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Messenger in Medical News

Five UCSF Scientists Elected to National Academy of Sciences

... which identifies and measures levels of messenger RNA -- a key step in the conversion of DNA code ... ribosome profiling, tracks the conversion of messenger RNA into protein, itself. Ribosomes are molecular machines that bind to messenger RNA and translate the RNA message into protein. ...

How cells change gears: New insights published in Nature Genetics

... or prevent "transcription"the process by which messenger RNA is generated from DNA. These messenger RNA strands then travel to cellular factories ... results, Ravasi explained. Measuring both messenger RNA and protein levels, is one example. Detection ...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

... prevent a gene's code from being translated from messenger RNA into protein. They were debuted in 1993, when ... released into the cytoplasm, microRNAs home in on messenger RNAs that share part of their genetic sequence. When they find them, they latch on, preventing the messenger RNA from being processed by the protein-making ...

UCSF team closer to creating safe embryonic-like stem cells

... prevent a gene's code from being translated from messenger RNA into protein. They were debuted in 1993, when ... released into the cytoplasm, microRNAs home in on messenger RNAs that share part of their genetic sequence. When they find them, they latch on, preventing the messenger RNA from being processed by the protein-making ...

NEC's new M155 Messenger Sets New Standards in Mobile Messaging

... ) The M155 messenger is a sophisticated wireless messaging device, ... practical and appealing The M155 messenger brings mobile messaging and ... http://www.nec-philips.com The M155 messenger provides an excellent communications device ...

Marc Feldmann and Sir Ravinder Maini win Dr. Paul Janssen Award for Biomedical Research

... rare for researchers to identify a molecular messenger in test tube studies, demonstrate its physiologic ... Maini investigated the role of cytokines, protein messenger molecules that drive inflammation, and found that ... clinical applicability of our discovery that a messenger molecule, TNF, was an effective target for ...

i'm Initiative Participants Select UNICEF as Top Charity in First Year of Microsoft's Initiative

... the top charity selected by users of Windows Live messenger which netted $255,000 for the ... organization. Twelve months ago Windows Live messenger launched the i'm Initiative in Washington D.C. as ... heartfelt thanks go out to users of Windows Live messenger for making UNICEF their Number One choice. They ...

RNA-associated introns guide nerve-cell channel production

... RNA are simply excised in the nucleus before the messenger RNA is transported to the cytoplasm and ... found that dendrites have the capacity to splice messenger RNA, a process once believed to only take place ... a guide or gatekeeper, says Eberwine. It keys the messenger RNA to the dendrite for local control of gene ...

Researchers led by Penn vet uncover the delicate protein balance behind the immune system response

... According to the researchers findings, messenger proteins Interleukin 27, or a combination of Interleukin 6 and another type of messenger molecule called transforming growth factor beta, ... These results suggest that modulating these messenger molecules could increase IL-10 concentrations ...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

... in chains of deoxyribonucleic acids (DNA), they are copied into chains of messenger ribonucleic acids (mRNA) that are "read" by cellular machines that build proteins. microRNAs bind to messenger RNAs, usually targeting them for breakdown or rendering them unfit to ...

Global Creative, Media and Technology Agency LBi Launches Cutting Edge Social Movement for the British Red Cross in Support of Refugee Week

... 'changing their online status' across all social networks, instant messenger and email during Refugee Week (15th-21st June). This is the first ... and communication platforms including: profile pictures, instant messenger avatars, Twitter hashtag set ups, a bebo skin, icons, blog badges and ...

Scientists find shared genetic link between the dental disease periodontitis and heart attack

... a protein, the two strands of DNA in the gene unravel. One strand produces messenger RNA, and will express a protein. Antisense RNA is complementary to the ... strand does not encode for a protein, but can bind specifically to the messenger RNA to form a duplex. Through this binding, the antisense strand inhibits ...

MicroRNA undermines tumor suppression

... translated into a protein. When a miRNA matches with and binds to a given messenger RNA coding for a specific protein, thereby preventing that messenger RNA from acting as a template for protein creation. To investigate ...

