Cell division find prompts overhaul of immune response modeling
... deaths. They also recorded how this variation in lymphocyte
behaviour was transmitted through cell ...
Professor Hodgkin said it appeared that when a lymphocyte
first divided chemicals were produced that were ... accurate information on the time it takes for a lymphocyte
to divide, the time taken to die and the number ...
Dr. Wei Sun, PhD, MD Joins SpectraCell Laboratories
... well as research
experience within the areas of lymphocyte
analysis, apoptosis, and T-cell culture.
... in an MD, PhD whose primary experience is with lymphocyte
is a perfect fit for SpectraCell," ...
A new light on tumor immunotherapy for gastric cancer
... are believed to be essential for stimulating tumor-specific cytotoxic T lymphocyte
(CTL) and inducing the protective and therapeutic anti-tumor immunity.
... were analysed by morphological observation, phenotype analysis, and mixed lymphocyte
reaction (MLR). BM-DCs were pulsed with tumor cell lysate obtained by ...
Antiviral therapy helps children at risk for post-transplant lymphoproliferative disease
... normal immune response to the virus, leading in some cases to uncontrolled lymphocyte
B proliferation. Antiviral therapy is one possible way to address the ... disease (PTLD) by blocking the viral replication that can lead to lymphocyte
After a median 8 months of treatment, EBV-DNA became ...
Blood Test Shows Statistically Significant Association With Alzheimer's Disease (AD), May Predict Conversion of Mild Cognitive Impairment to AD
... of the characteristic pathologies of the disease, the amyloid plaques and tau tangles. Most importantly, the findings validate the use of our lymphocyte
test as a biomarker of Alzheimer's disease and suggest that the test is predictive of cognitive deficit developing in MCI patients."
New Report Just Published: World Multiple Myeloma Therapeutics Market Report
Targeted Therapy II-34
Gene Therapy II-34
Monoclonal Antibody Treatment II-35
Hematological Cancer Drug Classes II-35
Hypomethylating Agents & Antimetabolites II-35
Early treatment of systemic onset JIA with anakinra restores the IL-18 response
... to normal, as observed in healthy controls. During follow-up, two patients flared following anakinra treatment.
*NK cells are a type of cytotoxic lymphocyte
that constitute a major component of the innate immune system. NK cells play a major role in the rejection of tumors and cells infected by viruses. ...
USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma
... of ALL. The USC scientists identified a specific enzyme known as the RAG complex that occasionally cuts the chromosome at an off-target site, causing lymphocyte
(blood) cells to proliferate uncontrollably.
They showed that the RAG complex selects the wrong target largely because the proteins in which the ...
Immune cells ameliorate hypertension-induced cardiac damage in mice
... Researchers in Berlin, Germany have found that a specific type of immune cell, the regulatory T lymphocyte
(Treg) plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were ...
John P. Cogswell, Ph.D., receives 2009 Alzheimer Award
... fluid of late stage AD patients. Again AD-specific changes were detected although here microRNAs with known and potential combinatorial effects on T lymphocyte
signaling and inflammation pathways were identified. Because the CSF contains memory T cells and antigen presenting cells involved in ...
Recent developments at Burnham Institute for Medical Research, May 2009
... are more effective at inhibiting ITK. This work was recently published in the Journal of Bioorganic and Medicinal Chemistry Letters .
Keeping B lymphocyte
proliferation in check
In response to pathogenic challenge, B lymphocytes rapidly proliferate to generate antibody-secreting cells that can ...
Aethlon Medical Discloses New HIV/AIDS Treatment Data
... has progressed to AIDS. By the end of the Hemopurifier(R) study, CD4+ T-cell percentage of total lymphocytes increased to 18.09%. Corresponding CD4 lymphocyte
counts decreased from 215 cells/uL to 168 cells/uL. Post study follow-on testing indicated that HIV viral load was 57% lower (43,398 iu/ml) than ...
Biotech company cofounded by BIDMC scientists targets natural killer T-cells
... role of NKT cells in the regulation of many immune responses."
Although NKT cells represent approximately .01 percent of the body's total lymphocyte
population, they serve as a central regulator of the immune system, playing a critical role in health and disease, according to Balk, a member of the ...
Protein helps immune cells to divide and conquer
"Since B cells can't rapidly divide and replicate without CD98hc, perhaps by blocking this protein we could stop the unchecked growth of B lymphocyte
cells that can result in cancer or block misdirected B cell attacks that can cause certain autoimmune diseases," said Ginsberg.
