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Mitochondrial in Medical News

Cell Protein Could Help Spur Malignancy

... results open the possibility that inhibiting the mitochondrial function of STAT3 could be a promising cancer ... university's medical school. "By knowing this mitochondrial function is critical, it may be possible to ... Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the ...

Research points to a new way to protect kidneys threatened by insufficient blood or toxins

... renal failure may be possible by blocking the mitochondrial fragmentation that occurs when kidneys don't get ... and leads to acute renal failure. "When mitochondrial fragmentation is blocked, it can save the cells ... in the cell, work together to make pores in the mitochondrial outer membrane. Cytochrome c, a protein that ...

Key protein in cellular respiration discovered

... codes for a protein (TFB1M) that is essential to mitochondrial protein synthesis. If TFB1M is missing, ... from progressive heart failure and increase mitochondrial mass, which is similar to what we find in patients with mitochondrial diseases." The scientists believe that the ...

JCI online early table of contents: April 6, 2009

... Augusta, have now provided new insight into the mitochondrial changes that occur in acute rodent kidney injury, ... protein Drp1, which is known to be involved in mitochondrial fission, and blocking its function substantially reduced mitochondrial fragmentation and apoptotic cell death. ...

Naturally fluorescent molecules may serve as cancer biomarker

... living cells, we should be able to monitor the mitochondrial activity and thus the integrity of any given ... a known inhibitor of some of these critical mitochondrial enzymes. The researchers found that the NADH ... Other neurodegenerative diseases related to mitochondrial anomalies can also be detected with our method," ...

Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference

... analytical instrument for the kinetic measure of mitochondrial oxygen consumption and cytoplasmic glycolysis in ... Compound Safety Prediction Group, who spoke about mitochondrial toxicity at the conference and one of the first ... diabetes, ageing and cancer, and to screen for mitochondrial toxicity. The XF96 Analyzer offers the ...

New study shows how spikes in nitrite can have

... implicated include some key proteins, such as mitochondrial aldehyde dehydrogenase, that have been shown by ... our findings will have broad implications for mitochondrial signalling and cardiac energetics," commented ... an ancient program aimed at fine-tuning mitochondrial function. Although the present study focussed on ...

Researchers & Department of Defense Question Multiple Vaccine Administration

... multiple vaccines concurrently. mitochondrial Disease in Autism Spectrum Disorder Patients, ... with autistic regression in persons with mitochondrial cytopathies." In a November 26th ... by Elliott and colleagues in August, the United mitochondrial Disease Foundation stated ...

Transgenomic Obtains Exclusive License to Mitochondrial DNA Damage Detection Technology

... license to patents covering a method for mitochondrial DNA (mtDNA) damage detection. The patents form ... this technology to follow damage and repair in mitochondrial and nuclear genomes. His laboratory has also ... reactive oxygen species cause significantly more mitochondrial DNA damage than nuclear damage in cells from ...

Mini heart attacks lessen damage from major ones

... long been thought that a group of proteins in the mitochondrial membrane act as a "safety valve" by dissipating ... such that they allow a proton leak across the mitochondrial membrane. The leak lowers the proton gradient ... is allowed to proceed. Brookes is part of the mitochondrial Research & Innovation Group (MRIG) at the Medical ...

2 UCSF scientists recognized for transformative research

... of the molecular mechanisms that underlie major mitochondrial functions, including energy production, setting ... "The transport of ions and molecules across the mitochondrial membranes is the foundation of the mitochondrial physiology and a lack of direct methods to ...

White blood cell uses DNA 'catapult' to fight infection

... that bacteria can activate eosinophils to release mitochondrial DNA in a catapult-like fashion to create a net ... infection, such as E. coli, they rapidly secrete mitochondrial DNA. This DNA binds to the granule proteins and ... eosinophil is able to survive after expelling its mitochondrial DNA. The researchers hope to learn more about ...

MitoAction Develops On-Line Resource for Mitochondrial Disease Care Providers

... Online Clinicians Guide to mitochondrial Disease Now Available, sponsored by Edison Pharma ... and symptom management of patients affected by mitochondrial disease. The Clinicians Symptom Guide to MITO ... mission to support, educate and advocate for the mitochondrial disease patient community through development of ...

Lifestyle can alter gene activity, lead to insulin resistance

... physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins ... the body's conversion of food to energy, known as mitochondrial oxidative phosphorylation, can lead to insulin ... help cells convert food to energy (the genes of mitochondrial oxidative phosphorylation). Transcription is a ...

