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Metabolize in Medical News

FDA Warns of Codeine Risk for Some Nursing Mothers

... Some women metabolize the drug quickly, raising chance of morphine ... mothers who use medicines containing codeine and metabolize the drug quickly may be putting their baby at ... These women are genetically predisposed to metabolize codeine more rapidly and completely than other ...

Gene Mutation Increases Drug Toxicity, Rejection Risk in Pediatric Kidney Transplants

... -- Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at ... specific point mutation in the gene that helps break down the drug, UGT, metabolize the drug slower. This point mutation, called UGT1A9-331, causes ...

Story ideas for health reporters covering the summer Olympic Games

... exercise causes lactic acid levels to build up faster than the body can metabolize it. For athletes, this can be good because in the process of generating ... Running Economy How well your muscles use oxygen and how well they can metabolize glucose without producing a lot of lactic acid in the skeletal muscle ...

A Sweet Way to Shield Baby's Teeth

... he added. A diet high in sugar promotes the bacteria that take in sugars, metabolize them, and produce the lactic acid that creates tooth decay, the researcher ... he added. The bacteria, which are the "bad actors" here, can't metabolize sugars from xylitol, and so they die off, Milgrom explained. Only the ...

Research findings may lead to new ways to study and fight diabetes

... Normally, a hormone called insulin signals a persons cells to take in and metabolize glucose. In diabetics, however, either not enough insulin is being ... and fatty acids in a very precise balance to regulate their metabolism. To metabolize fatty acids, PPAR-alpha breaks them up into small pieces and can then ...

Anti-smoking strategy targets fourth-graders, parents in rural and urban Georgia

... are huffing and puffing on or that you are exposed to. Whites tend to metabolize and excrete nicotine more quickly than blacks, resulting in more adverse ... in blacks, according to her previous studies looking at four genes that metabolize nicotine. Smoking rates among all Georgia students have increased since ...

Patents Issued Covering Stable Tablet Formulation and Once Daily Dosing Regimen for Kuvan

... form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency ...

European Medicines Agency (EMEA) Approves Cell Therapeutics, Inc.'s September Meeting Request to Discuss OPAXIO(TM) Marketing Authorization Application

... allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may ...

The microbial hydrocarbon diet

... the hydrocarbon n-hexadecane. The bacterium was initially isolated from the Daqing oil field in North East China where it had evolved the ability to metabolize this chemical. Bioremediation of hydrocarbons usually involves the application of a cultured bacterium that has been optimized to feed on the ...

Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer

... (Femara) and exemestane (Aromasin), "are one possible alternative to tamoxifen. There are also genotyping issues -- how different individuals metabolize the various drugs. This is not standard of care but it can be checked." More information There's more on tamoxifen at the U.S. National ...

BioMarin Receives 2009 Corporate Award for the Development of Kuvan

... genetic metabolic disorder that, when left untreated, can result in mental retardation and other neurological problems. Individuals with PKU cannot metabolize an essential amino called phenylalanine, or Phe, which is found in most foods; this results in a dangerous accumulation of Phe in the blood, which ...

Do Fad Diets Really Work?

... Eating at night makes you gain weight. While a full belly might not make for the most restful night of sleep, our bodies don't metabolize food differently in the evening than at other times of the day. Weight gain has nothing to do with when we eat, but rather what we eat and how much. ...

ASHG hosts fourth annual DNA Day essay contest, supports genetics education efforts

... the surprising complexity of phenylketonuria (or PKU), which is a rare, inherited single-gene disorder that affects a person's ability to properly metabolize the amino acid phenylalanine and, if left untreated, can cause problems with brain development that could lead to mental retardation. In her essay, ...

Scientists From 25 Countries Sequence Cow Genome

... both cows and humans have a gene for growth hormone, Taylor said. Scientists were able to tell that cows have specialized genes that help them metabolize food. And both genomes may have adapted to each other. "Humans drink a lot of cow's milk and that's resulted in a change in the human genome so we ...

