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Knock in Medical News

Nanomedical approach targets multiple cancer genes, shrinks tumors more effectively

... affect a bunch of proteins, we are able to knock out single genes." The Penn State researchers ... RNA" (siRNA) -- strands of RNA molecules that knock out specific genes -- could turn off the two ... when either gene was targeted alone. "If you knock down each of these two genes separately, you are ...

The vulnerable cancer cell

... but they contribute to abnormal cell growth and cancer. By using RNAi to knock down the expression of individual genes in cells bearing mutations in an ... -- single strands of RNA that fold back on themselves -- to selectively knock down the activity of serine/threonine kinases and tyrosine kinases. In ...

The National Kidney Foundation's 6th Annual Kidney Walk to Be Held on Saturday, October 13

... National Kidney Foundation is working to combat this problem with their knock Out Kidney Disease (KOKD) program, in which over 1,100 Washington area ... leading causes, diabetes and hypertension, are important elements of the knock Out Kidney Disease program. Equally important is educating about the dire ...

Muscle patterns in women may be linked to at risk positioning for ACL tears

... position is referred to as knee valgus, and increased knee valgus (more knock kneed) has been shown to be linked to ACL injury risk, said ... Injury Prevention Center. Think of a person who jumps and lands with knock knees (knees turned in) as opposed to a person who lands with minimal or ...

JCI table of contents: Sept. 4, 2007

... EDITOR'S PICK: It's a knock out: eIF4E-specific antisense oligonucleotides knock down cancer A new study by Jeremy Graff and colleagues from Eli ...

Photos: Don't Let Them See You Sweat This Summer

... deeply and focusing internally. Avoid sweat-inducing spicy foods and caffeinated beverages to help stay cool in the warmer weather. knock out body odor: Excessive underarm sweating can contribute to odors as the sweat dries and activates bacteria on your skin. Neutralize odors by ...

Multimedia Release: British Men Think Talking About Impotence is "Just Not Cricket"

... Phil Tufnell says, "I'm looking forward to sharing some top cricket stats with blokes this summer but before the Ashes gets underway, I want to knock about some facts on impotence: you're not alone if you experience it. In fact, if a large Test ground, such as Lord's, was full of men aged 40 and ...

Taking Aim at Relapse of Leukemia in Kids

... cells to infiltrate the brain and spinal cord. "What we have found is that leukemic cells over-express this receptor," Aifantis said. "If you knock out this receptor, these cells will not go to the brain under any circumstances." The researchers also found that a protein called CCL21 acts as a ...

Genes May Raise Risk of Neuroblastoma in Kids

... recurs, it is seldom treatable, experts say, because it invades the brain and spinal cord. In a study on mice, the researchers found that "if you knock out this receptor, these cells will not go to the brain under any circumstances," study senior author Ioannis Aifantis, co-director of the Cancer ...

Mentors Who Support Students Receive TCWF Champions of Health Professions Diversity Award

... from pursuing careers in the health professions or never find out that it is an option," Camacho said. "Sometimes we listen to people who try to knock us down. I have learned that anything is possible if you focus on your goals and dreams." Shirley Flores-Munoz Dr. Shirley Flores-Munoz ...

World first: Chinese scientists create pig stem cells

... Alternatively, because the swine flu virus needs to bind with a receptor on the cell membrane of the pig to enter the cells and proliferate, we could knock out this receptor in the pig via gene targeting in the pig induced pluripotent stem cell. If the receptor is missing, the virus will not infect the ...

Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer

... of the receptor, while neratinib blocks the intracellular portion. Researchers think that the combination may provide the one-two punch necessary to knock out the tumor cells. Forty-five women with trastuzumab-resistant breast cancer enrolled in the trial. In the phase I portion of the trial, women ...

Eye Protection is Essential for Texas Athletes

... the eye by a teammate, Stephen ended up with a large laceration on his left eyelid and a close encounter with permanent eye damage. "After the knock to my eye, all I could see was a black haze," Stephen recalls. "I was rushed to the emergency room in the middle of the game, where I was told that I ...

Eye Protection is Essential for Oklahoma Athletes

... the eye by a teammate, Stephen ended up with a large laceration on his left eyelid and a close encounter with permanent eye damage. "After the knock to my eye, all I could see was a black haze," Stephen recalls. "I was rushed to the emergency room in the middle of the game, where I was told that I ...

