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Kinase in Medical News

EntreMed Reports Second Quarter 2009 Financial Results

... is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of ... inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... (NTU). "BIBW 2992 is an irreversible tyrosine kinase inhibitor(1) whose clinical benefit we are hoping ... signal transduction inhibition and cell-cycle kinase inhibition. BIBW 2992 entered Phase IIb/III ... NSCLC, is ongoing. In the area of cell-cycle kinase inhibition, Boehringer Ingelheim is developing ...

Sunesis Pharmaceuticals Receives Milestone Payment From Biogen Idec

... Idec (Nasdaq: BIIB ) for the selection of a Raf kinase inhibitor development candidate for the treatment ... IND-enabling GLP preclinical work with the Raf kinase development candidate. "While our internal ... being made by Biogen Idec to advance a Raf kinase inhibitor toward the clinic," said Daniel ...

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

... Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds ... has multiple protein functions other than the kinase activity. A Japanese research group, led by Dr ... gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic ...

The vulnerable cancer cell

... promising drug targets: serine/threonine kinase 33 (STK33) and polo-like kinase 1 (PLK-1), as well as a host of other proteins. ... is that cancers bearing oncogenic mutations in a kinase are dependent on ...

Cylene to Announce New Data on Its First-in-Class Oral CK2 Inhibitor Against Cancer at BIO Conference

... of CX-4945, the Company's oral protein kinase inhibitor currently in Phase I clinical trials. ... a potent and selective oral inhibitor of protein kinase CK2, a previously unexploited molecular target ... therapeutic potential. Cylene's Serine/Threonine kinase Inhibitor program has also delivered orally ...

NCCN Updates Kidney Cancer Guidelines to Incorporate FDA Approval of Everolimus

... whose disease has progressed after treatment with kinase inhibitors. This recommendation comes on the ... whose disease has progressed after treatment with kinase inhibitors such as sunitinib (Sutent(R), ... cell carcinoma following failure of tyrosine kinase therapy. Everolimus targets a protein known ...

NCCN Presents Updates to NCCN Guidelines for Thyroid Carcinoma

... the expanded recommendation of small molecule kinase inhibitors, and revised procedures for evaluating ... consider commercially available, small molecule kinase inhibitors such as sorafenib (Nexavar(R), Bayer) ... clinical trials have shown that small molecule kinase inhibitors such as sorafenib and sunitinib can be ...

SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results

... with oral MP-470, a multi-targeted tyrosine kinase inhibitor, in combination with standard of care ... vivo activity of SGI-1776, an orally active PIM kinase inhibitor. Abstract 426: Effects of ... 480: MP-470, a novel multi-targeted tyrosine kinase inhibitor targeting Rad51 is not toxic to human ...

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1

... connection between two important protein kinase signaling pathways that are associated with ... for multiple types of cancer. The protein kinase LKB1 is a known tumor suppressor and the ... and survival. Mutations in the RAF kinase B-RAF have been found in many types of human ...

E. coli persists against antibiotics through HipA-induced dormancy

... atomic level, confirming that HipA is a protein kinase - an enzyme that works by transferring phosphate ... target molecules. HipA is a type of protein kinase that is uncommon in bacteria, said lead author ... at their serine or threonine amino acids. This kinase activity is more commonly associated with ...

S*BIO Announces Collaboration with Onyx for JAK2 Inhibitors in the North American and European Markets

... SB1518 is a small molecule JAK2-selective kinase inhibitor which has high potency against both the wild type JAK2 kinase and the JAK2 kinase with the V617F mutation. The V617F mutation is ...

New insight into aggressive childhood cancer

... lacking amplified MYCN. AURKA encodes the kinase Aurora A which is dysregulated in multiple types of cancer cells. Interestingly, Aurora A kinase activity was not required for N-Myc ... that small molecule inhibitors of Aurora A kinase may not be effective at inhibiting the oncogenic ...

EntreMed Focuses on Development of ENMD-2076

... candidate, ENMD-2076, an Aurora/angiogenesis kinase inhibitor, as part of the Company's overall plan ... ) ENMD-2076 is a unique small molecule kinase inhibitor which, in preclinical studies, has ... primarily ENMD-2076, a selective angiogenic kinase inhibitor, for the treatment of cancer. ...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

... therapy with lapatinib, a small-molecule tyrosine kinase inhibitor, and the aromatase inhibitor letrozole ... inhibitor of the HER2/ErbB2 tyrosine kinase receptor. Stimulation of HER2/ErbB2 is associated ... the Estrogen Receptor and the HER Tyrosine kinase Receptor Family: Molecular Mechanism and Clinical ...

