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Mammary in Medical News

Light Sciences Oncology Announces Results of Study on Immunotherapeutic Mechanism of Aptocine(TM), a Novel Light-Activated Drug Therapy for Cancer

... an aggressive, spontaneously metastasizing murine mammary tumor model that mirrors human breast cancer. When grown in the mammary fat pad of BALB/c mice, untreated 4T1 tumors ... sodium in a spontaneously metastasizing mammary tumor model. Abstract: 3052 Date: ...

Cell microenvironments hold key to future stem cell therapies

... microenvironments. "We found that adult human mammary stem and progenitor cells exhibit impressive ... combinations of components in the human mammary microenvironment that impose distinct cell fates. ... to stem cell function before. In all, adult mammary stem and progenitor cells were exposed to 8,000 ...

Dry beans inhibit development of mammary cancer

... of legume, dry beans, in reducing the risk of mammary cancer. To address whether dry bean consumption is associated with a reduction in mammary cancer, scientists at Colorado State University ... or seed coat pigments in the bean were related to mammary cancer. The study was funded by a grant from the ...

Breast cancer drug shows promise for treating, preventing progestin-dependent tumors

... and prevent emergence of progestin-accelerated mammary tumors in rats," said Salman Hyder, professor of ... to suppress growth of progestin-accelerated, mammary tumors in an animal model. When tumors reached a ... approximately 40 percent of progestin-accelerated mammary tumors. However, the drug did not induce ...

Embryonic pathway delivers stem cell traits

... precisely where researchers expect to find mammary epithelial stem cells. As he pondered these ... structures called mammospheresanother trait of mammary stem cells. Some cells in the resulting ... they could differentiate into two kinds of mammary cells. And cells in the mammospheres retained ...

Study finds that minimally invasive robotic bypass surgery provides health and economic benefits

... bypasses, surgeons can easily access two internal mammary arteries to use as the new bypass vessels rather ... traditional bypass operations, only one internal mammary artery is used while other bypasses are performed ... the target vessel, is superior with an internal mammary artery versus a vein. Dr. Poston says ...

Cancer prevention: stopping cancer before it can start

... receptor positive and estrogen receptor negative mammary tumorigenesis without hypercalcemic toxicity: ... set of studies, the researchers exposed rats to a mammary carcinogen, then injected groups of 15 animals ... control rats. Some treated rats developed small mammary tumors and some developed none at all, says Lee. ...

Georgetown researchers find stem cell marker controls 2 key cancer pathways

... breast stem cells can stimulate development of mammary cells by activating two critical cancer pathways. ... We wanted to see if it had a function in the mammary gland, Glazer says. They were especially ... experiments, the scientists found that, in mammary cell development, Msi1 ...

Findings point to molecular 'Achilles heel' for half of breast cancer tumors

... found was that they completely lacked the mammary gland tissue that normally encases breast milk ... puzzling, Frech said, because puberty-induced mammary gland development in female mice that simply lack ... of cyclin D1 would have a complete lack of mammary glands. This was striking, very unusual, she ....

Common Household Chemical Could Raise Breast Cancer Risk

... in the expression of genes present in the mammary gland," said lead researcher Dr. Jose Russo, a ... are studying the lifetime effect of BBP on the mammary gland, long before it starts developing under the ... and changes in the genetic profile of the mammary glands. While these effects wore off after ...

Household chemical may affect breast development

... has been found to affect the development of the mammary gland in rats and further studies will be ... to body weight and the genetic profile of the mammary gland. Dr Russo stated: "We are the first to ... modifications in the gene expression of the mammary tissue." Although these effects wore off once ...

JCI table of contents: Nov. 21, 2007

... of ER-alpha was observed to be lower in mammary tumors induced by aberrant expression of c-Rel than in normal mammary tissue. Further analysis determined that the ... TITLE: PKC-theta promotes c-Reldriven mammary tumorigenesis in mice and humans by repressing ...