Genetic changes outside nuclear DNA suspected to trigger more than half of all cancers

... team found 106 genes specific to head and neck cancer that were activated by the demethylation process. "Some of the genes regulate growth, others metabolize sugars and some have already been linked to cancer development," says Califano, who is director of head and neck cancer research at the Milton J. ...

Nuvilex, Inc. Launches Spring Break Initiatives Designed to Raise Visibility Among Key Demographic Group

... is packaged in a 2 ounce tube and it meant to be taken in one shot, followed by 16 ounces of water, before going to sleep. Last Shot helps the body metabolize the sugar in alcohol, thereby eliminating or at least minimizing hangovers. About Nuvilex, Inc. Nuvilex, formerly eFoodSafety.com, is an ...

New information points to safer methadone use for treatment of pain and addiction

... can interfere with the activity of P4503A but increase the activity of P4502B. This paradox is highly unusual, and because these two enzymes metabolize so many prescription drugs, there are many potential drug interactions that we'll be able to understand better if we can get a better handle on how ...

CTI Focuses on Late-Stage Drug Approvals and Commercialization and Cuts Operating Costs: to Close Bresso Research Center

... allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may ...

States Expand Newborn Screening for Life-Threatening Disorders; New March of Dimes Report Finds State-By-State Gaps Nearly Eliminated

... was born in was part of a pilot program to expand newborn screening in California." 3MCC is a serious disorder that leaves newborns unable to metabolize leucine -- an essential amino acid found in many forms of protein. But because Giana, now age six, was diagnosed early, she was put on a special diet ...

Controversial Chemical Lingers Longer in the Body: Study

... a new study says. The finding suggests that exposure to BPA may come from many different sources, not just food products, or that the body doesn't metabolize the chemical as fast as has been thought, the researchers said. The finding also adds to the controversy about the health consequences of exposure ...

Problems Tied to Obesity Also Seem to Affect Sleep

... Respiratory and Critical Care Medicine . A John Hopkins University study found a strong tie between insulin resistance -- the body's inability to metabolize glucose -- and sleep-disordered breathing (SDB), pauses or other abnormalities in breathing while sleeping. "What our research tells us is that ...

Sleep disordered breathing and obesity: Independent effects, causes

... "Our major finding was that, as we suspected, SDB was strongly associated with a decrease in the three major metabolic pathways that the body uses to metabolize glucose insulin sensitivity, glucose effectiveness, and pancreatic cell function independent of adiposity," said Dr. Punjabi. "What our research ...

New Year, Old Myths, New Fatalities

... Fact: Caffeine may help with drowsiness, but it doesn't counteract the effect of alcohol on decision-making or coordination. The body needs time to metabolize (break down) alcohol and even more time to return to normal. There are no quick cures--only time will help. Before You Celebrate -- Plan ...

Mayo Clinic researchers find tamoxifen's power comes from endoxifen

... be able to replace tamoxifen," says Dr. Goetz. "We believe it is the most potent metabolite, and we would not be restricted by CYP2D6's inability to metabolize it, or by limits on how much endoxifen the liver could make. It will take years before we know whether this is the case, but we are excited about the ...

New Vaccine May Help Type 1 Diabetics in Future

... in a 'civil war,' " said Ludvigsson. This civil war leads to a lack of insulin in the body, and insulin is a key hormone that allows the body to metabolize carbohydrates and sugar from foods. Without replacement insulin, people with type 1 diabetes would die. Even with treatment, there are numerous ...

UT Southwestern scientists discover leptin can also aid type 1 diabetics

... million people in the U.S., the pancreatic islet cells that produce insulin are destroyed. Type 1 diabetics must take insulin multiple times a day to metabolize blood glucose and regiment their diets. In comparison, patients with non-insulin dependent, or type 2, diabetes make insulin, but their bodies don't ...

Taking Codeine While Breast-Feeding May Harm Infant

... the health of their infant, new Canadian research suggests. The study indicates that a relatively rare genetic predisposition causes some women to metabolize codeine-laced drugs into morphine far faster than normal -- possibly harming the infant's central nervous system in the process. In such cases, ...

