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Molecule in Medical News

DURECT Corporation Announces Second Quarter 2009 Financial

... specific drug delivery challenges for both small molecule and biologic agents. Shortly after the end of ... SABER and DURIN technologies to both small molecule and biologic agents of interest to our ... compliance, efficacy and safety for small molecule and biologic drugs. For more information, please ...

Molecule plays early role in nonsmoking lung cancer

... at the National Cancer Institute has identified a molecule believed to play an early and important role in ... who had never smoked and found high levels of a molecule called miR-21. The levels were even higher in ... levels of that molecule. Furthermore, the molecule was equally high in early stage tumors and late ...

Leukemia cells evade immune system by mimicking normal cells, Stanford studies show

... cancer stem cells express higher levels of the molecule have a poorer prognosis than those whose cells ... injected into mice. The results indicate that the molecule may serve both as a prognostic factor and a ... diseased or dying cells by binding to a molecule on the macrophage's surface. The interaction ...

Molecule Helps Leukemia Cells Hide From Immune System

... had cancer stem cells with higher levels of this molecule have a poorer prognosis than those whose cells ... Stanford. The study findings show that the molecule could be a prognostic factor and a valuable ... stem cells from macrophages by binding to a molecule on the macrophage's surface. The macrophages are ...

Post-transplant combo can replace toxic immune-suppressing drugs in monkeys

... neither costimulation blockers (in this case, a molecule called CTLA4-Ig) or alefacept could prevent ... or self-reactive antibodies. CTLA4-Ig mimics a molecule found on T cells (CTLA4) and acts as a decoy. ... drugs. Alefacept targets memory T cells via a molecule on their surfaces called CD2, the authors found. ...

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

... presentation of data from its research on small molecule modulators of the Wnt pathway for ... study highlights the potential for using small molecule Wnt activators as osteogenic agents. Because ... The Company's poster entitled, "A small molecule activator of the canonical Wnt pathway stimulates ...

Purdue researchers create prostate cancer 'homing device' for drug delivery

... Purdue University researchers has synthesized a molecule that finds and penetrates prostate cancer cells ... agents and therapeutic drugs that can link to the molecule and be carried with it as cargo. A ... cancer in the United States this year. The molecule Low's team created attaches to prostate-specific ...

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

... including development of two small molecule antagonists, NBI-42902 and elagolix (aka ... developed NBI-30775 (R121919), a small molecule antagonist of the corticotrophin-releasing factor ... Chen also discovered NBI-31772, the first small molecule inhibitor for the insulin-like growth ...

Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration

... intellectual property rights covering small molecule compositions and methods for inducing bone ... to develop Stem Cell Modulators (SCMs), small molecule or biologic compounds that guide cell fate for ... a Phase 1b clinical trial of FT1050, a small molecule SCM designed to increase hematopoietic stem cell ...

Xenon Enters Cardiovascular Disease Collaboration With Merck & Co., Inc.

... an affiliate, to discover and develop novel small molecule candidates for the potential treatment of ... and select preclinical development of small molecule compounds for those targets selected by a joint ... development company engaged in developing small molecule therapies based on the genetic causes of select ...

Fate Therapeutics Adds Pratik Multani, M.D., M.S., as Vice President Clinical Development to Advance Upcoming Clinical Programs of Stem Cell Modulators

... pluripotent stem cell biology to find small molecule and biologic drug candidates that can modulate ... Fate Therapeutics is developing these small molecule and biologic SCMs to modulate the activity of ... industry as we are applying the power of small molecule and biologic drug development, where we can use ...

Recent developments at Burnham Institute for Medical Research, May 2009

... The inhibitors were designed by looking at small molecule compounds that are known to exert ITK inhibition, ... essential role for the beta integrin-associated molecule CD98 in B cell proliferation. B cells in mice ... disease involving free radical attack on a molecule called Drp1, which is important for the integrity ...

Molecule prompts damaged heart cells to repair themselves after a heart attack

... cells. The research findings indicate that the molecule affects developmental gene expression as early as ... of Molecular and Cellular Cardiology. "This molecule has the potential to reprogram cells in the body ... coronary endothelial cells in tissue culture. The molecule also encourages cardiac regeneration by ...

Naturally fluorescent molecules may serve as cancer biomarker

... Excess amounts of a naturally fluorescent molecule found in all living cells could serve as a ... dinucleotide, is a key coenzyme -- a non-protein molecule necessary for the functioning of an enzyme -- ... explained Heikal. "Since a free NADH molecule would rotate -- tumble -- faster than ...

Lung cancer: Molecular scissors determine therapy effectiveness

... called cetuximab, which attaches to a protein molecule that is found in large amounts on the surface of ... is the u-PAR protein which is considered a marker molecule for the invasion ability of cancer cells. ... for Allgayer that EGF-R itself, the target molecule of the drug cetuximab, did not correlate with ...

