Therapy should extend beyond childhood
... during the course of the disease, the products of metabolism
cause not only acute, but chronic toxic damage as ... In addition, intensive emergency treatment of the metabolism
must be carried out to prevent a metabolic crisis ... during the course of the disease, the products of metabolism
cause not only acute, but chronic toxic damage as ...
Brain Imaging (MRI/PET) and Measurements of Proteins in Spinal Fluid May Improve Alzheimer's Prediction and Diagnosis
... measured with MRI; relative rates of glucose metabolism
in certain, prespecified brain regions measured ... on those two measurements - that is, low glucose metabolism
combined with poor memory performance - were 15 ... Medicine, declines in regional cerebral glucose metabolism
(rCMglc) in the brain as measured with Positron ...
Memory test and PET scans detect early signs of Alzheimer's
... scores on a memory recall test and low glucose metabolism
in particular brain regions, as detected through ... found in the cerebrospinal fluid; and glucose metabolism
detected in PET brain scans. A low rate of glucose metabolism
in a particular brain region is considered a sign ...
Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281
... type 2 diabetes. sEH is an enzyme involved in the metabolism
of arachidonic acid, a key signaling molecule ... of concept that sEH inhibition modulates glucose metabolism
or blood pressure in patients with impaired ... demonstrate that AR9281 improves glucose
in rodent models of type 2 diabetes.
-- "A ...
Making Obese Mice Slim, Without Diet or Exercise
... appear in two studies in the June issue of Cell metabolism
In one of the studies, researchers inserted ... use this shunt pathway to manipulate fatty acid metabolism
in the liver is very exciting as a basic science ... of Medicine, New York City; June 2009, Cell metabolism
Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction
... that plays a key role in tumor formation, oxygen metabolism
and inflammation is involved in a pathway that ... pathway known to regulate cell growth and metabolism
in response to nutrients and growth factors.
... HIF-1 have mainly focused on its roles in oxygen metabolism
and tumor development", said Buck faculty member ...
Agios Pharmaceuticals' founders author Science review on cancer metabolism
... on discovering and developing novel cancer metabolism
drugs, announced that the leading scientific ... for physician and their patients."
is a new and exciting field of biology that ... state of the emerging biological field of cancer metabolism
and suggests that "a better understanding of ...
Online Diets Reviewed: Your Top 4 Metabolism Boosting, Fat Burning Plans
... This unexpected winner focuses on boosting your metabolism
to lose the weight for you, so the pounds keep ... on stabilizing and increasing each person's metabolism
paid off. They call it 'deceiving' your metabolism
while keeping your body healthy. In the end, the ...
Protein Might Be a Troublesome Nutrient
... director of the Sarah W. Stedman Nutrition and metabolism
Center at Duke University Medical Center in ... are published in the April issue of Cell metabolism
The next step is to figure out a way to ... and director, Sarah W. Stedman Nutrition and metabolism
Center, Duke University Medical Center, Durham, ....
Internal Clock and Metabolism May Be Linked
... in coordinating people's circadian clocks and metabolism
has been identified by U.S. researchers.
The ... of a connection between the circadian clock and metabolism
in animals could improve understanding of ... called SIRT1, an important regulator of aging, metabolism
The discovery that NAD and ...
Improved Genetic Test Product Empowers Individuals to Better Understand Their Unique Nutritional Needs
... an Individual's Susceptibility to Poor Vitamin B metabolism
and Oxidative Stress
WALTHAM, Mass., March ... genetic pattern as it relates to vitamin B metabolism
and response to oxidative stress and free ... variations of the genes tested for B-vitamin metabolism
may experience greater health benefits by adding ...
An Achilles heel in cancer cells
But Akt is also required for metabolism
and the proliferation of cancer cells, and it was as a byproduct of its role in metabolism
that the researchers were able to exploit Akt ... said. These ROS are highly reactive byproducts of metabolism
that can damage the cell. Cells usually respond ...
New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
... bound to plasma proteins is low (38%).
Approximately 79% of sitagliptin is excreted unchanged in the urine with metabolism
being a minor pathway of elimination.
... the primary enzyme responsible for the limited metabolism
of sitagliptin was CYP3A4, with contribution from ...
