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Metabolism in Medical News

Therapy should extend beyond childhood

... during the course of the disease, the products of metabolism cause not only acute, but chronic toxic damage as ... In addition, intensive emergency treatment of the metabolism must be carried out to prevent a metabolic crisis ... during the course of the disease, the products of metabolism cause not only acute, but chronic toxic damage as ...

Brain Imaging (MRI/PET) and Measurements of Proteins in Spinal Fluid May Improve Alzheimer's Prediction and Diagnosis

... measured with MRI; relative rates of glucose metabolism in certain, prespecified brain regions measured ... on those two measurements - that is, low glucose metabolism combined with poor memory performance - were 15 ... Medicine, declines in regional cerebral glucose metabolism (rCMglc) in the brain as measured with Positron ...

Memory test and PET scans detect early signs of Alzheimer's

... scores on a memory recall test and low glucose metabolism in particular brain regions, as detected through ... found in the cerebrospinal fluid; and glucose metabolism detected in PET brain scans. A low rate of glucose metabolism in a particular brain region is considered a sign ...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

... type 2 diabetes. sEH is an enzyme involved in the metabolism of arachidonic acid, a key signaling molecule ... of concept that sEH inhibition modulates glucose metabolism or blood pressure in patients with impaired ... demonstrate that AR9281 improves glucose metabolism in rodent models of type 2 diabetes. -- "A ...

Making Obese Mice Slim, Without Diet or Exercise

... appear in two studies in the June issue of Cell metabolism . In one of the studies, researchers inserted ... use this shunt pathway to manipulate fatty acid metabolism in the liver is very exciting as a basic science ... of Medicine, New York City; June 2009, Cell metabolism ...

Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction

... that plays a key role in tumor formation, oxygen metabolism and inflammation is involved in a pathway that ... pathway known to regulate cell growth and metabolism in response to nutrients and growth factors. ... HIF-1 have mainly focused on its roles in oxygen metabolism and tumor development", said Buck faculty member ...

Agios Pharmaceuticals' founders author Science review on cancer metabolism

... on discovering and developing novel cancer metabolism drugs, announced that the leading scientific ... for physician and their patients." Cancer metabolism is a new and exciting field of biology that ... state of the emerging biological field of cancer metabolism and suggests that "a better understanding of ...

Online Diets Reviewed: Your Top 4 Metabolism Boosting, Fat Burning Plans

... This unexpected winner focuses on boosting your metabolism to lose the weight for you, so the pounds keep ... on stabilizing and increasing each person's metabolism paid off. They call it 'deceiving' your metabolism while keeping your body healthy. In the end, the ...

Protein Might Be a Troublesome Nutrient

... director of the Sarah W. Stedman Nutrition and metabolism Center at Duke University Medical Center in ... are published in the April issue of Cell metabolism . The next step is to figure out a way to ... and director, Sarah W. Stedman Nutrition and metabolism Center, Duke University Medical Center, Durham, ....

Internal Clock and Metabolism May Be Linked

... in coordinating people's circadian clocks and metabolism has been identified by U.S. researchers. The ... of a connection between the circadian clock and metabolism in animals could improve understanding of ... called SIRT1, an important regulator of aging, metabolism and longevity. The discovery that NAD and ...

Improved Genetic Test Product Empowers Individuals to Better Understand Their Unique Nutritional Needs

... an Individual's Susceptibility to Poor Vitamin B metabolism and Oxidative Stress WALTHAM, Mass., March ... genetic pattern as it relates to vitamin B metabolism and response to oxidative stress and free ... variations of the genes tested for B-vitamin metabolism may experience greater health benefits by adding ...

An Achilles heel in cancer cells

... chemotherapy." But Akt is also required for metabolism and the proliferation of cancer cells, and it was as a byproduct of its role in metabolism that the researchers were able to exploit Akt ... said. These ROS are highly reactive byproducts of metabolism that can damage the cell. Cells usually respond ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... bound to plasma proteins is low (38%). metabolism Approximately 79% of sitagliptin is excreted unchanged in the urine with metabolism being a minor pathway of elimination. ... the primary enzyme responsible for the limited metabolism of sitagliptin was CYP3A4, with contribution from ...

