Weizmann Institute scientists' new technique gets to the root of cancer
... a cell's path of descent, called a cell lineage
tree, is shared by many branches of biology and ...
Therefore, by reconstructing a cancer cell lineage
tree and performing an analysis of mutations ... a subset of cells characterized by distinct lineage
features (e.g. greater depth)?'
So far, their ...
Microenvironment a main driver of aggressive multi-lineage leukemia disease type
... aggressive group of blood cancers known as mixed lineage
leukemias (MLL) and how the disease might be ... chronic myelogenous leukemia (CML).
leukemia (MLL) results when chromosome mutations ... adaptability of the leukemia stem cell in mixed lineage
"Our findings underscored that ...
Globetrotting black rat genes reveal spread of humans and diseases
... the Mekong Delta, and Indonesia.
The Indian lineage
spread to the Middle-East around 20,000 years ... during the Age of Exploration.
The East Asian lineage
moved from Taiwan to Japan, the Philippines, and ... a good match between the historic spread of each lineage
and ancient routes of human migration and trade, ...
JCI online early table of contents: Jan. 2, 2008
... not just in bone cells of the osteoblast lineage
and there are conflicting reports as to whether defects in cells other than osteoblast lineage
cells are involved in the disease that manifests ... that mutation of Phex only in osteoblast lineage
cells recapitulates the disease observed in ...
New genetic lineage of Ebola virus discovered in great apes
... and 2001, appear to belong to a single genetic lineage
originating from the first epidemic documented in ... the seven primates belonged to a new genetic lineage
of ZEBOV. This lineage, named B, showed 2 to 3% genetic divergence from lineage
A, the one in which scientists had hitherto ...
Bcl6 gene sculpts helper T cell to boost antibody production
... the molecular programming of Tfh establishes it as the fifth distinct lineage
of helper T cell.
Dong and colleagues will continue to characterize Tfh ... Th17 cell, which he and colleagues identified as the third T helper cell lineage
when conventional wisdom held that there were only two such lines. They ...
Scientists Identify Key Gene That Protects Against Leukemia
... HSCs are proliferating and the rate of differentiation toward the myeloid lineage
that ultimately results in leukemia. The striking analogy inspired the ... JunB-deficient mice consistently displayed higher levels of myeloid lineage
than the control group, indicating constant regeneration of a ...
Course of West Nile Infection Charted
... case study also highlights that this strain of the virus, West Nile virus lineage
2, which is endemic to Southern Africa, may cause severe disease and ... Venter added. "This contradicts the general belief that West Nile Virus lineage
2 only causes mild disease but rather suggests that it may be an ...
Genome sequence of lancelet shows how genes quadrupled during vertebrate evolution
... a tunicate, was previously thought to belong to the the earliest chordate lineage
because of the sea squirt's very simple body plan. Comparison of the lancelet, sea squirt and human genomes, however, show instead that the lancelet lineage
diverged before the tunicates and vertebrates.
"Sea squirts and their ...
Children's Hospital scientists identify possible target for prevention and treatment of pneumonia
... IL-22 and interleukin 17A (IL-17A) are produced by a recently discovered lineage
of cells known as T Helper Type 17 (Th17). Childrens researchers found evidence that the Th17 cell lineage
and its cytokines IL-22 and IL-17A have evolved to promote host defense ...
Cat's Genome Map Purrfected
... for human disease.
A four-year-old Abyssinian cat named Cinnamon, whose lineage
can be traced back several generations to Sweden, was the subject of the ... of with are similar to genetic problems in humans. For example, Cinnamon's lineage
carries a genetic mutation that causes a degenerative eye disease called ...
Established Medical Sub-Component Manufacturer Achieves ISO 13485 Certification
... of digital consumers we provide the right optical fiber, optical cable and components for efficient, cost-effective transmission. OFS' corporate lineage
dates back to 1876 and included technology powerhouses such as AT&T and Lucent Technologies (now Alcatel-Lucent). Today, OFS is owned by Furukawa ...
Ancient fossils shed light on anatomical changes accompanying evolution of first land vertebrates
... discovered that not all bones changed size at the same rate or in the same direction. This phenomenon can result in an overall reshaping from one lineage
to the next, explained Sidlauskas. "Sometimes a change in size can have indirect consequences for the shape of the animal," said Sidlauskas. "When ...
