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Knockout in Medical News

Persistent bacterial infection exploits killing machinery of immune cells

... the arginase gene in their macrophages (arginase knockout mice). After infecting the arginase knockout mice with the TB bacteria, they observed that the ... lungs. The researchers then infected arginase knockout mice with an intracellular parasite that causes ...

St. Jude finds 'dancing' hair cells are key to humans' acute hearing

... a malfunction of somatic motility. While the knockout experiments were strong evidence for the role of ... same kinds of hearing deficiency as the previous knockout mice, Zuo said. Therefore, we believe that these ... criticism of our earlier experiments with the knockout mice. The new experiments, Zuo said, thus firmly ...

Cocaine's effects on brain metabolism may contribute to abuse

... to chronically high levels of dopamine in the DAT knockout mice. It also suggests that dopamine levels may ... and motor function. Interestingly, DAT knockout mice have been suggested as an animal model for ... in metabolism in the thalamus region in the DAT knockout mice. This effect may likely be due to the effect ...

Possible safer target for anti-clotting drugs found

... platelet aggregation was restored. When calpain-1 knockout mice and mice lacking PTP1B were crossed to ... finding, the fact that the calpain-1 knockout mice have elevated PTP1B levels may prove ... in diabetes and obesity. "Our calpain-1 knockout mice with their elevated PTP1B levels offer a ...

Mouse model for mesothelioma reproduces human disease

... imaging, closely resembled human MM. Interestingly, Nf2;Ink4a/Arf knockout mice had a more invasive cancer when compared with Nf2;p53 knockout mice. The researchers went on to show that the loss of Ink4a makes a ...

Fragile X Syndrome Corrected in Mice

... paper that demonstrates a remarkable rescue of fragile X features when the knockout mouse is crossed with a mGluR5-deficient mouse," said Dr. Randi Hagerman, ... good evidence for this treatment in the trial of mGluR5 antagonists in the knockout mouse [lacking FMRP] and other animal models of fragile X, this genetic ...

Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis

... glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 Second Quarter Financial Results

... diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to ...

Gene's novel role may provide key to treating liver and neurodegenerative diseases

... human immune system responsible for fighting viruses and other pathogens that invade the body, the two scientists began developing the first in vivo knockout mouse model to closely examine FAIM's role in preventing programmed cell death. BTI Executive Director Miranda Yap, Ph.D., said, "The Immunology ...

AGA Institute presents cutting-edge research during DDW

... at the Epithelial Cell Interface. D. Polk (8:39 a.m.) Changes in Mucosal Homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 knockout Mice. D. Laubitz et al. (9:04 a.m.) Colitis-associated variant of TLR2 causes impaired mucosal repair due to TFF3 deficiency. A. Eyking et al. (9:21 ...

President Obama's New Knockout Mother's Day Message from Champ

... President Obama in his brand new inspirational diabetic diet cookbook. "Take a moment to grieve," Douglas said, in "Buster's Backyard Bar-B-Q knockout Diabetes Diet," available now on Amazon.com in both paperback and Kindle versions in time to order for Mother's Day, Sunday, May 10, 2009. Free ...

VARI researcher chosen for highly competitive Scholar-in-Training Award

... in cancer research and reaches an audience of thousands of the world's top scientists." Chen's research, entitled Proximal tubule-specific knockout of BHD in mouse kidney causes multicystic kidney disease and renal cancer pertains to a cancer called Birt-Hogg-Dub ( BHD) syndrome that affects the ...

U of I study shows benefits of hormone found in fat tissue

... he said. "And, when we gave non-obese mice leptin injections, they recovered three times faster. Leptin did not hasten recovery though in IL-1RA knockout mice," Sherry said. That earlier work was published in a recent issue of Brain, Behavior, and Immunity . In the Endocrinology study, one group ...

Pacquiao Hosts Post-Christmas/Post-Birthday Victory Celebration

... his claim to being the best boxer in the world today, pound-for-pound, after he capped his grand slam and record-breaking year with a technical knockout win over the legendary Oscar Dela Hoya. Pacquiao also won the 130-pound World Boxing Council title and the 135-pound WBC version, on his way to ...

Scientists exploring new compounds to target muscular dystrophy

... a kind of molecular stutter. These extra copies become part of large, faulty messenger RNA molecules that can mistakenly glom onto proteins and knockout their normal function. Earlier this decade, Thornton's team discovered that the faulty messenger RNA has a toxic effect on muscle and heart ....

Glutamate: Too much of a good thing in schizophrenia?

... with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: "The NMDA receptor antagonist model and the EAAT1 knockout animal push us to take a fresh look at the obstacles to treating cognitive impairments associated with schizophrenia, in other words, optimizing ...