Master molecular switch may prevent the spread of cancer cells to distant sites in the body

... synthesis -- together in different ways so that there can be more than one messenger RNA (mRNA) produced from the same gene. These mRNAs then go on to make ... of about 15,000 different cDNAs (DNA that has been synthesized from messenger RNAs) that each express a different gene and are arrayed on plates so that ...

Scientists exploring new compounds to target muscular dystrophy

... kind of molecular stutter. These extra copies become part of large, faulty messenger RNA molecules that can mistakenly glom onto proteins and knockout their ... Earlier this decade, Thornton's team discovered that the faulty messenger RNA has a toxic effect on muscle and heart tissue. The team found that the ...

Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find

... ANN ARBOR, Mich.---Like a sentry guarding the castle walls, a molecular messenger inside adult stem cells sounds the alarm when it senses hazards that could ... centrosomes in a dividing stem cell remain perpendicular to an adjoining messenger cell called the hub. Yamashita and her colleagues found that improper ...

Monitoring whether patients take medicines can help anticipate HIV treatment failure in Africa

... America +1 415-206-3462 db@epi-center.ucsf.edu Role for vegf messenger RNA in promoting malignancy of human colon cancer cells Vascular ... of Health Bioscience, Tokushima, Japan investigated the role of vegf messenger (m)RNA in a line of cells from a colonic cancer. They showed that these ...

Researchers who helped millions with arthritis receive prestigious Janssen Award

... acute ones too. Its great to see that through targeting other cytokine messenger molecules, as well as TNF, we now have the potential to tackle even more ... epitomized. It is extremely rare for researchers to identify a molecular messenger in test tube studies, demonstrate its physiologic relevance in animals and ...

Deafness and seizures result when mysterious protein deleted in mice

... point for gaining new insight into the role of glutamate, the chemical messenger carried by the protein, says the team, led by scientists at the University ... brain. While the neurotransmitter glutamate is the major excitatory messenger in the brain, the neurotransmitter GABA is the major inhibitory messenger, ...

Memantine and Alzheimer's disease

... necessary for the communication of brain cells fail: The stimulatory brain messenger acetylcholine is down-regulated, while over-activation of the messenger glutamate leads to the death of neurones. The first-generation of ...

Small RNAs can prevent spread of breast cancer

... cancer, stress responses and viral infections. Unlike the large messenger RNA (mRNA) molecules that code for cellular proteins, the microRNAs regulate gene activity by repressing or enhancing the translation of mRNAs. messenger RNA molecules are the genetic templates for proteins. In constructing ...

Neupro(R) Filed with the FDA for the Treatment of Advanced-Stage Parkinson's Disease

... people in the United States -- suffer primarily from a lack of dopamine, a messenger substance in the central nervous system, which is responsible for the ... 24 hours-a-day. Rotigotine is a drug that mimics dopamine, a chemical messenger that transmits impulses between nerve cells in the brain to produce ...

Freshly crushed garlic better for the heart than processed

... through a chemical reaction. Although best known as the stuff that gives rotten eggs their distinctive odor, hydrogen sulfide also acts as a chemical messenger in the body, relaxing blood vessels and allowing more blood to pass through. Processed and cooked garlic, however, loses its ability to generate ...

Scientists Reverse Muscular Dystrophy in Mice

... muscular dystrophy. Several years ago, this same group of researchers showed that a genetic flaw leads to the overproduction of a certain type of messenger RNA (mRNA) in cells, which affects muscle control and other cellular functions. The original defects in the DNA translate into expanded repeats ...

LSUHSC research identifies enzyme that makes survival molecule for key vision cells

... of the Journal of Biological Chemistry . Dr. Bazan's research team previously discovered neuroprotectin D1 (NPD1), a naturally produced chemical messenger that protects cells from injury caused by free radicals and other oxidative stress. Neuroprotectin D1 is derived from the omega-3 fatty acid, DHA ...

Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure

... patients experience low blood pressure and BNP lowered it further. The Mayo investigators discovered an alternative splicing (AS) of BNP in messenger RNA (produced by the same gene). When they shortened the amino acid sequence of ASBNP for testing, they found that it had the same therapeutic ...

Researchers Suggest That Oxidative Stress is Strongly Evident in the In-Utero Environment of the Fetus With Down Syndrome

... Donna Slonim, Ph.D., Associate Professor of Computer Science at Tufts University , conducted an analysis of the human genome from cell-free fetal messenger RNA in amniotic fluid surrounding fetuses. Their team identified molecular and biochemical pathway changes that were evident in the Down syndrome ...