Post-Workout Snack May Hamper Weight Loss
... said Barry S. Braun, director of the Energy metabolism
Laboratory at the University of Massachusetts ... the Journal of Applied Physiology, Nutrition and metabolism
and one paper published in the Journal of ... professor, kinesiology, and director, Energy metabolism
Laboratory, University of Massachusetts, Amherst; ...
Existing anti-obesity drugs may be effective against flu, hepatitis and HIV
... today in the journal Nature Biotechnology .
refers to all the reactions by which living ... that viral infection takes control of cellular metabolism
and drives, among other things, marked increases ... that if you target these increases in fatty acid metabolism
using existing anti-obesity and anti-metabolism ...
Penn researchers find a new role for a 'Foxy Old Gene'
... lab showed that FOXA2 was important for glucose metabolism
in the liver.
"Our interest in using genomics ... and the Institute for Diabetes, Obesity, and metabolism
ChIP-on-Chip assay stands for ... a cluster of genes involved in lipid and steroid metabolism
was identified by being bound to FOXA2," says ...
Same drug, different results: MUHC researcher on the path to personalized medicine
... of Methotrexate -- a drug that inhibits the metabolism
of folate -- on mice with an altered MTHFR gene, ... in the human MTHFR gene affects human folate metabolism
similarly. The results demonstrate that ... the common variant which interferes in folate metabolism
in human populations. Between 10 and 15 per cent ...
Weight Gain May Not Be Based Just on What You Eat
... the brain chemical serotonin influences fat metabolism
THURSDAY, June 5 (HealthDay News) -- ... published in the June issue of the journal Cell metabolism
Ashrafi and his colleagues noted that, while ... American Heart Association; June 2008, Cell metabolism
Hunger Hormone Makes Food Look More Tasty
... reported their findings in the May issue of Cell metabolism
The authors analyzed functional MRIs of ... of the division of endocrinology, diabetes, and metabolism
at Beth Israel Deaconess Medical Center in ... Harvard Medical School, Boston; May 2008, Cell metabolism
Hero Nutritionals Introduces a New Adult Vitamin for the Taste Buds
... all aimed at heart and
cardiovascular health with metabolism
boosts and antioxidants. The Slice of
Life family ... LDL
or "bad" cholesterol. The Omegas regulate metabolism
and help lower
cholesterol. According to the ... Finally, Energy with B12 boosts metabolism
while promoting a
healthy nervous system.
A potential sugar fix for tumors
In normal cells, growth factors regulate metabolism
and cell survival. Removing these factors leads to loss of glucose uptake and metabolism
and cell death. Cancer cells, however, maintain glucose metabolism
and resist cell death, even when deprived of ...
Fewer Steps Per Day Send Disease Markers Up
... Krogh-Madsen, from the Centre of Inflammation and metabolism
in Copenhagen. "It is of special interest that impaired metabolism
occurred without a total weight gain," she added. ... be doing, every lit bit helps in terms of keeping metabolism
healthy," she said. DeMille recommended getting a ...
Obesity chokes up the cellular power plant
... associated with pre-diabetic changes in sugar metabolism
and the action of the hormone insulin.
The ... difference in weight. The body composition and metabolism
of 14 of these pairs was carefully studied and a ... obesity and the early diabetic changes in the metabolism
of the fat twins. In the future it will be ...
University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
... enzyme that plays a crucial role in glycerol metabolism
a discovery that could lead to important ... Recent findings also have linked glycerol metabolism
to cellular processes related to aging, ... structural biology at Pitt. I think that glycerol metabolism
will be on the forefront of developing treatments ...
CSHL scientists discover new details of a gene-regulatory network governing metabolism
... Cold Spring Harbor, NY metabolism
is a central feature of life a myriad of ... cells, through the action of genes, adjust their metabolism
in response to changes in their sources of food. ... regulating-protein called Gal4p, to adapt the metabolism
of the yeast cell so that it can make use of ...
Cocaine's effects on brain metabolism may contribute to abuse
... mice, these effects on metabolism
are clearly independent of cocaine's effects on ... tomography, or PET scanning, to measure brain metabolism
in dopamine-transporter deficient mice (known as ... dopamine transporters had significantly higher metabolism
in the thalamus and cerebellum compared with ...
Research findings may lead to new ways to study and fight diabetes
... in the nucleus of cells that regulates the metabolism
of both glucose and fatty acids. The results of ... certain genes are turned on or off to control the metabolism
of fatty acids.