New 'knock-out' gene model provides molecular clues to breast cancer

... insights into the role of estrogen receptor in mammary gland development may help scientists better ... Unfortunately, because these mice lacked mammary glands as a consequence of genetic manipulation, ... in different parts of the body, including the mammary gland. Research has shown that about 70 percent ...

Periodic Dieting May Cut Breast Cancer Risk

... Those on the intermittent diet fared best, with only 9 percent developing mammary tumors compared to 35 percent of those chronically restricted and 71 ... how calorie restriction provides protection against the development of mammary tumors should help us identify pathways that could be targeted for ...

Novel gene predicts local recurrence in early onset breast cancer

... present at the ends of a branching network of ducts in the normal mammary gland which also are thought to be the site of origin of many breast ... culture systems designed to reproduce the tissue architecture of the mammary gland. The first experiment tested whether placing a normal DEAR1 ...

Novel gene predicts local recurrence in early-onset breast cancer

... present at the ends of a branching network of ducts in the normal mammary gland which also are thought to be the site of origin of many breast ... culture systems designed to reproduce the tissue architecture of the mammary gland. The first experiment tested whether placing a normal DEAR1 ...

Gene helps protect tumor suppressor in breast cancer

... we sought to determine if loss of Rak expression would transform normal mammary epithelial cells," Lin said. "We injected control cells or cells in which Rak was compromised into the mammary glands of healthy mice and monitored tumor growth. Notably, all the mice ...

Closing Open Heart Surgery: Saint Joseph's Performs Georgia's First Totally-Closed, Beating Heart Bypass Surgery

... surgery and has unmatched expertise in obtaining bilateral internal mammary arteries using the robotic surgical system. "This TECAB procedure for obtaining the mammary arteries is the gold standard of treatment for patients," says Dr. ...

Solos Endoscopy, Inc.'s MammoView(TM) Featured in December Issue of Surgical Products Magazine

... that allow Physicians direct visualization, while examining lesions in the mammary ducts. The MammoView(TM) product line employs advanced ... direct observation of extremely confined sites such as the lining of the mammary ducts, with minimal or no discomfort, as stated in the article. The system ...

In flurry of studies, researcher details role of apples in inhibiting breast cancer

... reports that fresh apple extracts significantly inhibited the size of mammary tumors in rats -- and the more extracts they were given, the greater the ... main cause of death of breast-cancer patients, as well as of animals with mammary cancer -- was evident in 81 percent of tumors in the control animals. ...

Normal Cells May Predict Cancer Virulence

... performed a series of experiments in mice. First, they injected normal mammary cells that contained cancer-inducing oncogenes, which could be switched on ... injected back into a new generation of mice, they developed into normal mammary glands. "It's a beginning," Podsypanina said. "It's an important step ...

Stem Cell Marker Controls Pair of Key Cancer Pathways

... that the Musashi1 (Msi1) gene can flip open two known cancer pathways in mammary cells. The gene had been shown in previous studies to be a stem cell ... a laboratory setting, shows the Msi1 gene regulates cell signaling in two mammary cells pathways -- Wnt and Notch. Both pathways help regulate stem cell ...

MRI 'best' for looking at breast cancer and more

... Israel. Blood supply of medial tumors is mainly through the internal mammary vessels while lateral tumors may be supplied by both the internal or lateral mammary branches. MRI is currently the best modality enabling us to visualize ...

Targeting aggressive breast cancers by putting them to sleep

... of breast cancer". "By artificially activating the Id1 protein in mouse mammary glands, we demonstrated that Id1 indeed contributes to cancer - and that mammary cancers with high levels of Id1 become very aggressive and highly ...

Environmental Toxin Collects in Breast Milk

... that perchlorate limited the amount of iodide transported to a mother's mammary glands. The only source of iodide a baby typically has is mother's milk, ... on how sodium iodide carries perchlorate to, and concentrates it in, mammary glands. The next steps in this research will include animal studies ...

McGill researchers link enzyme to breast cancer malignancy

... cancers, the McGill team was able to disable the function of FAK in the mammary gland. "When we did that, we basically blocked tumour progression in our ... for tumour progression from a pre-malignant to a malignant state in the mammary tumour system." Dr. Muller and his team made a similar breakthrough ...

