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Mitotic in Medical News

Lack of CHFR gene expression sets stage for breast cancer

... then line up in the middle of a structure, the mitotic spindle, which forms to aid cell division. The ... because some cancer drugs interact with the mitotic spindle as a way to curb cell division. ... alpha tubulin, a protein important in forming mitotic spindles, and with a ...

Key factor in brain development revealed, offers insight into disorder

... by helping regulate the orientation of the cells mitotic spindles -- the microtubules that draw the two ... Specifically, Lis 1 makes sure that the mitotic spindle is oriented perpendicular to the top and ... and weakened microtubules and an inability of the mitotic spindle to rotate the microtubules properly in ...

Experimental cancer pharmaceuticals under trial

... A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel ... The experimental drug, GSK923295A, inhibits the mitotic kinesin centromere-associated protein E (CENP-E), ... two, identical, daughter cells. The resulting mitotic arrest can lead to apoptosis, or cell death. A ...

A breakthrough in gastric carcinogenesis

... Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various ... MIN of gastric cancer patients. Both MIN and CHFR hypermethylation induce mitotic check point disruption and confer a survival advantage to the cells, ...

Cell division studies hint at future cancer therapy

... the American Cancer Society to pursue his studies. He focuses on the mitotic spindle, a sort of demarcation line that helps a dividing cell divvy up ... details may eventually lead to better cancer treatment, such as disrupting mitotic spindle organization so cancer cells cannot divide, Dr. Du says. The ...

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

... by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway). Cephalon holds exclusive rights to market and develop TREANDA in the United States. TREANDA is licensed ...

Scientists discover key event in prostate cancer progression

... prostate cancer, however, the receptors are reprogrammed to selectively regulate genes involved in actual cell division, that is, the mitotic phase of the cycle. A gene called UBE2C was a standout among these genes, and increased expression of that gene correlated with progression to the ...

17 of America's Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences

... of stem cells Jenn i fer G . D eL u c a, Ph. D . C olora d o St a te U n iv e r s i t y Mechanisms of mitotic chromosome segregation P a tr i ck J. Pad d iso n , Ph. D . Fred Hu t ch i nson Ca n cer R esea r ch Ce n ...

From mother to daughters: A central mystery in cell division solved

... that are also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle. As happens during muscle ...

Exercise Keeps the Brain Young

... researchers then looked at the ability of the brain to continue to produce neural cells. In middle-aged mice, the number of neural progenitor and mitotic cells in the hippocampus, a brain region intimately associated with learning and memory, decreased dramatically, Kuo explained. "Compared to the ...

Video: Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma

... by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway). Cephalon holds exclusive rights to market and develop TREANDA in the United States. TREANDA is licensed from ...

Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma

... by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway). Cephalon holds exclusive rights to market and develop TREANDA in the United States. TREANDA is licensed from ...

Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find

... to an adjoining messenger cell called the hub. Yamashita and her colleagues found that improper orientation of the centrosomes disrupts the mitotic machinery, steering it on a course toward stem-cell over-proliferation and cancer. The checkpoint mechanism senses when centrosomes are ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

... his sponsors Kenneth E. Prehoda, PhD, and Chris Q. Doe, PhD, at the University of Oregon, Eugene, Oregon, is investigating the molecular mechanism of mitotic spindle orientation during asymmetric cell division of model progenitor stem cells. Failure in this process can lead to aberrant cell division and ...

Newborn brain cells modulate learning and memory

... to normal brain function a question Gage is particularly interested in. In the past, methods to knock out neurogenesis, such as radiation and mitotic inhibitors that block all cell division have been rather crude, he says. So, maybe not surprisingly the literature is riddled with contradictory ...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

... rapid, sustained single- and double-strand DNA damage, which results in apoptosis, or programmed cell death, in the tumor. TREANDA also induces mitotic checkpoint inhibition, which results in non-apoptotic cell death. TREANDA causes DNA disruption that is both extensive and durable exhibiting a low ...

New Genetic Studies Carried Out in Cancer Therapy

... expected, involves genes that impair drug-induced mitotic arrest following knockdown. Silencing of these ... conclude that specific disruption of the mitotic checkpoint promotes paclitaxel resistance and ... suggest that paclitaxel-induced prolonged mitotic arrest may result in ceramide accumulation and ...

Characteristics of Fast-Growing Skin Cancers

... method was doubled-checked by comparing the rate of growth with the tumor mitotic rate, or the rate at which the cancer cells multiply. Those tumors with a faster mitotic rate also had a faster rate of growth as determined by the researchers’ ...

Scientists Demonstrate Heart Cell Replication in Mice

... mature, rod-shaped heart muscle cells (known as cardiomyocytes) with periostin in a Petri dish. About one per cent of the cells entered the mitotic cell cycle -- namely, they began dividing and replicating. "We found a small subpopulation of cells that could, with proper stimulation, ...

Sea Creature's Toxin Could Lead to Promising Cancer Treatment

... variants of diazonamide A in order to pin down how it prevents cancer cells from dividing. Normal cell division involves a structure called the mitotic spindle, which pulls apart the chromosomes before the cell splits. The spindle is primarily made out of a substance called tubulin. Some anti-cancer ...

Run Amok Enzyme Causes Same Problems in Both Humans and Fruit Flies

... (Numb) involved in the differentiation into neurons and neuroblast self-renewal (aPKC) are not sorted to their proper sides of the cell, and the mitotic spindle that provides cortical polarity becomes misaligned. The subsequent splitting leads to new cells with improper proteins mixes, including an ...

Prestigious Wilson Award Goes To Yale Cell Biologist Joel Rosenbaum

... with it, causing the cilia to shorten, and permitting the ciliary basal bodies/centrioles to migrate to the center of the cell to form the mitotic apparatus. Following chromosome separation, the amount of this IFT protein again increases, and the cell divides. If the amount of the IFT protein is ...

Anti-fungal drug - Griseofulvin may help treat cancer

... The authors found that the drug works as an anti-proliferative agent and inhibits cancer cells by affecting mitosis, or cell division, and mitotic spindle microtubule function. The authors conclude by saying- "A mild suppression of microtubule dynamics by griseofulvin in tumor cells, combined ...
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