Muscle Weakness Found in Some Autistic Children

... to an underlying genetic defect that's causing mitochondrial disease, which means the muscles don't get the ... they need. Conversely, it's possible that the mitochondrial disease may also play a role in the development ... with autism, about 20 percent have markers of mitochondrial disease in the blood," explained Dr. John ...

UMDF Statement on the Connection Between Mitochondrial Disease and Autism

... published reports of possible links between mitochondrial disorders and autism. "Recent published ... the urgent need for more research into mitochondrial disease, a devastating and often fatal ... that every 15 minutes a child is born with mitochondrial disease or will be ...

Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection

... team demonstrated how estrogen acts to regulate mitochondrial function in ways pivotal for protection against ... disease. These include: an increase of mitochondrial efficiency, enhancing the organelles ability to ... of the brain; and protection of neurons from mitochondrial toxins, which can induce ...

MITOCHONDRIAL DYSFUNCTION, VACCINES AND AUTISM: 1 in 50 Children Could Be at Risk

... safety officials to discuss concerns surrounding mitochondrial dysfunction, autism and vaccines. The call ... that, "Some researchers on the call reported that mitochondrial dysfunction is probably much more common than ... schedule. -- The genetic susceptibility for mitochondrial dysfunction is not rare. -- This DNA mutation ...

United Mitochondrial Disease Foundation Statement on Vaccines, Autism and Mitochondrial Disease

... executive director and CEO of the United mitochondrial Disease Foundation on reports of possible links ... that childhood vaccinations cause or worsen mitochondrial diseases, but there is very little scientific research in this area. mitochondrial diseases are as prevalent as childhood leukemia, ...

St. Jude Researchers Find Key Step in Programmed Cell Death

... similar to what happens if you remove the mitochondrial enzymes called HtrA2 or Parl." Exploring the ... understand why lymphocytes needed an active HtrA2 mitochondrial enzyme. This led them to discover that if active ... since accumulation of Bax in the outer mitochondrial membrane allows the release of proteins that set ...

St. Jude researchers find key step in programmed cell death

... similar to what happens if you remove the mitochondrial enzymes called HtrA2 or Parl. Exploring the ... understand why lymphocytes needed an active HtrA2 mitochondrial enzyme. This led them to discover that if active ... incorporation of a protein called Bax into the mitochondrial outer membrane did not occur. This was ...

Single Mutation in Mitochondrial DNA Weakens Heart, Muscles

... health, the researchers wrote. "Consequently, mitochondrial DNA mutations and their related energy defects ... Wallace, director of the Center for Molecular and mitochondrial Medicine and Genetics at the university, said in a prepared statement. "Therefore, mitochondrial energy deficiency may be a common factor in these ...

Michael J. Fox Foundation awards up to $3 million to industry teams

... chronic inflammation; trophic factors; and mitochondrial dysfunction. Christine Bulawa, PhD, of ... factories" of body cells. It is believed that mitochondrial function is decreased in people with Parkinson's disease and that mitochondrial toxins induce parkinsonian symptoms in animal ...

In silico modeling helps predict severity of mitochondrial disease

... Kingdom and the United States has revealed how mitochondrial diseases are passed from the mother to the next ... in Nature Genetics*, shows for the first time how mitochondrial diseases that cause muscle weakness, diabetes, ... therefore take a close look at the replication of mitochondrial DNA and the dynamics of cell division in mouse ...

Mitochondrial 'bottleneck' cracked

... able to predict a child's risk of developing a mitochondrial disease which can cause muscle weakness, ... have their own genetic information, known as mitochondrial DNA, or mtDNA, which is inherited. However, ... cells and therefore lead to disease. However, mitochondrial diseases differ both in location and severity ...

JCI online early table of contents: Jan. 10 2008

... and has provided evidence that alterations in mitochondrial function are the result, and not the cause, of ... and type 2 diabetes. The authors found that mitochondrial defects were present in diabetic, but not pre-diabetic glucose intolerant, mice. The mitochondrial disruptions were subsequently shown to be the ...

Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team

... ultimate goal is to block the propagation of this mitochondrial stress signaling and inhibit the expression of ... tumor progression in vivo by directly targeting mitochondrial transcription and induction of mitochondrial stress signaling. A unique feature of this ...

