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Mismatch in Medical News

Stroke therapy window might be extended past nine hours for some

... could still be salvageable," Dr. Copen said. "A mismatch between the lesions suggests that a patient might ... continued to demonstrate a diffusion-perfusion mismatch between nine and 24 hours after the onset of their strokes. "Patients who have a mismatch have been successfully treated up to nine hours ...

Not All Colon Cancer Patients Need Chemotherapy: Study

... DNA mismatch in some early stage cases makes therapy of little ... of colon cancer tumors are known as deficient DNA mismatch repair (dMMR) tumors, because they have lost the ... the 15 percent of patients who have defective mismatch repair did not receive any benefit from 5-FU ...

Mayo-led study finds smoking related to subset of colorectal cancers

... lacked some or all of four proteins, known as DNA mismatch repair (MMR) proteins. These proteins keep cells ... They analyzed the tumors for presence of four DNA mismatch repair proteins known to be active in cells ... likely to develop colorectal tumors with absent mismatch repair proteins. The association between ...

Brain Scans Shed Light on Dyslexia

... mismatch occurs between seeing letter and the sound it represents, study suggests ... the minds of people with dyslexia work. The key problem seems to be a mismatch between seeing the letter and connecting it to the sound it represents or ...

Bat Saliva-Based Stroke Drug Disappoints in Trial

... neurologists involved with the new drug are questioning. "The current mismatch model is insufficient to identify those patients who would benefit," Furlan said. "We need a more sophisticated mismatch model." But another school of thought among neurologists is that a ...

Other highlights in the Feb. 12 JNCI

... syndrome. Families that carried particular mutations in one of the DNA mismatch repair genes were more likely to have a family member with Muir-Torreassociated skin lesions than those with other mutations in the DNA mismatch repair genes. On the basis of our results, we suggest that Muir-Torre ...

MDS Nordion Submits Expression of Interest Proposal to Government of Canada on Medical Isotope and Generator Production

... Canadian Nuclear Safety Commission, stated "The issue is not whether, necessarily, there's any problem with a positive coefficient. It was a mismatch between the (value) predicted in their safety case in the computer codes that said it should be negative and the actual measurements in the reactor ...

Innovative New Wellness and Nutrition Program Leverages Latest Understanding of Relationship Between Diet and Genes

... Gene Smart(TM) Takes New Approach to Diet and Exercise to Live Longer, Healthier Lives WINSTON-SALEM, N.C., June 11 /PRNewswire/ -- The mismatch between today's typical diets and our genes has been a major contributor to the nation's health crisis, including obesity and chronic inflammatory ...

Gene Screen May Predict Colon Cancer's Return

... the two older screens. "The new tool is an independent important variable," Kerr said. "There would be 70 percent of patients in whom T-stage and mismatch will not be informative and we think that, in this group, the new tool will provide a useful addendum to the clinical decision-making process." ...

Genomic Health's Oncotype DX(R) Colon Cancer Test Predicts Individualized Recurrence Risk for Stage II Colon Cancer Patients

... clinical value beyond standard measures. The study showed that the colon cancer Recurrence Score maintained significance (p=0.008), independent of mismatch repair (MMR), also known as MSI (Microsatellite Instability), T-stage, nodes examined, grade and lymphovascular invasion. These findings, which ...

American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research

... RNA and microRNA biology Cholangiocarcinoma in Liver Transplantation Transplant Tourism Clinical Trials Impact of the Acceptable mismatch in Europe on the Transplantation Rate of Highly Sensitized Patients ... more vital presentations For more information about the ...

Living Kidney Donation Chains May Help More Get Transplants

... and Transplantation Network. Many of these people have a friend or family member who is willing to donate a kidney but can't because of a mismatch or other problem. People can find themselves unable to donate to a loved one if their blood type doesn't match or if they've developed certain ...

Also in the Feb. 24 JNCI

... John's, Newfoundland, and colleagues tested the ability of four models to distinguish between individuals who did and did not carry mutations in DNA mismatch repair genes. They examined a series of 725 colorectal cancer patients whose mutation status was known. By analyzing such factors as the age of ...