Post-Workout Snack May Hamper Weight Loss

... said Barry S. Braun, director of the Energy metabolism Laboratory at the University of Massachusetts ... the Journal of Applied Physiology, Nutrition and metabolism and one paper published in the Journal of ... professor, kinesiology, and director, Energy metabolism Laboratory, University of Massachusetts, Amherst; ...

Existing anti-obesity drugs may be effective against flu, hepatitis and HIV

... today in the journal Nature Biotechnology . metabolism refers to all the reactions by which living ... that viral infection takes control of cellular metabolism and drives, among other things, marked increases ... that if you target these increases in fatty acid metabolism using existing anti-obesity and anti-metabolism ...

Penn researchers find a new role for a 'Foxy Old Gene'

... lab showed that FOXA2 was important for glucose metabolism in the liver. "Our interest in using genomics ... and the Institute for Diabetes, Obesity, and metabolism at Penn. ChIP-on-Chip assay stands for ... a cluster of genes involved in lipid and steroid metabolism was identified by being bound to FOXA2," says ...

Same drug, different results: MUHC researcher on the path to personalized medicine

... of Methotrexate -- a drug that inhibits the metabolism of folate -- on mice with an altered MTHFR gene, ... in the human MTHFR gene affects human folate metabolism similarly. The results demonstrate that ... the common variant which interferes in folate metabolism in human populations. Between 10 and 15 per cent ...

Weight Gain May Not Be Based Just on What You Eat

... the brain chemical serotonin influences fat metabolism THURSDAY, June 5 (HealthDay News) -- ... published in the June issue of the journal Cell metabolism . Ashrafi and his colleagues noted that, while ... American Heart Association; June 2008, Cell metabolism ...

Hunger Hormone Makes Food Look More Tasty

... reported their findings in the May issue of Cell metabolism . The authors analyzed functional MRIs of ... of the division of endocrinology, diabetes, and metabolism at Beth Israel Deaconess Medical Center in ... Harvard Medical School, Boston; May 2008, Cell metabolism ...

Hero Nutritionals Introduces a New Adult Vitamin for the Taste Buds

... all aimed at heart and cardiovascular health with metabolism boosts and antioxidants. The Slice of Life family ... LDL or "bad" cholesterol. The Omegas regulate metabolism and help lower cholesterol. According to the ... Finally, Energy with B12 boosts metabolism while promoting a healthy nervous system. Hero ...

A potential sugar fix for tumors

... In normal cells, growth factors regulate metabolism and cell survival. Removing these factors leads to loss of glucose uptake and metabolism and cell death. Cancer cells, however, maintain glucose metabolism and resist cell death, even when deprived of ...

Fewer Steps Per Day Send Disease Markers Up

... Krogh-Madsen, from the Centre of Inflammation and metabolism in Copenhagen. "It is of special interest that impaired metabolism occurred without a total weight gain," she added. ... be doing, every lit bit helps in terms of keeping metabolism healthy," she said. DeMille recommended getting a ...

Obesity chokes up the cellular power plant

... associated with pre-diabetic changes in sugar metabolism and the action of the hormone insulin. The ... difference in weight. The body composition and metabolism of 14 of these pairs was carefully studied and a ... obesity and the early diabetic changes in the metabolism of the fat twins. In the future it will be ...

University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein

... enzyme that plays a crucial role in glycerol metabolism a discovery that could lead to important ... Recent findings also have linked glycerol metabolism to cellular processes related to aging, ... structural biology at Pitt. I think that glycerol metabolism will be on the forefront of developing treatments ...

CSHL scientists discover new details of a gene-regulatory network governing metabolism

... Cold Spring Harbor, NY metabolism is a central feature of life a myriad of ... cells, through the action of genes, adjust their metabolism in response to changes in their sources of food. ... regulating-protein called Gal4p, to adapt the metabolism of the yeast cell so that it can make use of ...

Cocaine's effects on brain metabolism may contribute to abuse

... mice, these effects on metabolism are clearly independent of cocaine's effects on ... tomography, or PET scanning, to measure brain metabolism in dopamine-transporter deficient mice (known as ... dopamine transporters had significantly higher metabolism in the thalamus and cerebellum compared with ...

Research findings may lead to new ways to study and fight diabetes

... in the nucleus of cells that regulates the metabolism of both glucose and fatty acids. The results of ... certain genes are turned on or off to control the metabolism of fatty acids. Hostetler and her colleagues ... link for the first time between fat and sugar metabolism and shows they are intimately linked and share ...

