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Myelogenous in Medical News

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... copay assistance program for Ph+ CML (Chronic myelogenous Leukemia or Chronic Myeloid Leukemia) patients ... Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with prescription copay ... Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adult patients resistant or ...

Function of molecular switch pinpointed in severe congenital neutropenia

... bacterial and fungal infections and acute myelogenous leukemia. Our discovery that humans and mice ... Besides being prone to infection or acute myelogenous leukemia, children with SCN can contract the bone ... cells and are at higher risk of developing acute myelogenous leukemia. ...

Pharmion and MethylGene Present Favorable Clinical Data From Combination MGCD0103/Vidaza(R) Study in Myelodysplastic Syndromes and Acute Myelogenous Leukemia at The 49th American Society of Hematology (ASH) Meeting

... with myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). A 53 percent response rate (n=19) ... About Myelodysplastic Syndromes (MDS) and Acute myelogenous Leukemia (AML) Myelodysplastic syndromes are a ... patients, while transformation from MDS to acute myelogenous leukemia (AML) occurs in up to 40 percent of ...

SGX Pharmaceuticals BCR-ABL Program to be Presented at the American Society of Hematology 49th Annual Meeting and Exposition

... BCR-ABL program for the treatment of chronic myelogenous leukemia (CML) at the upcoming American Society ... the Philadelphia chromosome) that causes chronic myelogenous leukemia or CML, a cancer of the bone marrow. ... inhibitors as treatments for chronic myelogenous leukemia and the ability to discover, develop and ...

Pharmion to Present Clinical Data on Key Hematology Products at American Society of Hematology (ASH) Annual Meeting

... in Patients with Relapsed, Refractory Acute myelogenous Leukemia (Abstract #911). Date / Time / ... Myelodysplastic Syndrome (MDS) and Acute myelogenous Leukemia (AML) (Abstract #444). Date / Time / ... Myelodysplastic Syndrome (MDS) and Acute myelogenous Leukemia (AML) (Abstract #444). Date / Time / ...

Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom

... developing a tool to more precisely diagnose genetic subtypes of acute myelogenous leukemia (AML) so that more appropriate individualized treatment can be ... Dr. Rowley showed that the Philadelphia Chromosome associated with chronic myelogenous leukemia (CML) was an abnormal translocation of two chromosomes. Her ...

Cepheid Announces European Release of Improved Test for BCR-ABL Chromosomal Translocation Associated With Chronic Myelogenous Leukemia (CML)

... to aid European clinicians in the monitoring of patients with Chronic myelogenous Leukemia (CML). The test runs on Cepheid's GeneXpert(R) System, the ... test is a powerful tool for monitoring patients being treated for Chronic myelogenous Leukemia," said Dr. Ellie Nacheva, MD PhD FRCPath, Head of Lab - Leukemia ...

First-Ever Mapping of Cancer Patient's Genome

... that they have decoded the complete DNA sequence of a person with acute myelogenous leukemia. There were some surprises -- eight previously unknown ... has already started genetic sequencing of a second person with acute myelogenous leukemia (AML), which Wilson said was chosen in part because "it is a ...

Vion Reports 2008 Second Quarter and Six-Month Results

... based on our two Phase II trials in elderly patients with acute myelogenous leukemia (AML). We intend to file this NDA in the first half of 2009." ... Cloretazine(R) (VNP40101M) with cytarabine in elderly patients with acute myelogenous leukemia, with temozolomide in brain tumors, and with stem cell ...

NYP/Columbia physician-scientists present at ASCO 44th annual meeting

... Gemtuzumab Ozogamicin Is Safe and Well Tolerated for Children With Acute myelogenous Leukemia (AML) After Allogeneic Stem Cell Transplantation Dr. Mitchell ... receptor CD33 is expressed in as much as 90 percent of childhood acute myelogenous leukemia (AML). The investigators found that Gemtuzamab therapy during ...

Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy

... that a combination of novel anti-cancer compounds is able to kill chronic myelogenous leukemia cells previously resistant to conventional forms of therapy. Chronic myelogenous leukemia, or CML, is a cancer of the bone marrow caused by a specific ...

Bayer Establishes US Special Access Program for Leukine(R) While Replacing Current Liquid Formulation

... lyophilized formulation temporarily reserved for patients with Acute myelogenous Leukemia (AML) and those experiencing bone marrow ... prioritize the supply of the lyophilized Leukine for patients with Acute myelogenous Leukemia (AML) and those who are experiencing bone marrow transplantation ...

