Blocker Therapy

... today announced the results of its study, "Association Between Tumor necrosis Factor (TNF) Blocker Out-of-Pocket (OOP) Expense and Member Decline to ... Adverse Cardiovascular Event Risk 1. Scott, D.L., Kingsley, G.H. Tumor necrosis factor inhibitors for rheumatoid arthritis. NEJM 2006;355:704-12. ...

New findings show Enbrel significantly reduced levels of C-reactive protein

... risk. ABOUT ENBREL ENBREL is a fully human soluble tumor necrosis factor (TNF) receptor. ENBREL was first approved in 1998 for moderate to ... Enbrel (etanercept)" ENBREL is a type of protein called a tumor necrosis factor (TNF) blocker that blocks the action of a substance your body's ...

Massive necrosis after trans-catheter treatment is more common in the presence of tumor capsule

... after trans-catheter treatment is heterogeneous, with a wide range of necrosis that cannot be accurately predicted. A study, published on the issue ... HCC underwent trans-catheter treatment. The research showed that massive necrosis after trans-catheter treatment is more common in the presence of tumor ...

Annals of Internal Medicine Tip Sheet for Nov. 20, 2007, Issue

... synthetic disease-modifying antirheumatic drugs (DMARDS) and anti-tumor necrosis factor drugs. The DMARDs evaluated were methotrexate, leflunomide, and sulfasalazine. The anti-tumor necrosis factor drugs were adalimumab, etanercept, and infliximab. Researchers ...

TNF Blockers May Help Some With Rheumatoid Arthritis

... with early rheumatoid arthritis (RA) who respond poorly to standard treatment with methotrexate may benefit from additional treatment with tumor necrosis factor (TNF) blockers, a Swedish study suggests. Previous research has shown that 20 percent to 40 percent of patients have a good response to ...

Certain Arthritis, Crohn's Drugs May Raise Kids' Cancer Risk: FDA

... the medicines may boost cancer risk in children and adolescents, the U.S. Food and Drug Administration announced Tuesday. The drugs, called tumor necrosis factor (TNF) blockers, work by interrupting a protein that causes inflammation and damage to bones, cartilage and other tissue. They include Remicade ...

For Treatment of Rheumatoid Arthritis, Surveyed Rheumatologists and Patients Differ In Their Perception of Bristol-Myers Squibb's Orencia

... of Bristol-Myers Squibb's Orencia is low among rheumatoid arthritis agents. Rheumatologists are less satisfied with the agent when compared to tumor necrosis factor-alpha (TNF-alpha) inhibitors across the top drivers of perception such as inducing remission, improving symptoms and slowing the progression ...

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

... United Kingdom A novel approach to characterize the distribution of a potentially therapeutic dominant-negative inhibitor of tumor necrosis factor in pre-clinical models of PD, and predict the scalability for an effective delivery of therapy in the human brain Lisa Lynn Shafer, PhD, ...

Brazil's Rheumatoid Arthritis Drug Market Will Grow $115 Million by 2013

... arthritis drug market in Brazil will grow from $200 million in 2008 to more than $315 million in 2013. The 2008 market leaders were the tumor necrosis factor-alpha (TNF-alpha) inhibitors Abbott's Humira and Schering-Plough's Remicade which recorded sales of $50 million and $43 million, respectively, ...

Peregrine Pharmaceuticals Reports Financial Results for Fiscal Year 2009

... a Chinese company that has the exclusive rights in the People's Republic of China to develop and market a version of Peregrine's radiolabeled tumor necrosis therapy (TNT) technology for the treatment of cancer. Peregrine will also make certain cash payments to CTL. In March 2009, Peregrine ...

News briefs from the July issue of CHEST

... "at risk" women during the smoking cessation process. Results showed that smoking cessation resulted in significant reductions in circulating tumor necrosis factor (TNF), soluble TNF receptors I and II, and soluble vascular cell adhesion molecule-1 (VCAM-1). Researchers conclude that there are rapid ...

Statins Might Stave Off Alzheimer's

... to the lead scientist on the project, Amalia Dolga. Earlier, Dolga had shown that statins seem to stimulate the protective capacity of tumor necrosis factor, a key player in the brain's immune response. In addition, some researchers have speculated that high cholesterol might be a risk factor for ...

New Drug Promising Against Rheumatoid Arthritis

... treating rheumatoid arthritis patients who don't respond to other drugs, according to a new study. Golimumab is from the family of drugs called tumor necrosis factor-a (TNF-a) inhibitors. The new study included 461 patients in 10 countries who were randomly selected to receive either injections of ...

Misonix Announces Participation in 2nd International Workshop on Focal Therapy

... impotence, or rectal problems. Visually Directed(TM) HIFU with the Sonablate 500 is a precision technology that is capable of creating localized necrosis in a controllable manner and appears ideal for applications in focal ablation. Additionally, it has been shown to reduce side effects when compared ...

3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis

... Copenhagen, Denmark, Friday 12 June 2009: Three new studies have individually shown the anti-TNF (tumour necrosis factor) therapy etanercept to be effective, with a good safety profile, in children under four years of age with juvenile idiopathic arthritis (JIA), ...

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

... pathway in which the circadian regulatory gene CRY was found to up-regulate expression of a gene which promotes the activation of TNF-alpha (tumour necrosis factor-alpha, a pro-inflammatory cytokine used by the body to boost the immune system) by two fold, when comparing mice with the CRY gene removed to ...

Cephalon Acquires Controlling Interest in Arana Therapeutics

... drugs that will improve the lives of patients with inflammatory diseases and cancer. The company's lead compound, ART621, is a new generation tumor necrosis factor (TNF) alpha blocker in development for patients with inflammatory diseases. Arana has a strong patent portfolio related to anti-TNF alpha ...

New Analyses from 16-Year Follow-up Trial with Betaseron(R) Demonstrated that Early and Sustained Treatment of Multiple Sclerosis Patients Enrolled in the Trial Affected Their Long-term Outcomes

... during treatment initiation may help reduce flu-like symptoms. BETASERON should be used with caution in patients with depression. Injection-site necrosis has been reported in 4% of patients in controlled trials. Patients should be advised of the importance of rotating injection sites. Female patients ...

SIMPONI(TM) (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... active rheumatoid arthritis, active psoriatic arthritis and active ankylosing spondylitis. SIMPONI is the first patient-administered anti-tumor necrosis factor (TNF)-alpha therapy that offers an effective once-monthly treatment option. Rheumatoid arthritis, psoriatic arthritis and ankylosing ...

Future for radioembolisation in patients with advanced hepatocellular carcinoma

... liver cirrhosis. 7.30% of the patients had portal vein thrombosis before therapy. Partial response rate was detected in 52%. With consideration of necrosis (EASL criteria) partial response was 80%. During the limited follow up, 2/70 patients died within the first month after therapy. 11/70 patients died ...
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