Born to Be Obese?

... was published in the February issue of Cell metabolism . Sebastien Bouret, an assistant professor of ... of the Division of Endocrinology, Diabetes and metabolism at Beth Israel Deaconess Medical Center, in ... School, both in Boston; February 2008, Cell metabolism ...

Bug guts map brings scientists closer to understanding different bugs' role in the body

... at a broad level, mainly concentrating on the metabolism of fat. This is partly because it is difficult ... fully defining how different gut bugs affect the metabolism the chemical reactions inside the body that keep ... molecular profiling of gut microbiota and host metabolism of a large cohort of people for a reasonably long ...

Evolution of human genome's 'guardian' gives people unique protections from DNA damage

... response for certain genes involved in DNA metabolism or repair to be mostly unique in humans. While ... and rhesus monkeys, researchers said DNA metabolism and repair function it is not shared at all with ... of vertebrates and non-vertebrates. DNA metabolism and repair capabilities controlled by p53 may ...

Lifestyle and cancer prevention: Making choices that change cancer risk

... to sunlight exposure, Tober said. Nicotine metabolism among African American and white smokers: Group ... we cant say from this study that differences in metabolism definitively account for lower quit rates, it ... metabolite of nicotine a product of nicotine metabolism and so it is a marker for exposure to tobacco, ...

Activating protein enhances average lifespan, limits age-related disease in mice

... St. Louis, Dec. 5, 2007 metabolism researchers at Washington University School of ... and chief of the Division of Endocrinology, metabolism and Lipid Research, had found that mice with ... in the animals by accelerating muscle metabolism with uncoupling protein delayed death and ...

A maternal link to Alzheimer's disease

... of Sciences. It is the first to compare brain metabolism among cognitively normal people who have a ... with an affected mother have reduced brain metabolism in the same brain regions as Alzheimers patients. ... have significant reductions in brain energy metabolism in certain regions of the brain. In some recent ...

Novo Nordisk Appoints Per Falk, M.D., Ph.D., as Vice President for Clinical, Medical and Regulatory Affairs for North America

... president of Clinical Development & Medical Affairs - Diabetes & metabolism where he was responsible for clinical development and medical affairs for all of Novo Nordisk's diabetes and metabolism products, including those in development and on the market. "As a ...

Why anorexic patients cling to their eating disorder

... University Hospital have discovered for the first time processes in brain metabolism that explain this disturbed eating behavior. The research work of the ... flow in various areas of the brain. Greater blood flow indicates higher metabolism and thus greater activity in this area of the brain. The participants ...

Food additive may one day help control blood lipids and reduce disease risk

... Herbert S. Gasser Professor and chief of the Division of Endocrinology, metabolism and Lipid Research. "When we gave the animals fibrate drugs that activated ... would regulate PPAR-alpha, we also knew that our ability to regulate the metabolism of fats and sugars was in place long before humans started making drugs. ...

Survey Reveals Women Aren't Doing All They Can to Support Breast Health

... and ginkgo to support memory and concentration, One A Day Women's Active metabolism for metabolism and energy support, One A Day Women's Prenatal with DHA to support healthy ...

-Contrave(R) Obesity Research Phase 3 Program Meets Co-Primary and Key Secondary Endpoints; Exceeds FDA Efficacy Benchmark for Obesity Treatments-

... system: one associated with controlling the balance of food intake and metabolism and another involved in controlling food preference, reward and cravings. ... weight loss over one year of treatment by reducing appetite, increasing metabolism and allowing the body to continue losing weight by offsetting its natural ...

Ben-Gurion U. researchers identify how stressed fat tissue malfunctions

... in the Endocrine Society's the Journal of Clinical Endocrinology and metabolism ( J. Clin. Endocrinol. Metab. 2009; 94:2507-251) "Fat tissue in ... pancreas and the brain. Normal communication is necessary for optimal metabolism and weight regulation. However, in obesity, fat (adipose) tissue becomes ...

TGen and USC researchers find genetic markers to help fight diabetes

... found that genetic variations in the PPARG gene were associated with TZD metabolism and the biological effects of TZD, and thereby contribute to the ... the scientists also systematically screened 28 key genes involved in TZD metabolism or PPARG-stimulated pathways. Of the markers examined, DiStefano and ...
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