Scoring system identifies MDS patients who have low-risk disease but a poor prognosis

... lethal. About 10 percent of patients have their MDS transform into acute myelogenous leukemia. Garcia-Manero and colleagues examined a number of potential ... were observed or received supportive care until MDS transformed into acute myelogenous leukemia. They then received supportive care such as blood transfusions ...

Finding key to cancer drug Gleevec's limitations

... disease in which too many of certain white blood cells are made in the bone marrow. It is also called chronic granulocytic leukemia or chronic myelogenous leukemia. An estimated 5,050 men and women will be diagnosed with chronic myeloid leukemia in 2009, and 470 will die of the disease, according to the ...

Damon Runyon Cancer Research Foundation awards $2.7M to 7 top young clinical investigators

... on the first use of a small molecule inhibitor drug for the treatment of two types of pediatric leukemias, acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML). He is also developing a new test to predict patient response to this drug. The Continuation Grant will be used to complete these ...

The Leukemia & Lymphoma Society Calls for Blood Cancer Research Program at the Department of Defense

... legislation." The Department of Defense already hosts research programs for breast and prostate cancers and, from 2001-2007, hosted a chronic myelogenous leukemia (CML) research program funded at $30 million over the six year period. About The Leukemia & Lymphoma Society The Leukemia ...

Donor Stem-Cell Transplant Best For Acute Myeloid Leukemia

... emphasize, their study gives the therapist an evidence-based perspective on the use of allogeneic stem-cell transplantation in the patient with acute myelogenous leukemia who has entered a chemotherapy-induced remission, always recognizing that these group data may require modification to satisfy the special ...

National Marrowthon Campaign Aims to Bring Nearly 50,000 to the Be The Match Registry(SM) in Two Weeks

... Matthew Nguyen is a pharmacy graduate student, distance cyclist and all-around overachiever who was diagnosed with acute myelogenous leukemia (AML) in June 2007. Since then, his life has been put on hold - graduate school, his wedding and his plans for the future. Matthew is ...

Hometown Grocer, Local Food Companies Team up to Support Pediatric Patients, Encourage 'Green' Lifestyle

... and our part to clean our world," said Adam. "And when it's all clean, then we can grow beautiful trees and flowers." Adam was diagnosed with chronic myelogenous leukemia in 2006. Since then, he has endured chemotherapy and a bone marrow transplant. When Adam has to stay in the hospital, he keeps busy by ...

Blood, Marrow Drive Offers Hope for Baseball Player, 15

... for the Brentwood Bandits and member of the Longwood Junior Varsity Baseball Team, suddenly fell ill last November. He was diagnosed with Acute myelogenous Leukemia (AML), a fast-growing cancer of the blood and bone marrow. Alex, who is undergoing chemotherapy, hopes that a bone marrow match may ...

Stem cells: Deathly awakening by interferon

... observation already suggests that this assumption is more than just wishful thinking: Patients suffering from a type of blood cancer called chronic myelogenous leukemia who are treated with a drug called Gleevec almost always relapse after drug treatment has ended. Several patients were given ...

MedPredict Publishes Two New Reports Providing Expert Analysis of Malignant Hematology Drug Development

... Society of Hematology (ASH) annual meeting. The first report, entitled "Thought Leader Insight & Analysis - AML/MDS," focuses on acute myelogenous leukemia and myelodysplastic syndrome. "This report highlights the most important data presented at ASH, and clarifies the ways these data will ...

Cell Therapeutics Receives $7.5 Million Under Joint Venture Agreement With Spectrum Pharmaceuticals

... rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow involvement prior to Zevalin therapy. Myelodysplasia or acute myelogenous leukemia was observed in 2 percent of patients (8 to 34 months after treatment). Zevalin should only be used by health care professionals qualified ...

Scientists identify new congenital neutropenia syndrome and causative gene mutation

... severity of neutropenia and results in improved clinical outcome and survival. However, SCN patients eventually may develop myelodysplasia or acute myelogenous leukemia. In recent years, significant progress has been made in identifying the genetic defects that cause SCN, but in many patients, the ...

Novel treatments show improvements in survival and response rates for leukemia and lymphoma

... the cancer grows acute leukemias grow quickly while chronic leukemias develop at a slower rate. Leukemias also are categorized as lymphocytic or myelogenous depending on whether they affect lymphocytes (a type of white blood cell) or stem cells found in the bone marrow. According to the National Cancer ...

Novel Treatments Demonstrate Improvements in Overall Survival and Response Rates in Difficult-To-Treat Forms of Leukemia and Lymphoma

... the cancer grows - acute leukemias grow quickly while chronic leukemias develop at a slower rate. Leukemias also are categorized as lymphocytic or myelogenous depending on whether they affect lymphocytes (a type of white blood cell) or stem cells found in the bone marrow. According to the National Cancer ...