Fall Into a New Routine with LISTERINE(R) WHITENING(R) VIBRANT WHITE(TM) Pre-Brush Rinse and LISTERINE(R) WHITENING(R) Pen

... any Daily Routine MORRIS PLAINS, N.J., Sept. 18 /PRNewswire/ -- "Dancing with the Stars" Judge Carrie Ann Inaba knows what it takes to develop a knockout dance routine and now she is using her expertise to show people how they can optimize their everyday routines to achieve a whiter smile. Carrie Ann ...

Stem cell regeneration repairs congenital heart defect

... patients with heritable dilated cardiomyopathy. Researchers transplanted 200,000 embryonic stem cells into the wall of the left ventricle of the knockout mice. After one month the treatment improved heart performance, synchronized electrical impulses and stopped heart deterioration, ultimately saving ...

Innate immune system targets asthma-linked fungus for destruction

... mucosa and enhances inflammation. The next step in our transdisciplinary research collaboration will be to use recombinant fungal proteins and fungal knockout mutants for specific genes to dissect the different molecular steps involved in the development and progression of this acute immune response." ...

Study provides clues to preventing and treating cancer spread

... the cell receptor CCR5 get fewer cancer metastases than normal mice. CCR5 helps control the migration of cells through the body. He injected these knockout mice with all types of cells from normal mice, to try to make the mice form more metastases of melanoma (skin cancer). The only cells that did it ...

Sound Pharmaceuticals Receives Additional DoD Funding for Its Hearing Regeneration Product

... For this reason, sensorineural hearing loss is irreversible and often progressive. Once auditory hair cells are lost they are never replaced. In p27 knockout mice, auditory hair cell regeneration occurs due to the unique ability of supporting cells to re-enter the cell cycle, proliferate and regenerate in ...

Study raises questions about prostate cancer therapies targeting IGF-1

... targeting IGF1 signaling. To test their reasoning they conducted a second experiment by crossing mice carrying the prostate-specific IGF-1R knockout alleles with transgenic mice that develop spontaneous prostate cancer when p53 and select other genes are compromised. The results were as predicted: ...

Dr. Mei honored by mental health research charity for schizophrenia studies

... an animal model that also expresses high levels of type I neuregulin. Most studies, including his, use models in which the genes are knocked out. knockout models do not mimic what is going on in the patient, says Dr. Mei. A recent $514,000, three-year grant from the National Institute of Mental Health ...

Dealing Cervical Cancer a Knockout Blow

... cancer continues to decline by almost 4 percent a year, thanks to the Pap test. But doctors now believe they are poised to deal cervical cancer a knockout blow, thanks to the HPV vaccine. In the nearly two years that have followed its approval, Gardasil has been added to the U.S. Centers for Disease ...

Brain scientist shedding light on learning, memory

... should have transmitted our genes to offspring, he says. Dr. Tsien and his colleagues made Doogie by over-expressing the NR2B gene and a conditional knockout by eliminating another NMDA receptor subunit. Doogie was better at remembering and putting things in context, able to quickly recognize something ...

Signaling protein helps limit damage in heart attack, Jefferson scientists show

... think that we can now begin to test the role of Gi in cardiac injury. In the work, Dr. Kochs group developed a transgenic mouse with a functional knockout of the Gi gene, meaning that it lacked a working gene. The scientists then simulated a heart attack, catheterization and reperfusion by tieing off a ...

Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinson's disease

... the JNK target protect dopaminergic neurons in both acute and chronic models of Parkinsons disease. Previous research has also shown that the JNK2/3 knockout mouse modelsmice that lack the gene for JNK2/3suffer fewer Parkinsons-like symptoms. The scientists hope to identify approximately three compounds ...

Protein deficiency leads to faster fat burning in mice, study shows

... deficiency leads to a lean animal. The next question is why, Mehta said. In order to answer why, we need to know which genes are changed in these knockout animals. The most prominent effect the scientists have been able to identify so far relates to the mitochondria, the principal energy source of ...

Genetic research unveils common origins for distinct clinical diagnoses

... fish. The researchers reasoned that if MKS and BBS are indeed the same condition, then fish with the MKS genes knocked out should mimic the BBS knockout fish. They did. The team then went on to test mutant versions of MKS genes in BBS fish and found that three genes originally attributed to MKS do ...

VBI, Mayo Clinic investigate link between fungal proteins, innate immunity and asthma

... the different molecular steps involved in the development and progression of inflammation and asthma. He added: We will create a series of fungal knockout mutants for specific genes that will be used to examine the specific role of fungal proteins in the activation of the innate immune system response. ...

High zinc status in lung cells slows growth and induces DNA damage-induced gene expression

... to induce G2/M cell cycle arrest. The importance of Gadd45 in G2/M regulation was further supported by findings of the inability of cells from Gadd45 knockout mice to arrest at the G2/M phase after exposure to UV radiation. In addition, a functional association between stress-activated mitogen-activated ...