Biological FM signal maintains inflammation in cancer, asthma and other diseases

... to treat disease? "The results of our work simultaneously aid and challenge drug designers; it will not simply be a matter of using a drug to knock down one key biological player in an inflammatory disease. This research tells us that cells in inflammatory tissues may use very precise timing to ...

Long-Term Mesothelioma Patient and Caregiver Couple Honored as 'Volunteer of the Year'

... medical treatments, Shelly devoted herself to the desperate need for research funding to develop new, more effective treatments. She began to knock on her legislators' doors, urging the federal government to meet its responsibility toward the tragedy of asbestos cancer and partner in the effort ...

Glass tables: An overlooked safety threat

... standards apply to glass tables, neither patio nor indoor furniture. Injuries are typically caused when children jump, sit or fall on glass tables or knock them over. The shattered glass or jagged edges of broken tables - can cause severe lacerations, leaving disfiguring scars and damaging tendons and ...

Limited resources, unlimited needs: Americans should ration health care, says MSU ethicist

... Fleck cites several examples of the health care paradox in America: Cancer treatment: Many lower-cost cancer treatments can successfully knock back the disease for years, though many patients cannot afford them. At the same time, Fleck said, there are advanced cancer therapies costing as ...

Thinking Man's Chimp Shows 1st Animal 'Planning'

... in the center of the exhibit's island. He was observed knocking on the rocks, apparently until he heard a hollow sound, then striking harder blows to knock off pieces. Zoo employees -- referred to as "informants" for the purposes of the study -- recalled removing hundreds of ammunition caches over the ...

SEIU Impersonates Nurses in Hostile Takeover Campaign Against California Nurses Association/NNOC

... into the banquet room. Some staffers, wearing purple bandanas over their faces to hide their identities, proceeded to punch, shove, kick, and knock union members to the floor who were in their way. In a subsequent website debate about the actions, Regan proudly defended his role and ...

Stanford study prevents pancreatic tumor growth in mice by inhibiting key protein

... the protein inhibits the tumor's ability to grow," said cancer biologist Amato Giaccia, PhD. "Ultimately, we'd like to be able to specifically knock out the expression of this protein in pancreatic tumors in humans." Pancreatic cancer is a highly aggressive and deadly disease that accounts for ...

St. Jude finds more than 100 gene variations linked with response to leukemia treatment

... this gene may be a marker we could use to predict outcome of therapy," Relling said. "IL15 might also represent a new target for novel drugs that knock out its activity and improve the outcome of patients with high levels of this interleukin." In addition, 21 of the 102 SNPs that predicted MRD ...

Turning back the Clock in Inherited Anemias

... Medical School and chair of pediatric oncology at Dana-Farber. "It's pretty clear that this gene is a silencer of fetal hemoglobin. If you could knock it down to a low level, you could turn on fetal hemoglobin." "The discovery of a single gene that profoundly affects fetal hemoglobin ...

'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis

... St. Louis Rams and the Pittsburgh Steelers. However, despite his NFL success, the disease that he calls his "toughest linebacker" still managed to knock him down occasionally. In 1997, while playing with the Steelers, he had a severe asthma attack during a nationally televised game. "Up until ...

Despite Credit Crunch, Medisave Sees Strong Sales Increase in 2008

... customers who are used to paying a premium for rapid shipping service or delivery guarantees. Wright said, "Changing purchasing habits has a knock on effect if customer expectations remain the same. If the parcel arrives later due to their selected cheaper delivery option and their perception of ...

America's Worst Restaurants for Kids Revealed

... or taco platters, which can easily top 1,000 calories. Don't think you'll escape by ordering up a salad, either -- even a leafy bowl at Chipotle can knock out more than half a day's worth of calories. Your Survival Strategy: Stick to the crispy tacos or burrito bowls, or saw a burrito in thirds. F ...

Cancer research highlights

... day of chemotherapy. Treating leukemia primarily involves killing the cancerous cells where they originate in the bone marrow. Chemotherapy can knock out bone marrow cells, but it also kills healthy cells, causing such side effects as immunodeficiency and weight loss. Doctors traditionally take a ...

