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Monoclonal in Medical News

Micromet, Inc. Reports Second Quarter 2009 Financial Results

... from the currently marketed EGFR-specific monoclonal antibodies Erbitux(R) (cetuximab) and Vectibix(R) ... the resistance of mutated tumor cells to those monoclonal antibodies. Micromet also presented data at the ... 2009 on a phase 1b combination study of its human monoclonal antibody adecatumumab with docetaxel in patients ...

QuikByte Software, Inc. and Sorrento Therapeutics, Inc. Announce Merger Agreement

... technology for the generation of fully human monoclonal antibodies, and QuikByte Software, Inc. (OTC ... technology for the generation of fully human monoclonal antibodies." Glenn L. Halpryn stated "We ... platform for the generation of fully human monoclonal antibodies based on its proprietary technology. ...

Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial

... follow-up are continuing. Bavituximab is a monoclonal antibody with a unique mechanism that enables the ... for anti-cancer treatments. Bavituximab is a monoclonal antibody that binds specifically to these ... company with a portfolio of innovative monoclonal antibodies in clinical trials for the treatment ...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

... antibody platform, as well as conventional monoclonal antibodies. BiTE antibodies represent a new class ... in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM ... with metastatic breast cancer. Micromet's monoclonal antibody MT293, also known as TRC093, is licensed ...

New Therapies, Including Novel Biologic Agents from Elan/Wyeth and Eli Lilly, Will Drive Robust 11 Percent Annual Growth In the Alzheimer's Disease Market

... that the launch and uptake of new anti-amyloid monoclonal antibodies, most notably Elan/Wyeth's ... disease market in 2018. While these two monoclonal antibodies are expected to offer superior ... and commercial promise are the anti-beta amyloid monoclonal therapies such as bapineuzumab and solanezumab, ...

Elusys Therapeutics and Lonza Enter Into Manufacturing Agreement

... for the production of Anthim(TM), a therapeutic monoclonal antibody in late stage development for the ... experience in large-scale manufacturing of monoclonal antibodies and a well-established reputation with ... is a high-affinity, humanized and deimmunized monoclonal antibody that targets the protective antigen of ...

ASCO Research Foundation Grant Will Support Study of Peregrine's Bavituximab in Lung Cancer

... with advanced lung cancer. Bavituximab is a monoclonal antibody with a unique mechanism that allows the ... for anti-cancer treatments. Bavituximab is a monoclonal antibody that binds specifically to these ... company with a portfolio of innovative monoclonal antibodies in clinical trials for the treatment ...

Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program

... stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and ... clinical program for Cotara(R), a targeted monoclonal antibody-based therapy being tested in a Phase II ... that links a radioactive isotope to a targeted monoclonal antibody designed to bind to the DNA histone ...

Two Targeted Therapies Likely Better Than One in Patients with Aggressive Lymphoma, Mayo Clinic Researchers Say

... with a cocktail of chemotherapy drugs, two monoclonal antibodies, instead of one, appear to offer ... the steroid drug prednisone, and rituximab, a monoclonal antibody. Diffuse large B-cell lymphoma is ... patients. Both epratuzumab and rituximab are monoclonal antibodies that attach to proteins commonly found ...

Two targeted therapies likely better than one in patients with aggressive lymphoma

... with a cocktail of chemotherapy drugs, two monoclonal antibodies, instead of one, appear to offer ... the steroid drug prednisone, and rituximab, a monoclonal antibody. Diffuse large B-cell lymphoma is one ... patients. Both epratuzumab and rituximab are monoclonal antibodies that attach to proteins commonly found ...

Amgen Highlights Data to Be Presented at ASCO

... of AMG 479, an investigational fully human monoclonal antibody antagonist of type 1 insulin-like growth ... fatal infusion reactions have occurred with other monoclonal antibody products. Stop infusion if a severe ... Denosumab Denosumab is the first fully human monoclonal antibody in late stage clinical development that ...

Micromet, Inc. Reports First Quarter 2009 Financial Results

... antibody platform, as well as conventional monoclonal antibodies. BiTE antibodies represent a new ... is overexpressed in many solid tumors. Its human monoclonal antibody adecatumumab, or MT201, also binds to ... with metastatic breast cancer. Micromet's monoclonal antibody MT293, also known as TRC093, is licensed ...

Do patients at risk for B-cell malignancy need antiviral treatment?

... clonality in the liver. Liver-infiltrating monoclonal B-cells were detected in the liver of 4 (10%) of ... HBV infection. Chi-square tesing showed the monoclonal B-cells infiltrating in the liver were more ... in 5 (71.4%) of 7 liver biopsy specimens with monoclonal B-cells infiltration. In 2 of 5 patients with ...

Scripps research scientists engineer new type of vaccination that provides instant immunity

... for the past few years on chemically programmed monoclonal antibodies, a new class of therapeutics that the ... molecules and non-targeting catalytic monoclonal antibodies self-assemble to target pathogens. monoclonal antibodies are produced in the laboratory from a ...

