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Locus in Medical News

Einstein scientists propose new theory of autism

... disorder caused by impaired regulation of the locus coeruleus, a bundle of neurons in the brain stem ... that scientific evidence directly points to the locus coeruleusnoradrenergic (LC-NA) system as being ... professor of neuroscience at Einstein. The locus coeruleus has widespread connections to brain ...

New Genetic Links to Baldness Discovered

... alopecia [hair loss]. We are sure that this new locus we found is the second most important." The ... said. "Screening for the X chromosome locus and also for this new one can possibly show the ... inherited from his mother. The new gene locus is on chromosome 20. Men and women alike have two ...

Also in the Sept. 9 JNCI

... Confirmation of Association with Chromosome 15 locus and Familial Lung Cancer Two ... reported an association between the 15q24-25.1 locus and sporadic lung cancer risk. To confirm ... found a strong association between the 15q24-25.1 locus and familial lung cancer. Two SNP variants were ...

Findings on bladder-brain link may point to better treatments for problems in sleep, attention

... structures, the Barrington's nucleus and the locus ceruleus, developed abnormal activity as a result of the bladder obstruction. In particular, the locus ceruleus showed persistently high activity, and ... but added that the brain circuits involving the locus ceruleus might be a useful target for drugs to ...

Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases

... Paris, France, Friday 13 June 2008: The TRAF1/C5 locus on chromosome 9 has been revealed to play a role ... a further link was also found between the gene locus and the presence of autoantibodies (antibodies ... of our study have shown that the TRAF/1C5 gene locus may have an important role in multiple autoimmune ...

Presentations at AHA expand on clinical utility of deCODE's DNA-based tests

... Room 265-266, presentation number 4404, "Variation in the 4q25 chromosomal locus predicts new-onset atrial fibrillation after cardiac surgery." Presenter: ... presentation number 5090, "Impact of adding a single allele in the 9p21 locus to traditional risk factors on risk classification for coronary heart ...

Researchers identify new genetic marker for breast cancer

... where a gene is located, was associated with breast cancer risk. That gene locus is on the long arm of chromosome 6. These research findings are of ... of the method of genome- wide association used to discover this new locus as well as others in recent months, said Bert Gold, PhD, a Staff Scientist ...

Evidence found for genes that affect risk of developing Alzheimer's disease

... and 70 percent of AD can be attributable to APOE, and we estimate this locus of three genes on chromosome 10 could be as important, she says. The effect of the chromosome 10 locus could be due to multiple genes, with each gene having a smaller effect ...

Scientists discover genetic variant associated with prostate cancer in African Americans

... the African American men in order to replicate and further localize a risk locus for prostate cancer, says Kittles. Using this information, the ... cancer is quite powerful. We identified a novel prostate cancer risk locus that maps within a gene region on 8q24, Kittles says. This region ...

Deaths, Injuries Increase With Higher Speed Limits

... States. The largest increase -- 9.1 percent -- was on rural interstates, followed by urban interstates at 4 percent. "These roads were the main locus of raised speed limits," they noted. Some states had imposed a 65 mph limit. Others went to 70, and still others, 75. The solution, said ...

Gum Disease, Heart Disease Share Genetic Link

... hadn't been confirmed. The University of Kiel team found that the two diseases share a genetic variant on chromosome 9. "We studied a genetic locus on chromosome 9p21.3 that had previously been identified to be associated with myocardial infarction [heart attack], in a group of 151 patients ...

Scientists find shared genetic link between the dental disease periodontitis and heart attack

... said that his team had discovered a genetic variant situated on chromosome 9 which was shared between the two diseases. "We studied a genetic locus on chromosome 9p21.3 that had previously been identified to be associated with myocardial infarction, in a group of 151 patients suffering from the ...

New study evaluates community response to personally controlled health information

... associated with sharing health information A need for help understanding technical or clinical issues Concerns about quality, accuracy and locus of responsibility for maintaining records Uncertainty about appropriate and safe read/edit access policies Consumer demands of the technology ...

Study IDs Variations in Black, White Genomes

... which in turn could result in neurological disease. It is also interesting to find out whether the type of mental retardation associated with this locus is more common in whites than in Africans or African-Americans. If this is true, then it might be one of the first reported diseases with differing ...

Brain Adapts to Age-Related Eye Disease

... in the United States. Patients often compensate for lack of central vision by rolling their eyes upward so they can utilize the preferred retinal locus (PRL), an undamaged area under and adjacent to the affected part of the retina. "Macular degeneration is a great opportunity to learn more about ...

Researchers identify novel genetic markers linked to increased risk of heart attack

... Thus the scientists were able to identify another region, this time localized on chromosome 6, which is associated with MI risk. The LPA gene at this locus regulates the concentration of a specific lipoprotein (Lp(a)), a particle which transports lipids in the blood. This finding, too, may be useful in ...

Also in the Oct. 28 JNCI

... risk. Several genes reside in that chromosomal region, including two that encode subunits of the nicotine receptor. It has not been clear whether the locus increases the risk of lung cancer by increasing the risk of smoking or if it has a direct impact on lung carcinogenesis or if it affects both causal ...

