DURECT Corporation Announces Second Quarter 2009 Financial
... specific drug delivery challenges for both small molecule
and biologic agents. Shortly after the end of ... SABER and DURIN technologies to both small
and biologic agents of interest to our ... compliance, efficacy and safety for small molecule
and biologic drugs. For more information, please ...
Molecule plays early role in nonsmoking lung cancer
... at the National Cancer Institute has identified a molecule
believed to play an early and important role in ... who had never smoked and found high levels of a molecule
called miR-21. The levels were even higher in ... levels of that molecule.
Furthermore, the molecule
was equally high in early stage tumors and late ...
Leukemia cells evade immune system by mimicking normal cells, Stanford studies show
... cancer stem cells express higher levels of the molecule
have a poorer prognosis than those whose cells ... injected into mice. The results indicate that the molecule
may serve both as a prognostic factor and a ... diseased or dying cells by binding to a molecule
on the macrophage's surface. The interaction ...
Molecule Helps Leukemia Cells Hide From Immune System
... had cancer stem cells with higher levels of this molecule
have a poorer prognosis than those whose cells ... Stanford.
The study findings show that the molecule
could be a prognostic factor and a valuable ... stem cells from macrophages by binding to a molecule
on the macrophage's surface. The macrophages are ...
Post-transplant combo can replace toxic immune-suppressing drugs in monkeys
... neither costimulation blockers (in this case, a molecule
called CTLA4-Ig) or alefacept could prevent ... or self-reactive antibodies.
CTLA4-Ig mimics a molecule
found on T cells (CTLA4) and acts as a decoy. ... drugs.
Alefacept targets memory T cells via a molecule
on their surfaces called CD2, the authors found. ...
Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway
... presentation of data from its research on small molecule
modulators of the Wnt pathway for ... study highlights the potential for using small molecule
Wnt activators as osteogenic agents. Because ...
The Company's poster entitled, "A small molecule
activator of the canonical Wnt pathway stimulates ...
Purdue researchers create prostate cancer 'homing device' for drug delivery
... Purdue University researchers has synthesized a molecule
that finds and penetrates prostate cancer cells ... agents and therapeutic drugs that can link to the molecule
and be carried with it as cargo.
A ... cancer in the United States this year.
Low's team created attaches to prostate-specific ...
Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry
... including development
of two small molecule
antagonists, NBI-42902 and elagolix (aka ... developed NBI-30775 (R121919), a small molecule
antagonist of the
corticotrophin-releasing factor ... Chen also
discovered NBI-31772, the first small molecule
inhibitor for the insulin-like
Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration
... intellectual property rights covering small molecule
compositions and methods for inducing bone ... to develop Stem Cell Modulators (SCMs), small molecule
or biologic compounds that guide cell fate for ... a Phase 1b clinical trial of FT1050, a small molecule
SCM designed to increase hematopoietic stem cell ...
Xenon Enters Cardiovascular Disease Collaboration With Merck & Co., Inc.
... an affiliate, to discover and develop novel small molecule
candidates for the potential treatment of ... and select preclinical development of small molecule
compounds for those targets selected by a joint ... development company engaged in developing small molecule
therapies based on the genetic causes of select ...
Fate Therapeutics Adds Pratik Multani, M.D., M.S., as Vice President Clinical Development to Advance Upcoming Clinical Programs of Stem Cell Modulators
... pluripotent stem cell biology to find small molecule
and biologic drug candidates that can modulate ... Fate Therapeutics is developing these small molecule
and biologic SCMs to modulate the activity of ... industry as we are applying the power of small molecule
and biologic drug development, where we can use ...
Recent developments at Burnham Institute for Medical Research, May 2009
... The inhibitors were designed by looking at small molecule
compounds that are known to exert ITK inhibition, ... essential role for the beta integrin-associated molecule
CD98 in B cell proliferation. B cells in mice ... disease involving free radical attack on a molecule
called Drp1, which is important for the integrity ...
Molecule prompts damaged heart cells to repair themselves after a heart attack
... cells. The research findings indicate that the molecule
affects developmental gene expression as early as ... of Molecular and Cellular Cardiology.
has the potential to reprogram cells in the body ... coronary endothelial cells in tissue culture. The molecule
also encourages cardiac regeneration by ...