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

... virus and seasonal H1N1 flu viruses. These human monoclonal antibodies, identical infection-fighting proteins ... influenza A viruses. Because large quantities of monoclonal antibodies can be made relatively quickly, after more testing, these influenza-specific monoclonal antibodies potentially could be used in ...

Repligen Announces ISO 9001:2000 Certification

... consumable used in the manufacture of therapeutic monoclonal antibodies. There are approximately 20 monoclonal antibodies that have received regulatory approval ... of drug were approximately $35 billion in 2008. monoclonal antibodies are the largest and one of the fastest ...

New treatment hope for prostate cancer

... Pei Xiang Xing said his group has produced a monoclonal antibody to a unique tumour marker for the treatment of prostate cancer. The monoclonal antibody is directed at cancer-producing cells ... cancer and other cancers such as leukaemia. The monoclonal antibody significantly inhibited cancer cell ...

GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer

... approved, ofatumumab would be the first anti-CD20 monoclonal antibody available for this patient population. ... ofatumumab Ofatumumab is an investigational monoclonal antibody that targets a membrane-proximal (close ... et al. Ofatumumab (HuMax-CD20), a Novel CD20 monoclonal Antibody, Is An Active Treatment for Patients ...

Intellect Neurosciences, Inc. Grants to Top Tier Global Pharmaceutical Company License to Certain Alzheimer's Patents and Patent Applications

... for our patent estate relating to the use of monoclonal antibodies designed to slow or arrest progression ... either by administering an externally generated monoclonal antibody (passive immunization) or by provoking ... safety features into its ANTISENILIN(R) monoclonal antibody and RECALL-VAX(TM) technology platforms ...

Researchers find predictive tests and early treatment delay progression of blood cell cancer

... are widely used in advanced-stage CLL. Both are monoclonal antibodies that produce an immune response ... and then to treat them with chemotherapy and monoclonal antibodies," he says. "We believe this new ... progresses, treatment with chemotherapy and monoclonal antibodies such as rituximab and alemtuzumab can ...

Centocor, Inc. Submits Application to FDA Requesting Approval of Golimumab for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... Trial of Golimumab, a Human Anti-TNF-alpha monoclonal Antibody, Administered Subcutaneously in Subjects ... with Psoriatic Arthritis Using a Human Anti-TNF monoclonal Antibody (GO-REVEAL) trial and the Golimumab - A ... human anti-tumor necrosis factor (TNF)-alpha monoclonal antibody, is currently in the most comprehensive ...

DSM and Crucell Sign Agreement with Avid Bioservices to Serve as First Pre-Approved U.S. Contract Manufacturer of PER.C6(R) Cell Line Proteins

... products such as recombinant proteins, including monoclonal antibodies. Compared to conventional production ... products such as recombinant proteins including monoclonal antibodies. Compared to conventional production ... of antibody manufacturing experience producing monoclonal antibodies and recombinant proteins in batch, ...

NYP/Weill Cornell physician-scientists present latest cancer findings at ASCO meeting

... anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 in patients with metastatic ... from a Phase II clinical trial showing that a monoclonal antibody designated "J591," carrying a payload of ... radioactive antibody drug. Currently, two other monoclonal antibodies carrying a radioactive payload are FDA ...

Adding epratuzumab to standard therapy

... ROCHESTER, Minn. -- Adding a second monoclonal antibody drug to chemotherapy looks promising for ... with the steroid drug prednisone and rituximab, a monoclonal antibody. Final results will be reported next ... is much like rituximab because both are monoclonal antibodies, and both attach to proteins commonly ...

Epitomics receives ISO 9001 certification for the production of Rabbit Monoclonal Antibodies.

... Epitomics' proprietary RabMAbs(TM) (Rabbit monoclonal Antibodies) for research, diagnostic and ... dedicated to developing its breakthrough rabbit monoclonal antibody technology for research, diagnostic and ... a unique and proprietary RabMAb(TM) (Rabbit monoclonal Antibody) technology which produces antibodies ...

Researchers Develop Quick Way to Create Human Antibodies

... protein sentinels of the immune system, called monoclonal antibodies, which mark and neutralize foreign ... in our ability to provide antigen-specific monoclonal antibodies quickly and efficiently," said Dr. ... from multiple clones of activated B cells. A monoclonal antibody, as its name implies, is the product of ...

Access Pharmaceuticals Announces New Data on Angiolix(R)

... London on Angiolix(R), a proprietary humanized monoclonal antibody. The new data, presented by Dr. Mahendra ... About Angiolix(R): Angiolix is a humanized monoclonal antibody that binds to a proprietary target ... uptake mechanism; Angiolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis ...

Drugs in the pipeline: new therapies that could change treatment strategies

... I study of AME-133v, an Fc-engineered humanized monoclonal antibody, in low-affinity Fc?RIIIa patients with ... LB-70 A second generation, highly targeted monoclonal antibody appears to provide benefit for some ... or relapsed after use of rituximab, the first monoclonal antibody therapy approved for use in lymphoma ...

