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Metabolite in Medical News

Advanced blood analysis may speed diagnosis of heart attacks

... heath status. But the technology to assess metabolite levels is in the early stages, as is the ... of their significance. For instance, how much metabolite levels normally vary between healthy individuals ... heart cells to reduced oxygen and found that one metabolite increased cell death, while two others decreased ...

DDT Compound Speeds Breast Cancer Growth

... Insecticide metabolite disrupts hormone-sensitive cells, study finds ... Breast Cancer Research , suggests that DDT's main metabolite blocks a pathway of a hormone that would ... de sant publique in Quebec found that the metabolite blocked the androgen receptors (AR) found on ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... beta-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl- ... Both lovastatin and its beta-hydroxyacid metabolite are highly bound (>95%) to human plasma proteins. ... of lovastatin and its beta-hydroxyacid metabolite (as measured by the area under the ...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

... was given fasting on day 1 or with a meal on day 8. Excretion of the main metabolite PAGN was similar between healthy adults and cirrhotic subjects. Urinary ... dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle ...

Urine test may determine if a smoker is at risk for lung cancer

... question." Yuan and colleagues hypothesized that the presence of the metabolite NNAL in a patient's urine might predict risk of lung cancer. This metabolite has been shown to induce lung cancer in laboratory animals, but the effect ...

Study sheds new light on link between obesity and infertility

... 2006 to April 2007. Dr. Robker and her colleagues measured hormone and metabolite levels in follicular fluid obtained from the subjects' ovaries during ... an altered ovarian follicular environment, particularly increased metabolite and androgen activity levels, which may be associated with poorer ...

AutoGenomics CYP 2C19 Test Used in Study to Personalize Clopidogrel (Plavix) Dosing in Patients

... antiplatelet effect, Clopidogrel requires biotransformation to an active metabolite by cytochrome P-450 enzymes. "Personalizing Clopidogrel dosing ... reduced function CYP C219 genetic variant had lower levels of the active metabolite resulting in a reduced antiplatelet response to the drug and a three-fold ...

Effective new treatment for schizophrenia

... (ER) tablets, an investigational drug which orally delivers the active metabolite of the drug risperidone, which is an already established efficacious ... Institute, comments, This study demonstrates the efficacy of the 9-hydroxy metabolite of risperidone that has antipsychotic efficacy and an acceptable safety ...

Study shines more light on benefit of vitamin D in fighting cancer

... to 177 countries to estimate the average serum level of a vitamin D metabolite of people living there. The data revealed an inverse association of ... who may order and interpret a simple blood test for a vitamin D metabolite [25(OH)D], and provide a dosage recommendation thats appropriate for the ...

Daiichi Sankyo and Lilly Receive U.S. FDA Approval for Effient(TM)

... as omeprazole, also inhibit CYP2C19(iii). As stated in the Plavix prescribing information, studies have shown that formation of clopidogrel's active metabolite may be affected by patients with reduced CYP2C19 function or by drugs that inhibit CYP2C19, including certain proton pump inhibitors such as ...

Hyperion Therapeutics Raises $60 Million Series C

... The most common adverse reactions associated with BUPHENYL were amenorrhea dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these ...

Jazz Pharmaceuticals to Present Data From First Phase III Study of Sodium Oxybate in Patients With Fibromyalgia

... the end of 2009. About Sodium Oxybate Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. ...

American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications

... layer of the skin). Etretinate was the first retinoid introduced for the treatment of severe psoriasis and was replaced by acitretin, the active metabolite of etretinate, in 1988. Efficacy & Dosage Clinical studies suggest that when used alone, acitretin is the least effective of the ...

Watson Launches GELNIQUE(TM) (oxybutynin chloride) Gel 10%, First and Only Topical Gel for Overactive Bladder (OAB)

... in the same way as orally administered oxybutynin. It bypasses fist-pass metabolism, which reduces the formation of the N-desethyloxybutynin metabolite (N-DEO), which may be linked to unwanted side effects such as dry mouth and constipation. In clinical trials, GELNIQUE users reported low levels of ...

Benzene Litigation Conference July 24

... who said the panel will "update benzene litigators regarding benzene-containing products currently in litigation, cases regarding the benzene metabolite hydroquinone, recent scientific research identifying benzene-related chromosomes and genes which can be used to establish causation, new studies ...