Foundation Venture Capital Group Invests in Company Working to Protect Healthy Tissue During Cancer Treatment

... Inc., a company involved in developing kinase inhibitors that may keep normal cells healthy ... Longevica scientists discovered that if the EF2 kinase (a protein involved in the regulation of protein ... Group. "A breakthrough in the use of this kinase could positively affect millions of people ...

EntreMed Reports Clinical Program Progress and Company Update

... as the Company seeks partners for its ENMD-2076 kinase inhibitor and rheumatoid arthritis programs ... discussions for its Aurora/angiogenesis kinase inhibitor, ENMD-2076, and for Panzem(R) in ... for cancer. ENMD-2076, a selective angiogenic kinase inhibitor, and ENMD-1198, a novel antimitotic ...

EntreMed Teams with JSB-Partners to Expedite Partnering of its Aurora Kinase Program

... activities for its lead Aurora A/angiogenesis kinase inhibitor, ENMD-2076. (Logo: ... ENMD-2076 is a novel, orally-active, selective kinase inhibitor with potent activity against Aurora A ... PDGFR), and antiproliferative (Flt-3, Src, c-Kit) kinase inhibition. ENMD-2076 has demonstrated ...

Researchers unveil vital key to cancer

... the structure is critical for the design of new kinase inhibitors as therapeutic agents, an area of ... to the pharmaceutical industry. Over 100 kinase inhibitors are currently in clinical trials, and the revolutionary kinase inhibitor Glivec was approved for treating ...

Activation of LYN kinase is associated with imatinib-resistance in CML patients

... Activation of LYN kinase is associated with resistance to imatinib ... of overexpression and gene silencing of LYN kinase in CML cell lines treated with imatinib. They ... found that overexpression and activation of LYN kinase was associated with imatinib resistance in both ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... HEr2, etc.) 13 agents targeting the Aurora kinase family 11 histone deacetylase inhibitors (HDAC) ... (AFP) receptor (RECAF); Akt; anaplastic lymphoma kinase (ALK); androgen receptor (Ar); angiopoietin-1; ... sulfate proteoglycan 4 (CSPG4); C-Jun N-terminal kinase (JNK); c- Myb; c-Myc; colony stimulating factor 1 ...

Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy

... Bcr/Abl. Such agents include MK-0457, a Bcr/Abl kinase inhibitor that also targets another protein called an aurora kinase. Aurora kinase plays an important role in mitosis and cell ... as well as enhanced disruption of aurora kinase and mitosis. In addition, the group demonstrated ...

Novel enzyme inhibitor paves way for new cancer drug

... and his colleagues set out to create a lipid kinase inhibitor using a metal complex in its structure. ... ligands, or chemical building blocks, to increase kinase selectivity, he says. Working with Eric ... inhibit PI3K, the scientists identified a protein kinase inhibitor known as DW2. The scientists then ...

ACT Biotech Acquires Clinical and Early Stage Oncology Portfolio Licenses From Bayer Healthcare

... has acquired an anti-angiogenic receptor tyrosine kinase inhibitor entering Phase II clinical studies for ... in this agreement is a first-in-class multi-mode kinase inhibitor in late preclinical stage with ... has obtained a collection of novel small molecule kinase inhibitors, which have the potential to become an ...

EGFR protects cancer cells from starvation via a kinase-independent mechanism

... clinical trials aimed solely at interfering with kinase activity and suggests new directions for ... that most of EGFRs functions were mediated by its kinase activity, and several compounds that specifically inhibit the kinase activity of the EGFR were developed with the aim ...

Unexpected role: EGFR protects cancer cells from starving

... activation by growth factors - its tyrosine kinase activity -- have gotten response rates in 10 ... that the receptor is active independent of its kinase activity," Fidler said. "Up until now everyone - ... normal cells, Fidler said. "Inhibiting the kinase activity of the receptor does not interfere with ...

Mutation database helps personalized treatment of lung cancer

... known to affect treatment with the newer tyrosine kinase inhibitor class of drugs. "We have known for ... mutations correlate with response to tyrosine kinase inhibitors for lung cancer patients," says Dr. ... non-small-cell lung cancers treated with tyrosine kinase inhibitors (TKIs) would help clinicians determine ...