David G. Mutch Elected 41st President of the Society of Gynecologic Oncologists

... chapters on the treatment of cancers of the female reproductive tract. Currently, Dr. Mutch is the co-PI on an NIH grant looking at defective DNA mismatch repair in endometrial cancers. Prior to being named SGO's president, Dr. Mutch served as the Society's President Elect, was the Chair of the ...

Positive Outlook Cuts Chances of Dementia

... "We have shrinking resources for doing any type of Alzheimer's work in a time when the population for the disease is growing, and there is clearly a mismatch between the public health imperative that Alzheimer's brings us and our reaction to it," said Thies. "What we really need are enough resources to ...

Certified ER Docs in Short Supply to Meet Future Needs

... the worst-case scenario the goal would never be met. Even under the best-case scenario, it would take more than a decade to achieve the goal. "The mismatch between the supply and demand ... is a longstanding problem," said Camargo, an associate professor of emergency medicine at Harvard Medical School. ...

Parents Not Best Barometer of Kid's Eating, Exercise Habits

... Survey found mismatch between perception, reality FRIDAY, Jan. 9 (HealthDay News) -- Parents may not always be the best barometer of their child's eating and ...

Supply of board-certified emergency physicians unlikely to meet projected needs

... 100 percent staffing of all emergency departments with board-certified emergency physicians would not happen for more than a decade. "The mismatch between the supply and demand for residency-trained, board-certified emergency physicians is a longstanding problem," Camargo says. "The need for ...

The Cancer Genome Atlas reports first results, Johns Hopkins Kimmel Cancer Center collaborates

... the commonly-used alkylating agent temozolomide, the new TCGA research found that treatment also appears to cause mutations in other genes, known as mismatch repair genes, essential to DNA repair. These mutations, they believe, lead to recurrence of the cancer, and these recurrent tumors contain unusually ...

After ER visit, many patients in a fog, U-M study finds

... of two emergency departments, and were released to go home. They compared those interviews with the patients' medical records, and found a serious mismatch between what doctors and nurses found or advised, and what patients comprehended. What's worse, patients were pretty sure of what they "knew" 80 ...

Telemedicine a Cost-Effective Alternative to ER Visits

... McConnochie, a professor of pediatrics at the University of Rochester's Golisano Children's Hospital at Strong, said in a prepared statement. "This mismatch of needs and resources is inefficient, costly and impersonal for everyone involved." McConnochie and his colleagues, who direct a Rochester-based ...

Telemedicine could eradicate many expensive ED visits

... M.D., M.P.H., the studys lead investigator and a professor of Pediatrics at the University of Rochesters Golisano Childrens Hospital at Strong. This mismatch of needs and resources is inefficient, costly and impersonal for everyone involved. McConnochie and colleagues who direct Health-e-Access, a ...

Donor Dogs Give the Gift of Life

... predisposing problem that we can foresee." Dogs are different from humans, Hale said, in that they lack natural antibodies that can trigger blood mismatch reactions. However, once any dog has received one transfusion, those antibodies will be created, rendering a second transfusion much riskier unless ...

Study uncovers cause of flu epidemics

... Last year the infections were dominated by H1N1 but we had no way of predicting it, said Nelson. This year the vaccine failure is due to the H3N2 mismatch because researchers picked the wrong strain. The H1N1 virus is particularly unusual because it disappeared completely in 1957, only to ...

Study: highly involved patients don't always see better health outcomes

... preferences didn't match their doctors' role preferences. While this study did not assess providers' preferences, previous research suggests that a mismatch between patients' and providers' role preferences impacts adherence to treatment recommendations. (See related UI study at ...

AST to Address New Concept in Organ Allocation at March 13-16 Winter Symposium

... based on several candidate-specific factors, including age, diabetes status, BMI, albumin, degree of sensitization (PRA), and degree of HLA mismatch with a potential donor. The goal of this new system is to provide the most kidneys possible to those who will benefit most. There are many issues to ...