2-way cell talk provides clues about neuromuscular disease

... may be missing and motor neurons are not happy. To find out what that signal is, his lab is comparing genetic expression in the beta-catenin knockout mouse to that of a normal mouse to see which genes are up- or down-regulated. Those genes may be targeted by beta-catenin and may serve as this ...

Genetic difference predicts antidepressant response

... to be drawn is that any drug administered to treat CNS diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical point of view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases ...

Genetics May Determine Antidepressants' Effectiveness

... administered to treat CNS (central nervous system) diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical point of view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases ...

A tricky tumor virus

... cells. One of these signal proteins is the factor TRADD. TRADD stands for TNF-receptor 1-associated death domain protein. The scientists used TRADD knockout cell lines which they had established by removing the TRADD gene from the genome of human B-cells in order to demonstrate that TRADD is an essential ...

Other highlights in the Jan. 8 JNCI

... with BHD carry mutations in the BHD tumor suppressor gene. Masaya Baba, M.D., Ph.D., of the National Cancer Institute in Frederick, Md., used a knockout mouse model to examine the role of the BHD gene in kidney function and tumor development. The mice without the BHD gene had enlarged kidneys ...

Receptor protein appears to be key in breakdown of kidney filtration

... the receptors presence is required for the breakdown of podocyte structure. After the gene encoding uPAR was introduced into podocytes of the knockout mice, they began expressing the receptor within 24 hours and became susceptible to the proteinuria-inducing treatment. The researchers then showed ...

Molecular pathway appears crucial in development of pulmonary fibrosis

... This pathway appears to be involved in several steps in the development of fibrosis, including the leaking of blood vessels, which is why the LPA1 knockout mice are so dramatically protected. If were right, then targeting this pathway should be a very exciting new therapeutic strategy for IPF. Luster ...

Scripps research scientists discover chemical triggers for aggression in mice

... to lack the VNO did not have aggression responses, suggesting this organ plays a key role, but other researchers had made similar findings with knockout mice lacking the MOE. To further explore this aspect of signal processing, the Stowers team used an assay of their own design that allows the ...

Genes identified that protect against heart damage from chemotherapy

... says Dr. Flores-Rozas, noting that its dose related and cumulative. They did studies in relatively simple yeast cells from Dr. Anil Cashikars yeast knockout collection. Yeast, which have about 6,000 genes compared to humans 30,000, are good models for study of human cells because they include the same ...
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(Date:4/23/2014)... School of Public Health-Bloomington has bolstered the link between ... strong association between heme iron, found only in meat, ... found that heme iron consumption increased the risk for ... was found between nonheme iron, which is in plant ... The study was published online ahead of print in ...
(Date:4/23/2014)... in their mid-thirties and forties, face a devastating ... two decades. "Mutant" protein clusters, long blamed for ... the primary focus of therapies in development by ... Prof. Gerardo Lederkremer and Dr. Julia Leitman of ... Immunology, in collaboration with Prof. Ulrich Hartl of ...
(Date:4/23/2014)... Scarborough research shows that male black widow spiders prefer ... rare example of mate preference by male spiders. ... MacLeod and Maydianne Andrade, a professor in UTSC,s Department ... and the wild that males overwhelmingly chose to mate ... widows can tell whether a potential mate is well-fed ...
Breaking Biology News(10 mins):Study: Iron consumption can increase risk for heart disease 2On the defensive 2On the defensive 3Picky male black widow spiders prefer well-fed virgins 2
(Date:4/23/2014)... April 23, 2014Men whose testosterone falls below normal levels ... be overweight and have heart disease and type 2 ... testosterone-deficient men for further testing and possible treatment is ... Health , a peer-reviewed publication from Mary Ann Liebert, ... Journal of Men,s Health website at ...
(Date:4/23/2014)... As evidence mounts showing the potential health benefits of ... people are taking supplements. And the chemical industry is ... supplements, health effects could deter growth, so the industry ... claims, according to the cover story in Chemical ... of the American Chemical Society. , Melody M. Bomgardner, ...
(Date:4/23/2014)... from the Cancer Science Institute of Singapore (CSI Singapore) ... cancer specific stem cell which causes gastric cancer. This ... for the treatment of this disease and other types ... Chan Shing Leng, Research Assistant Professor at CSI Singapore, ... of a cell surface protein, CD44v8-10, marks gastric cancer ...
(Date:4/23/2014)... Ritalin, may prevent the depletion of self-control, according to ... of the Association for Psychological Science. , Self-control can ... to focus attention on a boring textbook are hard ... for this difficulty: Exerting self-control for a long period ... on subsequent tasks. , "It is as if self-control ...
(Date:4/22/2014)... Government and industry leaders visited the New Jersey ... President Joel S. Bloom for the launch of ... corporation that provides a new model for business ... higher education assets and investment. U.S. Senator Cory ... CEO Joe Taylor, New Jersey Lieutenant Governor Kim ...
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