Hostetler and her colleagues ... link for the first time between fat and sugar metabolism
and shows they are intimately linked and share ...
Born to Be Obese?
... was published in the February issue of Cell metabolism
Sebastien Bouret, an assistant professor of ... of the Division of Endocrinology, Diabetes and metabolism
at Beth Israel Deaconess Medical Center, in ... School, both in Boston; February 2008, Cell metabolism
Bug guts map brings scientists closer to understanding different bugs' role in the body
... at a broad level, mainly concentrating on the metabolism
This is partly because it is difficult ... fully defining how different gut bugs affect the metabolism
the chemical reactions inside the body that keep ... molecular profiling of gut microbiota and host metabolism
of a large cohort of people for a reasonably long ...
Evolution of human genome's 'guardian' gives people unique protections from DNA damage
... response for certain genes involved in DNA metabolism
or repair to be mostly unique in humans. While ... and rhesus monkeys, researchers said DNA metabolism
and repair function it is not shared at all with ... of vertebrates and non-vertebrates. DNA metabolism
and repair capabilities controlled by p53 may ...
Lifestyle and cancer prevention: Making choices that change cancer risk
... to sunlight exposure, Tober said.
among African American and white smokers: Group ... we cant say from this study that differences in metabolism
definitively account for lower quit rates, it ... metabolite of nicotine a product of nicotine metabolism
and so it is a marker for exposure to tobacco, ...
Activating protein enhances average lifespan, limits age-related disease in mice
... St. Louis, Dec. 5, 2007 metabolism
researchers at Washington University School of ... and chief of the Division of Endocrinology, metabolism
and Lipid Research, had found that mice with ... in the animals by accelerating muscle metabolism
with uncoupling protein delayed death and ...
A maternal link to Alzheimer's disease
... of Sciences. It is the first to compare brain metabolism
among cognitively normal people who have a ... with an affected mother have reduced brain metabolism
in the same brain regions as Alzheimers patients. ... have significant reductions in brain energy metabolism
in certain regions of the brain. In some recent ...
Novo Nordisk Appoints Per Falk, M.D., Ph.D., as Vice President for Clinical, Medical and Regulatory Affairs for North America
... president of Clinical Development & Medical Affairs - Diabetes & metabolism
where he was responsible for clinical development and medical affairs for all of Novo Nordisk's diabetes and metabolism
products, including those in development and on the market.
"As a ...
Why anorexic patients cling to their eating disorder
... University Hospital have discovered for the first time processes in brain metabolism
that explain this disturbed eating behavior.
The research work of the ... flow in various areas of the brain. Greater blood flow indicates higher metabolism
and thus greater activity in this area of the brain.
The participants ...
Food additive may one day help control blood lipids and reduce disease risk
... Herbert S. Gasser Professor and chief of the Division of Endocrinology, metabolism
and Lipid Research. "When we gave the animals fibrate drugs that activated ... would regulate PPAR-alpha, we also knew that our ability to regulate the metabolism
of fats and sugars was in place long before humans started making drugs. ...
Survey Reveals Women Aren't Doing All They Can to Support Breast Health
... and ginkgo to support memory and concentration, One A Day Women's Active metabolism
and energy support, One A Day Women's Prenatal with DHA to support healthy ...
-Contrave(R) Obesity Research Phase 3 Program Meets Co-Primary and Key Secondary Endpoints; Exceeds FDA Efficacy Benchmark for Obesity Treatments-
... system: one associated with controlling the balance of food intake and metabolism
and another involved in controlling food preference, reward and cravings. ... weight loss over one year of treatment by reducing appetite, increasing metabolism
and allowing the body to continue losing weight by offsetting its natural ...
Ben-Gurion U. researchers identify how stressed fat tissue malfunctions
... in the Endocrine Society's the Journal of Clinical Endocrinology and metabolism
( J. Clin. Endocrinol. Metab. 2009; 94:2507-251)
"Fat tissue in ... pancreas and the brain. Normal communication is necessary for optimal metabolism
and weight regulation. However, in obesity, fat (adipose) tissue becomes ...
TGen and USC researchers find genetic markers to help fight diabetes
... found that genetic variations in the PPARG gene were associated with TZD metabolism
and the biological effects of TZD, and thereby contribute to the ... the scientists also systematically screened 28 key genes involved in TZD metabolism
or PPARG-stimulated pathways.
Of the markers examined, DiStefano and ...