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Mucosa in Medical News

Narrow band imaging colonoscopy identifies flat dysplastic lesions in ulcerative colitis patients

... NBI colonoscopy. Protruding lesions and flat mucosa were observed by NBI magnifying colonoscopy at a ... surrounding mucosa. Otherwise, indistinctive flat mucosa was assessed. The surface structure was ... in protrusions (2/20 sites, 10%) than in flat mucosa (3/276 sites, 1.1%, P = .038; however, correction ...

New therapeutic targets in the treatment of ulcerative colitis

... and TNF-alpha were over expressed in the colonic mucosa of patients with ulcerative colitis. The over ... matrix, and subsequently damages the colonic mucosa and causes ulceration and inflammatory changes in ... cells to produce more MMP-1, aggravating the mucosa damage. Meanwhile, MMP-1 promoted secretion of ...

DFMO may affect Barrett's esophagus

... synthesis called ornithine decarboxylase (ODC). "ODC activity in Barrett's mucosa has been shown to be significantly higher in Barrett's than in normal adjacent mucosa from the same patients," Sinicrope said. "Since DFMO inhibits polyamine ...

JCI online early table of contents: Feb. 7, 2008

... is not well understood. By studying explant cultures of human colonic mucosa (the lining of the large intestine), Anne Jarry and colleague,s at INSERM ... colonic mucosa. Depletion of IL-10 in explant cultures of human colonic mucosa led to increased expression of pro-inflammatory factors such as IFN-gamma, ...

BDSI files FDA NDA for BEMA Fentanyl

... Given the sensitivity many cancer patients have associated with their oral mucosa (i.e., cheeks and gums), we took extra care to examine what effects our dosage form (that adheres to the oral mucosa before dissolving) might have in this area. We are very pleased to report ...

Access Pharmaceuticals Announces New MuGard Commercial Strategy in North America

... chemotherapy and radiotherapy, is estimated to be in excess of $5 billion world-wide. MuGard forms a protective coating over the oral mucosa when swirled gently around the mouth. In a comparison of cancer patients receiving standard mucositis care with those patients receiving MuGard, the ...

Access Pharmaceuticals Announces Commercial Launch of MuGard(TM) in Norway by SpePharm

... chemotherapy and radiotherapy, is estimated to be in excess of $5 billion world-wide. MuGard forms a protective coating over the oral mucosa when swirled gently around the mouth. In a comparison of cancer patients receiving standard mucositis care with those patients receiving MuGard, the ...

Pre-chewed Food Could Transmit HIV

... HIV and that transmission does not occur in kissing," Gaur said. "The exception is that transmission can occur when the people involved have damaged mucosa in their mouths, and blood is mixed with the saliva." St. Jude Children's Research Hospital St. Jude Children's Research ...

Econiche(TM) Vaccine Efficacy Summarized in July Issue of Foodborne Pathogens and Disease

... measured 42, 63, and 84 days post-vaccination at the feedyard, then on day 85 at the abattoir (meat processor). Colonization of the terminal rectal mucosa was also measured on day 85 at the abattoir. For fecal shedding, regional vaccine efficacy of the ALLVAC group compared to the NOVAC pens was 63% ...

GIE: Gastrointestinal Endoscopy June issue study highlights

... hepatology, Stanford University School of Medicine, Cal., stated that "whether the optimal withdrawal time to allow complete visualization of colonic mucosa for an average endoscopist should be six or 10 minutes or another time interval still needs to be better defined. Optimal withdrawal is essential to ...

Access Pharmaceuticals Announces Commercial Launch of MuGard(TM) in Greece by SpePharm

... for the treatment of oral mucositis is estimated to be in excess of $1 billion world-wide. MuGard forms a protective coating over the oral mucosa when swirled gently around the mouth. In a comparison of cancer patients receiving standard mucositis care with those patients receiving MuGard, the ...

Bioniche Represented at House of Commons Sub-Committee on Food Safety

... A. Moxley et al concluded that a two-dose vaccine regimen effectively reduced the probability for E. coli O157:H7 colonization of the terminal rectal mucosa (TRM) of commercially fed cattle at harvest. In this study, vaccinated cattle were 92% less likely to be colonized with E. coli O157:H7 than ...

Access Pharmaceuticals Provides Update on Global Launch of MuGard(TM)

... the target population of patients requiring this important treatment option," he continued. MuGard forms a protective coating over the oral mucosa when swirled gently around the mouth. In a comparison of cancer patients receiving standard mucositis care with those patients receiving MuGard, the ...

Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?

... for nearly 6 months. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/day was started. The patient's diarrhea dramatically disappeared the following ....

Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical

... including HIV infection, AIDS, and Crohn's disease; inadequate secretion of intrinsic factor resulting from lesions that destroy the gastric mucosa and other conditions associated with gastric atrophy including multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, ...

New Clinical Study News for Treatment of Sinusitis, Sinus Infection and Allergy Sufferers Now Have a New Effective Form of Relief through Sinus Dynamics

... size of the mist particle of the Sinus Dynamics SinusAero Nebulizer penetrates the ostium for achieving topical deposition of medications on the mucosa of the paranasal sinus cavities; including the hard-to-reach maxillary sinus. Additionally, the study discusses the fact that the deposition of the ...

New Clinical Study News for Treatment of Sinusitis - Sinus Infection and Allergy Suffers Now Have a New Effective Form of Relief through Sinus Dynamics

... size of the mist particle of the Sinus Dynamics SinusAero Nebulizer penetrates the ostium for achieving topical deposition of medications on the mucosa of the paranasal sinus cavities; including the hard-to-reach maxillary sinus. Additionally, the study discusses the fact that the deposition of ...

Econiche(TM) Vaccine Shows 92% Reduction in Colonization of E. coli O157 in Vaccinated Cattle

... against type III secreted proteins of enterohemorrhagic Escherichia coli O157:H7 on the probability to detect the same organism from terminal rectal mucosa (TRM) as a measure of gut colonization. The TRM is the most significant point of colonization by E. coli O157 in cattle. Vaccine was administered to ...

Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

... in the EA group was significantly increased with respect to that of the NSAID-induced ulceration group. The total NO likely protected the gastric mucosa against NSAID-induced toxicity. In conclusion, EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense ....

Colorectal cancer: Immunological tests for more accurate detection of cancer precursors

... portion of the almost 73,000 colorectal cancers diagnosed in Germany each year could be avoided. If precancerous lesions growths of the intestinal mucosa called adenomas are detected and removed at an early stage, there is a great chance that cancer will not develop at all. Therefore, statutory ...

Magnetic-anchor-guided endoscopic submucosal dissection shows promise for gastric cancer

... direct visualization of the inner most lining of the gastrointestinal tract. This inner lining is called the mucosa. Many cancers originate from the mucosa of the gastrointestinal tract. Some examples include colon, esophageal and gastric (stomach) cancer. Precancerous changes and early stage ...

Helicobacter pylori can multiply in autophagic vesicles

... countries and 20-50% in industrialized countries. Infection of the stomach with H. pylori induces a local immune response with infiltration of the mucosa by macrophages, neutrophils and lymphocytes. Although the innate and adaptive immune responses are activated, the bacterium is rarely eliminated and ...

RingingCedarsofRussia.org Releases Pine Nut Oil Research Showing That Digestive and Stomach Disorders Respond to Unique Super Food: Siberian Pine Nut Oil

... effective in the complex treatment of erosive ulcerous lesions of the stomach." But remarkably, besides reduced inflammation of stomach mucosa and the duodenum, it also improved emotional reactions and restoration of sleep. The unique qualities which moved the Siberian pine nut oil into the ...

What is the effect of fluoxetine on mast cell?

... players in the establishment of innate immunity as well as modulators of adaptive immune responses. The role of mast cells in the gastrointestinal mucosa is not only to react to antigens, but also to actively regulate the barrier and transport properties of the intestinal epithelium. In clinical ...

What is the mechanism of the chronic radiation enteritis?

... without causing histological damage, fractionated radiation induced elevated expression of IL-1beta, TNF alpha, MCP-1, and iNOS in distal colonic mucosa during the early post-irradiation phase. At that time, a Th2 profile was confirmed by expression of both the Th2-specific transcription factor GATA-3 ...

Gut instinct: Salmonella bacteria's molecular tactics to cause illness

... conditions, digestive enzymes, bile salts, antimicrobial peptides, and other hazards as they pass through the stomach and intestine, and invade the mucosa of the small intestine. Once they make contact with the intestinal lumen, their goal is to secure a safe havenwithin the cells of the intestinal ...