The CD98hc protein ...
Genetic evidence points to potential therapeutic bypass for autoimmune process
... development in these mice, the researchers were able to induce Treg cells in external laboratory cell cultures from Carma1-deficient, peripheral T lymphocyte
white blood cells. They determined these cells could still be transformed into Treg cells by incubation with a combination of immune system molecules ...
Gene Governs Response to Leukemia Chemotherapy
It's unknown how the gene works at this point, but Downing speculated that it has to do with the gene's role in regulating the formation of lymphocyte
Diagnostic tests need to be developed before the study results -- which also need to be replicated -- can be of benefit to patients, the ...
Rockefeller University's Center for Clinical and Translational Science funds 18 new pilot studies
... student, Michel C. Nussenzweig's Laboratory of Molecular Immunology, to identify antibodies for a possible immune-based HIV vaccine, employing B cell lymphocyte
sorting and immunoglobulin cloning techniques.
Jonathan Schmitz, biomedical fellow, Vincent A. Fischetti's Laboratory of Bacterial Pathogenesis ...
What is the mechanism of the chronic radiation enteritis?
... raise the question whether the post-irradiation Th2 polarization in the intestine (both acute and delayed) may result from changes in the dynamics of lymphocyte
Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology
... Abstract 1555 TITLE: Phenotypic and Functional Effects of Novel Akt Inhibitor Perifosine on Immune System
Session Name: Lymphocytes and lymphocyte
Activation Poster I Presentation Time: 5:30 PM - 7:30 PM Location: Moscone Center, Hall A Poster Board no.: I-660 Copies of the above referenced ...
Biogen Idec's baminercept alfa shows promise in patients with rheumatoid arthritis
"Treatment of cynomolgus monkeys with Baminercept alfa (BG9924, LTR-Ig) results in modulation of a specialized vasculature implicated in lymphocyte
trafficking to areas of chronic inflammation" (Poster SAT0040 Saturday, June 14, 10:15 12:00 CEST)
"We are excited to take part in the Annual ...
Multiple Independent Studies Report on Use of Cylex's Immune Cell Function Assay in Postoperative Monitoring of Kidney, Liver, and Heart Transplant Recipients
... from Loyola University Medical Center in Maywood, IL, assesses relative values of cell-mediated immunity, white blood cell count, and lymphocyte
count in monitoring 26 heart transplant patients of whom 15 had various infections.
-- "Sirolimus (SRL) blunts mitogen response at trough (C0) ...
Florida EMS and Fire Vehicles to Stock Cyanokit(R) 5g (hydroxocobalamin for injection) ANTIDOTE ("Cyanokit") for Cyanide Poisoning
... (>5%) are transient and include
chromaturia (red-colored urine), erythema (skin redness), rash, increased
blood pressure, nausea, headache, decreased lymphocyte
injection site reactions. Usage may interfere with some clinical laboratory
If the decision is made to administer another ...
Suspected cause of type 1 diabetes caught 'red-handed' for the first time
... foreign invaders like bacteria and viruses and eliminate them, clearing infections. But when interaction between an antigen-presenting cell and a lymphocyte
leads to a part of the body being mistakenly identified as alien, the resulting attack harms the body, causing autoimmune diseases.
St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia
... altered was one called PAX5,
followed by a gene designated IKZF1. Its protein, Ikaros, is involved in
the development and differentiation of B lymphocyte
cells, which are part
of the immune system.
"The vast majority of pediatric acute lymphoblastic leukemias are of
B-cell lineage," Downing ...
St. Jude discovery offers new avenues to understanding an aggressive form of leukemia
... altered was one called PAX5, followed by a gene designated IKZF1. Its protein, Ikaros, is involved in the development and differentiation of B lymphocyte
cells, which are part of the immune system.
"The vast majority of pediatric acute lymphoblastic leukemias are of B-cell lineage," Downing said.
A new more effective tuberculosis screening test for HIV victims
... the TST whatever the stage of development of the disease. Nevertheless the ability to respond to the ELISPOT test decreases with the decrease in CD4 lymphocyte
count, which appears to indicate the limits of this type of test in severely immunosuppressed individuals, as advanced-stage HIV infected patients ...
JCI table of contents: Feb. 21, 2008
... Bethesda, have outlined an HCT approach for the treatment of metastatic kidney cancer that caused tumor regression associated with a tumor-targeted lymphocyte
response in several patients.