NCCN Presents Updates to NCCN Guidelines for Thyroid Carcinoma

... Suppression, the expanded recommendation of small molecule kinase inhibitors, and revised procedures for ... to consider commercially available, small molecule kinase inhibitors such as sorafenib (Nexavar(R), ... data from clinical trials have shown that small molecule kinase inhibitors such as sorafenib and sunitinib ...

ProteoTech to Present at 9th International Conference for Alzheimer's and Parkinson's Disease - Prague, Czech Republic, March 11-15, 2009

... Phase 1A human clinical trial with the small molecule Exebryl-1 for the treatment of mild-to-moderate ... talk is entitled: "Exebryl-1: A Novel Small molecule Currently in Human Clinical Trials as a ... "Synuclere(TM): Development of a Novel Small molecule that Effectively Reduces Alpha-Synuclein ...

NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting

... new preclinical data related to NVC-422, the lead molecule in NovaBay's, proprietary Aganocide(R) class of ... About NVC-422 NVC-422 is the lead molecule in NovaBay's Aganocide class of compounds. ... stable analog of an anti-infective molecule produced by white blood cells. NovaBay believes ...

ProteoTech Receives Funding From The Michael J. Fox Foundation for Parkinson's Disease Research to Develop Tools for Imaging Alpha-Synuclein Aggregation in Living Parkinson's Brain

... scientists will utilize ProteoTech's small molecule platform drug technology to develop new imaging ... Disease Research to develop a new small molecule targeting alpha-synuclein in Parkinson's brain. ... human clinical trials for its orally active small molecule drug Exebryl-1 for the treatment of ...

Technique May Let More Women Use Tamoxifen

... in Washington, D.C. The Swedish team now "have a molecule suggested that may, in fact, succeed. The ... pointed out, Wnt-5a is probably too large a molecule to be administered directly to patients. But Foxy-5, a smaller molecule and a Wnt-5a analog (look-alike) developed in the ...

Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression

... for the technology. Moreover, this is the second molecule that IMTECH has under license with Nostrum, the ... patented recombinant DNA based biopharmaceutical molecule licensed to a foreign pharmaceutical company by ... in India, Caerulomycin is the first small molecule being licensed by IMTECH to a foreign company, ...

Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity

... Y (NPY), a centrally acting signaling molecule thought to be involved in regulation of energy ... is a once-daily, oral, centrally acting, small molecule neuropeptide Y (NPY) Y5 receptor antagonist that ... Laboratories. NPY is an orexigenic signaling molecule that plays a role in meal initiation and ...

Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes

... type 2 diabetes produce only small amounts of a molecule called LSR in the liver, as reported by ... appears to be responsible for this. LSR, a molecule found in the bowel and primarily in the liver, is ... we have shown for the first time that the LSR molecule plays a central role in lipid metabolism," Herzig ...

USC study finds that green tea blocks benefits of cancer drug

... chemical interaction between molecules. The EGCG molecule and the Velcade molecule were able to form chemical bonds, meaning that the Velcade molecule could no longer bind to its intended target ...

GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer

... cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B-cells.(9) This epitope is different from the ... CD20 antibodies currently available.(10) The CD20 molecule is a key target in CLL therapy because it is ...

S*BIO Announces Collaboration with Onyx for JAK2 Inhibitors in the North American and European Markets

... About SB1518 SB1518 is a small molecule JAK2-selective kinase inhibitor which has high ... and clinical development of novel targeted small molecule drugs for the treatment of cancer with leading ... is developing and marketing Nexavar(R), a small molecule drug. Nexavar is currently approved for the ...

Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

... the mechanism while examining a non-coding RNA molecule called MALAT1. Resident in the cell nucleus, ... what these processed parts of the original MALAT1 molecule do, their disparate destinations in the cell ... on a signal at its end that protects the new molecule from degradation and marks it for export out of ...

Scientists exploring new compounds to target muscular dystrophy

... "This discovery gives us, for the first time, a molecule that targets the wayward RNA at the root of ... is a first step toward developing a drug-like molecule that perhaps could be used someday to treat the disease. This lead molecule provides a framework for moving forward." ...

Leeds researchers reshape the future of drug discovery

... put it simply, if researchers need a cube-shaped molecule to target a particular protein, they may well ... down the chemical chain and restitches the molecule together in a completely different way each time. ... like a molecular square dance, where atoms in the molecule swap partners - and the exciting thing is that we ...

Substance tackles skin cancer from 2 sides

... and using a two-pronged attack, a novel designer molecule fights malignant melanoma. It was created and ... in this process. At the same time, the novel molecule also puts pressure on the tumour in a different ... that we can attack the cancer with one designer molecule along two completely different routes,' Professor ...