Potential lung disease biomarkers yield clues to COX-2 inhibitor side effects

... disease. The researchers had hypothesized that early-stage lung injury could "turn on" the COX-2 gene, increasing levels of the major prostaglandin metabolite PGE-M in the urine. In addition to determining PGE-M levels, the investigators also looked at levels of the biomarker leukotriene E4 (LTE4), ...

New Data Presented at AUA's Annual Conference Prove GELNIQUE(TM) (oxybutynin chloride) 10% gel is an Effective, Safe Option for Female Overactive Bladder (OAB) Patients

... in the same way as orally administered oxybutynin. It bypasses fist-pass metabolism, which reduces the formation of the N-desethyloxybutynin metabolite (N-DEO), which may be linked to unwanted side effects such as dry mouth and constipation. In clinical trials, GELNIQUE users reported low levels of ...

Colon cancer shuts down receptor that could shut it down

... with cancer-killing potential. Researchers report in the April issue of Cancer Research that the GPR109A receptor is activated by butyrate, a metabolite produced by fiber-eating bacteria in the colon. The receptor puts a double-whammy on cancer by sending signals that trigger cell death, or apoptosis, ...

Biomarker associated with poor outcome in aggressive childhood cancer

... information about the molecular signals that are involved in the progression of this often devastating pediatric cancer. Retinoic acid (RA) is a metabolite of Vitamin A that has important influences over the processes of growth and differentiation. RA mediates gene expression by interacting with retinoic ...

Alcohol 'flush' signals increased cancer risk among East Asians

... DNA damage and has other cancer-promoting effects. ALDH2 is the main enzyme responsible for breaking down acetaldehyde into acetate, a non-toxic metabolite in the body. East Asians have two main variants of the ALDH2 gene -- one that produces an enzyme with normal activity, and another that results in ...

Transporter could help breast cancer cells commit suicide

... Muthusamy, assistant professor of biochemistry and molecular biology in the Medical College of Georgia School of Medicine. Pyruvate is a metabolite in the blood that is lethal to rapidly-multiplying cells, like cancer, and transporters bring substances like pyruvate inside cells. Since breast ...

Researchers discover metabolite linked to aggressive prostate cancer

... of the cells and the biochemistry that occurs during cancer development," says Chinnaiyan, a Howard Hughes Medical Institute investigator. One metabolite in particular, sarcosine, appeared to be one of the strongest indicators of advanced disease. Levels of sarcosine, an amino acid, were elevated in 79 ...

Survey of metabolites finds new prostate cancer marker

... that as prostate cancer develops and progresses, sarcosine levels increase in both tumor cells and urine samples, suggesting that measurements of the metabolite could aid in non-invasively diagnosing the disease. Researchers might also be able to inhibit prostate cancer's spread by designing drugs that ...

Urine Test May One Day Predict Prostate Cancer

... Chinnaiyan said. The findings are preliminary, though, Chinnaiyan noted, and it would be years before a test or treatment based on the metabolite could be available. Ideally, he said, researchers would like to find other metabolites associated with prostate cancer that would help predict the ...

Instrumentation Laboratory Wins Extended Agreement With MedAssets Supply Chain Systems for Critical Care Portfolio

... care analyzers, reagents, consumables and service, including IL's flagship product, the GEM Premier 4000 analyzer for blood gas, electrolyte and metabolite and integrated CO-Oximetry testing. This analyzer features IL's patented Intelligent Quality Management (iQM), a real-time, automated, quality ...

Gene Boosts Drinkers' Colon Cancer Risk

... The team examined how disease risk might be affected by the varying speeds with which white individuals convert ethanol (alcohol) into a particularly metabolite called acetaldehyde. This ethanol-to-acetaldehyde conversion process can be particularly rapid among those whites who carry a particular gene ...

Mayo Clinic researchers find tamoxifen's power comes from endoxifen

... SAN ANTONIO - Mayo Clinic researchers have discovered that a chemical known as endoxifen appears to be the primary metabolite responsible for the effectiveness of tamoxifen in treating breast cancer, and that it works against cancer in an entirely unexpected way. Their ...