Three Italian Multicenter Studies Report High (>70%) Rates of Complete Remission (CR) Utilizing Zevalin Radio-Immunotherapy (RIT) in Treatment of Newly Diagnosed or Relapsed or Refractory Non-Hodgkin's Lymphoma

... from the European Institute of Oncology, Milan treated 13 patients with relapsed or refractory primary gastric NHL including 9 patients with mucosa Associated Lymphoid Tissue or MALT with a single dose of Zevalin. Ten of 13 patients achieved a CR with all 9 patients (100%) with MALT achieving a ...

Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder

... an array of extracellular matrix proteins. As the principal advantage of systemic therapy is its potential to target not only the skin but also the mucosa of the mouth and gastrointestinal tract, the clinical testing of efficacy of human bone marrow for the treatment of human RDEB is underway to ...

Bone marrow-derived stem cells may offer novel therapeutic option for skin disorder

... an array of extracellular matrix proteins. As the principal advantage of systemic therapy is its potential to target not only the skin but also the mucosa of the mouth and gastrointestinal tract, the clinical testing of efficacy of human bone marrow for the treatment of human RDEB is underway to ...

Dormant stem cells for emergencies

... Many specialized cells, such as in the skin, intestinal mucosa or blood, have a lifespan of only a few days. For these tissues to function, a steady replenishment of specialized cells is indispensable. This is ...

How do Lactobacilli treat Helicobacter pylori-related diseases?

... have demonstrated H. pylori stimulates the release of interleukin-8 (IL-8) from gastric epithelia, which initiates inflammatory damage to gastric mucosa and plays a crucial role in the pathogenesis of H. pylori infections. H. pylori lipopolysaccharide ( H. pylori -LPS) is the major initiator in ....

Which is more accurate, serology test or C14-urea breath test?

... are reports suggesting that there is an association between the level of H. pylori IgG antibodies and the severity of inflammation of the gastric mucosa and also between antibody level and a current peptic ulcer. If so, the level, not only positively or not, of H. pylori IgG antibody tests might be ...

Innate immune system targets asthma-linked fungus for destruction

... sustained defense mechanism results in chronic inflammation. It has been shown previously that degranulation of eosinophils causes damage of airway mucosa and enhances inflammation. The next step in our transdisciplinary research collaboration will be to use recombinant fungal proteins and fungal ...

JCI online early table of contents: July 10, 2008

... recruited to sites of infection. TITLE: APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa AUTHOR CONTACT: Bertrand Huard Geneva University Medical Center, Geneva, Switzerland. Phone: 41-22-379-58-11; Fax: 41-22-379-58-02; E-mail: ...

Bioniche Presents E. coli O157:H7 Vaccine Data to World Buiatrics Congress in Budapest, Hungary

... with a three-dose vaccination and natural exposure to E. coli O157:H7, vaccinated animals were less likely to be colonized by the bacteria in the mucosa of the terminal rectum at harvest (OR=0.014, p<0.0001), resulting in a vaccine colonization efficacy of 98.3%. A two-dose vaccination was used to ...

Different type of colon cancer vaccine reduces disease spread, Jefferson scientists show

... carrying with them all the antigens that typically reside in the mucosal system. They continue to be expressed by tumors that originate in the mucosa even when those tumors metastasize into the systemic compartment where they don't belong." Dr. Waldman sees GCC as "the poster child" for mucosal ...

Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding

... Currently, capsule endoscopy cannot be used to biopsy or treat any conditions. Diagnostic results of CE may be reduced when visibility of the mucosa is impaired because of intestinal content or slow capsule progression. Prior to this study, there was only a limited consensus that preparations or ...

Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors

... issue of the World Journal of Gastroenterology. Helicobacter pylori (H pylori) is a gram-negative spiral bacterium that infects the human gastric mucosa and is associated with gastritis, gastroduodenal ulcer disease, gastric carcinoma, and lymphoma of mucosa-associated lymphoid tissue. An accurate ...

How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?

... involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma. Adhesion of the bacteria to the gastric mucosa is an essential step for colonization and infection. It is therefore important to know factors that influence the binding of the bacteria to ...

New techniques improve imaging quality, not diagnosis of Barrett's esophagus

... Chromoendoscopy is a technique in which staining agents are applied to the gastrointestinal tract to improve the images of the esophageal mucosa captured during endoscopies. The stains enable technicians to see surface patterns or functional characteristics that may suggest early neoplasia, ...
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