Vion Updates Conference Call Information

... agent, is being evaluated in a Phase II pivotal trial as a single agent in elderly patients with previously untreated de novo poor-risk acute myelogenous leukemia. Clinical trials of laromustine (Cloretazine(R), VNP40101M) with cytarabine in elderly patients with acute myelogenous leukemia, with ...

Vion Reports 2008 Third Quarter and Nine-Month Results

... agent, is being evaluated in a Phase II pivotal trial as a single agent in elderly patients with previously untreated de novo poor-risk acute myelogenous leukemia. Clinical trials of laromustine (Cloretazine(R), VNP40101M) with cytarabine in elderly patients with acute myelogenous leukemia, with ...

Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis

... drug Gleevec an inhibitor of c-kit reduced the metabolic activity and size of the tumors. Because Gleevec is already prescribed for chronic myelogenous leukemia and other cancers, the researchers were able to secure fast regulatory approval for a phase 2 clinical trial of the drug in children and ...

Cancer requires support from immune system to develop, UT Southwestern researchers report

... to develop tumors were given the drug imatinib mesylate, also known as Gleevec. The drug, known to inhibit c-kit, currently is used to treat chronic myelogenous leukemia and other cancers. Positron emission tomography scans showed that Gleevec halved the metabolic activity of the tumors, while later ...

The Leukemia & Lymphoma Society Awards Major Grant to Stanford Researcher

... of related disorders in which damaged bone marrow cells can't mature into functional blood cells. The disorders frequently progress to acute myelogenous leukemia (AML). Her team has recently identified new molecular markers than can help identify the MDS stem cells that have progressed to AML, and are ...

ASP announces 2008 T. Franklin Williams Scholars

... Research Award Heidi D. Klepin, MD Wake Forest University School of Medicine Functional and Cognitive Assessment in Older Adults with Acute myelogenous Leukemia American Society of Hematology-ASP Geriatric Hematology Research Award Amie L. Meditz, MD University of Colorado School of Medicine ...

Activation of LYN kinase is associated with imatinib-resistance in CML patients

... Activation of LYN kinase is associated with resistance to imatinib (Gleevec) in patients with chronic myelogenous leukemia (CML), researchers report in the June 24 online issue of the Journal of the National Cancer Institute . Imatinib is the standard therapy ...

Cancer Drug Gleevec Could Fight Stroke

... cancer might also boost stroke patients' survival, new research suggests. Gleevec, long hailed as a "wonder drug" against cancers such as chronic myelogenous leukemia (CML), will be tested to see if it can boost the effectiveness and limit the side effects of the clot-dissolving drug tissue plasminogen ...

Math could help cure leukemia

... might be that math could help cure cancer. In a recent study that combined math and medicine, researchers have shown that patients with chronic myelogenous leukemia (CML) may be cured of the disease with an optimally timed cancer vaccine, where the timing is determined based on their own immune response. ...

MicroRNA controls expression of oncogenes

... miRNA, miR-203, is silenced by both genetic and epigenetic mechanisms in several mouse and human blood cell malignancies, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. The researchers went on to show that transcriptional silencing of miR-203 lead to upregulation ...

Microenvironment a main driver of aggressive multi-lineage leukemia disease type

... Institute. The four major types are acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML). Mixed lineage leukemia (MLL) results when chromosome mutations involving the MLL gene fuse with certain partner genes. These ...

Vion Pharmaceuticals Announces Presentation of Data from Phase III Trial of Cloretazine(R) (VNP40101M) and Cytarabine in Relapsed Acute Myelogenous Leukemia at the ASCO(R) Annual Meeting

... untreated de novo poor-risk acute myelogenous leukemia. Clinical trials of Cloretazine(R) (VNP40101M) with cytarabine in elderly patients with acute myelogenous leukemia, with temozolomide in brain tumors, and with stem cell transplantation in advanced hematologic malignancies, are also being conducted. ...

Bayer Announces Availability of Reformulated Liquid Leukine(R)

... has an important role in reducing life-threatening infections and early death due to infections among older adults (> 55 years of age) with acute myelogenous leukemia (AML). Further, sargramostim is an important therapy in cancer supportive care and has a proven survival benefit in patients experiencing ...

New Therapy Kills Human Leukemia Cells in Mice

... human leukemia cells in mice, researchers say. The NK cells reduced by 60 percent to 85 percent human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells in test mice with aggressive human leukemias, according to the study. The findings are to be presented at the May 16 ...
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