Newborns exposed to maternal smoking more irritable, difficult to soothe

... of cigarette use during pregnancy assessed shortly after babies were born. This was verified biochemically by measuring cotinine, the primary metabolite of nicotine, in the mother's saliva. Cotinine is readily passed from mother to infant, with the baby absorbing nearly as much as the mother does. ...

Studies show novel device may enhance chemotherapy treatment in brain tumors

... SNO STUDY DETAILS The in vitro study looked at the effects of TTFields alone and in combination with DTIC, a precursor of MTIC (the active metabolite of Temozolomide) in human GBM cells. The results demonstrated that, when applied together with DTIC, TTFields drastically increased the sensitivity ...

Waters To Unveil Xevo TQ MS Applications for Improved Drug Discovery at AAPS 2008

... with an Easy-to use Tandem Quadrupole Mass Spectrometer -- An Introduction to UPLC Technology -- An Intelligent UPLC/TOF MS Workflow for metabolite Identification -- A Simple, Strategic Approach to Method Development -- Maximizing Sensitivity and Flexibility in a Bioanalytical Assay with ...

Moms' Smoking Linked to Increased Risk of Birth Defects

... on women's self-reported smoking habits during pregnancy. Instead, researchers used the more reliable method of measuring the levels of cotinine, a metabolite of nicotine, in the blood from about 500 pregnant women. "This research is the first time we've been able to measure something -- in this case ...

New evidence strengthens link between cigarette smoke exposure and poor infant health

... and 2005 from pregnant women enrolled in the California Expanded AFP (alpha fetoprotein) program. The researchers measured the levels of cotinine, a metabolite of nicotine, to determine whether the mothers smoked during pregnancy. They found that women who smoked during pregnancy were nearly 2.5 times more ...

Moms' smoking linked to increased risk of birth defects

... on women's self-reported smoking habits during pregnancy. Instead, researchers used the more reliable method of measuring the levels of cotinine, a metabolite of nicotine, in the blood from about 500 pregnant women. "This research is the first time we've been able to measure something in this case ...

New CHARISMA Outcome Study Results Validate Aspirin Effect

... is the only FDA-cleared test that measures urinary 11dhTxB2 to accurately determine aspirin effect in apparently healthy individuals. 11dhTxB2 is a metabolite of thromboxane, the target of aspirin therapy. The new findings, published in the October 21 issue of the American Heart Association's ...

UNC trial: oral contraceptives may ease suffering of women with severe PMS

... of continuous administration of birth control pills, so the ability of the study to identify the role of neurosteroids like allopregnanolone (a metabolite of progesterone) in PMDD is unique. During the trial, researchers will test three groups of 27 women for a three-month period. One group will ...

Dietary Supplement May Prevent Breast Cancer

... two known risk factors for breast cancer. Resveratrol induces an enzyme called quinone reductase, which reduces the estrogen metabolite back to inactive form and reduces breast cancer risk, Rogan explained. The findings, which are in the July issue of Cancer Prevention Research , ...

Watson Announces Oxybutynin Topical Gel NDA Accepted for Filing by FDA for the Treatment of Overactive Bladder

... concentrations over a 24-hour period. By administering oxybutynin through the skin, OTG avoids first pass metabolism and the resultant high metabolite levels seen with oral oxybutynin dosing. A nickel-sized, one-gram unit dose of OTG, applied once daily, delivers about 4mg oxybutynin each day. ...

Gene May Be Key to Pregnancy Complication

... high blood pressure, protein in the urine and swelling. The COMPT (catechol-O-methyltransferase) gene is involved in breaking out estrogen into a metabolite called 2ME (2-methoxyestradiol), which prevents a shortage of oxygen in the placenta. When the gene does not function properly, levels of 2-ME are ...

Other highlights in the April 29 JNCI

... pesticides and metabolites tested. For example, men in the highest quartile for DDE (p,p'-dichlorodiphenyldichloroethylene)--which is a persistent metabolite of DDT (p,p'-dichlorodiphenyltrichloroethane)--were 1.7 times more likely to develop testicular germ cell tumors than those with the lowest ...

Drug Failed to Reduce Heart Attack Risk After Bypass

... fibrillation or kidney function TUESDAY, April 1 (HealthDay News) -- Researchers found that giving patients MC-1, a naturally occurring metabolite of vitamin B6, before and after bypass surgery didn't reduce the risk of heart attack or cardiovascular death. "Coronary artery bypass graft ...
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