Naturally fluorescent molecules may serve as cancer biomarker
... Excess amounts of a naturally fluorescent molecule
found in all living cells could serve as a ... dinucleotide, is a key coenzyme -- a non-protein molecule
necessary for the functioning of an enzyme -- ... explained Heikal. "Since a free NADH molecule
would rotate -- tumble -- faster than ...
Lung cancer: Molecular scissors determine therapy effectiveness
... called cetuximab, which attaches to a protein molecule
that is found in large amounts on the surface of ... is the u-PAR protein which is considered a marker molecule
for the invasion ability of cancer cells. ... for Allgayer that EGF-R itself, the target molecule
of the drug cetuximab, did not correlate with ...
NCCN Presents Updates to NCCN Guidelines for Thyroid Carcinoma
... Suppression, the expanded recommendation of small molecule
kinase inhibitors, and revised procedures for ... to consider commercially available, small molecule
kinase inhibitors such as sorafenib (Nexavar(R), ... data from clinical trials have shown that small molecule
kinase inhibitors such as sorafenib and sunitinib ...
ProteoTech to Present at 9th International Conference for Alzheimer's and Parkinson's Disease - Prague, Czech Republic, March 11-15, 2009
... Phase 1A human clinical trial with the small molecule
Exebryl-1 for the treatment of mild-to-moderate ... talk is entitled: "Exebryl-1: A Novel Small molecule
Currently in Human Clinical Trials as a ... "Synuclere(TM): Development of a Novel Small molecule
that Effectively Reduces Alpha-Synuclein ...
NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting
... new preclinical data related to NVC-422, the lead molecule
in NovaBay's, proprietary Aganocide(R) class of ...
NVC-422 is the lead molecule
in NovaBay's Aganocide class of compounds. ... stable analog of an anti-infective molecule
produced by white blood cells. NovaBay believes ...
ProteoTech Receives Funding From The Michael J. Fox Foundation for Parkinson's Disease Research to Develop Tools for Imaging Alpha-Synuclein Aggregation in Living Parkinson's Brain
... scientists will utilize ProteoTech's small molecule
platform drug technology to develop new imaging ... Disease Research to develop a new small molecule
targeting alpha-synuclein in Parkinson's brain. ... human clinical trials for its orally active small molecule
drug Exebryl-1 for the treatment of ...
Technique May Let More Women Use Tamoxifen
... in Washington, D.C. The Swedish team now "have a molecule
suggested that may, in fact, succeed. The ... pointed out, Wnt-5a is probably too large a molecule
to be administered directly to patients.
But Foxy-5, a smaller molecule
and a Wnt-5a analog (look-alike) developed in the ...
Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression
... for the technology. Moreover, this is the second molecule
that IMTECH has under license with Nostrum, the ... patented recombinant DNA based biopharmaceutical molecule
licensed to a foreign pharmaceutical company by ... in India, Caerulomycin is the first small molecule
being licensed by IMTECH to a foreign company, ...
Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity
... Y (NPY), a centrally acting signaling molecule
thought to be involved in regulation of energy ... is a once-daily, oral, centrally acting, small molecule
neuropeptide Y (NPY) Y5 receptor antagonist that ... Laboratories. NPY is an orexigenic signaling molecule
that plays a role in meal initiation and ...
Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
... type 2 diabetes produce only small amounts of a molecule
called LSR in the liver, as reported by ... appears to be responsible for this. LSR, a molecule
found in the bowel and primarily in the liver, is ... we have shown for the first time that the LSR molecule
plays a central role in lipid metabolism," Herzig ...
USC study finds that green tea blocks benefits of cancer drug
... chemical interaction between molecules. The EGCG molecule
and the Velcade molecule
were able to form chemical bonds, meaning that the Velcade molecule
could no longer bind to its intended target ...
GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer
... cell surface), small loop epitope (a portion of a molecule
to which an antibody binds) on the CD20 molecule
on B-cells.(9) This epitope is different from the ... CD20 antibodies currently available.(10) The CD20 molecule
is a key target in CLL therapy because it is ...
S*BIO Announces Collaboration with Onyx for JAK2 Inhibitors in the North American and European Markets
SB1518 is a small molecule
JAK2-selective kinase inhibitor which has high ... and clinical development of novel targeted small molecule
drugs for the treatment of cancer with leading ... is developing and marketing Nexavar(R), a small molecule
drug. Nexavar is currently approved for the ...
Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
... the mechanism while examining a non-coding RNA molecule
called MALAT1. Resident in the cell nucleus, ... what these processed parts of the original MALAT1 molecule
do, their disparate destinations in the cell ... on a signal at its end that protects the new molecule
from degradation and marks it for export out of ...
Scientists exploring new compounds to target muscular dystrophy
... "This discovery gives us, for the first time, a molecule
that targets the wayward RNA at the root of ... is a first step toward developing a drug-like molecule
that perhaps could be used someday to treat the disease. This lead molecule
provides a framework for moving forward."
Leeds researchers reshape the future of drug discovery
... put it simply, if researchers need a cube-shaped molecule
to target a particular protein, they may well ... down the chemical chain and restitches the molecule
together in a completely different way each time. ... like a molecular square dance, where atoms in the molecule
swap partners - and the exciting thing is that we ...
Substance tackles skin cancer from 2 sides
... and using a two-pronged attack, a novel designer molecule
fights malignant melanoma. It was created and ... in this process. At the same time, the novel molecule
also puts pressure on the tumour in a different ... that we can attack the cancer with one designer molecule
along two completely different routes,' Professor ...
Red Meat Helps Spur a Food Poison Germ
... causes food poisoning by targeting a non-human molecule
that's absorbed into the body through red meat. ... in on human cells with a non-human, cellular molecule
on their surface. One of its favorite targets ... release issued by his university. "The Neu5Gc molecule
is absorbed into the body, making it a target for ...
Recipe for cell reprogramming adds protein
... CAMBRIDGE, Mass. (August 6, 2008) A drug-like molecule
called Wnt can be substituted for the cancer gene ... retrovirus with a naturally occurring signaling molecule
called Wnt3a. When added to the fluid surrounding ... into IPS cells.
"We're not sure if the Wnt molecule
is doing the same thing as c-Myc or complementing ...
Molecule Uses Cellular Recycling to Treat Kidney Cancer
MONDAY, July 7 (HealthDay News) -- A molecule
that uses a cellular recycling process called ... VHL-deficient kidney cancer and identified a molecule
called STF-62247, which enhanced autophagy in VHL-deficient cells. The molecule
didn't affect cells with normal VHL.
"We have ...
Stanford researchers find molecule that kills kidney cancer cells
But that could change, thanks to a new molecule
found by Stanford University School of Medicine ... the researchers said, a drug created from this molecule
would help fight the life-threatening disease ... tumor cells. Giaccia's team searched for a small molecule
that would kill cancer cells when this VHL gene ...
Researchers identify promising cancer drug target in prostate tumors
... , the researchers say the growth-stimulating molecule
called p110beta -- part of a cellular signaling ... PhD, and Pixu Liu, MD, PhD.
The p110beta molecule
and a counterpart, p110alpha, are "isoforms" -- ... inhibitors as well."
Both forms of the p110 molecule
have dual tasks: they are involved in responding ...
Immune Molecule Key to Preventing Organ Rejection
... MONDAY, June 23 (HealthDay News) -- An immune molecule
called HLA-G dimer plays a powerful role in ... in mice and are currently studying whether this molecule
is at work in kidney transplant patients who don't experience organ rejection.
"This is a molecule
with huge potential to regulate immune response," ...
JCI table of contents: June 20, 2008
... guinea pigs. These effects were abolished using a molecule
that inhibited a protein known as TRPA1. ... effects by inducing DCs to express more of a molecule
known as IDO, which is a suppressor of DC ... that PR3 and NE destroy an anti-inflammatory molecule
known as PGRN and in this way help to promote ...
Immune molecule that plays a powerful role in avoiding organ rejection identified
... graft survive, researchers say.
"This is a molecule
with huge potential to regulate immune response," ... that being able to control a tumor's use of this molecule
could offer a new way to target tumors for ... protective covering. "The expression of the MHC molecule
for some reason goes up - an infection might ...
Duke chemist has new way to tell right from left
... profound birth defects because one shape of the molecule
was therapeutic and the other was dangerous.
... at zero C to -40 C, the new process uses a small molecule
called a "chiral auxiliary" to attach pieces to a molecule
being built, which causes the new pieces to have ...
Gut Bacteria Fights Inflammatory Bowel Disease
... Mouse study finds molecule
boosted cells eliminating colitis, Crohn's ... WEDNESDAY, May 28 (HealthDay News) -- A molecule
produced by intestinal bacteria can eliminate ...
Previous research has found that the sugar molecule
polysaccharide A (PSA), which is produced by a ...