Craig W. Philips Takes Helm at CTI

... allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may ...

Mayo Clinic on the Summer Olympic Games: Better Athletes, the Physiology of Performance, the Lactate Threshold, the Aging Athlete and Much More

... Dr. Joyner says. Old Wives' Tales - The Lactate Threshold Intense exercise causes lactic acid levels to build up faster than the body can metabolize it. For athletes, this can be good because in the process of generating lactic acid, energy for muscle is also being generated. However, Dr. Joyner ...

Vitalize(TM) Receives Top Multivitamin Rating

... . About Vitalize Vitalize is available in Men's, Women's, Senior Women's Gold and Canadian Formulas. The makers of Vitalize also produce metabolize for weight management and Mobilize for joint support. More information about Vitalize can be found at http://www.creatingwellness.com . About ...

DNA Direct and Iverson Genetics Announce Partnership to Provide Personalized Patient Reports for Warfarin Dosing Test Results

... type of testing into standard patient care." Over two million patients are prescribed warfarin in the United States each year, one third of whom metabolize it differently than expected and experience a higher risk of bleeding.(1) Approximately 85,000 serious bleeding events and 17,000 strokes each year ...

Same drug, different results: MUHC researcher on the path to personalized medicine

... diseases are often treated with medications that affect folate metabolism, but physicians are not trained to verify how patients naturally metabolize folate, even though this could be an important factor in effective treatment. "This is a first step towards personalized medicine that is based ...

Islet Cell Transplants Aid Type 1 Diabetics

... fewer side effects. Islet cells -- also called beta cells -- are cells in the pancreas that produce insulin, a hormone necessary for the body to metabolize glucose, or blood sugar. In type 1 diabetes, the rarer form of the disease, antibodies in the body mistakenly attack the islet cells and destroy ...

Other highlights in the April 29 JNCI

... 2D6 (CYP2D6) converts tamoxifen into its metabolically active form called endoxifen. The enzymes encoded by different variants of the CYP2D6 gene metabolize tamoxifen at different rates. For example, women who carry two copies of the CYP2D6 *4 allele have less endoxifen in their blood than women who ...

Muscle Weakness Found in Some Autistic Children

... according to the United Mitochondrial Disease Foundation (UMDF). Mitochondria are vital to survival, because they make oxygen available to cells and metabolize food into energy for cells to thrive. Defects in mitochondria can lead to cell injury, or even cell death, according to UMDF. Symptoms of ...

Molecular science could further improve leukemia survival, say St. Jude researchers

... them from toxicity. For instance, a genetic alteration affects an enzyme called thiopurine methyltransferase. Children with this alteration cannot metabolize a certain anti-cancer drug, and the active metabolite of the drug can accumulate in the body until it reaches toxic levels. About 10 percent of ...

Fewer Steps Per Day Send Disease Markers Up

... 60 percent, suggesting that the body was no longer efficiently processing glucose (energy) from food and needed to increase insulin production to metabolize the sugar in food. The second group included 10 men with an average age of 23.8 years and a BMI of 22.1. At the start of the study, their ...

Study helps explain fundamental process of tumor growth

... oxygen consumption a reversal of the Warburg effect. We were able to show that only cells which express the M2 form of pyruvate kinase and metabolize glucose in the way described by Otto Warburg 80 years ago had the ability to form tumors in mice, notes Cantley. In addition, the investigators ...

Protein deficiency leads to faster fat burning in mice, study shows

... shown to some extent that there is increased fatty acid oxidation. We found that they use more oxygen, so that means they are using this oxygen to metabolize fat, convert it into carbon dioxide and expel it when they breathe, said Madhu Mehta, a clinical consultant and co-author on the study and assistant ...

Hazelden Publishing Unveils Valuable New Resource for Women Seeking Recovery From Addiction

... and receiving treatment are unique for women because: -- Women start using alcohol and drugs for different reasons than men. -- Women metabolize alcohol and drugs different than men, enabling them to become addicted more quickly and experience more progressive and destructive ...
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