Old diabetes drug teaches experts new tricks

... in communication and works directly in the liver cells. "Rather than an interpreter of insulin-liver communication, metformin takes over as the messenger itself," says senior investigator Fred Wondisford, M.D., who heads the metabolism division at Hopkins Children's. "Metformin actually mimics the ...

Boost Natural Killer Cells to Prevent Swine Flu

... of Americans consume over 75 grams of high fructose corn syrup daily. Since different parts of the immune system work together, through chemical messenger systems, increasing neutrophil activity can enhance Natural Killer Cell activity. Florida Detox and Wellness Institute has perfected ...

Administrative Advantage Selects ZyDoc e-Transcription Platform for Clients

... practice, featuring a full complement of user-requested enhancements, including: Secure web-based delivery to any PC desktop via Bulletproof messenger Quicker uploading and transmission of digital handheld dictations from any location - even from home or secure hospital networks Online ...

Progress Reported Against Gene Involved in Hepatitis C

... in many people. Tai and his colleagues examined whether using small interfering RNAs (siRNAs) to block each of the approximately 21,000 predicted messenger RNA transcripts in the human genome had any effect on HCV replication. The siRNA scan identified 96 genes that appear to play a role in HCV ...

The Walter and Eliza Hall Institute Announces the Next Director

... and as a PhD student, Hilton worked at WEHI with two giants of molecular haematology, Professors Don Metcalf and Nicos Nicola, to purify and patent a messenger protein called LIF, which is used by laboratories around the world to culture mouse embryonic stem cells. After his PhD, Hilton spent two ...

Device aims to decrease wait period for patients needing immunotherapy

... in preclinical tests is taking a sample of human T cells, increasing their number through stimulation and then genetically transferring desired messenger RNA (mRNA) into the T cells. The mRNA, once inside the T cells, produces a protein called chimeric antigen receptor (CAR), which allows the T cells ...

Stem cells: Deathly awakening by interferon

... wake up stem cells from their dormancy. Andreas Trumpp and Marieke Essers from his team have now reported in Nature that interferon-alpha, a messenger substance of the immune system, acts like an alarm clock for hematopoietic stem cells. The scientists have thus shown for the first time that ...

Wyeth Pharmaceuticals and Santaris Pharma Announce Strategic Alliance to Develop RNA-based Medicines

... on Santaris Pharma's proprietary Locked Nucleic Acid (LNA) drug platform, which allows specific targeting and regulation of microRNAs (miRNAs) and messenger RNAs (mRNAs) as a means to affect gene expression mediated by the targeted RNAs. Under the terms of the agreement, Santaris Pharma will receive ...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

... are key players in determining which genes get switched on and which get turned off. RNA Polymerase II, for instance, is vital in the production of messenger RNAs that specify the amino acid sequences of each of the proteins in the cell. Despite having evolved from Pol II, Pol IV and V do not appear to be ...

Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival

... in this study, Dicer (so named because it dices up RNA) and Drosha, are involved in two types of RNA interference. These researchers measured messenger RNA (mRNA) levels of Dicer and Drosha in tissue samples from 111 patients with ovarian cancer, then correlated these findings with information on ...

Management and Network Services Completes Agreement with MultiPlan

... cost management solutions, with an estimated 40 million consumers accessing its networks. Management and Network Services, LLC is a full service, messenger model network of affiliated skilled nursing and rehabilitation providers, serving the needs of commercial insurers, self insureds, TPAs, and Federal ...

Dormant stem cells for emergencies

... group, the "active" stem cells, divide continuously about once a month. However, in an emergency such as an injury of the bone marrow or if the messenger substance G-CSF is released, the dormant cell population awakes. Once awakened, it shows the highest potential for self-renewal ever to be observed ...

Tiny sacs released by brain tumor cells carry information that may guide treatment

... first analyzed tumor cells from three glioblastomas and verified that the cells released exosomes containing RNA and protein molecules. Some messenger RNAs related to activities such as cell proliferation and migration, angiogenesis, and immune response were highly abundant in the exosomes. When ...
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