'Mini transplant' patients' outcomes similar using related and unrelated donor cells

... June 2006. After adjusting for confounding factors such as comorbidities, relapse risk, patient age, stem-cell source, preparative regimen, and sex mismatch of donor and recipient, researchers found no statistically significant differences between patients who received unrelated and related matched donor ...

Fit to fight: $1 million grant to focus on firefighters' health

... Brown said, even though work at the fire scenes usually involves short but intense exertions of power and strength, not aerobic activity. "The mismatch is comparable to training an athlete for the wrong sport," Brown said. ...

FDA Approves Expanded Label for FluMist(R) to Include Children Two to Five Years of Age

... strains are circulating strains that are different from those included in manufacturing the season's flu vaccines. According to CDC data, vaccine mismatch has occurred to varying degrees in five of the last 11 flu seasons, most recently during the 2005-2006 season. About FluMist FluMist is a live ...

Psychiatrists are the least religious of all physicians

... who share their views on lifes big questions," Curlin said. That may be especially true in psychiatry, where communication is so essential. The mismatch in religious beliefs between psychiatrists and patients may make it difficult for patients suffering from emotional or personal problems to find ...

Virus Could Help Drive Obesity

... our society," said Kahn, who is also a professor of medicine at Harvard Medical School. "In general, to become obese there has to be some sort of mismatch between energy intake and energy expenditure," she noted. Again, that gets back to the same old advice: Eat healthfully and exercise regularly to ...

New Screening Protocol Identifies More Case Of Lynch Syndrome

... nonpolyposis colorectal cancer (HNPCC), is caused by mutations in DNA mismatch repair genes, the genes that fix errors that occur during DNA replication. ... HNPCC. From those families, 112 patients were screened for mutations in mismatch repair genes, often a telltale sign of HNPCC. The screening procedure ...

New Test May Better Identify Certain Colorectal Cancer Types

... Some people with colorectal cancer have defects in their so-called DNA mismatch repair genes. Researchers test for these mutations by looking for a gene ... identified--and more accurately ruled out--patients with defects in DNA mismatch repair genes. Furthermore, their results suggest that an even simpler test ...

Model Predicts Colon Cancer Inheritable Genetic Defects

... a person’s probability of carrying a particular defect within so-called mismatch repair genes. The study is published in the September 27, 2006, issue of ... duplication of the genetic code when new cells are made, and are known as mismatch repair (MMR) genes. Of the projected 600,000 MMR mutation carriers in the ...

Moon, the Best Place to Assess the Earths Climate Changes

... the instruments on its surface from getting good measurements from the poles. What is more, a day on the Moon lasts 28 Earth days. The mismatch makes it difficult to interpret variations in radiation, which can be caused by seasons on Earth, Wielicki says, and also observes that placing ...

Cord Blood Transplant Benefits Blood Cancer Patients

... Remarkably, mismatched cord blood performed as well as matched bone marrow as measured by leukemia-free survival rates, providing the degree of mismatch was limited and the number of cord blood cells available was sufficient. Furthermore, study participants who received matched cord blood had a ...

Cord Blood Yields Better Results Than Bone Marrow Transplant for Cancer Patients

... Researchers found that mismatched cord blood was as good as matched bone marrow after measuring leukemia-free survival rates, implying that the mismatch was in a limited degree and the amount of cord blood cells that existed were adequate. The study also found that participants who got matched ...

Are Computer-aided Mammogram Reports Reliable?

... from which the mammogram reports were taken, had adopted computer-aided technology to decipher the mammograms. The study revealed the enormous mismatch in diagnosis when computer aided technology was used to decipher mammograms. In the case of human-deciphered mammograms, 98 out of every 1,000 women ...

Breakthrough in Converting Blood Groups

... there is no time to determine the patient's own group. An additional pressure on type-O blood, particularly in the United States, comes from the mismatch between blood donors and recipients. Most US donors are Caucasian, amongst whom 45 per cent of people are blood group O. But more than half of ...
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