AGA Institute presents cutting-edge research during DDW
... (9:05 a.m.)
The Basic Science Plenary session presentations (Monday, June 1, 8 - 10 a.m. CDT, Room S406A) include:
ADAM10 is Required for Cell lineage
Specification of the Intestinal Epithelium. K. L. VanDussen et al. (8:05 a.m.)
Genetic ablation of the Notch signaling promotes TGF-β-induced ...
Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors
... stem cells.
"Our study results suggest that co-transplanting BMSCs induce undifferentiated embryonic stem cells to differentiate into a neuronal lineage
by neurotrophic factor production, resulting in suppression of tumor formation in SCI model mice," said corresponding author Dr. Masahide Yoshikawa ...
Scientists Still Baffled About Origins of Swine Flu
... are similar to what had already been seen in the Americas circulating in pigs that we knew about. The acquisition of two new genes from the Eurasian lineage
has never been seen in the U.S."
Pigs are sometimes imported to Europe and Asia from the Americas for breeding purposes, but not the other way ...
K-State Researcher Finds That the 1918 Spanish Flu Virus Can Infect Swine and Resulted in Current Lineage of H1N1 Swine Influenza Viruses
... in swine and cause mild respiratory disease. The 1918 virus spread through the pig population, adapted to the swine and resulted in the current lineage
of the H1N1 swine influenza viruses. The researchers' study is published in the May 2009 Journal of Virology.
"This study emphasizes that an ...
MRSA study suggests strategy shift needed to develop effective therapeutics
... Otto, Ph.D., directed the study, which involved analyzing DNA sequences of the major epidemic forms of S. aureus. The research team found that the lineage
of the bacteria fell into three distinct families: (1) USA300 and its forefather, USA500, which are epidemic in U.S. hospital and community settings; ...
Double Your Income With Thai Yoga Bodywork?
... as a long time Krishna devotee, Mukti
effectively illuminates how the sacred art of Nuad Borarn, more commonly known
as Thai Massage, is a direct lineage
in the sacred yogic arts being practiced
by millions. With tens of thousands of students around the globe, a successful
accredited school, and a ...
MMI Investments, L.P. Calls on Chemed Board to Pursue a Tax-Free Spin-Off of One of Its Two Businesses
... strategic alternatives and fair market valuations. Logic clearly dictates that Roto-Rooter and Vitas do not belong together, and but for Chemed's lineage
as a diversified conglomerate, they would already be separate entities. We believe this combination creates no synergy and is inhibiting value ...
Leukemia stem cells have more in common with embryonic stem cells than adult stem cells
... the number of LSCs, and a poor prognosis in leukemia.
"Importantly, the shared transcriptional features of LSCs, ESCs, normal mid-myeloid lineage
cells, and a diverse set of poor-prognosis human malignancies support the broader conclusion that cancer stem cells may be aberrantly self-renewing ...
Penn researchers unlock molecular origin of blood stem cells
... generate new blood cells for therapy.
"The ultimate goal for stem cell therapies is to take embryonic stem cells and push them down a particular lineage
to replace diseased or dead cells in human adults or children," says Speck. For instance, in theory embryonic stem cells could be tweaked in a lab to ...
Children of Centenarians Face Lower Heart Risks
... highlight the cardiovascular leg up children of centenarians appear to inherit from their parents.
But, Adams added, while good genetic lineage
may portend a longer life, it doesn't guarantee protection against all diseases.
"You might expect that centenarian offspring would do better as ...
JCI online early table of contents: Nov. 6, 2008
... of esophageal cancer.
TITLE: A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage
Anil K. Rustgi
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-0154; Fax: (215) ...
Renowned Kyudo (Zen archery) Master Kanjuro Shibata Sensei to Present in L.A.
The Los Angeles Shambhala Meditation Center offers practice and study
in the lineage
of Shambhala Buddhism. It is part of Shambhala
International, an international community of urban meditation and rural
retreat centers founded by the ...