Also in the May 27 JNCI

... Gordon Peters, Ph.D., of Cancer Research UK London Research Institute provides a broad review of mouse and human data regarding the complex p16/ARF locus and melanoma. Although there are more data pointing to p16s role in melanoma, Peters concludes that researchers should not ignore ARFs possible ...

Genetic loci assigned for musical aptitude in Finnish families

... genes affecting cell extension and migration during neural development. Interestingly, an overlapping region previously associated with genetic locus for dyslexia was found raising a question about common evolutionary background of music and language faculties. The results show that musical ...

Genetic variations raise lung cancer risk for smokers and ex-smokers

... population studied. The paper is one of three published by Nature this week from three unique teams that have identified the same genetic locus as associated with increased lung cancer risk. The findings are a major step forward in identifying those at high risk for non-small cell lung cancer ...

To bet or not to bet: How the brain learns to estimate risk

... risk predictions. The finding was particularly interesting, notes lead author and EPFL professor Peter Bossaerts, because the anterior insula is the locus of where we integrate and process emotions. "This represents an important advance in our understanding of the neurological underpinnings of risk, ...

Scientists identify brain abnormalities underlying key element of borderline personality disorder

... time, the research team observed heightened levels of activation during the tests in other areas of the patients' brains, including the amygdala, a locus for emotions such as anger and fear, and some of the brain's other limbic regions, which are linked to emotional processing. "In the frontal ...

Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations

... License with University of Pittsburgh Brings Additional Key Gene locus as a Development Opportunity for Recently-Funded Company NEW HAVEN, Conn., Oct. 23 /PRNewswire/ -- Optherion, Inc., a company developing ...

Obesity Rate in U.S. Still Climbing

... in 19 states, up from 14 states last year and 9 in 2005. In 1991, no state had an adult obesity rate exceeding 20 percent. The South is a locus of the problem, possessing 10 of the 15 states with the highest rates of adult obesity. In addition, the South also had eight of the 10 states with ...

Alcohol Dehydrogenase Gene may Protect from Developing Alcoholism

... at two loci, ADH1B and ADH1C.// The three alleles at the ADH1B locus have previously been linked with protection from alcohol dependence, a new ... and drug-use history. Each participant was genotyped at the ADH1B locus through a blood sample, and also provided a number of other health ...

Identifying bacteria made amiable

... of comparative gene sequences that are held on databases such as the Multi locus Sequence Typing, there is a potential for fast, cheap bacteria strain ... used for fingerprinting such as Pulse Field Gel Electrophoresis or Multi locus Enzyme Electrophoresis have problems with replication between ....

Childhood Abuse Increases the Risk of Alcoholism

... the interaction between MAOA and childhood trauma. They note that previous research showed that people with the low activity variant at the MAOA-LPR locus have hyperactivation of the hippocampus when retrieving negative emotional information. ...

Black and White in ‘Shades of Grey

... result in a condition called Albinism . Neuromelanin is a dark pigment present in the neurons of the brain nuclei such as the Substantia Nigra, locus Ceruleus, the nucleus associated with the Vagus nerve and the Raphe nucleus of the Pons Medulla. The neuromelanins are usually not found at birth, ...

Proteins in lungs of patients with cystic fibrosis

... agents, Bingle said. The human genome project localized the PLUNC (palate, lung and nasal epithelium clone) gene to chromosome 20. A genetic locus in this region directs the production of a family of at least 10 proteins. Some of the proteins are short, referred to as "SPLUNCs," while others are ...

Researchers Uncover Gene That Raises Risk for Type 1 Diabetes

... genes in the HLA region of chromosome 6. This research indicates an unexpected genetic determination of type 1 diabetes with a major unknown genetic locus and suggests that future research should concentrate on defining the additional genes in the HLA region that cause diabetes.” The research also ...

Research Reveal A New Angle On Neural Circuits.

... revision of thinking about how experience works on our brains," noted Turrigiano. "Instead of targeting exclusively excitatory networks, a major locus of plasticity lies within the inhibitory networks. Our data show that inhibitory networks within the cortex are highly plastic, and that some ...

Rural Poor are Better off Than Slum Dwellers: UN Report

... and Bangladesh, are as badly off as, if not worse off than, their rural relatives, says a new UN-HABITAT report released Saturday //. As the locus of poverty shifts from rural areas to urban centres, UN-HABITAT's "State of the World's Cities" report provides concrete data to reveal that the ...

WHO Rules Out Human Transmission Of Bird Flu In 4 Cases

... been only 225 human cases, 128 of them fatal, since the current outbreak started in South East Asia in December 2003. Indonesia is currently a locus of the disease with 49 cases, second only to Vietnam with 93 cases. (Source:PTI ...

Genes Affect Drinking Behavior Of Smokers

... to those which had already been identified by previous studies. The alcohol-use phenotypes are affected by two loci on chromosome four and one locus on chromosome two, which precede alcoholism. As many as 200 genes are involved in chromosome four, some of which play a role in alcohol metabolism. ...

Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis

... transgene in various strains of inbred mice and through quantitative trait genetic mapping showed the presence of a putative metastasis efficiency locus on mouse chromosome 19. This chromosome region, which is orthologous to human 11q12-13, harbors a known metastasis suppressor gene Brms1. However, ...
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