Home in Prominent Shelter Island, New York, Ablaze; Saved by the FIT-5 Fire Fighting Device

... ARA Safety is a world leader in innovative fire and life safety technology. ARA Safety's revolutionary Fire Interruption Technology (FIT) fire knock down tool is saving lives and reducing property loss in cities and towns across North America. ARA Safety's fire and life safety technologies also ...

Novel enzyme inhibitor paves way for new cancer drug

... types are associated with cancer, others are not. The trick to building inhibitors with low side effects and toxicity is to create inhibitors that knock out the troublesome isoforms without disrupting the other types, Marmorstein says ...

Arsenic-based therapy shown to help eradicate leukemia-initiating cells

... leaving behind the dormant LICs. But in determining that PML serves to guard the LICs that have been left behind, we also discovered that if we knock out PML [through pharmacologic means], the LICs will lose their braking abilities and run out of gas, thereby commiting the fatal error of ...

Unexpected role: EGFR protects cancer cells from starving

... interfere with intracellular glucose remains to be seen, but it's a terrific target to shoot for." The team concludes that it may be necessary to knock down both EGFR's glucose-related role and its growth-inducing kinase activity in order to attack cancers of the epithelium - tissue that lines the ...

Secrets of cellular signaling shed light on new cancer stem cell therapies

... followed by chemotherapy. The intent is to use the Notch inhibitor to make cancer stem cells sensitive to the chemotherapy---a one-two punch to knock out tumors. If the treatment is effective, the results could help sway some cancer-stem-cell skeptics. The Notch pathway sends signals from a ...

Angina drug potentially useful against heart rhythm disorders

... which makes the heart more susceptible to fatal arrhythmias. The condition may go unnoticed until sports, strong emotions or even loud noises knock the heart out of rhythm, causing loss of pulse and consciousness (syncope). Sudden death will then occur if the heart is not restarted with a ...

Gene 'knockout' floors tobacco carcinogen

... professor of crop science, and Dr. Ramsey Lewis, assistant professor of crop science, teamed with colleagues from the University of Kentucky to knock out a gene known to turn nicotine into nornicotine. Nornicotine is a precursor to the carcinogen N-nitrosonornicotine (NNN). Varying percentages of ...

Stopping a receptor called 'nogo' boosts the synapses

... also explain something that has puzzled scientists, said Giger. Mice with damaged spinal cords that have been treated with compounds designed to knock out the nogo receptor seem to improve a bit, even though scientists have never been able to demonstrate nerve regrowth in those mice. It may be that ...

Stroke Risk Factors Drain Memory

... a lot of other people think is happening, is that people develop small strokes that are not significantly big enough to disable you, but cumulatively knock your [mental] condition down," Howard said. Mini-strokes are not that uncommon, he said. Starting at age 55, about 10 percent of people who report ...

Microbial 'cheaters' help scientists ID 'social' genes

... investigation took five years and required the detailed study of some 10,000 randomly mutated strains of D. discoideum. "The basic idea was to knock out genes at random and put each mutant through 10 rounds germination, growth and development to identify mutations that led to cheating," Strassmann ...

Newborn brain cells modulate learning and memory

... tool to track the contribution of newborn neurons to normal brain function a question Gage is particularly interested in. In the past, methods to knock out neurogenesis, such as radiation and mitotic inhibitors that block all cell division have been rather crude, he says. So, maybe not surprisingly ...

American Tailgaters Association, ESPN's Sean Salisbury and George Foreman Unite in the Fight Against Pediatric Cancers Around Super Bowl XLII

... disease that is cancer, and has vowed to do his part to lessen the burden on those suffering from cancers terrible "blow." About the George Foreman knock Out Pediatric Cancer Initiative Founded by boxing heavyweight great George Foreman, KnockOutPediatricCancer seeks to raise funds to benefit The ...

Newly discovered virus linked to deadly skin cancer

... of a much larger picture. Now we need to find out how it works, she said. Once the virus integrates, it could express an oncoprotein, or it could knock out a gene that suppresses tumor growth. Either way, the results are bound to be interesting. This is the second tumor-associated virus discovered ...
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(Date:7/8/2015)... , July 8, 2015 Summary Pancreatic ... the fourth most fatal, with a mortality rate of ... prognosis of pancreatic cancer patients has highlighted a significant ... is not being met by the current market. ... of products with varying molecule types and mechanisms of ...
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