The authors detected tumor-targeted lymphocytes known as CD8+ T cells in the blood of patients with metastatic ...
Researchers find new way to block destructive rush of immune cells
... enable the front end to gain traction, and the tail to let go, the cell cannot migrate.
Kims team found that a subset of integrins, including lymphocyte
functionassociated antigen-1 (LFA-1), control whether or not the tail end of the T cell can let go (de- adhesion). Data revealed for the first time ...
Gentler chemotherapy before stem cell transplant causes long-term remission of follicular lymphoma
... All 47 achieved complete remission after receiving matched blood stem cells from donors. One patient relapsed at 18 months. After receiving a donor lymphocyte
infusion, the patient began a continuous complete response at 24 months. The other patient relapsed at 20 months and was found to have graft failure. ...
EpiCept Releases New Data Demonstrating Prolonged Five-Year Leukemia-Free Survival for AML Patients Treated with Ceplene(TM) + IL-2
... from the Department of Internal Medicine, University of Goteborg in
a presentation entitled, "Histamine Dihydrochloride Maintains Cytoxic
Effector T lymphocyte
Function and Viability under Conditions of Oxidative
In the study, researchers recovered autoreactive T-cells from AML
patients and ...
EpiCept Announces Presentation of New Ceplene(TM) Data at the 49th Annual Meeting of the American Society of Hematology
... Mats L. Brune, et al; University of Goteborg, Goteborg, Sweden.
Poster # 499 Title: "Histamine Dihydrochloride Maintains Cytoxic Effector lymphocyte
Function and Viability under Conditions of Oxidative Stress." Session Name: Lymphocytes, Natural Killer, and Dendritic Cells II. Presenter: Ana ...
High-fat diet makes mice susceptible to liver injury
... steatosis, and insulin resistance similar to that seen in humans. (Mice in the control group were fed a normal diet.) They examined the mices hepatic lymphocyte
population by flow cytometry. The researchers then injected the mice with liver inflammation-causing exogenous lipopolysaccarhide (LPS, a bacterial ...
A low prevalence of H pylori in HIV-positive patients
... to H pylori infection. Various opportunistic infections of Upper gastrointestinal tract is likely to occur in HIV-positive patients with a CD4 lymphocyte
counts less than 200/muL, such as CMV infection, Candida esophagitis.
Another interesting conclusion is that 84 % of HIV-positive patients ...
Treating obstructive sleep apnea, preventing heart attacks and strokes
... put forth a number of potential pathways whereby OSA could contribute to atherosclerosis progression, including inflammation, oxidative stress, lymphocyte
activation, and high-density lipoprotein dysfunction. CPAP treatment could reverse several of these pathways, they wrote.
Still, the ...
Pregnancy may slow -- not accelerate -- progression to AIDS
... between pregnancy and HAART.
Although the pregnant women in the study were younger than the non-pregnant women, had higher initial CD4+ lymphocyte
counts (white blood cells that are attacked by HIV), and a smaller amount of HIV RNA in their plasma, their risk of disease progression remained ...
JCI table of contents: Sept. 4, 2007
... small molecules for the treatment chronic inflammatory conditions such as colitis.
TITLE: Aberrant activation of integrin alpha4beta7 suppresses lymphocyte
migration to the gut
CBR Institute for Biomedical Research, Boston, Massachusetts, USA.
Phone: (617) ...
Study identifies key player in the body's immune response to chronic stress
... and begin to atrophy, said Dr. Shi.
Immune system organs include the thymus, spleen, lymph nodes and bone marrow.
By determining the role of lymphocyte
death in a stressed immune system, we may be able to develop therapies to maintain a healthy immune system, which can help in space and in clinical ...
Lymphocyte Count Found to Be a Predictor of Survival for Young Patients With Leukemia
... over the past decade has shown that the absolute lymphocyte
count (ALC), a measure of normal immune cells ... the study showed that AML patients who had a low lymphocyte
count on day 15 of treatment had a five-year ... overall survival rate while those with a low lymphocyte
count had a 55% overall survival rate. ...
A Single Biological Mechanism Behind Several Autoimmune Disorders
... between immunoglobulins and IGF-1R as a cause of inflammation and lymphocyte
infiltration in both Graves’ disease and rheumatoid arthritis.
The ... for IGF-1R as a determinant of immune responses through fibroblast and lymphocyte
activation and expansion. This further implicates IGF-1R in the ...