Study helps explain fundamental process of tumor growth

... growth, and identifies the M2 form of pyruvate kinase (PKM2), an enzyme involved in sugar metabolism, ... that in contrast to the forms of pyruvate kinase found in most normal adult tissues, only PKM2, ... had shown that this M2 form was the pyruvate kinase form used by all cancer cells. In order to ...

Early Phase II results show bosutinib safe, effective for CML

... very little toxicity compared to other tyrosine kinase inhibitors at this stage of the clinical trial," ... Philadelphia Chromosome. Bcr-Abl is a tyrosine kinase that fuels an overabundance of white blood cells ... and nilotinib (Tasigna(r)), is a tyrosine kinase inhibitor. The researchers also found that ...

Eliminating Influence of Hyperactive Genes That Help Regulate Cell Development Shows Potential as Additional Target Therapy for Chronic Myelogenous Leukemia

... for about 25 percent of patients) and tyrosine kinase inhibitors. These inhibitors are designed to block the tyrosine kinase enzyme's ability to stimulate cellular pathways ... to this therapy suggest that inhibiting this kinase activity alone is not sufficient to eliminate all ...

Targets on the horizon: Emerging therapies and novel targets

... of potent small molecule inhibitors of protein kinase D: Abstract A 237. A team of researchers from ... CRT0059359, a small molecule inhibitor of protein kinase D (PKD), a key part of a chemical signaling ... We think this is the first viable protein kinase D inhibitor that has come to light and our ...

Combination targets: some drugs may work best when they work together

... strategies to enhance responses induced by EGFR kinase inhibitors in mutant EGFR-dependent lung ... lung cancer patients treated with the tyrosine kinase inhibitor (TKI), erlotinib, by combining it with ... from lung cancer patients harbor mutations in the kinase domain of the epidermal growth factor receptor ...

Clinical studies in the pipeline: the therapies of tomorrow in trials today

... Dr. Zhu says. Sunitinib is a receptor tyrosine kinase inhibitor designed to target and block VEGFR2 ... Dr. Thompson says. Sorafenib, a tyrosine kinase inhibitor approved for use in December 2005 under ... characterization of OSI-906: A novel IGF-1R kinase inhibitor in clinical trials: Number C192 ...

Novel strategy under study for aggressive leukemia

... heat shock protein 90 inhibitors. It uses protein kinase inhibitors to reduce the function of any ... standard therapies have failed. Several FLT-3 kinase inhibitors are under study for a variety of ... lab was the first to show the mutant protein kinase is particularly susceptible to depletion by ...

UCSD study reveals the regulatory mechanism of key enzyme

... the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role ... design drugs that specifically block the protein kinase activity involved in cancer or cardiac disease. ... that serves as a prototype for the entire protein kinase family. This family of enzymes has more than 500 ...

UCSD study reveals the regulatory mechanism of key enzyme

... the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role ... design drugs that specifically block the protein kinase activity involved in cancer or cardiac disease. ... that serves as a prototype for the entire protein kinase family. This family of enzymes has more than 500 ...

Study suggests brain tumors need treatment with multiple 'targeted' drugs

... fresh specimens of brain tumors, three or more kinase inhibitors were needed to quell the abnormal ... Perhaps the problem was that other kinase pathways were also sending abnormal growth ... samples from newly diagnosed patients. The kinase inhibitor imatinib (Gleevec) had little effect on ...

Emory researchers identify signaling protein for multiple myeloma

... that causes over-expression of a tyrosine kinase called fibroblast growth factor receptor 3 ... malignant cells. We identified Ribosomal S6 kinase 2 (RSK2), which is a protein factor that mediates ... the oncogenic FGFR3 and its downstream protein kinase RSK2, which plays a critical role in regulation ...

Study finds heart failure is rare among leukemia patients on imatinib

... in cells. The drug also blocks a hybrid tyrosine kinase known to cause CML and Philadelphia-positive ALL. ... says research continues to address how tyrosine kinase inhibition might affect cardiovascular risk. "We ... earlier to increase the success of tyrosine kinase inhibitors in CML patients," Durand says. ...

A new molecular zip code, and a new drug target for Huntington's disease

... it cannot kill a brain cell. This means that a kinase inhibitor drug may be effective for Huntington's disease. kinase inhibitors form the largest number of successful ... support in hand at McMaster to quickly hunt this kinase down, and find potential new drugs for ...
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