Bradmer announces new additions to management team

... 27 years of experience in leading therapeutic monoclonal antibody and recombinant protein cGMP ... the manufacturing of two radio-labeled monoclonal antibodies approved by the FDA for the treatment of cancer, as well as other various types of monoclonal antibodies. In 2006-2007, he was responsible for ...

Combo Treatment Best for Melanoma, Advanced Ovarian Cancer

... and clinical experience have shown that certain monoclonal antibodies increase the immune system's ... the immune response. Blocking CTLA-4 with a monoclonal antibody offers a way to keep the immune response ... studied whether combining GVAX vaccines with monoclonal antibody therapy could lengthen remissions and ...

Vaccine/antibody therapy effective, milder side effects in melanoma and ovarian cancer

... 18, reflects efforts to untangle the benefits of monoclonal antibody therapy from its drawbacks, which result ... the immune response. Blocking CTLA-4 with a monoclonal antibody -- a protein uniquely fit for the job -- ... experience have shown that CTLA-4-targeting monoclonal antibodies do increase the immune system's ...

Sanofi-aventis Announces 2007 Earnings Ahead of Guidance Sharp Rise in Proposed Dividend

... covering the discovery and development of human monoclonal antibodies, with the objective of bringing at ... a new tuberculosis vaccine) and with Crucell (in monoclonal rabies antibodies), plus an alliance with the ... of action and its properties, as compared with monoclonal antibodies, give it the potential to be a more ...

VaxGen and Raven biotechnologies Announce Signing of Definitive Merger Agreement

... held company focused on the development of monoclonal antibody therapeutics (MAbs) for treating cancer, ... company with a robust pipeline of monoclonal antibody candidates in oncology, proprietary ... company focused on the development of monoclonal antibody therapeutics for treating cancer. ...

Targets on the horizon: Emerging therapies and novel targets

... in humans are underway. AR36A36.11.1, a monoclonal antibody targeting CD59, enhances complement ... trials. AR47A6.4.2, a functional naked monoclonal antibody targeting Trop-2, demonstrates in vivo ... sulfate proteoglycan (MCSP). Unlike regular monoclonal antibodies used in cancer therapies, BiTE ...

A fresh look at existing therapies: Researchers explore ways to teach approved drugs new tricks

... cancers. Combination of CP-751871, a human monoclonal antibody against the IGF-1 receptor, with ... in B-cell lymphomas: Abstract no. 267 If one monoclonal antibody has revolutionized treatment of B-cell ... improved survival in mice who received the monoclonal antibody treatment cocktail, the Garden State ...

Laboratory at UI plays major role in diagnosing cancer

... distributor of cancer-fighting proteins, called monoclonal antibodies, and the specialized cells, called ... what has been missing is a complete repertoire of monoclonal antibodies for diagnostics and therapy against ... places the DSHB as the key distributor of both monoclonal antibodies and the immortal hybridoma cell lines ...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

... Targeted Therapy II-34 Gene Therapy II-34 Immunotherapy II-34 monoclonal Antibody Treatment II-35 Vaccines II-35 Donor Lymphocyte Infusion ... Plans Acquisition of ViaCell II-51 Favrille Announces Acquisition of monoclonal Antibody Range from Diversa II-52 Johnson & Johnson Secures ...

Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform

... a unique target for cancer diagnostics and therapeutics. Bavituximab is a monoclonal antibody that specifically targets PS exposed on the surface of the cells ... Inc. is a biopharmaceutical company with a portfolio of innovative monoclonal antibodies in clinical trials for the treatment of cancer and serious ...

Access Pharmaceuticals Announces Initiation of Two New Cobalamin(TM) Oral Insulin Drug Delivery Collaborations

... to deliver actives ranging from small molecules to siRNA to monoclonal antibodies . As siRNA needs to be delivered intracellularly to be ... on the natural vitamin B12 uptake mechanism; and Angiolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to ...

Morphotek(R), Inc. Announces FDA Acceptance of Investigational New Drug Application for MORAb-004, a Monoclonal Antibody for the Treatment of Solid Tumors

... for Cancer Research (LICR). The endosialin protein as well as a precursor monoclonal antibody specific for endosialin, which is related to MORAb-004, were ... a biopharmaceutical company specializing in the development of therapeutic monoclonal antibodies; Eisai Medical Research Inc., a clinical development group; ...
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(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- LiveScan ... has agreed to a partnership with Gabriel Health ... fastest growing Certified Nursing Assistant preparatory ... Institute  an exclusive member of Binary,s LiveScan service ... Biometrics will improve its service capabilities by ...
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(Date:8/21/2014)... BOSTON -- Nine researchers from Beth Israel ... included in "The World,s Most Influential Scientific Minds ... from Thomson Reuters ScienceWatch, a web resource for science ... scientists recognized as among the most influential "are performing ... to the advancement of their science," according to a ...
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