Red Meat Helps Spur a Food Poison Germ

... causes food poisoning by targeting a non-human molecule that's absorbed into the body through red meat. ... in on human cells with a non-human, cellular molecule on their surface. One of its favorite targets ... release issued by his university. "The Neu5Gc molecule is absorbed into the body, making it a target for ...

Recipe for cell reprogramming adds protein

... CAMBRIDGE, Mass. (August 6, 2008) A drug-like molecule called Wnt can be substituted for the cancer gene ... retrovirus with a naturally occurring signaling molecule called Wnt3a. When added to the fluid surrounding ... into IPS cells. "We're not sure if the Wnt molecule is doing the same thing as c-Myc or complementing ...

Molecule Uses Cellular Recycling to Treat Kidney Cancer

... MONDAY, July 7 (HealthDay News) -- A molecule that uses a cellular recycling process called ... VHL-deficient kidney cancer and identified a molecule called STF-62247, which enhanced autophagy in VHL-deficient cells. The molecule didn't affect cells with normal VHL. "We have ...

Stanford researchers find molecule that kills kidney cancer cells

... organ. But that could change, thanks to a new molecule found by Stanford University School of Medicine ... the researchers said, a drug created from this molecule would help fight the life-threatening disease ... tumor cells. Giaccia's team searched for a small molecule that would kill cancer cells when this VHL gene ...

Researchers identify promising cancer drug target in prostate tumors

... , the researchers say the growth-stimulating molecule called p110beta -- part of a cellular signaling ... PhD, and Pixu Liu, MD, PhD. The p110beta molecule and a counterpart, p110alpha, are "isoforms" -- ... inhibitors as well." Both forms of the p110 molecule have dual tasks: they are involved in responding ...

Immune Molecule Key to Preventing Organ Rejection

... MONDAY, June 23 (HealthDay News) -- An immune molecule called HLA-G dimer plays a powerful role in ... in mice and are currently studying whether this molecule is at work in kidney transplant patients who don't experience organ rejection. "This is a molecule with huge potential to regulate immune response," ...

JCI table of contents: June 20, 2008

... guinea pigs. These effects were abolished using a molecule that inhibited a protein known as TRPA1. ... effects by inducing DCs to express more of a molecule known as IDO, which is a suppressor of DC ... that PR3 and NE destroy an anti-inflammatory molecule known as PGRN and in this way help to promote ...

Immune molecule that plays a powerful role in avoiding organ rejection identified

... graft survive, researchers say. "This is a molecule with huge potential to regulate immune response," ... that being able to control a tumor's use of this molecule could offer a new way to target tumors for ... protective covering. "The expression of the MHC molecule for some reason goes up - an infection might ...

Duke chemist has new way to tell right from left

... profound birth defects because one shape of the molecule was therapeutic and the other was dangerous. ... at zero C to -40 C, the new process uses a small molecule called a "chiral auxiliary" to attach pieces to a molecule being built, which causes the new pieces to have ...

Gut Bacteria Fights Inflammatory Bowel Disease

... Mouse study finds molecule boosted cells eliminating colitis, Crohn's ... WEDNESDAY, May 28 (HealthDay News) -- A molecule produced by intestinal bacteria can eliminate ... Previous research has found that the sugar molecule polysaccharide A (PSA), which is produced by a ...
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(Date:9/15/2014)... released today by the National Academy of Sciences, ... and strategies for the program and will guide ... years (2015-2020). In addition, the program announced ... in 2015, will include exploratory grants, early-career research ... $500 million, 30-year program to be run by ...
(Date:9/15/2014)... in the oceans, there must be enough dissolved ... extreme oxygen-starvation produces "dead zones" that decimate marine ... oxygen levels decline, energy is increasingly diverted away ... in impacts on the ecology and biogeochemistry of ... oxygen minimum zones (OMZs) have expanded due to ...
(Date:9/15/2014)... who transplanted combinations of wild, domesticated, and ... to new environments found that within 5 ... foreign genes from wild populations that hybridized ... Applications study provides evidence that natural ... that hybridized populations experience as a result ...
Breaking Biology News(10 mins):NAS Gulf Research Program announces strategic vision, initial opportunities 2NAS Gulf Research Program announces strategic vision, initial opportunities 3NAS Gulf Research Program announces strategic vision, initial opportunities 4Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
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Breaking Medicine News(10 mins):Health News:Sept. 25 Webinar to Offer Health Plan, Employer Strategies to Control Compounded Medication Costs 2Health News:True Science Cosmetics, LLC Launches True Lipz™ 2Health News:David Bell Joins Triad Semiconductor's Board of Directors 2Health News:Carey Danis & Lowe Reports On $73 Million Boston Scientific Verdict 2Health News:Beautiful Sapphire Evening Dresses Provided By iFitDress.com 2
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