Mouse mammary tumor virus can replicate in human cells

... Mouse mammary tumor virus (MMTV) - which causes mammary cancer in mice - can replicate and spread in human cells, research ...

Asian spice could reduce breast cancer risk in women exposed to hormone replacement therapy

... multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands. In previous studies, MU researchers showed that progestin accelerated the development of certain tumors by increasing production of a ...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

... Ehemann V, Hermani A, Ensmann H, Mayer D (2009) Analysis of signalling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines. Endocrine-Related Cancer 16: 429-441 ...

New piece found in colorectal cancer puzzle

... the transition between severe dysplasia and colorectal cancer. According to Vogel, "It has previously been shown that overexpression of prostasin in mammary and prostate cancer cells reduces the invasive properties of cancer cells and that high prostasin expression in gastric tumours is associated with ...

Researchers identify 4 new targets for breast cancer

... strains, each strain expressing one of the receptors or autotaxin. At 24 months, none of the 44 original cancer-resistant mice developed mammary gland cancer. Only one case of inflammation and two cases of a potentially precancerous accumulation of cells known as hyperplasia were noted. ...

Researchers identify four new targets for breast cancer

... strains, each strain expressing one of the receptors or autotaxin. At 24 months, none of the 44 original cancer-resistant mice developed mammary gland cancer. Only one case of inflammation and two cases of a potentially precancerous accumulation of cells known as hyperplasia were noted. ...

A feasible, simple and convenient model for study of rectal carcinoma

... staging in imaging. Many studies have described the implantation of the VX2 cell strain into the muscle, kidney, lung, pleural, ossature, and mammary gland of rabbit in order to produce an in situ tumor model that mimics the human condition for research of possible treatments. The implantation ...

Gene alterations associated with response to anthracycline therapy for breast cancer

... in responsiveness is due to TOP2A , Kathleen I. Pritchard, M.D., of the University of Toronto, and colleagues re-analyzed data from the randomized mammary 5 trial, conducted by the National Cancer Institute of Canada Clinical Trials Group. This trial compared an anthracycline-containing regimen ...

Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS

... model, normal human breast tissue is engineered to express oncogenes and is then introduced into mice where it forms human breast tissue in the mouse mammary microenvironment. The tumors which then develop spontaneously acquire common and distinct mutations during tumor progression. This process results in ...

Solos Endoscopy, Inc.'s Breast Endoscopy System Featured in January Issue of Outpatient Surgery Magazine

... before a mammogram would, as stated in the article. Using the MammoView(TM), doctors can enter the breast through the nipple, navigate through the mammary ducts, where most breast cancers originate and develop, and use irrigation and video technology to observe any abnormalities. The procedure lasts ...

Saint Joseph's Adds Renowned Cardiothoracic Surgeon

... TECAB. He has numerous world's firsts in robotic and minimally-invasive cardiac surgery and has unmatched expertise in obtaining bilateral internal mammary arteries using the robotic surgical system. "For cardiac patients, these techniques allow multi-vessel - two and three vessels -- bypass ...

Michigan Collaboration Saves Lives, Improves Outcomes for Heart Surgery Patients

... to benefit all heart surgery patients in the state. Significant outcomes to date include: -- Increased use of the internal mammary artery (IMA) graft for coronary bypass among seven cardiac surgery programs from 82.1 percent in 2005 to 91.3 percent in 2008. The use of IMA is ...

Einstein researchers discover protein that contributes to cancer spread

... expressed in the invasive and metastatic subpopulation of tumor cells in breast tumors. The current study shows that Menainv forces tumor cells in mammary tumors of mice to become invasive and eventually metastasize to the lung. ...

Tumors grow faster without blood-supply promoting molecule

... created a strain of mice in which most inflammatory cells were missing the gene for VEGF, then cross-bred them with a strain that reliably develops mammary tumors and is commonly used to study breast cancer. "The blood vessels look more organized and less leaky in the engineered mice," said Christian ...
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