Making 'good' fat from muscle and vice versa
... biology of fat cells at the University of Stockholm, said that the two reports "take us a step closer to the ultimate goal of promoting the brown fat lineage
as a potential way of counteracting obesity."
The Spiegelman group has long studied fat cells both as a model for normal and abnormal cell ...
Woman aquires new accent after stroke
... Svigny, associate professor of cognitive science in the Department of Communication Studies & Multimedia at McMaster University. "Her family lineage
is Irish and Danish, and neither of her parents ever lived anywhere but in southern Ontario."
Karin Humphreys, the principal investigator in the ...
Cells on path to becoming mature T-cells more flexible than commonly thought
... for better understanding how T-cell leukemias and other disorders arise.
It is critically important to understand the life history of the T-cell lineage
and to define the steps that multipotent progenitor cells take to mature to T cells, says lead author Jeremiah Bell, PhD, Postdoctoral Fellow in the ...
An unexpected way to cause leukemia
... EMBLs Mouse Biology Unit now prove that a mutation in a protein called C/EBPa causes acute myeloid leukaemia (AML), a type of leukaemia affecting one lineage
of white blood cells, in mice.
10 percent of all patients suffering from AML have this mutation, but we could never be sure if it causes the ...
Fossils Push Back Bipedalism to 6 Million Years Ago
... that this very early member of the hominin family tree was bipedal, anthropologists say.
"Upright walking is one of the very first traits in our lineage
to occur. So this finding reinforces that and pushes the date back even farther," said study co-author Brian Richmond, associate professor of ...
Study uncovers cause of flu epidemics
... hybrid H1N2 viruses.
If we really want effective vaccines each year, our surveillance has to be much broader than simply looking at one lineage
and its evolution, and trying to figure out how it is going to evolve by mutation, said Nelson. You have to look at a much bigger picture.
MedImmune Prepared to Support Implementation of Expanded ACIP Recommendations for Influenza Vaccinations
... respectively). The mismatched strains that circulated during the studied season were A/California-like (H3N2), B/Florida and B/Victoria lineage
strains. MedImmune strongly supports the CDC's efforts to encourage vaccination
against influenza throughout the season even if there is evidence ...
Domestic cat genome sequenced
... comparative analysis of the domestic cat genome ( Felis catus ).
The DNA of a 4-year-old Abyssinian cat named Cinnamon, whose well-documented lineage
can be traced back several generations to Sweden, has been sequenced. Cinnamon is one of several mammals that are currently being analyzed using ...
The genetics of MLL leukemogenesis
... colleagues identify the gene Meis1 as a critical player in the establishment of leukemia stem cells, and the development of MLL leukemia.
leukemia (MLL) is a distinctive type of leukemia distinguished from the more prevalent acute lymphoblastic leukemia (ALL) by the presence of a break ...
Study reveals how stem cells decide to become either skeletal or smooth muscle
... have been studying the somite, a group of cells in the human fetus known to develop into skeletal muscle. The team in Southwestern did cell lineage
and tracking studies and found that myocardin is expressed briefly in the somite during development in mice, but then disappears from that region of ...
Unique role for blood formation gene identified
... the September issue of Cell Stem Cell.
The investigators created a mouse model to track the function of a gene called MLL, which stands for Mixed lineage
Leukemia. The gene acts in bone marrow stem cells and controls key aspects of their growth to generate all the mature blood cells. If disrupted, it ...
Nobel Prize for Medicine
... publication from 1976, Sulston described the cell lineage
fro a part of the developing nervous system. He sowed that the cell lineage
is invariant, i.e. every nematode underwent ... seminal discovery that specific cells in the cell lineage
always die through programmed cell death and that ...
Evolution of HIV from African Greek Monkeys
... immunodeficiency virus, or SIV, first infected those monkeys after the lineage
split into four species. The new research reveals the split happened about ... scientists thought SIV infected an ancestor of green monkeys before the lineage
split, much longer ago.
"Studying SIV helps us learn more about ...
Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
... can be unfolded through this discovery related to the culture, customs, lineage
or gene-pool, birth, death, disease, health, food habits and even the ... like health, stature, disease, age and cause of mortality, gene pool, lineage
or race apart from the additional cultural activities like the mortuary ...