Cellular Disorder Might Influence Behavior

... help improve understanding about the link between mitochondrial malfunction and mental illness in humans, they said. Previous research found that mitochondrial disorders may contribute to many kinds of health ... stroke, diabetes, or heart disease. Major mitochondrial genetic defects have been identified in patients ...

Carbon monoxide counteracts one side-effect of an anti-cancer drug

... effects are due to inhibition by DOX of mitochondrial biogenesis, a term used to describe cellular ... his colleagues at Duke University Medical Center, mitochondrial biogenesis was recovered in DOX-treated rodents ... (CO) or overexpression of the protein HO-1. mitochondrial biogenesis is known to depend on the presence of ...

JCI table of contents: Nov. 21, 2007

... effects are due to inhibition by DOX of mitochondrial biogenesis, a term used to describe cellular ... his colleagues at Duke University Medical Center, mitochondrial biogenesis was recovered in DOX-treated rodents ... (CO) or overexpression of the protein HO-1. mitochondrial biogenesis is known to depend on the presence of ...

Fighting obesity may be as easy as ATP, says UH researcher

... techniques, that detect metabolic activity in mitochondrial complexes. Often considered the powerhouses of ... will focus on electrode-based sensors that detect mitochondrial enzymes in action and may lead to development of ... be able to distinguish normal from dysfunctional mitochondrial activity. Millers collaborators include ...

Study looks at mitochondrial variation in sperm traits and sperm competitive ability

... Foundation to investigate the effects of natural mitochondrial variation on sperm traits and sperm competitive ability. Researchers have found mitochondrial mutations to be one of the primary causes of low ... as a model system, will encompass whole-genome mitochondrial sequencing, a comprehensive analysis of the ...

JCI table of contents: Sept. 4, 2007

... were also required to maintain normal levels of mitochondrial DNA, which is important for maintaining normal ... that this study indicates that inherited mitochondrial DNA–depletion syndromes in humans (a fatal class ... kinase regulates ribonucleotide reductase and mitochondrial homeostasis AUTHOR CONTACT: Gerald S. ...

Study Puts 1 Alzheimer's Theory in Doubt

... hypothesis is that there is a defect in the mitochondrial energy production system in cells, Moraes ... c oxidase ( COX ) gene, which is important for mitochondrial energy production. In addition, so-called ... around, as has been thought, Moraes said. "The mitochondrial defect in Alzheimer's disease appears to be a ...

DNA Testing Lays Romanov Murder Mystery to Rest

... and teeth which were subjected to three types of genetic testing: mitochondrial DNA, autosomal STR and Y-STR testing. The mitochondrial tests (mitochondria are passed through the mother) confirmed that the ...

Glissandra Skincare Inc. Launches Website Showcasing New and Novel Anti-Aging Skincare Products

... in comprehensively combating the leading causes of skin aging, including mitochondrial decay, oxidative damages, inflammation, adverse environmental factors, and ... ingredient to have reported the ability to simultaneously reverse mitochondrial Decay and enhance cellular anti-oxidant capability," says Huang. ...

Best New Product Awards Winners Named at Molecular Medicine Tri-Conference

... Analyzer is the first analytical instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in a 96-well microplate. ... cells in minutes, using a label-free, non-destructive method. Measure mitochondrial function in primary cells, adherent cells, tumor and suspension cells and ...

A new light on the anti-tumor mechanisms of Scutellaria barbata

... ESB-induced apoptosis, cells treated with ESB underwent a rapid loss of mitochondrial transmembrane potential(delta psi m), release of mitochondrial cytochrome c into cytosol, induction of caspase-3 activity in a ...

Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery

... disorders, such as Parkinson's disease, have highlighted the importance of mitochondrial function and energy production in the maintenance of normal neural ... HD neurodegeneration by linking nuclear transcription interference with mitochondrial dysfunction at the level of the transcription co-activator PGC-1a an ...

'Iceman' Mummy Has No Modern Kin

... Age. In the new study, Italian researchers sequenced the mummy's mitochondrial DNA, which is transmitted from mother to child, after taking samples from ... report that the mummy is the oldest human to have had his or her mitochondrial DNA decoded. "What you're looking at really is a little museum of our ...
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(Date:7/10/2014)... German . An ... a central step of photosynthesis in action for the first ... State University used the world,s most powerful X-ray flashlight at ... of a molecular complex called photosystem II as it splits ... oxygen in earth,s atmosphere. The researchers report their results in ...
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